Ufuk Koca - Academia.edu (original) (raw)

Papers by Ufuk Koca

Current Molecular Pharmacology, Dec 16, 2021

Acta Biologica Turcica, Mar 20, 2021

Silk fibers are made by silkworms and spiders, produced in the form of non-woven fiber with prote... more Silk fibers are made by silkworms and spiders, produced in the form of non-woven fiber with protein structure. The silk obtained from the Bombyx mori silkworm, which is the most widely used, has many different and attractive features that have been won recognition for 5,000 years. When the raw silk fiber is examined, the fibroin layer is seen on the inside of the fiber and the layer of sericin covering the fiber on the outer part. 72-81% of the raw silk fiber is fibroin and the remaining 19-28% is sericin. The sericin layer, covering the perfect brightness of the fibroin part of the silk, gives the silk fiber a yellowish color and stiffness. Silk fibroin has been the subject of biotechnological and biomedical studies with its elastic, strong, biocompatible, biodegradable and thermally stable properties. The fact that silk is easily available in fiber forms from cocoons is the preferred reason for silk fibroin; It can be obtained in different forms such as gel, powder or membrane and thus varies in application areas. Its dense or porous structure, controllable solubility and oxygen permeability, the diversity of the usage area and the availability of the material have enabled the use of silk in many different sectors except the textile sector, which is the traditional application area. In this review, structure of silk protein fibroin from B. mori and its usage in health were compiled.

Apple Academic Press eBooks, Oct 4, 2020

Turkish journal of pharmaceutical sciences, 2008

Primus armeniaca L. (Rosaceae), known as apricot, is one of the major export products of Turkey a... more Primus armeniaca L. (Rosaceae), known as apricot, is one of the major export products of Turkey and its seed oil has become quite popular in cosmetics industry. On this purpose, fatty acid analysis of the seed oils of three apricot cultivars (Primus armeniaca L.) from different localities in Turkey (Kalecik, Bodrum, and Malatya) was carried out by both gas chromotography (GC) and gas chromatography-mass spectrometry (GC-MS). The results showed that various differences were observed among the fatty acid contents of these three apricot seed oils. According to our data, it was found that the Malatya sample had the richest in linolenic acid content (10.87%) and the Bodrum sample had the highest in linoleic acid (34.77%). On the other hand, Kalecik-originated one was found to contain the lowest palmitic acid amount among all samples studied.

World Journal of Gastroenterology, Oct 21, 2021

Information about the coronavirus disease 2019 (COVID-19) pandemic is still evolving since its ap... more Information about the coronavirus disease 2019 (COVID-19) pandemic is still evolving since its appearance in December 2019 and has affected the whole world. Particularly, a search for an effective and safe treatment for COVID-19 continues. Botanical mixtures contain secondary metabolites (such as flavonoids, phenolics, alkaloids, essential oils etc.) with many therapeutic effects. In this study, the use of herbal treatments against COVID-19 was evaluated. Medical synthetic drugs focus mainly on respiratory symptoms, however herbal therapy with plant extracts may be useful to relieve overall symptoms of COVID-19 due to the variety of bioactive ingredients. Since COVID-19 is a virus that affects the respiratory tract, the antiviral effects of botanicals/plants against respiratory viruses have been examined through clinical studies. Data about COVID-19 patients revealed that the virus not only affects the respiratory system but different organs including the gastrointestinal (GI) system. As GI symptoms seriously affect quality of life, herbal options that might eliminate these problems were also evaluated. Finally, computer modeling studies of plants and their active compounds on COVID-19 were included. In summary, herbal therapies were identified as potential options for both antiviral effects and control of COVID-19 symptoms. Further data will be needed to enlighten all aspects of COVID-19 pathogenesis, before determining the effects of plants on severe acute respiratory syndrome coronavirus 2.

