Trieumy Tran Le - Academia.edu (original) (raw)

Papers by Trieumy Tran Le

Research paper thumbnail of A comparison of initial treatment setup accuracy in external beam radiation therapy (EBRT) for prone pelvic patients using temporary ink skin marks with and without tattoos

Poster: "2014 CSM / R-0217 / A comparison of initial treatment setup accuracy in external be... more Poster: "2014 CSM / R-0217 / A comparison of initial treatment setup accuracy in external beam radiation therapy (EBRT) for prone pelvic patients using temporary ink skin marks with and without tattoos " by: " J. Weerappah , E. Mottau, T. Tran Le, D. McKenzie; MELBOURNE/AU"

Research paper thumbnail of Oesophageal IGRT considerations for SBRT of LA-NSCLC: barium-enhanced CBCT and interfraction motion

Radiation Oncology

Background To determine the optimal volume of barium for oesophageal localisation on cone-beam CT... more Background To determine the optimal volume of barium for oesophageal localisation on cone-beam CT (CBCT) for locally-advanced non-small cell lung cancers (NSCLC) and quantify the interfraction oesophageal movement relative to tumour. Methods Twenty NSCLC patients with mediastinal and/or hilar disease receiving radical radiotherapy were recruited. The first five patients received 25 ml of barium prior to their planning CT and alternate CBCTs during treatment. Subsequent five patient cohorts, received 15 ml, 10 ml and 5 ml. Six observers contoured the oesophagus on each of the 107 datasets and consensus contours were created. Overall 642 observer contours were generated and interobserver contouring reproducibility was assessed. The kappa statistic, dice coefficient and Hausdorff Distance (HD) were used to compare barium-enhanced CBCTs and non-enhanced CBCTs. Oesophageal displacement was assessed using the HD between consensus contours of barium-enhanced CBCTs and planning CTs. Results...

Research paper thumbnail of Contrast enhanced oesophageal avoidance for stereotactic body radiotherapy: Barium vs. Gastrografin

Technical Innovations & Patient Support in Radiation Oncology

Introduction: SABR may facilitate treatment in a greater proportion of locally-advanced NSCLC pat... more Introduction: SABR may facilitate treatment in a greater proportion of locally-advanced NSCLC patients, just as it has for early-stage disease. The oesophagus is one of the key dose-limiting organs and visualization during IGRT would better ensure toxicity is avoided. As the oesophagus is poorly seen on CBCT, we assessed the extent to which this is improved using two oral contrast agents. Materials & methods: Six patients receiving radiotherapy for Stage I-III NSCLC were assigned to receive 50 mL Gastrografin or 50 mL barium sulphate prior to simulation and pre-treatment CBCTs. Three additional patients who did not receive contrast were included as a control group. Oesophageal visibility was determined by assessing concordance between six experienced observers in contouring the organ. 36 datasets and 216 contours were analysed. A STAPLE contour was created and compared to each individual contour. Descriptive statistics were used and a Kappa statistic, Dice Coefficient and Hausdorff distance were calculated and compared using a t-test. Contrast-induced artefact was assessed by observer scoring. Results: Both contrast agents significantly improved the consistency of oesophagus localisation on CBCT across all comparison metrics compared to CBCTs without contrast. Barium performed significantly better than Gastrografin with improved kappa statistics (p = 0.007), dice coefficients (p < 0.001) and Hausdorff distances (p = 0.002), although at a cost of increased image artefact. Discussion: Barium produced lower delineation uncertainties but more image artefact, compared to Gastrografin and no contrast. It is feasible to use oral contrast as a tool in IGRT to help guide clinicians and therapists with online matching and monitoring of the oesophageal position.

Research paper thumbnail of PUB035 Feasibility of Stereotactic Ablative Radiotherapy (SABR) for Locally-Advanced Non-Small Cell Lung Cancer (NSCLC)

Journal of Thoracic Oncology

Conclusion: Survival in patients treated with CRS or CS is superior to other treatment modalities... more Conclusion: Survival in patients treated with CRS or CS is superior to other treatment modalities across all stages, but the use of CRS and CS is low when compared to other modalities. Future studies need to determine why multimodality treatments including CRS and CS are used so sparingly despite the recognized survival benefit.

Research paper thumbnail of Feasibility of stereotactic body radiotherapy for locally-advanced non-small cell lung cancer

Clinical and Translational Radiation Oncology

SBRT was feasible for approximately half of the locally-advanced NSCLC patients we assessed and f... more SBRT was feasible for approximately half of the locally-advanced NSCLC patients we assessed and for these patients has the potential to reduce a 30 fraction course to 12 fractions. Using SBRT in this setting requires compromises in techniques and further compromises may allow SBRT in a greater proportion of patients.

Research paper thumbnail of Feasibility of stereotactic body radiotherapy for locally-advanced non-small cell lung cancer

Clinical and Translational Radiation Oncology

SBRT was feasible for approximately half of the locally-advanced NSCLC patients we assessed and f... more SBRT was feasible for approximately half of the locally-advanced NSCLC patients we assessed and for these patients has the potential to reduce a 30 fraction course to 12 fractions. Using SBRT in this setting requires compromises in techniques and further compromises may allow SBRT in a greater proportion of patients.

