Toader Zaharie - Academia.edu (original) (raw)
Papers by Toader Zaharie
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
The authors have studied 12 cases of bone giant cell tumors and have shown that the increase in a... more The authors have studied 12 cases of bone giant cell tumors and have shown that the increase in aggressiveness is accompanied by higher values of mitotic activity and nuclear features (area, perimeter, long and short axes), which might be useful for grading the bone giant cell tumors.
Journal of Gastrointestinal and Liver Diseases
Background and Aims: The aim of this study is to determine whether activated hepatic stellate cel... more Background and Aims: The aim of this study is to determine whether activated hepatic stellate cells (HSCs) may represent a prognostic marker of progressive liver fibrosis in chronic viral hepatitis C (VHC) before antiviral therapy. The possible correlation between HSCs immunohistochemical features, histopathological aspects and clinical data before therapy were also studied. Methods: This retrospective pilot study was conducted on 27 liver biopsies from VHC patients before antiviral therapy. HSCs’s immunohistochemical analysis used the antibodies alpha-smooth muscle actin (α-SMA), glial fibrillary acidic protein (GFAP) and vinculin. We correlated immunopositive HSCs with HCV load, liver stiffness (LS), fibrosis stage and necro-inflammatory degree before treatment. Also, we assessed the association between liver fibrosis after therapy, the sustained virological response at 12 weeks after therapy (SVR 12) and the type of therapy. Results: HSCs were increased in VHC patients compared t...
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
The study of nuclear parameters (long and short nuclear axes, nuclear axes ratio, nuclear area) r... more The study of nuclear parameters (long and short nuclear axes, nuclear axes ratio, nuclear area) revealed differences both between the primary breast tumors and their lymph node metastases and between the lymph nodes isolated from the same axilla. The results are discussed in terms of tumor progression.
Pediatric Research, 2011
Introduction: The plasmatic level of EPO (erythropoietin) is high in the umbilical cord when oxyg... more Introduction: The plasmatic level of EPO (erythropoietin) is high in the umbilical cord when oxygen supply is affected. Aim: This study aimed to present the level of plasmatic EPO at birth as well as early complications occurred in newborns with Intrauterine Growth Restriction (IUGR). Material and methods: A prospective study was done on 33 newborns in Neonatology Department ,Cluj, Romania between January 2008-2009(case group) and 32 healthy newborns(control group). The plasmatic level of EPO was determined with Elisa technique. The following parameters were assessing for both groups: Apgar score, Astrup parameters, post asphyxia syndrome and the perinatal pathology. Epi Info 6 was used for statistical analysis. Results: The study group had the weight of 1747.57±728.31 g, ponderal index of 1.91±0.37 and gestational age of 33.45±4.29 weeks. The EPO values were significant higher 56.49±7.80mUI/ml in the study group versus control group 42.45±17.53mUI/ml (p= 0.0001).The EPO was significantly higher also for those who developed meconium aspiration syndrome (76.72±1199mUI/ml) compared to those who developed NTT (neonatal transient tachypnea)-23.60±0.28mUI/ml (p=0.004); and it was higher in those who needed inotrop support-111.05±49.14mUI/ml compare with hemodynamic stable newborns-46.52±52.11mUI/ml (p=0.017). There could not be identified any significant differences between the EPO values of those who developed other complications (hypoxic-ischemic encephalopathy, infection or cerebral hemorrhage) (p=0.398). Conclusions: The plasmatic level of the EPO was significantly high in newborn who developed a severe respiratory pathology and were hemodynamic unstable. There could not be identify any link between plasmatic level of EPO and HIE, sepsis, or cerebral hemorrhage.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2019
We present the case of a 51-year-old male admitted for asthenia, fatigability, nausea, inappetenc... more We present the case of a 51-year-old male admitted for asthenia, fatigability, nausea, inappetence, weight loss, watery diarrhea, lower limb paresthesia and diagnosed after further investigations with Whipple's disease (WD). The evolution was favorable under antibiotic therapy but after a period of time the patient was no longer compliant to the treatment and psychotic manifestations, general status alteration and finally the decease occurred. WD is a condition caused by Tropheryma whipplei (TW) bacterium in people with altered macrophage degrading capacity and it is lethal without early treatment.
Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
This is a retrospective study of 3069 newborns admitted to the Neonatology Department of the 1st ... more This is a retrospective study of 3069 newborns admitted to the Neonatology Department of the 1st Obstetrics and Gynaecology Clinic of Cluj-Napoca, Romania. We considered 38 newborns with the diagnosis of neonatal asphyxia. The neuroimaging performed was transphontanellar ultrasonography, CT-scan, MRI, depending on case. Post asphyxic syndrome evaluation, complete neurological examination, EEG and neuroimaging were performed. The incidence of neonatal asphyxia was 1.15%. Neurological signs were present in 63.15% of the cases. Neurological aspects of newborns were present in different grades of hypoxic-ischaemic encephalopathy. EEG signs were present in 33.3% preterm newborns and 50% newborns at term. Transphontanellar ultrasonography showed different grades of intraventricular hemorrhage, periventricular leukomalacia in 35%. CT-scan was performed in 3 cases. MRI evaluation was performed in 8 cases and showed different types of cerebral ischaemia and cerebral atrophy. Neuroimaging is ...
Archives of Disease in Childhood, 2014
Zeitschrift für Gastroenterologie, 2014
UNLABELLED Strategies in ventilation and in exposure to the oxygen that minimise lung injury impr... more UNLABELLED Strategies in ventilation and in exposure to the oxygen that minimise lung injury improved the prognosis of the extremely low weight newborns. Avoiding intubation can prevent the reduction of mucociliary flow, injury of the mucosa and infection. Using early CPAP isn't unanimous; there are differences between studies in what are concerned: the beginning of the treatment, gestational age, methods. CPAP is used in the treatment of respiratory arrest of infants since 1971, initially endotracheal, than with different nasal instruments. The studies evaluate the benefits of prophylactic or curative CPAP. OBJECTIVES To compare the necessity for mechanical ventilation and surfactant administration, complications and the period of hospitalisation in VLBW and ELBW, that were under prophylactic or curative CPAP. MATERIAL AND METHOD We made a prospective study on 90 newborns, during january 2004 and june 2006, that were not intubated in the delivery room with no major malformation...
Gastroenterología y Hepatología
Ultrasound in Medicine & Biology
Annali italiani di chirurgia, Jan 13, 2017
Endometriosis is a disease represented by the presence of extra uterine endometrial tissue. It is... more Endometriosis is a disease represented by the presence of extra uterine endometrial tissue. It is a rare condition, and malignant transformation is seldom. We report a case with clear cell adenocarcinoma oncogenesis on abdominal wall scar that appeared after years of a caesarian section. After diagnosis, surgical treatment was performed twice, due to the fact that the margins were infiltrated with tumor cells, with replacement of the defect with a polypropylene mesh. The patient was cured and discharged with a favorable prognostic. To the best of our knowledge, there are few reported cases of clear cell adenocarcinoma arising from abdominal wall endometriosis. It is a rare condition that appears mostly after abdominal surgical interventions that clinicians must be aware. Abdominal wall, Endometriosis, Cesarean section, Clear cell adenocarcinoma, Malignant transformation.