Apple Academic Press eBooks, Oct 4, 2020

IEEE Transactions on Biomedical Engineering, 2010

Journal of Trace Elements in Medicine and Biology

Boronic acid compounds and natural flavonoid compound quercetin were handled to synthesize novel ... more Boronic acid compounds and natural flavonoid compound quercetin were handled to synthesize novel two ligands encoded as B1(2,2'-(1,4-phenylenebis (benzo [1,3,2] dioxaborole-2,5-diyl)) bis (3,5,7-trihydroxy-4H- chromen-4-one) and B2 (3.3.6. 3,5,7-trihydroxy-2-(2-(6-methoxypyridin-3-yl)benzo[d][1,3,2]dioxaborol-5-yl)-4H-chromene-4). Antioxidant activities of synthesized compounds were examined in vitro. Antioxidant features of B1 and B2 were investigated by 2,2-diphenyl picryl hydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and CUPRIC reducing antioxidant capacity (CUPRAC) methods. Anticholinesterase effects of ligands were determined by acetylcholinesterase and butyrylcholinesterase methods, cytotoxic effects of ligand (B2) were applied to healthy breast and colon cancer cell lines by MTT method, as well as urease and tyrosinase enzyme activities were determined. Moreover, antibacterial properties of the compounds were analyzed by detecting th...

Nigerian Journal of Natural Products and Medicine, 2006

No Abstracts. Nigerian Journal of Natural Products and Medicine Vol.10(0) 2006: pp.82-83

İstanbul Journal of Pharmacy

and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofil... more and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofilm formation of human pathogens.

Bu çalışmada, son yıllarda tüm yaş gruplarında bitkisel ürünlere yönelimin artmasından yola çıkar... more Bu çalışmada, son yıllarda tüm yaş gruplarında bitkisel ürünlere yönelimin artmasından yola çıkarak, çocuk polikliniğine başvuran çocukların ve ebeveynlerinin bitkisel ürün kullanımının araştırılması ve değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Anket çalışması, Gülhane Eğitim ve Araştırma Hastanesi Çocuk Hastalıkları Polikliniği'ne başvuran 200 ebeveynle yüz yüze görüşülerek gerçekleştirilmiştir. Katılımcıların demografik özellikleri ve bitkisel ürün kullanımı, sağlık personeline danışma durumları, bitkisel ürünler ile ilgili düşünceleri hakkında bilgi edinilmiş ve istatistiksel analizlerle değerlendirilmiştir. Bulgular: Anket sonuçlarına göre çocukların 36'sının (%18) kronik hastalığı olup 31'inin (%86) tedavi amaçlı bitkisel ürün kullandığı tespit edilmiştir. Ebeveynlerin 162'si (%81), çocukları için en çok soğuk algınlığı, öksürük, gaz sancısı tedavisi için bitki veya bitkisel ürün uygulamış ve bu ürünleri çoğunlukla aktarlardan temin etmiştir. Bitkisel ürün kullanımı erkek ebeveynlerde, kadınlara göre daha yüksek olup aynı rahatsızlığı çeken kişilerin fayda görmesi aileler tarafından önemli bir kriter olarak göz önünde bulundurulmuştur. Bitkisel ürün tercihlerinde arkadaş ve akraba tavsiyeleri etkili olmuştur. Ailelerin 86'sının (%53) hekim veya sağlık personeline danışmadan bitkisel ürünleri kullandığı, 134'ünün (%82,5) bitkisel ürünleri kullanmadan önce güvenli olup olmadığını araştırdığı, 129'unun (%80) bitkisel ürünlerden fayda gördüğünü ifade ettiği, 96'sının (%59) ise bitkisel yöntemlerin etkin ve güvenilir olduğunu düşündüğü anket sonucunda tespit edilmiştir. Sonuç: Bitkisel ve doğal ürünlerle tedavi yöntemlerinin tıbbi ilaçlardan daha doğal ve yan etkisinin daha az olduğunun aileler tarafından ifade edildiği görülmüş olup, konu ile ilgili hekim veya sağlık personeline verilecek eğitimler ile ailelerin daha doğru yönlendirilebileceği düşünülmektedir. Anahtar Kelimeler: Fitoterapi; çocuklar için fitoterapötikler; pediatri; geleneksel ve tamamlayıcı tıp; bitkisel tedavi. Investigation of Herbs and Herbal Products Utilization in Children ABSTRACT Aim: In study, it was aimed to investigate and evaluate the use of herbs/herbal products by children and their parents who applied to the pediatric outpatient clinic, since the tendency to herbal products has increased in all age groups in recent years. Material and methods: Materials and Methods: The survey was conducted by face-to-face interviews with 200 parents who applied to the Gulhane Training and Research Hospital Pediatrics Polyclinic. Information about the demographic characteristics of the participants, use of herbals, consultation with health personnel, and opinions about herbals were obtained and evaluated with statistical analysis. Results: According to results, 36(18%) of the families have children with chronical disease and 31(86%) use herbal products. 162(81%) of families apply herbals for their children. Phytotherapeutics are mostly used for cold, cough, gas pain symptoms. Herbals are mostly obtained from herbalists. Herbals use is higher in men than in women. Suggestions of friends, family and relatives are effective in herbals preferences. In addition, experience of people who suffer and benefit from the same disease is considered as an important criterion by families. 129(80%) of families benefit from herbals and 134(82.5%) of them research whether it is safe before using herbals. 86(53%) of families use herbals without consulting physician/healthcare staff, 96(59%) think that herbal methods are effective and safe and feel better

