Turgut Çavuşoğlu - Academia.edu (original) (raw)

Papers by Turgut Çavuşoğlu

Acta Cirurgica Brasileira, 2018

Purpose: To investigate the possible effects of argan oil on the healing of colorectal anastomose... more Purpose: To investigate the possible effects of argan oil on the healing of colorectal anastomoses. Methods: In Group 1 (sham), laparotomy was performed and the colon was mobilized. In the control (Group 2) and argan oil (Group 3) groups, colonic resection and anastomosis were applied. To the control and sham groups, 2 mL of 0.9% NaCl was administred rectally, and in the argan oil group, 2 mL/day argan oil was applied rectally for 7 days. Results: The mean bursting pressures of the argan oil and sham groups were significantly higher than the values in the control group. A significant difference was determined between the tissue hydroxyproline and prolidase levels of control group and other groups. Histopathologically, argan oil showed significant beneficial effects on colonic wound healing. In the argan oil and sham groups, the tissue malondialdehyde and fluorescent oxidation product levels were found to be lower and total sulfhydryl levels were higher than the control group. Conclusions: The rectally administered argan oil was observed to have significantly ameliorated wound healing parameters and exerted a significant antioxidant effect. This is the first study in the literature about the beneficial effects of argan oil on colorectal anastomoses.

Background and aim: The cases of 10 liver hydatid cysts without thoracic involvement are presente... more Background and aim: The cases of 10 liver hydatid cysts without thoracic involvement are presented that were operated on with a transthoracic approach and the results are reviewed in the light of the relevant literature. Material and methods: A total of 10 cases, who were operated on using a transthoracic approach (5 male, 5 female), were evaluated retrospectively. Results: The mean age was 37.7 years (range 16-52 years). One female had 3 cysts, 1 had 2 cysts, and a solitary cyst was present in the remaining patients. All patients were operated on transthoracally. The postoperative course was uneventful in all patients except the 1 case that had 3 hydatid cysts, which was complicated with prolonged drainage from the chest tube. This drainage decreased gradually over 20 days and the chest tube was removed on the postoperative 21st day. The average hospital stay was 9.4 days (range, 6 - 24 days). Conclusion: Hydatid cysts located in the dome of the liver were safely operated on using ...

Acta cirurgica brasileira, 2017

To investigate the potential protective effects of erdosteine against the harmful effects of isch... more To investigate the potential protective effects of erdosteine against the harmful effects of ischemia-reperfusion injury on the liver in an experimental rat model. Forty rats were divided into 4 groups. In the sham group, only the hepatic pedicle was mobilized. No other manipulation or treatment was performed. In the other groups, ischemia was achieved by clamping the hepatic pedicle for 60 min. After that, 90 min reperfusion was provided. In the control group, no treatment was given. In the perioperative treatment group, 100 mg/kg erdosteine was administered 2 hours before ischemia induction. In the preoperative treatment group, 100 mg/kg/day erdosteine was administered daily for ten days before the operation. At the end of the procedures, blood and liver samples were obtained for biochemical and histopathological assessment. Treatment with erdosteine ameliorated the histopathological abnormalities when compared with the control group. Furthermore, this treatment significantly decr...

Journal of investigative surgery : the official journal of the Academy of Surgical Research, Jan 28, 2018

Purpose/Aim of the study: Inflammation and oxidative stress are two significant factors affecting... more Purpose/Aim of the study: Inflammation and oxidative stress are two significant factors affecting the degree of liver damage in obstructive jaundice. The aim of this study was to evaluate the effect of calcium dobesilate (CaDob), an effective antioxidant and anti-inflammatory drug, on damage to liver caused by experimental obstructive jaundice. 30 rats in total were randomly placed into three groups, each group consisting of 10 rats. The sham group (Group 1) only received solely laparotomy. In the control group (Group 2), ligation was applied to the biliary tract and no treatment was implemented. In the CaDob group (Group 3), following ligation of the biliary tract, 100 mg/kg/day CaDob was implemented via an orogastric tube for a 10-day period. Liver tissue and blood samples were taken for histopathological and biochemical examination. The CaDob group had significantly lower test values for serum liver functions when compared to the control group. Statistically lower levels of tissu...