Medical Ultrasonography, Jun 1, 2012
The aim of this study was to evaluate the added value of contrast-enhanced ultrasound (CEUS) in t... more The aim of this study was to evaluate the added value of contrast-enhanced ultrasound (CEUS) in the pancreatic cystic mass (PCM) diagnosis by using a qualitative and quantitative analysis in order to make a relevant characterization. Between December 2008 and November 2011, 37 patients with PCM discovered at ultrasound examination were prospectively followed. A qualitative and quantitative CEUS analysis was performed in order to differentiate etiologies of the PCM. In the quantitative analysis several parameters were followed: Peak Intensity (PI), Time to Peak (TTP), maximum ascending gradient (GRAD), Time to maximum gradient (TTG) and Area Under the Curve (AUC). Normalized ratios were also calculated. In all patients a definite cytological or histological diagnosis was obtained. Thirty-seven patients were studied: 12 with pancreatitis-associated pseudocyst and 25 with cystic tumors (10 serous cystic adenoma, 5 mucinous cystic adenoma, 6 cystadenocarcinomas, 2 solid pseudopapillary tumors and 2 intraductal papillary mucinous neoplasms). There was a significant difference of the nAUC and nTTP between pseudocyst and cystic tumors, p=0.03 and p=0.01, respectively. A normalized TTP value above 7 sec was suggestive for the diagnosis of pseudocysts with 79.16 % accuracy. There was a significant difference of nTTP and nTTG between the benign and malignant lesions. nTTP < 9 sec and nTTG < 8.5 sec rules out malignant cysts in almost 90% of cases. The CEUS is useful in the diagnosis of PCM. The quantitative analysis of the enhancement of the cystic wall may discriminate the different types of the PCM.
Pneumologia, 2008
Strategies in ventilation and in exposure to the oxygen that minimise lung injury improved the pr... more Strategies in ventilation and in exposure to the oxygen that minimise lung injury improved the prognosis of the extremely low weight newborns. Avoiding intubation can prevent the reduction of mucociliary flow, injury of the mucosa and infection. Using early CPAP isn't unanimous; there are differences between studies in what are concerned: the beginning of the treatment, gestational age, methods. CPAP is used in the treatment of respiratory arrest of infants since 1971, initially endotracheal, than with different nasal instruments. The studies evaluate the benefits of prophylactic or curative CPAP. Objectives: To compare the necessity for mechanical ventilation and surfactant administration, complications and the period of hospitalisation in VLBW and ELBW, that were under prophylactic or curative CPAP. Material and method: We made a prospective study on 90 newborns, during january 2004 and june 2006, that were not intubated in the delivery room with no major malformations. Preventive CPAP was applied in the first half an hour after birth. therapeutical CPAP was applied only in infants with the necessity in oxygen over 40%, to maintain the saturation between 90 - 95%. Group A (curative CPAP) - 25 cases, the average for gestational age 30,30+/-2,45 weeks and for birth weight 1588,00+/-573,05. For group B the averages were: 30,08+/-2,30 weeks and 1508,50+/-400,83 grams. Results: Surfactant was necessary in 40% of group A, over 23% in group B (p = 0,269). Mechanical ventilation in first 72 hours of life was necessary in 18 cases (72%) - A and in 35 cases (53,84%) - B. The necessity for CPAP in hours: 92,15+/-3,85 in group A, over 112,25+/-5,75 group B (p = 0,044). Complications we considered: PDA and cerebral hemorrhage. We had 8 cases (38%) of group A with PDA, significantly different of group B: 5 cases (7,69%). Cerebral hemorrhage was absent in 40% of group A and in 73,84% in group B (p = 0,11). Conclusions: CPAP is a non invasive method with benefits in the treatment of the respiratory arrest in preterm newborn of 28 - 32 gestational weeks. Using early CPAP may reduce: necessity for surfactant, mechanical ventilation and PDA.
Pneumologia (Bucharest, Romania)
Strategies in ventilation and in exposure to the oxygen that minimise lung injury improved the pr... more Strategies in ventilation and in exposure to the oxygen that minimise lung injury improved the prognosis of the extremely low weight newborns. Avoiding intubation can prevent the reduction of mucociliary flow, injury of the mucosa and infection. Using early CPAP isn't unanimous; there are differences between studies in what are concerned: the beginning of the treatment, gestational age, methods. CPAP is used in the treatment of respiratory arrest of infants since 1971, initially endotracheal, than with different nasal instruments. The studies evaluate the benefits of prophylactic or curative CPAP. To compare the necessity for mechanical ventilation and surfactant administration, complications and the period of hospitalisation in VLBW and ELBW, that were under prophylactic or curative CPAP. We made a prospective study on 90 newborns, during january 2004 and june 2006, that were not intubated in the delivery room with no major malformations. Preventive CPAP was applied in the firs...