Records of Natural Products, 2017

Journal of Medicinal Food, 2011

Turkish journal of pharmaceutical sciences, Sep 19, 2022

Objectives: The lack of a specific proven treatment for coronavirus disease-2019 (COVID-19) has l... more Objectives: The lack of a specific proven treatment for coronavirus disease-2019 (COVID-19) has led individuals to use different treatment options. Although their effects on COVID-19 have not been proven, interest in dietary supplements and aromatherapy has increased during the pandemic period. In this study, use of dietary supplements and aromatherapy was investigated for COVID-19 among individuals living within the borders of Türkiye. Materials and Methods: This cross-sectional survey study was conducted among 310 individuals. The questionnaire was prepared using online Google Forms and communicated to the participants via social media platforms. The data obtained from the study were analyzed with the statistical program. Results: The analyzes of the survey revealed that participants increased the usage of supplements mostly prophylactic and for treatment purposes during COVID-19 pandemic, 31.9% individuals declared that they consumed herbal tea/products, 38.1% of them used vitamin/mineral supplements (multivitamin-mineral, vitamins B1, B6, B12, C, D, calcium, coenzyme Q10, iron, magnesium, selenium, and zinc), and 18.4% of the individuals applied aromatherapy (meaning treatment with essential oils). As a result of the study, the most commonly used supplement was vitamin D, the most commonly consumed tea was green tea, the essential oil was thyme oil, and the most eaten vegetable was garlic. Moreover, other frequently used herbal products were found to contain ginger and onion as food and peppermint and eucalyptus oils as aromatherapeutics. Participants often reported that they found it safe to use elevated levels of herbs or herbal products against COVID-19. Conclusion: Among the individuals participating in this study, it has been observed that the use of dietary supplements has increased during the COVID-19 pandemic period. The study revealed that vitamin D is prominent in self-medication use. Moreover, interest in aromatherapy and dietary supplements has increased. Among aromatherapeutics, thyme stood out over the applied essential oils.