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017

The purpose of this experimental study was to evaluate the potential effects on the healing of co... more The purpose of this experimental study was to evaluate the potential effects on the healing of colorectal anastomoses of the rectal administration of Ankaferd Blood Stopper (ABS). Thirty Wistar-Albino male rats were randomly separated into 3 groups. In the sham group, only laparotomy and colonic mobilization was performed. In the other 2 groups, colon transection and anastomosis were carried out. Saline (2 mL, 0.9% NaCl) was given rectally via a feeding tube for 10 days after the surgical procedure in the sham and control groups. In Group 3 (ABS group), the rats were treated with rectally administered ABS (2 mL/day) for 10 days. In all groups, after the measurement of bursting pressures, tissue samples were collected for the measurement of tissue hydroxyproline and prolidase levels, and for histopathological evaluation on postoperative day 11. The rectal administration of ABS showed positive effects on bursting pressures, tissue prolidase and hydroxyproline levels, and the histopath...

Acta Cirurgica Brasileira, 2016

To investigate the potential protective effects of enoxaparin against the adverse events of carbo... more To investigate the potential protective effects of enoxaparin against the adverse events of carbon dioxide (CO 2) pneumoperitoneum. METHODS: Thirty four rats were divided into three groups: Group 1 (sham) underwent insertion of Veress needle into the abdomen and 90 min of anesthesia with no gas insufflation. The animals in control and enoxaparin groups were subjected to 90 min of 14 mmHg CO 2 pneumoperitoneum. Enoxaparin (100 u/kg) was administered subcutaneously to the rats in enoxaparin group one hour before the operation. After 90 min of pneumoperitoneum, the rats were allowed for reperfusion through 60 min. Blood and liver samples were obtained for biochemical and histopathological examination. RESULTS: Treatment with enoxaparin decreased the histopathological abnormalities when compared with the control group. The highest levels of oxidative stress parameters were found in control group. The use of enoxaparin decreased the levels of all oxidative stress parameters, but the difference between the control and enoxaparin groups was not statistically significant. CONCLUSION: Enoxaparin ameliorated the harmful effects of high pressure CO 2 pneumoperitoneum on the liver.

The Tokai journal of experimental and clinical medicine, 1996

To investigate the pathogenesis of post-thyroidectomy hypocalcemia calcium, phosphate, calcitonin... more To investigate the pathogenesis of post-thyroidectomy hypocalcemia calcium, phosphate, calcitonin, parathormone, albumin, triiodothyronine and thyroxine levels were monitored during operation and postoperatively in 25 female patients undergoing bilateral subtotal thyroidectomy for non-toxic nodular goiter. A highly significant fall in uncorrected serum calcium and albumin levels started with the completion of lobectomies and a significant correlation between the course of serum calcium and albumin levels were seen, an early peak in calcitonin corresponded well with the a drop in corrected calcium and inorganic phosphate levels. An overt parathyroid response to hypocalcemia was not observed. We conclude, on the basis of the postoperative hypoalbuminemia, that a calcitonin leak triggered the early onset of hypocalcemia while an insufficient parathyroid response contributed to the post-thyroidectomy hypocalcemia.