Medical ultrasonography, 2012
The aim of this study was to evaluate the added value of contrast-enhanced ultrasound (CEUS) in t... more The aim of this study was to evaluate the added value of contrast-enhanced ultrasound (CEUS) in the pancreatic cystic mass (PCM) diagnosis by using a qualitative and quantitative analysis in order to make a relevant characterization. Between December 2008 and November 2011, 37 patients with PCM discovered at ultrasound examination were prospectively followed. A qualitative and quantitative CEUS analysis was performed in order to differentiate etiologies of the PCM. In the quantitative analysis several parameters were followed: Peak Intensity (PI), Time to Peak (TTP), maximum ascending gradient (GRAD), Time to maximum gradient (TTG) and Area Under the Curve (AUC). Normalized ratios were also calculated. In all patients a definite cytological or histological diagnosis was obtained. Thirty-seven patients were studied: 12 with pancreatitis-associated pseudocyst and 25 with cystic tumors (10 serous cystic adenoma, 5 mucinous cystic adenoma, 6 cystadenocarcinomas, 2 solid pseudopapillary ...
Journal of gastrointestinal and liver diseases : JGLD, 2012
AIMS. The aim of this study was to evaluate the leading causes of discrepancies between imaging s... more AIMS. The aim of this study was to evaluate the leading causes of discrepancies between imaging studies [contrast enhanced ultrasound (CEUS) and contrast enhanced computer tomography (CECT)] diagnosis and histology in patients presenting to a tertiary referral center with previously detected pancreatic masses by standard abdominal ultrasound. METHODS. We performed a prospective longitudinal observational study on 76 patients with pancreatic masses: 57 (75%) patients with solid pancreatic tumors and 19 (25%) patients with cystic and mixed pancreatic masses. For each tumor the CEUS and CECT features were analyzed and compared with the final histological diagnosis. RESULTS. Testing the performance of CEUS and CECT in evaluating the benign or malignant etiology of pancreatic masses, we obtained a probability of 82% for CEUS and of 83% for CECT, for a randomly selected individual from the pancreatic tumor group to have an imaging result indicating suspicion for malignancy. We obtained di...
Gastrointestinal Endoscopy, 2014
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
The authors have studied 12 cases of bone giant cell tumors and have shown that the increase in a... more The authors have studied 12 cases of bone giant cell tumors and have shown that the increase in aggressiveness is accompanied by higher values of mitotic activity and nuclear features (area, perimeter, long and short axes), which might be useful for grading the bone giant cell tumors.
Journal of Gastrointestinal and Liver Diseases
Background and Aims: The aim of this study is to determine whether activated hepatic stellate cel... more Background and Aims: The aim of this study is to determine whether activated hepatic stellate cells (HSCs) may represent a prognostic marker of progressive liver fibrosis in chronic viral hepatitis C (VHC) before antiviral therapy. The possible correlation between HSCs immunohistochemical features, histopathological aspects and clinical data before therapy were also studied. Methods: This retrospective pilot study was conducted on 27 liver biopsies from VHC patients before antiviral therapy. HSCs’s immunohistochemical analysis used the antibodies alpha-smooth muscle actin (α-SMA), glial fibrillary acidic protein (GFAP) and vinculin. We correlated immunopositive HSCs with HCV load, liver stiffness (LS), fibrosis stage and necro-inflammatory degree before treatment. Also, we assessed the association between liver fibrosis after therapy, the sustained virological response at 12 weeks after therapy (SVR 12) and the type of therapy. Results: HSCs were increased in VHC patients compared t...
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
The study of nuclear parameters (long and short nuclear axes, nuclear axes ratio, nuclear area) r... more The study of nuclear parameters (long and short nuclear axes, nuclear axes ratio, nuclear area) revealed differences both between the primary breast tumors and their lymph node metastases and between the lymph nodes isolated from the same axilla. The results are discussed in terms of tumor progression.