Evidence-based Complementary and Alternative Medicine, 2011

Achillea species are widely used for diarrhea, abdominal pain, stomachache and healing of wounds ... more Achillea species are widely used for diarrhea, abdominal pain, stomachache and healing of wounds in folk medicine. To evaluate the wound healing activity of the plant, extracts were prepared with different solvents; hexane, chloroform, ethyl acetate and methanol, respectively from the roots of Achillea biebersteinii. Linear incision by using tensiometer and circular excision wound models were employed on mice and rats. The wound healing effect was comparatively evaluated with the standard skin ointment Madecassol. The n-hexane extract treated groups of animals showed 84.2% contraction, which was close to contraction value of the reference drug Madecassol (100%). On the other hand the same extract on incision wound model demonstrated a significant increase (40.1%) in wound tensile strength as compared to other groups. The results of histoptological examination supported the outcome of linear incision and circular excision wound models as well. The experimental data demonstrated that A. biebersteinii displayed remarkable wound healing activity. 2 Evidence-Based Complementary and Alternative Medicine 2. Materials and Methods 2.1. Plant Material. Achillea biebersteinii Afan. aerial parts were collected from Beynam forest, Ankara, Turkey, in May 2007 and was identified by Prof. Dr M. Vural from the Department of Botany, Faculty of Art and Science, Gazi University. A voucher specimen was deposited in the Herbarium of Faculty of Pharmacy, Gazi University (GUE-2602). 2.2. Extraction. Following dissection of the aerial parts of A. biebersteinii Afan., they were shade dried. Each 30 g aerial parts was submitted to successive solvent extractions seperatelly with n-hexane, chloroform, ethyl acetate and methanol at room temperature for a day (500 ml each solvent). This was repeated in two trials. After filtration, the extracts were evaporated at 40 • C (Buchi, Switzerland) to dryness in vacuo. Yields of each extracts were 7.9% for nhexane, 4.8% for diethyl ether, 1.3% for ethyl acetate and 15.3% for methanol.

Turkish journal of pharmaceutical sciences, 2017

Journal of dermatology and skin science, Nov 24, 2020

Transdermal drug delivery system is an administration route, where active molecules are administe... more Transdermal drug delivery system is an administration route, where active molecules are administered through the skin with advantages of a lesser amount of hepatic first pass effect, constant plasma drug concentration and safety. The skin has a barrier function for the passage of medicines as well as toxic molecules, thus, permeation boosters/enhancers are used to increase the permeability of medication through the skin. In this mini review, recent studies on essential oils that can be used to increase skin penetration in transdermal applications and the possible mechanisms of their effects are reviewed. Essential oils increase skin penetration by interacting with the stratum corneum (SC). They were found to be successful in increasing skin penetration of both lipophilic and hydrophilic drugs. Moreover, essential oils do not accumulate in the body since they are volatile, and also are easily discharged from the body through feces and urine. They are preferred because essential oils are natural, mostly do not damage the skin while increasing skin penetration, less toxic, and less allergenic.

Current Molecular Pharmacology, Dec 16, 2021

Acta Biologica Turcica, Mar 20, 2021

Silk fibers are made by silkworms and spiders, produced in the form of non-woven fiber with prote... more Silk fibers are made by silkworms and spiders, produced in the form of non-woven fiber with protein structure. The silk obtained from the Bombyx mori silkworm, which is the most widely used, has many different and attractive features that have been won recognition for 5,000 years. When the raw silk fiber is examined, the fibroin layer is seen on the inside of the fiber and the layer of sericin covering the fiber on the outer part. 72-81% of the raw silk fiber is fibroin and the remaining 19-28% is sericin. The sericin layer, covering the perfect brightness of the fibroin part of the silk, gives the silk fiber a yellowish color and stiffness. Silk fibroin has been the subject of biotechnological and biomedical studies with its elastic, strong, biocompatible, biodegradable and thermally stable properties. The fact that silk is easily available in fiber forms from cocoons is the preferred reason for silk fibroin; It can be obtained in different forms such as gel, powder or membrane and thus varies in application areas. Its dense or porous structure, controllable solubility and oxygen permeability, the diversity of the usage area and the availability of the material have enabled the use of silk in many different sectors except the textile sector, which is the traditional application area. In this review, structure of silk protein fibroin from B. mori and its usage in health were compiled.

Apple Academic Press eBooks, Oct 4, 2020

Turkish journal of pharmaceutical sciences, 2008

Primus armeniaca L. (Rosaceae), known as apricot, is one of the major export products of Turkey a... more Primus armeniaca L. (Rosaceae), known as apricot, is one of the major export products of Turkey and its seed oil has become quite popular in cosmetics industry. On this purpose, fatty acid analysis of the seed oils of three apricot cultivars (Primus armeniaca L.) from different localities in Turkey (Kalecik, Bodrum, and Malatya) was carried out by both gas chromotography (GC) and gas chromatography-mass spectrometry (GC-MS). The results showed that various differences were observed among the fatty acid contents of these three apricot seed oils. According to our data, it was found that the Malatya sample had the richest in linolenic acid content (10.87%) and the Bodrum sample had the highest in linoleic acid (34.77%). On the other hand, Kalecik-originated one was found to contain the lowest palmitic acid amount among all samples studied.