Ophthalmologica, 2007

Aims: To evaluate preoperative and postoperative conjunctival surface changes in multinodular goi... more Aims: To evaluate preoperative and postoperative conjunctival surface changes in multinodular goiter (MNG) patients and to compare their results with healthy control subjects. Methods: Twenty MNG patients who had undergone near total thyroidectomy were evaluated pre- and postoperatively at the end of the 3rd month and the 1st year by performing tear function tests and conjunctival impression cytologic analysis. These results were compared with the results of 15 healthy volunteers. Results: When preoperative and postoperative tear function parameters were compared, the mean Schirmer test value and BUT value were decreased, the mean Rose Bengal staining score was increased during the postoperative period. These differences were statistically significant at the end of the 1st year (p < 0.001). The average goblet cell density of the MNG patients decreased significantly during the postoperative period when compared with the preoperative values (p < 0.001). All these findings of the...

Journal of Investigative Surgery, 2003

We investigated the possible use of D-lactate as a predictor in the diagnosis of appendicitis. C-... more We investigated the possible use of D-lactate as a predictor in the diagnosis of appendicitis. C-reactive protein level (CRP) and leukocyte counts were also evaluated. Venous blood D-lactate, CRP, and leukocyte counts were measured preoperatively in 53 patients undergoing surgery for appendicitis, as well as in 20 healthy subjects. Levels of all three parameters in the surgical patients were significantly higher than in the control group (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.05). Previous studies have shown that venous D-lactate is more specific to the intestine than CPR or leukocyte count. Based on our data, venous D-lactate, which had the lowest false-negative rate among these laboratory parameters, may be a useful diagnostic marker for appendicitis. None of these parameters were helpful in identifying the type of the appendicitis.

Journal of Investigative Surgery, 2011

This study was established to assess the effects of low dose enoxaparin on plasma malondialdehyde... more This study was established to assess the effects of low dose enoxaparin on plasma malondialdehyde levels during laparoscopic cholecystectomy as a model of ischemia-reperfusion. Fifty patients, scheduled for laparoscopic cholecystectomy, were randomized into two groups of 25 patients in each. In enoxaparin group, patients had 20 mg/0.2 ml subcutaneous (sc) enoxaparin 2 hr before surgery. Blood samples were obtained for malondialdehyde, alanine transferase, aspartate transferase, measurements before the insufflation, 1 min before deflation, and 20 min after deflation. Plasma malondialdehyde concentrations were insignificant between enoxaparin and control groups before insufflation (1.64 ± 2.66 vs. 2.45 ± 4.42 μmol l(-1); p = 0.44) and 1 min before deflation (1.55 ± 2.61 vs. 3.66 ± 5.68 μmol l(-1); p = 0.38). Malondialdehyde levels significantly increased in control group 20 min after deflation in respect to enoxaparin group (1.52 ± 2.67 vs. 6.04 ± 7.85 μmol l(-1)), (p = 0.049). In control group, plasma malondialdehyde concentrations increased significantly compared with initial level throughout the study (p = 0.001). Within enoxaparin group, no statistically significant change was observed (p = 0.28). Plasma alanine transferase and aspartate transferase levels increased similarly in both groups during the study (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05). Alanine transferase and aspartate transferase increases within each group were statistically significant for all times (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). As a conclusion, mini dose of enoxaparin used sc&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;ly 2 hr before the operation, prevented the malondialdehyde increase during reperfusion period after laparoscopic cholecystectomy without causing any bleeding disorder while having no effect on serum alanine transferase, aspartate transferase increase.

Material and Methods: A 15x25 mm full thickness defect at anterior abdominal wall was created in ... more Material and Methods: A 15x25 mm full thickness defect at anterior abdominal wall was created in 30 guinea pigs (study and control groups of 15 each). In the control group, polypropylene mesh at proper size was sutured to the edge of the defect. In the study group, two layer large size polypropylene mesh attached to each other centrally with a poliglactin suture; was placed as it surrounded the abdominal wall defect edges internally and externally. The extraabdominal layer was attached to the anterior fascia with poliglactin sutures not involving the inner surface of abdominal wall. At 30 days, the animals were sacrificed and the prevalence, presence and resistance of the adhesions were evaluated by using a scoring system.