Pediatric Research, 2011
Introduction: The plasmatic level of EPO (erythropoietin) is high in the umbilical cord when oxyg... more Introduction: The plasmatic level of EPO (erythropoietin) is high in the umbilical cord when oxygen supply is affected. Aim: This study aimed to present the level of plasmatic EPO at birth as well as early complications occurred in newborns with Intrauterine Growth Restriction (IUGR). Material and methods: A prospective study was done on 33 newborns in Neonatology Department ,Cluj, Romania between January 2008-2009(case group) and 32 healthy newborns(control group). The plasmatic level of EPO was determined with Elisa technique. The following parameters were assessing for both groups: Apgar score, Astrup parameters, post asphyxia syndrome and the perinatal pathology. Epi Info 6 was used for statistical analysis. Results: The study group had the weight of 1747.57±728.31 g, ponderal index of 1.91±0.37 and gestational age of 33.45±4.29 weeks. The EPO values were significant higher 56.49±7.80mUI/ml in the study group versus control group 42.45±17.53mUI/ml (p= 0.0001).The EPO was significantly higher also for those who developed meconium aspiration syndrome (76.72±1199mUI/ml) compared to those who developed NTT (neonatal transient tachypnea)-23.60±0.28mUI/ml (p=0.004); and it was higher in those who needed inotrop support-111.05±49.14mUI/ml compare with hemodynamic stable newborns-46.52±52.11mUI/ml (p=0.017). There could not be identified any significant differences between the EPO values of those who developed other complications (hypoxic-ischemic encephalopathy, infection or cerebral hemorrhage) (p=0.398). Conclusions: The plasmatic level of the EPO was significantly high in newborn who developed a severe respiratory pathology and were hemodynamic unstable. There could not be identify any link between plasmatic level of EPO and HIE, sepsis, or cerebral hemorrhage.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2019
We present the case of a 51-year-old male admitted for asthenia, fatigability, nausea, inappetenc... more We present the case of a 51-year-old male admitted for asthenia, fatigability, nausea, inappetence, weight loss, watery diarrhea, lower limb paresthesia and diagnosed after further investigations with Whipple's disease (WD). The evolution was favorable under antibiotic therapy but after a period of time the patient was no longer compliant to the treatment and psychotic manifestations, general status alteration and finally the decease occurred. WD is a condition caused by Tropheryma whipplei (TW) bacterium in people with altered macrophage degrading capacity and it is lethal without early treatment.
Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
This is a retrospective study of 3069 newborns admitted to the Neonatology Department of the 1st ... more This is a retrospective study of 3069 newborns admitted to the Neonatology Department of the 1st Obstetrics and Gynaecology Clinic of Cluj-Napoca, Romania. We considered 38 newborns with the diagnosis of neonatal asphyxia. The neuroimaging performed was transphontanellar ultrasonography, CT-scan, MRI, depending on case. Post asphyxic syndrome evaluation, complete neurological examination, EEG and neuroimaging were performed. The incidence of neonatal asphyxia was 1.15%. Neurological signs were present in 63.15% of the cases. Neurological aspects of newborns were present in different grades of hypoxic-ischaemic encephalopathy. EEG signs were present in 33.3% preterm newborns and 50% newborns at term. Transphontanellar ultrasonography showed different grades of intraventricular hemorrhage, periventricular leukomalacia in 35%. CT-scan was performed in 3 cases. MRI evaluation was performed in 8 cases and showed different types of cerebral ischaemia and cerebral atrophy. Neuroimaging is ...
Archives of Disease in Childhood, 2014
Zeitschrift für Gastroenterologie, 2014
UNLABELLED Strategies in ventilation and in exposure to the oxygen that minimise lung injury impr... more UNLABELLED Strategies in ventilation and in exposure to the oxygen that minimise lung injury improved the prognosis of the extremely low weight newborns. Avoiding intubation can prevent the reduction of mucociliary flow, injury of the mucosa and infection. Using early CPAP isn't unanimous; there are differences between studies in what are concerned: the beginning of the treatment, gestational age, methods. CPAP is used in the treatment of respiratory arrest of infants since 1971, initially endotracheal, than with different nasal instruments. The studies evaluate the benefits of prophylactic or curative CPAP. OBJECTIVES To compare the necessity for mechanical ventilation and surfactant administration, complications and the period of hospitalisation in VLBW and ELBW, that were under prophylactic or curative CPAP. MATERIAL AND METHOD We made a prospective study on 90 newborns, during january 2004 and june 2006, that were not intubated in the delivery room with no major malformation...