World Journal of Gastroenterology, Oct 21, 2021

Information about the coronavirus disease 2019 (COVID-19) pandemic is still evolving since its ap... more Information about the coronavirus disease 2019 (COVID-19) pandemic is still evolving since its appearance in December 2019 and has affected the whole world. Particularly, a search for an effective and safe treatment for COVID-19 continues. Botanical mixtures contain secondary metabolites (such as flavonoids, phenolics, alkaloids, essential oils etc.) with many therapeutic effects. In this study, the use of herbal treatments against COVID-19 was evaluated. Medical synthetic drugs focus mainly on respiratory symptoms, however herbal therapy with plant extracts may be useful to relieve overall symptoms of COVID-19 due to the variety of bioactive ingredients. Since COVID-19 is a virus that affects the respiratory tract, the antiviral effects of botanicals/plants against respiratory viruses have been examined through clinical studies. Data about COVID-19 patients revealed that the virus not only affects the respiratory system but different organs including the gastrointestinal (GI) system. As GI symptoms seriously affect quality of life, herbal options that might eliminate these problems were also evaluated. Finally, computer modeling studies of plants and their active compounds on COVID-19 were included. In summary, herbal therapies were identified as potential options for both antiviral effects and control of COVID-19 symptoms. Further data will be needed to enlighten all aspects of COVID-19 pathogenesis, before determining the effects of plants on severe acute respiratory syndrome coronavirus 2.

Apple Academic Press eBooks, Oct 4, 2020

IEEE Transactions on Biomedical Engineering, 2010

Journal of Trace Elements in Medicine and Biology

Boronic acid compounds and natural flavonoid compound quercetin were handled to synthesize novel ... more Boronic acid compounds and natural flavonoid compound quercetin were handled to synthesize novel two ligands encoded as B1(2,2'-(1,4-phenylenebis (benzo [1,3,2] dioxaborole-2,5-diyl)) bis (3,5,7-trihydroxy-4H- chromen-4-one) and B2 (3.3.6. 3,5,7-trihydroxy-2-(2-(6-methoxypyridin-3-yl)benzo[d][1,3,2]dioxaborol-5-yl)-4H-chromene-4). Antioxidant activities of synthesized compounds were examined in vitro. Antioxidant features of B1 and B2 were investigated by 2,2-diphenyl picryl hydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and CUPRIC reducing antioxidant capacity (CUPRAC) methods. Anticholinesterase effects of ligands were determined by acetylcholinesterase and butyrylcholinesterase methods, cytotoxic effects of ligand (B2) were applied to healthy breast and colon cancer cell lines by MTT method, as well as urease and tyrosinase enzyme activities were determined. Moreover, antibacterial properties of the compounds were analyzed by detecting th...

Nigerian Journal of Natural Products and Medicine, 2006

No Abstracts. Nigerian Journal of Natural Products and Medicine Vol.10(0) 2006: pp.82-83

İstanbul Journal of Pharmacy

and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofil... more and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofilm formation of human pathogens.