Research paper thumbnail of A comparison of initial treatment setup accuracy in external beam radiation therapy (EBRT) for prone pelvic patients using temporary ink skin marks with and without tattoos

Poster: "2014 CSM / R-0217 / A comparison of initial treatment setup accuracy in external be... more Poster: "2014 CSM / R-0217 / A comparison of initial treatment setup accuracy in external beam radiation therapy (EBRT) for prone pelvic patients using temporary ink skin marks with and without tattoos " by: " J. Weerappah , E. Mottau, T. Tran Le, D. McKenzie; MELBOURNE/AU"

Research paper thumbnail of Oesophageal IGRT considerations for SBRT of LA-NSCLC: barium-enhanced CBCT and interfraction motion

Radiation Oncology

Background To determine the optimal volume of barium for oesophageal localisation on cone-beam CT... more Background To determine the optimal volume of barium for oesophageal localisation on cone-beam CT (CBCT) for locally-advanced non-small cell lung cancers (NSCLC) and quantify the interfraction oesophageal movement relative to tumour. Methods Twenty NSCLC patients with mediastinal and/or hilar disease receiving radical radiotherapy were recruited. The first five patients received 25 ml of barium prior to their planning CT and alternate CBCTs during treatment. Subsequent five patient cohorts, received 15 ml, 10 ml and 5 ml. Six observers contoured the oesophagus on each of the 107 datasets and consensus contours were created. Overall 642 observer contours were generated and interobserver contouring reproducibility was assessed. The kappa statistic, dice coefficient and Hausdorff Distance (HD) were used to compare barium-enhanced CBCTs and non-enhanced CBCTs. Oesophageal displacement was assessed using the HD between consensus contours of barium-enhanced CBCTs and planning CTs. Results...

Research paper thumbnail of Contrast enhanced oesophageal avoidance for stereotactic body radiotherapy: Barium vs. Gastrografin

Technical Innovations & Patient Support in Radiation Oncology

Introduction: SABR may facilitate treatment in a greater proportion of locally-advanced NSCLC pat... more Introduction: SABR may facilitate treatment in a greater proportion of locally-advanced NSCLC patients, just as it has for early-stage disease. The oesophagus is one of the key dose-limiting organs and visualization during IGRT would better ensure toxicity is avoided. As the oesophagus is poorly seen on CBCT, we assessed the extent to which this is improved using two oral contrast agents. Materials & methods: Six patients receiving radiotherapy for Stage I-III NSCLC were assigned to receive 50 mL Gastrografin or 50 mL barium sulphate prior to simulation and pre-treatment CBCTs. Three additional patients who did not receive contrast were included as a control group. Oesophageal visibility was determined by assessing concordance between six experienced observers in contouring the organ. 36 datasets and 216 contours were analysed. A STAPLE contour was created and compared to each individual contour. Descriptive statistics were used and a Kappa statistic, Dice Coefficient and Hausdorff distance were calculated and compared using a t-test. Contrast-induced artefact was assessed by observer scoring. Results: Both contrast agents significantly improved the consistency of oesophagus localisation on CBCT across all comparison metrics compared to CBCTs without contrast. Barium performed significantly better than Gastrografin with improved kappa statistics (p = 0.007), dice coefficients (p < 0.001) and Hausdorff distances (p = 0.002), although at a cost of increased image artefact. Discussion: Barium produced lower delineation uncertainties but more image artefact, compared to Gastrografin and no contrast. It is feasible to use oral contrast as a tool in IGRT to help guide clinicians and therapists with online matching and monitoring of the oesophageal position.

Research paper thumbnail of PUB035 Feasibility of Stereotactic Ablative Radiotherapy (SABR) for Locally-Advanced Non-Small Cell Lung Cancer (NSCLC)

Journal of Thoracic Oncology

Conclusion: Survival in patients treated with CRS or CS is superior to other treatment modalities... more Conclusion: Survival in patients treated with CRS or CS is superior to other treatment modalities across all stages, but the use of CRS and CS is low when compared to other modalities. Future studies need to determine why multimodality treatments including CRS and CS are used so sparingly despite the recognized survival benefit.

Research paper thumbnail of Feasibility of stereotactic body radiotherapy for locally-advanced non-small cell lung cancer

Clinical and Translational Radiation Oncology

SBRT was feasible for approximately half of the locally-advanced NSCLC patients we assessed and f... more SBRT was feasible for approximately half of the locally-advanced NSCLC patients we assessed and for these patients has the potential to reduce a 30 fraction course to 12 fractions. Using SBRT in this setting requires compromises in techniques and further compromises may allow SBRT in a greater proportion of patients.

Research paper thumbnail of Feasibility of stereotactic body radiotherapy for locally-advanced non-small cell lung cancer

Clinical and Translational Radiation Oncology

SBRT was feasible for approximately half of the locally-advanced NSCLC patients we assessed and f... more SBRT was feasible for approximately half of the locally-advanced NSCLC patients we assessed and for these patients has the potential to reduce a 30 fraction course to 12 fractions. Using SBRT in this setting requires compromises in techniques and further compromises may allow SBRT in a greater proportion of patients.