Tsolmon Boldoo - Academia.edu (original) (raw)

Papers by Tsolmon Boldoo

Research paper thumbnail of Tobacco smoking clusters in households affected by tuberculosis in an individual participant data meta-analysis of national tuberculosis prevalence surveys: Time for household-wide interventions?

PLOS global public health, Feb 29, 2024

Peer Review History: PLOS recognizes the benefits of transparency in the peer review process; the... more Peer Review History: PLOS recognizes the benefits of transparency in the peer review process; therefore, we enable the publication of all of the content of peer review and author responses alongside final, published articles. The editorial history of this article is available here:

Research paper thumbnail of Delays in health seeking, diagnosis and treatment for tuberculosis patients in Mongolia: an analysis of surveillance data, 2018-2021

PubMed, Mar 19, 2024

Early diagnosis and treatment of infectious tuberculosis (TB) is essential to the attainment of g... more Early diagnosis and treatment of infectious tuberculosis (TB) is essential to the attainment of global targets specified in the End TB Strategy. Using case-based TB surveillance data, we analysed delays in health seeking, diagnosis and treatment among TB patients in Mongolia from 2018 to 2021. We calculated the median and interquartile range (IQR) for "diagnostic delay," defined as the time from symptom onset to diagnosis, subdivided into "health-seeking delay" (time from symptom onset to first visit to a health facility) and "health facility diagnostic delay" (time from first health facility visit to diagnosis), and for "treatment delay," defined as the time from diagnosis to start of treatment. We also calculated "total delay," defined as the time from symptom onset to treatment start. Based on data for 13 968 registered TB patients, the median total delay was estimated to be 37 days (IQR, 19-76). This was mostly due to health-seeking delay (median, 23 days; IQR, 8-53); in contrast, health facility diagnostic delay and treatment delay were relatively short (median, 1 day; IQR, 0-7; median, 1 day; IQR, 0-7, respectively). In 2021, health-seeking delay did not differ significantly between men and women but was shorter in children than in adults and shorter in clinically diagnosed than in bacteriologically confirmed TB cases. Health-seeking delay was longest in the East region (median, 44.5 days; IQR, 20-87) and shortest in Ulaanbaatar (median, 9; IQR, 14-64). TB treatment delay was similar across sexes, age groups and types of TB diagnosis but slightly longer among retreated cases and people living in Ulaanbaatar. Efforts to reduce TB transmission in Mongolia should prioritize decreasing delays in health seeking.

Research paper thumbnail of Use of Double Test Biomarkers to Predict Fetal Nuchal Translucency Thickness in the Diagnosis of Trisomy 21: A Compromise between Sensitivity and Specificity

Central Asian Journal of Medical Sciences

Objectives: The aim of study is to determine the sensitivity and specificity of screening for fet... more Objectives: The aim of study is to determine the sensitivity and specificity of screening for fetal trisomy 21 in the first trimester of pregnancy using a combination of maternal serum biomarkers and ultrasonography. The objectives of this study were to first duplicate and confirm within the Mongolian population, the results of other similar studies. Our results corroborated closely with those of other studies and further allowed us to draw conclusions and recommendations unique to Mongolia. A second objective was to apply these results to everyday obstetric practices within Mongolia and advance the state of prenatal care for all Mongolian women. Methods: Obstetric History: The obstetric history was recorded, and serum biomarkers were measured in 415 pregnancies.The degree of risk for trisomy 21 and other fetal aneuploidy were calculated using maternal age, the results of maternal serum pregnancy-associated plasma protein-A, free beta human chorionic gonadotropin, and fetal nuchal t...

Research paper thumbnail of Social inequality in smoking in mongolia

Population medicine, Apr 26, 2023

Population Medicine considers the following types of articles: • Research Papers-reports of data ... more Population Medicine considers the following types of articles: • Research Papers-reports of data from original research or secondary dataset analyses. • Review Papers-comprehensive, authoritative, reviews within the journal's scope. These include both systematic reviews and narrative reviews. • Short Reports-brief reports of data from original research. • Policy Case Studies-brief articles on policy development at a regional or national level. • Study Protocols-articles describing a research protocol of a study. • Methodology Papers-papers that present different methodological approaches that can be used to investigate problems in a relevant scientific field and to encourage innovation. • Methodology Papers-papers that present different methodological approaches that can be used to investigate problems in a relevant scientific field and to encourage innovation. • Letters to the Editor-a response to authors of an original publication, or a very small article that may be relevant to readers. • Editorials-articles written by the Editorial Board or by invited experts on a specific topic. Research Papers Articles reporting research may be full length or brief reports. These should report original research findings within the journal's scope. Papers should generally be a maximum of 4000 words in length, excluding tables, references, and abstract and key points of the article, whilst it is recommended that the number of references should not exceed 36.