Bu çalışmada, son yıllarda tüm yaş gruplarında bitkisel ürünlere yönelimin artmasından yola çıkar... more Bu çalışmada, son yıllarda tüm yaş gruplarında bitkisel ürünlere yönelimin artmasından yola çıkarak, çocuk polikliniğine başvuran çocukların ve ebeveynlerinin bitkisel ürün kullanımının araştırılması ve değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Anket çalışması, Gülhane Eğitim ve Araştırma Hastanesi Çocuk Hastalıkları Polikliniği'ne başvuran 200 ebeveynle yüz yüze görüşülerek gerçekleştirilmiştir. Katılımcıların demografik özellikleri ve bitkisel ürün kullanımı, sağlık personeline danışma durumları, bitkisel ürünler ile ilgili düşünceleri hakkında bilgi edinilmiş ve istatistiksel analizlerle değerlendirilmiştir. Bulgular: Anket sonuçlarına göre çocukların 36'sının (%18) kronik hastalığı olup 31'inin (%86) tedavi amaçlı bitkisel ürün kullandığı tespit edilmiştir. Ebeveynlerin 162'si (%81), çocukları için en çok soğuk algınlığı, öksürük, gaz sancısı tedavisi için bitki veya bitkisel ürün uygulamış ve bu ürünleri çoğunlukla aktarlardan temin etmiştir. Bitkisel ürün kullanımı erkek ebeveynlerde, kadınlara göre daha yüksek olup aynı rahatsızlığı çeken kişilerin fayda görmesi aileler tarafından önemli bir kriter olarak göz önünde bulundurulmuştur. Bitkisel ürün tercihlerinde arkadaş ve akraba tavsiyeleri etkili olmuştur. Ailelerin 86'sının (%53) hekim veya sağlık personeline danışmadan bitkisel ürünleri kullandığı, 134'ünün (%82,5) bitkisel ürünleri kullanmadan önce güvenli olup olmadığını araştırdığı, 129'unun (%80) bitkisel ürünlerden fayda gördüğünü ifade ettiği, 96'sının (%59) ise bitkisel yöntemlerin etkin ve güvenilir olduğunu düşündüğü anket sonucunda tespit edilmiştir. Sonuç: Bitkisel ve doğal ürünlerle tedavi yöntemlerinin tıbbi ilaçlardan daha doğal ve yan etkisinin daha az olduğunun aileler tarafından ifade edildiği görülmüş olup, konu ile ilgili hekim veya sağlık personeline verilecek eğitimler ile ailelerin daha doğru yönlendirilebileceği düşünülmektedir. Anahtar Kelimeler: Fitoterapi; çocuklar için fitoterapötikler; pediatri; geleneksel ve tamamlayıcı tıp; bitkisel tedavi. Investigation of Herbs and Herbal Products Utilization in Children ABSTRACT Aim: In study, it was aimed to investigate and evaluate the use of herbs/herbal products by children and their parents who applied to the pediatric outpatient clinic, since the tendency to herbal products has increased in all age groups in recent years. Material and methods: Materials and Methods: The survey was conducted by face-to-face interviews with 200 parents who applied to the Gulhane Training and Research Hospital Pediatrics Polyclinic. Information about the demographic characteristics of the participants, use of herbals, consultation with health personnel, and opinions about herbals were obtained and evaluated with statistical analysis. Results: According to results, 36(18%) of the families have children with chronical disease and 31(86%) use herbal products. 162(81%) of families apply herbals for their children. Phytotherapeutics are mostly used for cold, cough, gas pain symptoms. Herbals are mostly obtained from herbalists. Herbals use is higher in men than in women. Suggestions of friends, family and relatives are effective in herbals preferences. In addition, experience of people who suffer and benefit from the same disease is considered as an important criterion by families. 129(80%) of families benefit from herbals and 134(82.5%) of them research whether it is safe before using herbals. 86(53%) of families use herbals without consulting physician/healthcare staff, 96(59%) think that herbal methods are effective and safe and feel better