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, 2020

Amaç: Tiroid bez hastalıkları en önemli endokrin sorunlarından biridir. Tiroid ince iğne aspirasy... more Amaç: Tiroid bez hastalıkları en önemli endokrin sorunlarından biridir. Tiroid ince iğne aspirasyon biyopsisi (TİİAB)'nin ana rolü; hastaları cerrahi ve konservatif tedavi seçenekleri açısından ayırt etmektir. Bu çalışma ile Ankara Eğitim ve Araştırma Hastanesi’nde tiroidektomi operasyonu uygulanmış hastalara ilişkin tiroid ince iğne aspirasyon biyopsisi (TİİAB) sonuçları ile histopatoloji rapor sonuçlarının karşılaştırılarak, tiroid nodüllerindeki İİAB etkinliğinin değerlendirilmesi amaçlanmıştır.Gereç ve Yöntemler: Ankara Eğitim ve Araştırma Hastanesi’nde 2007-2012 yılları arasında TİİAB sonucu önemi belirsiz atipi (AUS) tanısı konulan ve troidektomi operasyonu yapılan hastaların histopatolojik verileri karşılaştırıldı.Bulgular: Çalışmamıza toplam 87 hasta dahil edildi. 77 (% 88.5) hasta kadın, 10 (% 11.5) hasta erkekti. 77 kadın hastaya 55'i (% 71.4) benign, 22'si (% 28.6) malign nodül teşhisi konuldu. On erkek hastanın 8'ine (% 80) benign, 2'sine (% 20) mali...

Turkish Journal of Trauma and Emergency Surgery, 2018

BACKGROUND: This study investigates the protective effect of calcium dobesilate (CaDob), an effec... more BACKGROUND: This study investigates the protective effect of calcium dobesilate (CaDob), an effective antioxidant and anti-inflammatory drug, on experimental liver ischemia-reperfusion injury (IRI). METHODS: Forty rats were divided into four groups. In Group 1, (sham), only hepatic pedicle was induced. In Group 2 (control), hepatic pedicle was reperfused for 90 min after being clamped for 60 min. No treatment was given in Group 1 and 2. In Group 3 (perioperative CaDob), 100 mg/kg CaDob was given 2 hours prior to the operation in which hepatic pedicle was reperfused for 90 min following a 60-min clamp. In Group 4 (preoperative CaDob), after 100 mg/kg/day CaDob was given for 10 days before the operation, hepatic pedicle was clamped for 60 min and reperfused for 90 minutes. At the end of these procedures, blood and liver tissue samples were collected for biochemical and histopathological assessment. RESULTS: Liver function tests and tissue oxidative stress parameters were significantly lower in the preoperative and perioperative treatment groups than the control group. Furthermore, it was observed that histopathological injury in the control group significantly decreased in both perioperative and preoperative treatment groups. CONCLUSION: Calcium dobesilate demonstrated a significant hepatoprotective effect in terms of its antioxidant and anti-inflammatory effects.

Annals of Surgical Treatment and Research, 2016

Purpose: Seroma is among the most common complications of laparoscopic total extraperitoneal (TEP... more Purpose: Seroma is among the most common complications of laparoscopic total extraperitoneal (TEP) for especially large indirect inguinal hernia, and may be regarded as a recurrence by some patients. A potential area localized behind the mesh and extending from the inguinal cord into the scrotum may be one of the major etiological factors of this complication. Our aim is to describe a novel tech nique in preventing pseudorecurrence by using fibrin sealant to close that potential dead space. Methods: Forty male patients who underwent laparoscopic TEP for indirect inguinal hernia with at least 100-mL volume were included in this prospective clinical study. While fibrin sealant was used to close the potential dead space in the study group, nothing was used in the control group. The volume of postoperative fluid collection on ultrasound was compared between the groups. Results: Patient characteristics and the volumes of hernia sac were similar between the 2 groups. The mean volume of postoperative fluid collection was found as 120.2 mL in the control group and 53.7 mL in the study group, indicating a sta tistical significance (P < 0.001). Conclusion: Minimizing the potential dead space with a fibrin sealant can reduce the amount of postoperative fluid collection, namely the incidence of pseudorecurrence.