Gastroenterología y Hepatología
Ultrasound in Medicine & Biology
Annali italiani di chirurgia, Jan 13, 2017
Endometriosis is a disease represented by the presence of extra uterine endometrial tissue. It is... more Endometriosis is a disease represented by the presence of extra uterine endometrial tissue. It is a rare condition, and malignant transformation is seldom. We report a case with clear cell adenocarcinoma oncogenesis on abdominal wall scar that appeared after years of a caesarian section. After diagnosis, surgical treatment was performed twice, due to the fact that the margins were infiltrated with tumor cells, with replacement of the defect with a polypropylene mesh. The patient was cured and discharged with a favorable prognostic. To the best of our knowledge, there are few reported cases of clear cell adenocarcinoma arising from abdominal wall endometriosis. It is a rare condition that appears mostly after abdominal surgical interventions that clinicians must be aware. Abdominal wall, Endometriosis, Cesarean section, Clear cell adenocarcinoma, Malignant transformation.
Medical Ultrasonography, Jun 1, 2012
The aim of this study was to evaluate the added value of contrast-enhanced ultrasound (CEUS) in t... more The aim of this study was to evaluate the added value of contrast-enhanced ultrasound (CEUS) in the pancreatic cystic mass (PCM) diagnosis by using a qualitative and quantitative analysis in order to make a relevant characterization. Between December 2008 and November 2011, 37 patients with PCM discovered at ultrasound examination were prospectively followed. A qualitative and quantitative CEUS analysis was performed in order to differentiate etiologies of the PCM. In the quantitative analysis several parameters were followed: Peak Intensity (PI), Time to Peak (TTP), maximum ascending gradient (GRAD), Time to maximum gradient (TTG) and Area Under the Curve (AUC). Normalized ratios were also calculated. In all patients a definite cytological or histological diagnosis was obtained. Thirty-seven patients were studied: 12 with pancreatitis-associated pseudocyst and 25 with cystic tumors (10 serous cystic adenoma, 5 mucinous cystic adenoma, 6 cystadenocarcinomas, 2 solid pseudopapillary tumors and 2 intraductal papillary mucinous neoplasms). There was a significant difference of the nAUC and nTTP between pseudocyst and cystic tumors, p=0.03 and p=0.01, respectively. A normalized TTP value above 7 sec was suggestive for the diagnosis of pseudocysts with 79.16 % accuracy. There was a significant difference of nTTP and nTTG between the benign and malignant lesions. nTTP < 9 sec and nTTG < 8.5 sec rules out malignant cysts in almost 90% of cases. The CEUS is useful in the diagnosis of PCM. The quantitative analysis of the enhancement of the cystic wall may discriminate the different types of the PCM.
Pneumologia, 2008
Strategies in ventilation and in exposure to the oxygen that minimise lung injury improved the pr... more Strategies in ventilation and in exposure to the oxygen that minimise lung injury improved the prognosis of the extremely low weight newborns. Avoiding intubation can prevent the reduction of mucociliary flow, injury of the mucosa and infection. Using early CPAP isn't unanimous; there are differences between studies in what are concerned: the beginning of the treatment, gestational age, methods. CPAP is used in the treatment of respiratory arrest of infants since 1971, initially endotracheal, than with different nasal instruments. The studies evaluate the benefits of prophylactic or curative CPAP. Objectives: To compare the necessity for mechanical ventilation and surfactant administration, complications and the period of hospitalisation in VLBW and ELBW, that were under prophylactic or curative CPAP. Material and method: We made a prospective study on 90 newborns, during january 2004 and june 2006, that were not intubated in the delivery room with no major malformations. Preventive CPAP was applied in the first half an hour after birth. therapeutical CPAP was applied only in infants with the necessity in oxygen over 40%, to maintain the saturation between 90 - 95%. Group A (curative CPAP) - 25 cases, the average for gestational age 30,30+/-2,45 weeks and for birth weight 1588,00+/-573,05. For group B the averages were: 30,08+/-2,30 weeks and 1508,50+/-400,83 grams. Results: Surfactant was necessary in 40% of group A, over 23% in group B (p = 0,269). Mechanical ventilation in first 72 hours of life was necessary in 18 cases (72%) - A and in 35 cases (53,84%) - B. The necessity for CPAP in hours: 92,15+/-3,85 in group A, over 112,25+/-5,75 group B (p = 0,044). Complications we considered: PDA and cerebral hemorrhage. We had 8 cases (38%) of group A with PDA, significantly different of group B: 5 cases (7,69%). Cerebral hemorrhage was absent in 40% of group A and in 73,84% in group B (p = 0,11). Conclusions: CPAP is a non invasive method with benefits in the treatment of the respiratory arrest in preterm newborn of 28 - 32 gestational weeks. Using early CPAP may reduce: necessity for surfactant, mechanical ventilation and PDA.
