Ujjal Roy - Academia.edu (original) (raw)
Papers by Ujjal Roy
Blood
4710 Background The BCR-ABL fusion gene results from the translocation t(9;22). It is the hallmar... more 4710 Background The BCR-ABL fusion gene results from the translocation t(9;22). It is the hallmark of chronic myeloid leukemia (CML) and is present in a poor risk subgroup of precursor B cell Acute Lymphoblastic Leukemia(ALL),which represents 25 to 30% of adult ALL and 3 to 5 % of childhood ALL. So far, the BCR-ABL aberration has been detected by cytogenetics, FISH or PCR, all techniques that are time consuming and require special facilities. We developed a simple flow cytometric bead assay for detection of the BCR-ABL fusion protein in cell lysates,using a bead bound catching antibody against one side of the fusion protein and a fluorochrome-conjugated detection antibody against the other side of the fusion protein. Flow cytometry allows for the discrimination of particles on the basis of attributes such as, size and fluroscence. BDTM Cytometric Bead. The aim of our study was to see the effectiveness of Flowcytometric detection of BCR-ABL and cost effectiveness of the method. Mater...
Chemical Reviews, Apr 14, 2010
... Ujjal Kanti Roy and Sujit Roy* . Organometallics & Catalysis Laboratory, Department ... more ... Ujjal Kanti Roy and Sujit Roy* . Organometallics & Catalysis Laboratory, Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur-721302, India. Chem. Rev. ... Biography. Ujjal Kanti Roy received B.Sc. (Honors) in Chemistry in 1999 and his M.Sc. ...
Inorganica Chimica Acta, May 30, 2012
Org. Chem. Front., 2014
ABSTRACT
RSC Advances, 2014
ABSTRACT Interactions of norharmane (S), with different ions have been studied using spectroscopy... more ABSTRACT Interactions of norharmane (S), with different ions have been studied using spectroscopy, NMR and density functional studies. A significant gradual change both in absorption and emission spectra was observed upon addition of fluoride anions. The spectral change in the absorption and emission bands of norharmane (S) is found to be specific to fluoride ion; it is unaffected by the presence of other ions. Hydrogen bond mediated proton transfer from norharmane to fluoride is mainly attributed to the fluoride selective signaling behavior. Calculations of the transition energies of the norharmane (S), anionic species of norharmane (S�) and hydrogen bonded complexes (S/F�) show that the added fluoride anion could capture the proton in the free N–H moiety instead of the hydrogen-bonding one. Experimental results reveal that the longwavelength absorption band in the presence of fluoride ion is due to the formation of anion.
RSC Advances, 2014
ABSTRACT Binding interactions of a newly developed drug molecule namely 3,3′-bis(indolyl)-4-chlor... more ABSTRACT Binding interactions of a newly developed drug molecule namely 3,3′-bis(indolyl)-4-chlorophenylmethane (BICPM) with α-cyclodextrin have been studied using steady state and picosecond time resolved fluorometric techniques. A significant increase both in steady state anisotropy (r) and in the average rotational correlation time in the CD environments compared with that in a pure aqueous phase indicates that the rotational dynamics of BICPM are substantially slowed down upon binding with the α-cyclodextrin. Critical spectral analysis reveals the formation of two types of inclusion complex between the fluorophore and α-cyclodextrin (α-CD) depending on the relative population of the two. The stoichiometries and association constants of these complexes have been determined by monitoring the fluorescence data. Hydrodynamic radii of the formed 1:2 probe-α-cyclodextrin supramolecular complex have also been determined. From the determined hydrodynamic radii and from molecular docking analysis it is argued that probably two CD cavity shields the indole moiety in a face-to-face manner.
Encyclopedia of Reagents for Organic Synthesis, 2001
Tetrahedron, 2006
Alcohols Q 0230 Highly Efficient Water-Promoted Allylation and Propargylation of Arylepoxides via... more Alcohols Q 0230 Highly Efficient Water-Promoted Allylation and Propargylation of Arylepoxides via Rearrangement-Carbonyl Addition.-Homoallylic and homopropargylic alcohols are synthesized in good yields by a one-pot procedure involving the palladium-catalyzed, SnCl2-mediated reaction of aryl epoxides with allylic or propargylic bromides. The reaction is promoted by the addition of a limited amount of water to generate a reactive organotin species. The target alcohols are formed by simultaneous epoxide rearrangement and carbonyl addition with exclusive γ-regioselectivity.-(ROY, U. K.;
Medicolegal Aspects in Obstetrics and Gynecology, 2008
Encyclopedia of Reagents for Organic Synthesis, 2001
Encyclopedia of Reagents for Organic Synthesis, 2001
The Analyst, 2012
The synthesis of sensor S is shown in Scheme 1. This is synthesized simply by condensation of 4-c... more The synthesis of sensor S is shown in Scheme 1. This is synthesized simply by condensation of 4-chlorobenzaldehyd and indole. A mixuture of 4-chlorobenzaldehyde (1 mmol), indole (2 mmol) and I 2 (0.2 mmol) in acetonitrile (10 ml) was stirred at room temperature for one minute. After completion of the reaction (TLC, <1 min), the mixture treated with aq. Na 2 S 2 O 3 solution (5%, 10 ml) and the product was extracted with ethyl acetate (3×5 ml). The combined organic layer was dried with anhydrous sodium sulphate, concentrated in vacuo and purified by column chromatography (ethyl acetate:petroleum ether=1:9) to afford the pure product. Product was characterized by NMR and elemental analysis data.