Turkiye Klinikleri Journal of Gastroenterohepatology, 1993

Ankara Üniversitesi Tıp Fakültesi Genel Cenahi ABD, ANKARA ÖZET 73 karaciğer hemangioma'sından ol... more Ankara Üniversitesi Tıp Fakültesi Genel Cenahi ABD, ANKARA ÖZET 73 karaciğer hemangioma'sından oluşan bu seride %92.3'ü kadın olan hastalarda belirtilerin meydana çık ması için geçen süre 29.2 aydır. Fizik muayenede %100 oranında tümör bulundu. Bir hastada, abse öntanısıyla yapılan ponksiyon sonucu rüptür vardı. Bir hastada selek ti! hepatik anjiografi ve 6 hastada Ultrasonografi ile ameli yat öncesi doğru tanı konabildi. Öntanıda yanılma oranı %47'dir. Tedavide 3 defa atipik lobektomi, 5 defa Art.hepatica ligatür'ü ve 5 defa da radyoterapi kullanıldı. Erken post-operatif dönemde morbidité ve mortalité yoktur. 1-4 yıl izlenen uzak sonuçlar memnunluk verici olmuştur.

Turkiye Klinikleri Journal of Case Reports, 2002

Turkiye Klinikleri Journal of Gastroenterohepatology, 1991

ÖZET Safra yollarına açılmış 32 hastadan meydana gelen bir K.H. serisi sunuldu. Tanıda en çok yar... more ÖZET Safra yollarına açılmış 32 hastadan meydana gelen bir K.H. serisi sunuldu. Tanıda en çok yardımcı yöntem Üllrasonografı olur. Yanlış ön lanı oranı %10'dur. Oddi sfınkleri'ndeki patolojinin tedavisi için sistematik (T) drenajı uygulandı. Bu tedavinin, hastalığın fızyopalolojisi yönünden en uygun yöntem olduğu düşünüldü. Total morbidité %36,5'dir. Mor talité yoktur. Uzak sonuçlar cesaret verici olmuştur.

Turkiye Aile Hekimligi Dergisi, 2013

Bu dergide yer alan yazı, makale, fotoğraf ve illüstrasyonların elektronik ortamlarda dahil olmak... more Bu dergide yer alan yazı, makale, fotoğraf ve illüstrasyonların elektronik ortamlarda dahil olmak üzere kullanma ve çoğaltılma hakları Türkiye Aile Hekimleri Uzmanlık Derneği'ne aittir. Yazılı ön izin olmaksızın materyallerin tamamının ya da bir bölümünün çoğaltılması yasaktır. © Rights to the use and reproduction, including in the electronic media, of all communications, papers, photographs and illustrations appearing in this journal belong to Turkish Association of Family Physicians. Reproduction without prior written permission of part or all of any material is forbidden.

Türk Yoğun Bakım Derneği Dergisi, 2012

Bu çalışmada, parenteral yoldan farklı lipid içeren nutrisyon solüsyonu ile beslenen yoğun bakım ... more Bu çalışmada, parenteral yoldan farklı lipid içeren nutrisyon solüsyonu ile beslenen yoğun bakım hastalarında biyokimyasal parametrelerdeki değişikliklerin ve nutrisyonun etkinliğinin karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya dahil edilen 45 yoğun bakım hastası, soya yağı bazlı (Grup 1), zeytinyağı bazlı (Grup 2) ve MCT/LCT bazlı (Grup 3) lipid içeren nutrisyon solüsyonu almak üzere randomize olarak 3 gruba ayrıldı. Hastaların gereksinimleri olan kalori Schofield eşitliği kullanılarak hesaplandı.