Research paper thumbnail of Association of diabetes, smoking, and alcohol use with subclinical-to-symptomatic spectrum of tuberculosis in 16 countries: an individual participant data meta-analysis of national tuberculosis prevalence surveys

Research paper thumbnail of Epidemiology of tuberculosis in Mongolia: analysis of surveillance data, 2015-2019

Western Pacific Surveillance and Response, Apr 18, 2023

Research paper thumbnail of Socioeconomic predictors over the life course of healthy ageing index in older Eastern Europeans

Population Medicine

Population Medicine considers the following types of articles: • Research Papers-reports of data ... more Population Medicine considers the following types of articles: • Research Papers-reports of data from original research or secondary dataset analyses. • Review Papers-comprehensive, authoritative, reviews within the journal's scope. These include both systematic reviews and narrative reviews. • Short Reports-brief reports of data from original research. • Policy Case Studies-brief articles on policy development at a regional or national level. • Study Protocols-articles describing a research protocol of a study. • Methodology Papers-papers that present different methodological approaches that can be used to investigate problems in a relevant scientific field and to encourage innovation. • Methodology Papers-papers that present different methodological approaches that can be used to investigate problems in a relevant scientific field and to encourage innovation. • Letters to the Editor-a response to authors of an original publication, or a very small article that may be relevant to readers. • Editorials-articles written by the Editorial Board or by invited experts on a specific topic. Research Papers Articles reporting research may be full length or brief reports. These should report original research findings within the journal's scope. Papers should generally be a maximum of 4000 words in length, excluding tables, references, and abstract and key points of the article, whilst it is recommended that the number of references should not exceed 36.

Research paper thumbnail of Correction to: Figure 3 in Association between household solid fuel use and tuberculosis: cross-sectional data from the Mongolian National Tuberculosis Prevalence Survey

Environmental Health and Preventive Medicine

Research paper thumbnail of Patient delay and health system delay of patients with newly diagnosed pulmonary tuberculosis in Mongolia, 2016-2017

Nagoya Journal of Medical Science, May 1, 2022

Research paper thumbnail of Health-Seeking Behavior among Tuberculosis Suspected Cases in Major Cities of Mongolia

Central Asian Journal of Medical Sciences

Research paper thumbnail of Spinale intradurale Tumoren

Research paper thumbnail of Sex-adjusted approach to baseline variables demonstrated some improved predictive capabilities for disease severity and survival in patients with Coronavirus Disease 19

Informatics in Medicine Unlocked

Research paper thumbnail of Correction to: Association between household solid fuel use and tuberculosis: cross-sectional data from the Mongolian National Tuberculosis Prevalence Survey

Environmental Health and Preventive Medicine

Following the publication of the original article [1] the authors noticed that the correction req... more Following the publication of the original article [1] the authors noticed that the correction requested in Table 4 was not implemented. The "₮ "should be inserted in the "()" following "Household monthly income" as shown below. "Household monthly income (₮); n (%)". The original article [1] has been updated.

Research paper thumbnail of 1091Evaluation of symptom screening methods for tuberculosis: secondary analysis of Mongolian nationwide tuberculosis prevalence survey

International Journal of Epidemiology

Background Symptom screening for tuberculosis (TB) is a key component for identifying TB suspects... more Background Symptom screening for tuberculosis (TB) is a key component for identifying TB suspects and TB cases, particularly in resource-limited countries. This study aimed to evaluate the effectiveness of symptom screening using TB-related symptoms including the standard symptom screening criterion of chronic cough: cough for two weeks or more, to identify TB cases in the general population. Methods This study is a secondary analysis of the nationwide population-based, cross-sectional survey for TB prevalence in Mongolia in 2014-2015. Each TB-related symptom was compared between bacteriologically confirmed TB cases and bacteriologically negative participants. Results Of the 50,309 adults who received symptom screening, 248 were diagnosed as bacteriologically confirmed TB cases. The sensitivity and specificity of standard symptom screening of cough for two weeks or more were 20.6% and 95.3%, respectively. The higher sensitivity and lower specificity were reported in chronic sputum: ...

