Trilochan Satapathy - Academia.edu (original) (raw)
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Papers by Trilochan Satapathy
Artificial Cells, Blood Substitutes and Biotechnology, 2010
The present work describes the formulation and evaluation of the gastroretentive system of Itopri... more The present work describes the formulation and evaluation of the gastroretentive system of Itopride hydrochloride. In this research, we have formulated floating hydrogel-based microspheres employing calcium carbonate (CaCO(3)) as a gas forming agent dispersed in alginate matrix. In vitro characterizations such as drug content, particle size, and drug release were carried out. GI motility was determined by administration of charcoal meal to rats. Results demonstrated that prepared microspheres were spherical in shape with smooth surface, good loading efficiency, and excellent buoyancy. The gastro retentive dosage form of itiopride demonstrated significant antacid, anti-ulcer, and anti-GERD activity after 12 hours in comparison with the conventional dosage form.
In recent year, considerable attention has been focused on the formulation and development of new... more In recent year, considerable attention has been focused on the formulation and development of new drug for orally targeted drug delivery systems. The oral route is most popular route of drug administration. Conventional dosage forms are unable to control either the rate or site of action. When a drug is delivered as a conventional dosage form they show very short gastric retention time. As such the drug which act locally in the stomach or get degraded by the colonic bacteria or/ and alkaline pH of the small intestine cannot be formulate as conventional dosage form. In conventional dosage forms, fluctuating drug level may lead to some side effect and dosing interval is short, this leads to poor patient compliance. At present a number of approaches are utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), swelling and expanding system, mucoadhesive system, high density system, modified system and other delayed gastric emptying systems.
Artificial Cells, Blood Substitutes and Biotechnology, 2010
The present work describes the formulation and evaluation of the gastroretentive system of Itopri... more The present work describes the formulation and evaluation of the gastroretentive system of Itopride hydrochloride. In this research, we have formulated floating hydrogel-based microspheres employing calcium carbonate (CaCO(3)) as a gas forming agent dispersed in alginate matrix. In vitro characterizations such as drug content, particle size, and drug release were carried out. GI motility was determined by administration of charcoal meal to rats. Results demonstrated that prepared microspheres were spherical in shape with smooth surface, good loading efficiency, and excellent buoyancy. The gastro retentive dosage form of itiopride demonstrated significant antacid, anti-ulcer, and anti-GERD activity after 12 hours in comparison with the conventional dosage form.
In recent year, considerable attention has been focused on the formulation and development of new... more In recent year, considerable attention has been focused on the formulation and development of new drug for orally targeted drug delivery systems. The oral route is most popular route of drug administration. Conventional dosage forms are unable to control either the rate or site of action. When a drug is delivered as a conventional dosage form they show very short gastric retention time. As such the drug which act locally in the stomach or get degraded by the colonic bacteria or/ and alkaline pH of the small intestine cannot be formulate as conventional dosage form. In conventional dosage forms, fluctuating drug level may lead to some side effect and dosing interval is short, this leads to poor patient compliance. At present a number of approaches are utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), swelling and expanding system, mucoadhesive system, high density system, modified system and other delayed gastric emptying systems.