Tong Wu - Academia.edu (original) (raw)

Papers by Tong Wu

Droit et société, 2010

Distribution électronique Cairn.info pour Editions juridiques associées. © Editions juridiques as... more Distribution électronique Cairn.info pour Editions juridiques associées. © Editions juridiques associées. Tous droits réservés pour tous pays. La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que dans les limites des conditions générales d'utilisation du site ou, le cas échéant, des conditions générales de la licence souscrite par votre établissement. Toute autre reproduction ou représentation, en tout ou partie, sous quelque forme et de quelque manière que ce soit, est interdite sauf accord préalable et écrit de l'éditeur, en dehors des cas prévus par la législation en vigueur en France. Il est précisé que son stockage dans une base de données est également interdit. « Gouverner le travail par la loi ». Conflits du travail et luttes pour le droit dans une entreprise de Shanghai (2003-2007

IEEE PES Power Systems Conference and Exposition, 2004.

Journal of Bioinformatics and Computational Biology, 2011

Pancreatic cancer is the fourth leading cause of cancer deaths in the United States with five-yea... more Pancreatic cancer is the fourth leading cause of cancer deaths in the United States with five-year survival rates less than 5% due to rare detection in early stages. Identification of genes that are directly correlated to pancreatic cancer survival is crucial for pancreatic cancer diagnostics and treatment. However, no existing GWAS or transcriptome studies are available for addressing this problem. We apply lasso penalized Cox regression to a transcriptome study to identify genes that are directly related to pancreatic cancer survival. This method is capable of handling the right censoring effect of survival times and the ultrahigh dimensionality of genetic data. A cyclic coordinate descent algorithm is employed to rapidly select the most relevant genes and eliminate the irrelevant ones. Twelve genes have been identified and verified to be directly correlated to pancreatic cancer survival time and can be used for the prediction of future patient's survival.

Molecular Diagnostics and Treatment of Pancreatic Cancer, 2014

Abstract Pancreatic cancer is a highly malignant disease with a five-year survival rate less than... more Abstract Pancreatic cancer is a highly malignant disease with a five-year survival rate less than 5%. Advances in modern data collection technology have revolutionized the way that we study the complex biological systems, allowing pancreatic cancer researchers to make genome-wide expression profiling within tumors in a fast, precise, and cost-effective way. How to correctly analyze and interpret the high-dimensional and complex gene expression data is a key to understanding the hidden regulatory mechanisms. In this work, we first introduce a LASSO penalized Cox regression method to identify individual genes that are directly related to survival time of pancreatic cancer patients. A cyclic coordinate descent algorithm is used for the computation of high-dimensional data (number of genes larger than number of patients). Then, we introduce a doubly regularized Cox regression method, which integrates pathway information into our analysis, to identify both genes and signaling pathways related to pancreatic cancer survival. Both methods are applied to a pancreatic cancer microarray dataset and identify several genes and signaling pathways correlated to pancreatic cancer survival. Our findings can help cancer researchers design new strategies for the early detection and diagnosis of pancreatic cancer.

IEEE Transactions on Power Systems, 2005

In practice, locational marginal prices (LMPs) are usually calculated by assembling their three c... more In practice, locational marginal prices (LMPs) are usually calculated by assembling their three components: the reference price, the congestion price, and the loss price. Explicit formulas for calculating the three components based on the single-slack power-flow formulation can be found in the literature. This letter presents the formulas for calculating the three components based on a distributed-slack power-flow formulation.

IEEE Transactions on Power Systems, 2004

A detailed AC OPF-based formulation for procuring, pricing, and settling energy and ancillary ser... more A detailed AC OPF-based formulation for procuring, pricing, and settling energy and ancillary service in simultaneous auctions by integrated market systems is presented. The paper provides clear definitions of Locational Marginal Prices for energy and Ancillary Service Marginal Prices in terms of Lagrange multipliers. The characteristics of the prices are analyzed especially when economic substitution among ancillary services is required. The paper also evaluates the conditions under which opportunity costs are incurred to units that provide ancillary services. It is particularly shown that the intuitive belief that the provision of regulation down service does not incur opportunity cost to the provider, in general, is not true.

BMC Systems Biology, 2014

Background: Recent global genomic analyses identified 69 gene sets and 12 core signaling pathways... more Background: Recent global genomic analyses identified 69 gene sets and 12 core signaling pathways genetically altered in pancreatic cancer, which is a highly malignant disease. A comprehensive understanding of the genetic signatures and signaling pathways that are directly correlated to pancreatic cancer survival will help cancer researchers to develop effective multi-gene targeted, personalized therapies for the pancreatic cancer patients at different stages. A previous work that applied a LASSO penalized regression method, which only considered individual genetic effects, identified 12 genes associated with pancreatic cancer survival. Results: In this work, we integrate pathway information into pancreatic cancer survival analysis. We introduce and apply a doubly regularized Cox regression model to identify both genes and signaling pathways related to pancreatic cancer survival. Conclusions: Four signaling pathways, including Ion transport, immune phagocytosis, TGFb (spermatogenesis), regulation of DNA-dependent transcription pathways, and 15 genes within the four pathways are identified and verified to be directly correlated to pancreatic cancer survival. Our findings can help cancer researchers design new strategies for the early detection and diagnosis of pancreatic cancer.

Applied Energy, 2004

A reasonable estimation of the optimal tilt angle of a fixed collector for maximizing its energy ... more A reasonable estimation of the optimal tilt angle of a fixed collector for maximizing its energy collection must be done based on the monthly global and diffuse radiation on a horizontal surface. However, the monthly diffuse radiation is not always available in many places. In this paper, a simple mathematical procedure for the estimation of the optimal tilt angle of a collector is presented based on the monthly horizontal radiation. A comparison of the optimal tilt angles of collectors obtained from expected monthly diffuse radiation and that from the actual monthly diffuse radiation showed that this method gives a good estimation of the optimal tilt angle, except for places with a considerably lower clearness index. A contour map of the optimal tilt angle of the south-facing collectors used for the entire year in China is also outlined, based on monthly horizontal radiation of 152 places around the country, combing the optimal tilt angle of another 30 cities based on the actual monthly diffuse radiation.