Research paper thumbnail of Genetic Mutations Associated with Isoniazid Resistance in Mycobacterium tuberculosis in Mongolia

Antimicrobial Agents and Chemotherapy

Globally, mutations in the katG gene account for the majority of isoniazid-resistant strains of M... more Globally, mutations in the katG gene account for the majority of isoniazid-resistant strains of Mycobacterium tuberculosis. Buyankhishig et al analyzed a limited number of Mycobacterium tuberculosis strains in Mongolia and found that isoniazid resistance was mainly attributable to inhA mutations. The GenoType® MTBDRplus assay was performed for isolates collected in the First National Tuberculosis Prevalence Survey and the Third Anti-Tuberculosis Drug Resistance Survey to investigate genetic mutations associated with isoniazid resistance in Mycobacterium tuberculosis in Mongolia. Of the 409 isoniazid-resistant isolates detected by the GenoType® MTBDRplus assay, 127 (31.1%) were resistant to rifampicin, 294 (71.9%) had inhA mutations without katG mutations, 113 (27.6%) had katG mutations without inhA mutations, and two (0.5%) strains had mutations in both the inhA and katG genes. Of the 115 strains with any katG mutation, 114 (99.1%) had mutations in codon 315 (S315T). Of the 296 trai...

Research paper thumbnail of Association between household solid fuel use and tuberculosis: cross-sectional data from the Mongolian National Tuberculosis Prevalence Survey

Environmental Health and Preventive Medicine

Background Tuberculosis (TB) and indoor air pollution (IAP) are equally critical public health is... more Background Tuberculosis (TB) and indoor air pollution (IAP) are equally critical public health issues in the developing world. Mongolia is experiencing the double burden of TB and IAP due to solid fuel combustion. However, no study has assessed the relationship between household solid fuel use and TB in Mongolia. The present study aimed to assess the association between household solid fuel use and TB based on data from the Mongolian National Tuberculosis Prevalence Survey (MNTP Survey). Method The MNTP Survey was a nationally representative population-based cross-sectional survey targeting households in Mongolia from 2014 to 2015, with the aim of evaluating the prevalence of TB. The survey adopted a multistage cluster sampling design in accordance with the World Health Organization prevalence survey guidelines. Clusters with at least 500 residents were selected by random sampling. A sample size of 98 clusters with 54,100 participants was estimated to be required for the survey, and...

Research paper thumbnail of Tobacco smoking clusters in households affected by tuberculosis in an individual participant data meta-analysis of national tuberculosis prevalence surveys: Time for household-wide interventions?

PLOS global public health, Feb 29, 2024

Peer Review History: PLOS recognizes the benefits of transparency in the peer review process; the... more Peer Review History: PLOS recognizes the benefits of transparency in the peer review process; therefore, we enable the publication of all of the content of peer review and author responses alongside final, published articles. The editorial history of this article is available here:

Research paper thumbnail of Delays in health seeking, diagnosis and treatment for tuberculosis patients in Mongolia: an analysis of surveillance data, 2018-2021

PubMed, Mar 19, 2024

Early diagnosis and treatment of infectious tuberculosis (TB) is essential to the attainment of g... more Early diagnosis and treatment of infectious tuberculosis (TB) is essential to the attainment of global targets specified in the End TB Strategy. Using case-based TB surveillance data, we analysed delays in health seeking, diagnosis and treatment among TB patients in Mongolia from 2018 to 2021. We calculated the median and interquartile range (IQR) for "diagnostic delay," defined as the time from symptom onset to diagnosis, subdivided into "health-seeking delay" (time from symptom onset to first visit to a health facility) and "health facility diagnostic delay" (time from first health facility visit to diagnosis), and for "treatment delay," defined as the time from diagnosis to start of treatment. We also calculated "total delay," defined as the time from symptom onset to treatment start. Based on data for 13 968 registered TB patients, the median total delay was estimated to be 37 days (IQR, 19-76). This was mostly due to health-seeking delay (median, 23 days; IQR, 8-53); in contrast, health facility diagnostic delay and treatment delay were relatively short (median, 1 day; IQR, 0-7; median, 1 day; IQR, 0-7, respectively). In 2021, health-seeking delay did not differ significantly between men and women but was shorter in children than in adults and shorter in clinically diagnosed than in bacteriologically confirmed TB cases. Health-seeking delay was longest in the East region (median, 44.5 days; IQR, 20-87) and shortest in Ulaanbaatar (median, 9; IQR, 14-64). TB treatment delay was similar across sexes, age groups and types of TB diagnosis but slightly longer among retreated cases and people living in Ulaanbaatar. Efforts to reduce TB transmission in Mongolia should prioritize decreasing delays in health seeking.

