UMAIR AHMED - Academia.edu (original) (raw)

Papers by UMAIR AHMED

Research paper thumbnail of Brain abscess in children

Indian journal of pediatrics, 1988

Patients and Methods The medical records of the patients diagnosed as having intracranial infecti... more Patients and Methods The medical records of the patients diagnosed as having intracranial infective lesions and cared for at our hospital during four and half years period (1982-86) from May 1982 to December 1986 were reviewed. Total 181 cases could be categorised ...

Research paper thumbnail of Frequency and characteristic features of portal hypertensive gastropathy in patients with viral cirrhosis

To determine the frequency and specific characteristic features of portal hypertensive gastropath... more To determine the frequency and specific characteristic features of portal hypertensive gastropathy (PHG) in cirrhosis due to viral etiology. Cross-sectional descriptive study. The Aga Khan University Hospital, Karachi, from June 2006 till June 2008. Patients with hepatitis B and C cirrhosis were included who underwent screening esophago-gastroduodenoscopy (EGD) for varices. Baveno III consensus statement was used for diagnosing PHG on

Research paper thumbnail of Precipitating Factors and The Outcome of Hepatic Encephalopathy in Liver Cirrhosis

Objective: To determine precipitants of hepatic encephalopathy (HE) and their impact on hospital ... more Objective: To determine precipitants of hepatic encephalopathy (HE) and their impact on hospital stay and mortality. Study Design: Cross-sectional, analytical study. Place and Duration of Study: The Aga Khan University Hospital, from January 2005 to December 2007. Methodology: Consecutive patients admitted with different grades of HE were evaluated between January 2005 and December 2007. The precipitants of HE were correlated

Research paper thumbnail of Diagnostic Accuracy of Qualitative Versus Quantitative Tuning Forks

Journal of Clinical Neuromuscular Disease, 2014

To assess the diagnostic accuracy of the Rydel-Seiffer tuning fork versus the qualitative 128-Hz ... more To assess the diagnostic accuracy of the Rydel-Seiffer tuning fork versus the qualitative 128-Hz tuning fork for detecting sensory axonal neuropathy. One hundred consecutive patients seen at the Neurology Outpatient Electromyography clinic at a major academic center were recruited and consented for this study. Study personnel who were blinded to results of nerve conduction studies collected data on vibratory perception with both tuning forks at bilateral (1) great toe and (2) distal interphalangeal joint on the second digit. Published normative data were used to determine abnormal scores for the Rydel-Seiffer tuning fork and the qualitative tuning fork; axonal neuropathy was determined based on sensory nerve action potential amplitudes as per our electromyography laboratory standards. A total of 186 sensory nerves from 100 patients were tested with tuning forks and nerve conduction studies. The sensitivity and specificity of the Rydel-Seiffer tuning fork to detect axonal neuropathy was 26% and 89%, respectively, and the sensitivity and specificity of the conventional 128-Hz tuning fork to detect axonal neuropathy was 20% and 88%, respectively. The extended McNemar test showed no significant difference in sensitivity or specificity between the 2 tuning forks (χ = 1.695; P = 0.43). There is no difference in diagnostic accuracy between the Rydel-Seiffer tuning fork and conventional tuning fork for detecting sensory axonal neuropathies; however, the Rydel-Seiffer is easier to use and may be superior for longitudinal assessments.

Research paper thumbnail of Virological and clinical characteristics of hepatitis delta virus in South Asia

Background & Aims: There is a paucity of data on the impact of hepatitis D virus (HDV) in patient... more Background & Aims: There is a paucity of data on the impact of hepatitis D virus (HDV) in patients with hepatitis B virus (HBV) infection from South Asia. We studied the impact of HDV co-infection on virological and clinical characteristics.

Research paper thumbnail of Outcomes in culture positive and culture negative ascitic fluid infection in patients with viral cirrhosis: cohort study

Background: Ascitic fluid infection (AFI) in cirrhotic patients has a high morbidity and mortalit... more Background: Ascitic fluid infection (AFI) in cirrhotic patients has a high morbidity and mortality. It has two variants namely, spontaneous bacterial peritonitis (SBP) and culture negative neutrocytic ascites (CNNA). The aim of this study was to determine the outcome in cirrhotic patients with culture positive (SBP) and culture negative neutrocytic ascites.

Research paper thumbnail of Antibacterial activity of the venom of Heterometrus xanthopus

Indian Journal of Pharmacology, 2012

Heterometrus xanthopus (Scorpion) is one of the most venomous and ancient arthropods. Its venom c... more Heterometrus xanthopus (Scorpion) is one of the most venomous and ancient arthropods. Its venom contains anti-microbial peptides like hadrurin, scorpine, Pandinin 1, and Pandinin 2 that are able to effectively kill multidrug-resistant pathogens. The present study was conducted to evaluate the anti-bacterial activity of H. xanthopus venom. Six Gram-positive and Gram-negative bacterial strains were tested against 1/100, 1/10, and 1/1 fractions of distilled water diluted and crude venom. 1/100 and 1/10 dilutions were not successful in any of the six bacterial strains studied while the 1/1 dilution was effective on Bacillus subtilis ATCC 6633, Salmonella typhimurium ATCC 14028, and Pseudomonas aeruginosa ATCC 27853 with highest zone of inhibition were obtained on B. subtilis. Crude venom was effective against Enterococcus faecalis ATCC 14506, B. subtilis, S. typhimurium, and P. aeruginosa. The most effective results were observed on B. subtilis.