Pneumologia (Bucharest, Romania)
Strategies in ventilation and in exposure to the oxygen that minimise lung injury improved the pr... more Strategies in ventilation and in exposure to the oxygen that minimise lung injury improved the prognosis of the extremely low weight newborns. Avoiding intubation can prevent the reduction of mucociliary flow, injury of the mucosa and infection. Using early CPAP isn't unanimous; there are differences between studies in what are concerned: the beginning of the treatment, gestational age, methods. CPAP is used in the treatment of respiratory arrest of infants since 1971, initially endotracheal, than with different nasal instruments. The studies evaluate the benefits of prophylactic or curative CPAP. To compare the necessity for mechanical ventilation and surfactant administration, complications and the period of hospitalisation in VLBW and ELBW, that were under prophylactic or curative CPAP. We made a prospective study on 90 newborns, during january 2004 and june 2006, that were not intubated in the delivery room with no major malformations. Preventive CPAP was applied in the firs...
Medical ultrasonography, 2012
The aim of this study was to evaluate the added value of contrast-enhanced ultrasound (CEUS) in t... more The aim of this study was to evaluate the added value of contrast-enhanced ultrasound (CEUS) in the pancreatic cystic mass (PCM) diagnosis by using a qualitative and quantitative analysis in order to make a relevant characterization. Between December 2008 and November 2011, 37 patients with PCM discovered at ultrasound examination were prospectively followed. A qualitative and quantitative CEUS analysis was performed in order to differentiate etiologies of the PCM. In the quantitative analysis several parameters were followed: Peak Intensity (PI), Time to Peak (TTP), maximum ascending gradient (GRAD), Time to maximum gradient (TTG) and Area Under the Curve (AUC). Normalized ratios were also calculated. In all patients a definite cytological or histological diagnosis was obtained. Thirty-seven patients were studied: 12 with pancreatitis-associated pseudocyst and 25 with cystic tumors (10 serous cystic adenoma, 5 mucinous cystic adenoma, 6 cystadenocarcinomas, 2 solid pseudopapillary ...
Journal of gastrointestinal and liver diseases : JGLD, 2012
AIMS. The aim of this study was to evaluate the leading causes of discrepancies between imaging s... more AIMS. The aim of this study was to evaluate the leading causes of discrepancies between imaging studies [contrast enhanced ultrasound (CEUS) and contrast enhanced computer tomography (CECT)] diagnosis and histology in patients presenting to a tertiary referral center with previously detected pancreatic masses by standard abdominal ultrasound. METHODS. We performed a prospective longitudinal observational study on 76 patients with pancreatic masses: 57 (75%) patients with solid pancreatic tumors and 19 (25%) patients with cystic and mixed pancreatic masses. For each tumor the CEUS and CECT features were analyzed and compared with the final histological diagnosis. RESULTS. Testing the performance of CEUS and CECT in evaluating the benign or malignant etiology of pancreatic masses, we obtained a probability of 82% for CEUS and of 83% for CECT, for a randomly selected individual from the pancreatic tumor group to have an imaging result indicating suspicion for malignancy. We obtained di...
Gastrointestinal Endoscopy, 2014