Research paper thumbnail of Use of Double Test Biomarkers to Predict Fetal Nuchal Translucency Thickness in the Diagnosis of Trisomy 21: A Compromise between Sensitivity and Specificity

Central Asian Journal of Medical Sciences

Objectives: The aim of study is to determine the sensitivity and specificity of screening for fet... more Objectives: The aim of study is to determine the sensitivity and specificity of screening for fetal trisomy 21 in the first trimester of pregnancy using a combination of maternal serum biomarkers and ultrasonography. The objectives of this study were to first duplicate and confirm within the Mongolian population, the results of other similar studies. Our results corroborated closely with those of other studies and further allowed us to draw conclusions and recommendations unique to Mongolia. A second objective was to apply these results to everyday obstetric practices within Mongolia and advance the state of prenatal care for all Mongolian women. Methods: Obstetric History: The obstetric history was recorded, and serum biomarkers were measured in 415 pregnancies.The degree of risk for trisomy 21 and other fetal aneuploidy were calculated using maternal age, the results of maternal serum pregnancy-associated plasma protein-A, free beta human chorionic gonadotropin, and fetal nuchal t...

Research paper thumbnail of Social inequality in smoking in mongolia

Population medicine, Apr 26, 2023

Population Medicine considers the following types of articles: • Research Papers-reports of data ... more Population Medicine considers the following types of articles: • Research Papers-reports of data from original research or secondary dataset analyses. • Review Papers-comprehensive, authoritative, reviews within the journal's scope. These include both systematic reviews and narrative reviews. • Short Reports-brief reports of data from original research. • Policy Case Studies-brief articles on policy development at a regional or national level. • Study Protocols-articles describing a research protocol of a study. • Methodology Papers-papers that present different methodological approaches that can be used to investigate problems in a relevant scientific field and to encourage innovation. • Methodology Papers-papers that present different methodological approaches that can be used to investigate problems in a relevant scientific field and to encourage innovation. • Letters to the Editor-a response to authors of an original publication, or a very small article that may be relevant to readers. • Editorials-articles written by the Editorial Board or by invited experts on a specific topic. Research Papers Articles reporting research may be full length or brief reports. These should report original research findings within the journal's scope. Papers should generally be a maximum of 4000 words in length, excluding tables, references, and abstract and key points of the article, whilst it is recommended that the number of references should not exceed 36.

Research paper thumbnail of Association of diabetes, smoking, and alcohol use with subclinical-to-symptomatic spectrum of tuberculosis in 16 countries: an individual participant data meta-analysis of national tuberculosis prevalence surveys

Research paper thumbnail of Epidemiology of tuberculosis in Mongolia: analysis of surveillance data, 2015-2019

Western Pacific Surveillance and Response, Apr 18, 2023

Research paper thumbnail of Socioeconomic predictors over the life course of healthy ageing index in older Eastern Europeans

Population Medicine

Population Medicine considers the following types of articles: • Research Papers-reports of data ... more Population Medicine considers the following types of articles: • Research Papers-reports of data from original research or secondary dataset analyses. • Review Papers-comprehensive, authoritative, reviews within the journal's scope. These include both systematic reviews and narrative reviews. • Short Reports-brief reports of data from original research. • Policy Case Studies-brief articles on policy development at a regional or national level. • Study Protocols-articles describing a research protocol of a study. • Methodology Papers-papers that present different methodological approaches that can be used to investigate problems in a relevant scientific field and to encourage innovation. • Methodology Papers-papers that present different methodological approaches that can be used to investigate problems in a relevant scientific field and to encourage innovation. • Letters to the Editor-a response to authors of an original publication, or a very small article that may be relevant to readers. • Editorials-articles written by the Editorial Board or by invited experts on a specific topic. Research Papers Articles reporting research may be full length or brief reports. These should report original research findings within the journal's scope. Papers should generally be a maximum of 4000 words in length, excluding tables, references, and abstract and key points of the article, whilst it is recommended that the number of references should not exceed 36.