Records of Natural Products, 2017

Journal of Medicinal Food, 2011

Turkish journal of pharmaceutical sciences, Sep 19, 2022

Objectives: The lack of a specific proven treatment for coronavirus disease-2019 (COVID-19) has l... more Objectives: The lack of a specific proven treatment for coronavirus disease-2019 (COVID-19) has led individuals to use different treatment options. Although their effects on COVID-19 have not been proven, interest in dietary supplements and aromatherapy has increased during the pandemic period. In this study, use of dietary supplements and aromatherapy was investigated for COVID-19 among individuals living within the borders of Türkiye. Materials and Methods: This cross-sectional survey study was conducted among 310 individuals. The questionnaire was prepared using online Google Forms and communicated to the participants via social media platforms. The data obtained from the study were analyzed with the statistical program. Results: The analyzes of the survey revealed that participants increased the usage of supplements mostly prophylactic and for treatment purposes during COVID-19 pandemic, 31.9% individuals declared that they consumed herbal tea/products, 38.1% of them used vitamin/mineral supplements (multivitamin-mineral, vitamins B1, B6, B12, C, D, calcium, coenzyme Q10, iron, magnesium, selenium, and zinc), and 18.4% of the individuals applied aromatherapy (meaning treatment with essential oils). As a result of the study, the most commonly used supplement was vitamin D, the most commonly consumed tea was green tea, the essential oil was thyme oil, and the most eaten vegetable was garlic. Moreover, other frequently used herbal products were found to contain ginger and onion as food and peppermint and eucalyptus oils as aromatherapeutics. Participants often reported that they found it safe to use elevated levels of herbs or herbal products against COVID-19. Conclusion: Among the individuals participating in this study, it has been observed that the use of dietary supplements has increased during the COVID-19 pandemic period. The study revealed that vitamin D is prominent in self-medication use. Moreover, interest in aromatherapy and dietary supplements has increased. Among aromatherapeutics, thyme stood out over the applied essential oils.

Evidence-based Complementary and Alternative Medicine, 2011

Achillea species are widely used for diarrhea, abdominal pain, stomachache and healing of wounds ... more Achillea species are widely used for diarrhea, abdominal pain, stomachache and healing of wounds in folk medicine. To evaluate the wound healing activity of the plant, extracts were prepared with different solvents; hexane, chloroform, ethyl acetate and methanol, respectively from the roots of Achillea biebersteinii. Linear incision by using tensiometer and circular excision wound models were employed on mice and rats. The wound healing effect was comparatively evaluated with the standard skin ointment Madecassol. The n-hexane extract treated groups of animals showed 84.2% contraction, which was close to contraction value of the reference drug Madecassol (100%). On the other hand the same extract on incision wound model demonstrated a significant increase (40.1%) in wound tensile strength as compared to other groups. The results of histoptological examination supported the outcome of linear incision and circular excision wound models as well. The experimental data demonstrated that A. biebersteinii displayed remarkable wound healing activity. 2 Evidence-Based Complementary and Alternative Medicine 2. Materials and Methods 2.1. Plant Material. Achillea biebersteinii Afan. aerial parts were collected from Beynam forest, Ankara, Turkey, in May 2007 and was identified by Prof. Dr M. Vural from the Department of Botany, Faculty of Art and Science, Gazi University. A voucher specimen was deposited in the Herbarium of Faculty of Pharmacy, Gazi University (GUE-2602). 2.2. Extraction. Following dissection of the aerial parts of A. biebersteinii Afan., they were shade dried. Each 30 g aerial parts was submitted to successive solvent extractions seperatelly with n-hexane, chloroform, ethyl acetate and methanol at room temperature for a day (500 ml each solvent). This was repeated in two trials. After filtration, the extracts were evaporated at 40 • C (Buchi, Switzerland) to dryness in vacuo. Yields of each extracts were 7.9% for nhexane, 4.8% for diethyl ether, 1.3% for ethyl acetate and 15.3% for methanol.

Turkish journal of pharmaceutical sciences, 2017

Journal of dermatology and skin science, Nov 24, 2020

Transdermal drug delivery system is an administration route, where active molecules are administe... more Transdermal drug delivery system is an administration route, where active molecules are administered through the skin with advantages of a lesser amount of hepatic first pass effect, constant plasma drug concentration and safety. The skin has a barrier function for the passage of medicines as well as toxic molecules, thus, permeation boosters/enhancers are used to increase the permeability of medication through the skin. In this mini review, recent studies on essential oils that can be used to increase skin penetration in transdermal applications and the possible mechanisms of their effects are reviewed. Essential oils increase skin penetration by interacting with the stratum corneum (SC). They were found to be successful in increasing skin penetration of both lipophilic and hydrophilic drugs. Moreover, essential oils do not accumulate in the body since they are volatile, and also are easily discharged from the body through feces and urine. They are preferred because essential oils are natural, mostly do not damage the skin while increasing skin penetration, less toxic, and less allergenic.