Research paper thumbnail of Brain abscess in children

Indian journal of pediatrics, 1988

Patients and Methods The medical records of the patients diagnosed as having intracranial infecti... more Patients and Methods The medical records of the patients diagnosed as having intracranial infective lesions and cared for at our hospital during four and half years period (1982-86) from May 1982 to December 1986 were reviewed. Total 181 cases could be categorised ...

Research paper thumbnail of Frequency and characteristic features of portal hypertensive gastropathy in patients with viral cirrhosis

To determine the frequency and specific characteristic features of portal hypertensive gastropath... more To determine the frequency and specific characteristic features of portal hypertensive gastropathy (PHG) in cirrhosis due to viral etiology. Cross-sectional descriptive study. The Aga Khan University Hospital, Karachi, from June 2006 till June 2008. Patients with hepatitis B and C cirrhosis were included who underwent screening esophago-gastroduodenoscopy (EGD) for varices. Baveno III consensus statement was used for diagnosing PHG on

Research paper thumbnail of Precipitating Factors and The Outcome of Hepatic Encephalopathy in Liver Cirrhosis

Objective: To determine precipitants of hepatic encephalopathy (HE) and their impact on hospital ... more Objective: To determine precipitants of hepatic encephalopathy (HE) and their impact on hospital stay and mortality. Study Design: Cross-sectional, analytical study. Place and Duration of Study: The Aga Khan University Hospital, from January 2005 to December 2007. Methodology: Consecutive patients admitted with different grades of HE were evaluated between January 2005 and December 2007. The precipitants of HE were correlated

Research paper thumbnail of Diagnostic Accuracy of Qualitative Versus Quantitative Tuning Forks

Journal of Clinical Neuromuscular Disease, 2014

To assess the diagnostic accuracy of the Rydel-Seiffer tuning fork versus the qualitative 128-Hz ... more To assess the diagnostic accuracy of the Rydel-Seiffer tuning fork versus the qualitative 128-Hz tuning fork for detecting sensory axonal neuropathy. One hundred consecutive patients seen at the Neurology Outpatient Electromyography clinic at a major academic center were recruited and consented for this study. Study personnel who were blinded to results of nerve conduction studies collected data on vibratory perception with both tuning forks at bilateral (1) great toe and (2) distal interphalangeal joint on the second digit. Published normative data were used to determine abnormal scores for the Rydel-Seiffer tuning fork and the qualitative tuning fork; axonal neuropathy was determined based on sensory nerve action potential amplitudes as per our electromyography laboratory standards. A total of 186 sensory nerves from 100 patients were tested with tuning forks and nerve conduction studies. The sensitivity and specificity of the Rydel-Seiffer tuning fork to detect axonal neuropathy was 26% and 89%, respectively, and the sensitivity and specificity of the conventional 128-Hz tuning fork to detect axonal neuropathy was 20% and 88%, respectively. The extended McNemar test showed no significant difference in sensitivity or specificity between the 2 tuning forks (χ = 1.695; P = 0.43). There is no difference in diagnostic accuracy between the Rydel-Seiffer tuning fork and conventional tuning fork for detecting sensory axonal neuropathies; however, the Rydel-Seiffer is easier to use and may be superior for longitudinal assessments.

Research paper thumbnail of Virological and clinical characteristics of hepatitis delta virus in South Asia

Background & Aims: There is a paucity of data on the impact of hepatitis D virus (HDV) in patient... more Background & Aims: There is a paucity of data on the impact of hepatitis D virus (HDV) in patients with hepatitis B virus (HBV) infection from South Asia. We studied the impact of HDV co-infection on virological and clinical characteristics.

Research paper thumbnail of Outcomes in culture positive and culture negative ascitic fluid infection in patients with viral cirrhosis: cohort study

Background: Ascitic fluid infection (AFI) in cirrhotic patients has a high morbidity and mortalit... more Background: Ascitic fluid infection (AFI) in cirrhotic patients has a high morbidity and mortality. It has two variants namely, spontaneous bacterial peritonitis (SBP) and culture negative neutrocytic ascites (CNNA). The aim of this study was to determine the outcome in cirrhotic patients with culture positive (SBP) and culture negative neutrocytic ascites.

Research paper thumbnail of Antibacterial activity of the venom of Heterometrus xanthopus

Indian Journal of Pharmacology, 2012

Heterometrus xanthopus (Scorpion) is one of the most venomous and ancient arthropods. Its venom c... more Heterometrus xanthopus (Scorpion) is one of the most venomous and ancient arthropods. Its venom contains anti-microbial peptides like hadrurin, scorpine, Pandinin 1, and Pandinin 2 that are able to effectively kill multidrug-resistant pathogens. The present study was conducted to evaluate the anti-bacterial activity of H. xanthopus venom. Six Gram-positive and Gram-negative bacterial strains were tested against 1/100, 1/10, and 1/1 fractions of distilled water diluted and crude venom. 1/100 and 1/10 dilutions were not successful in any of the six bacterial strains studied while the 1/1 dilution was effective on Bacillus subtilis ATCC 6633, Salmonella typhimurium ATCC 14028, and Pseudomonas aeruginosa ATCC 27853 with highest zone of inhibition were obtained on B. subtilis. Crude venom was effective against Enterococcus faecalis ATCC 14506, B. subtilis, S. typhimurium, and P. aeruginosa. The most effective results were observed on B. subtilis.