Research paper thumbnail of Correction to: Figure 3 in Association between household solid fuel use and tuberculosis: cross-sectional data from the Mongolian National Tuberculosis Prevalence Survey

Environmental Health and Preventive Medicine

Research paper thumbnail of Patient delay and health system delay of patients with newly diagnosed pulmonary tuberculosis in Mongolia, 2016-2017

Nagoya Journal of Medical Science, May 1, 2022

Research paper thumbnail of Health-Seeking Behavior among Tuberculosis Suspected Cases in Major Cities of Mongolia

Central Asian Journal of Medical Sciences

Research paper thumbnail of Spinale intradurale Tumoren

Research paper thumbnail of Sex-adjusted approach to baseline variables demonstrated some improved predictive capabilities for disease severity and survival in patients with Coronavirus Disease 19

Informatics in Medicine Unlocked

Research paper thumbnail of Correction to: Association between household solid fuel use and tuberculosis: cross-sectional data from the Mongolian National Tuberculosis Prevalence Survey

Environmental Health and Preventive Medicine

Following the publication of the original article [1] the authors noticed that the correction req... more Following the publication of the original article [1] the authors noticed that the correction requested in Table 4 was not implemented. The "₮ "should be inserted in the "()" following "Household monthly income" as shown below. "Household monthly income (₮); n (%)". The original article [1] has been updated.

Research paper thumbnail of 1091Evaluation of symptom screening methods for tuberculosis: secondary analysis of Mongolian nationwide tuberculosis prevalence survey

International Journal of Epidemiology

Background Symptom screening for tuberculosis (TB) is a key component for identifying TB suspects... more Background Symptom screening for tuberculosis (TB) is a key component for identifying TB suspects and TB cases, particularly in resource-limited countries. This study aimed to evaluate the effectiveness of symptom screening using TB-related symptoms including the standard symptom screening criterion of chronic cough: cough for two weeks or more, to identify TB cases in the general population. Methods This study is a secondary analysis of the nationwide population-based, cross-sectional survey for TB prevalence in Mongolia in 2014-2015. Each TB-related symptom was compared between bacteriologically confirmed TB cases and bacteriologically negative participants. Results Of the 50,309 adults who received symptom screening, 248 were diagnosed as bacteriologically confirmed TB cases. The sensitivity and specificity of standard symptom screening of cough for two weeks or more were 20.6% and 95.3%, respectively. The higher sensitivity and lower specificity were reported in chronic sputum: ...

Research paper thumbnail of Genetic Mutations Associated with Isoniazid Resistance in Mycobacterium tuberculosis in Mongolia

Antimicrobial Agents and Chemotherapy

Globally, mutations in the katG gene account for the majority of isoniazid-resistant strains of M... more Globally, mutations in the katG gene account for the majority of isoniazid-resistant strains of Mycobacterium tuberculosis. Buyankhishig et al analyzed a limited number of Mycobacterium tuberculosis strains in Mongolia and found that isoniazid resistance was mainly attributable to inhA mutations. The GenoType® MTBDRplus assay was performed for isolates collected in the First National Tuberculosis Prevalence Survey and the Third Anti-Tuberculosis Drug Resistance Survey to investigate genetic mutations associated with isoniazid resistance in Mycobacterium tuberculosis in Mongolia. Of the 409 isoniazid-resistant isolates detected by the GenoType® MTBDRplus assay, 127 (31.1%) were resistant to rifampicin, 294 (71.9%) had inhA mutations without katG mutations, 113 (27.6%) had katG mutations without inhA mutations, and two (0.5%) strains had mutations in both the inhA and katG genes. Of the 115 strains with any katG mutation, 114 (99.1%) had mutations in codon 315 (S315T). Of the 296 trai...

Research paper thumbnail of Association between household solid fuel use and tuberculosis: cross-sectional data from the Mongolian National Tuberculosis Prevalence Survey

Environmental Health and Preventive Medicine

Background Tuberculosis (TB) and indoor air pollution (IAP) are equally critical public health is... more Background Tuberculosis (TB) and indoor air pollution (IAP) are equally critical public health issues in the developing world. Mongolia is experiencing the double burden of TB and IAP due to solid fuel combustion. However, no study has assessed the relationship between household solid fuel use and TB in Mongolia. The present study aimed to assess the association between household solid fuel use and TB based on data from the Mongolian National Tuberculosis Prevalence Survey (MNTP Survey). Method The MNTP Survey was a nationally representative population-based cross-sectional survey targeting households in Mongolia from 2014 to 2015, with the aim of evaluating the prevalence of TB. The survey adopted a multistage cluster sampling design in accordance with the World Health Organization prevalence survey guidelines. Clusters with at least 500 residents were selected by random sampling. A sample size of 98 clusters with 54,100 participants was estimated to be required for the survey, and...