Tetrahedron Letters, 2007
The 3-C 3 strategy involves (i) Pd(0)/SnX 2 (X = Cl, Br) mediated generation of allyltin(IV) from... more The 3-C 3 strategy involves (i) Pd(0)/SnX 2 (X = Cl, Br) mediated generation of allyltin(IV) from allyl bromide in anhydrous DCM, (ii) formation of homoallyloxytin(IV) intermediate I from allyltin(IV) and an aldehyde, and (iii) coupling of I with an aldehyde, an aryl epoxide or an arene as the third partner to afford tetrahydropyrans, benzyl tetrahydropyrans or 4,4-diarylbut-1-enes, respectively.
Tetrahedron Letters, 2007
A one-pot Barbier protocol is described for the facile formation of homoallyl sulfonamides from s... more A one-pot Barbier protocol is described for the facile formation of homoallyl sulfonamides from sulfonimines and allyl or crotyl bromide in the presence of SnCl 2 , and catalytic Pd 2 (dba) 3 AECHCl 3 at room temperature.
Blood
4710 Background The BCR-ABL fusion gene results from the translocation t(9;22). It is the hallmar... more 4710 Background The BCR-ABL fusion gene results from the translocation t(9;22). It is the hallmark of chronic myeloid leukemia (CML) and is present in a poor risk subgroup of precursor B cell Acute Lymphoblastic Leukemia(ALL),which represents 25 to 30% of adult ALL and 3 to 5 % of childhood ALL. So far, the BCR-ABL aberration has been detected by cytogenetics, FISH or PCR, all techniques that are time consuming and require special facilities. We developed a simple flow cytometric bead assay for detection of the BCR-ABL fusion protein in cell lysates,using a bead bound catching antibody against one side of the fusion protein and a fluorochrome-conjugated detection antibody against the other side of the fusion protein. Flow cytometry allows for the discrimination of particles on the basis of attributes such as, size and fluroscence. BDTM Cytometric Bead. The aim of our study was to see the effectiveness of Flowcytometric detection of BCR-ABL and cost effectiveness of the method. Mater...
Chemical Reviews, Apr 14, 2010
... Ujjal Kanti Roy and Sujit Roy* . Organometallics & Catalysis Laboratory, Department ... more ... Ujjal Kanti Roy and Sujit Roy* . Organometallics & Catalysis Laboratory, Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur-721302, India. Chem. Rev. ... Biography. Ujjal Kanti Roy received B.Sc. (Honors) in Chemistry in 1999 and his M.Sc. ...
Inorganica Chimica Acta, May 30, 2012
Org. Chem. Front., 2014
ABSTRACT
RSC Advances, 2014
ABSTRACT Interactions of norharmane (S), with different ions have been studied using spectroscopy... more ABSTRACT Interactions of norharmane (S), with different ions have been studied using spectroscopy, NMR and density functional studies. A significant gradual change both in absorption and emission spectra was observed upon addition of fluoride anions. The spectral change in the absorption and emission bands of norharmane (S) is found to be specific to fluoride ion; it is unaffected by the presence of other ions. Hydrogen bond mediated proton transfer from norharmane to fluoride is mainly attributed to the fluoride selective signaling behavior. Calculations of the transition energies of the norharmane (S), anionic species of norharmane (S�) and hydrogen bonded complexes (S/F�) show that the added fluoride anion could capture the proton in the free N–H moiety instead of the hydrogen-bonding one. Experimental results reveal that the longwavelength absorption band in the presence of fluoride ion is due to the formation of anion.
RSC Advances, 2014
ABSTRACT Binding interactions of a newly developed drug molecule namely 3,3′-bis(indolyl)-4-chlor... more ABSTRACT Binding interactions of a newly developed drug molecule namely 3,3′-bis(indolyl)-4-chlorophenylmethane (BICPM) with α-cyclodextrin have been studied using steady state and picosecond time resolved fluorometric techniques. A significant increase both in steady state anisotropy (r) and in the average rotational correlation time in the CD environments compared with that in a pure aqueous phase indicates that the rotational dynamics of BICPM are substantially slowed down upon binding with the α-cyclodextrin. Critical spectral analysis reveals the formation of two types of inclusion complex between the fluorophore and α-cyclodextrin (α-CD) depending on the relative population of the two. The stoichiometries and association constants of these complexes have been determined by monitoring the fluorescence data. Hydrodynamic radii of the formed 1:2 probe-α-cyclodextrin supramolecular complex have also been determined. From the determined hydrodynamic radii and from molecular docking analysis it is argued that probably two CD cavity shields the indole moiety in a face-to-face manner.
Encyclopedia of Reagents for Organic Synthesis, 2001
Tetrahedron, 2006
Alcohols Q 0230 Highly Efficient Water-Promoted Allylation and Propargylation of Arylepoxides via... more Alcohols Q 0230 Highly Efficient Water-Promoted Allylation and Propargylation of Arylepoxides via Rearrangement-Carbonyl Addition.-Homoallylic and homopropargylic alcohols are synthesized in good yields by a one-pot procedure involving the palladium-catalyzed, SnCl2-mediated reaction of aryl epoxides with allylic or propargylic bromides. The reaction is promoted by the addition of a limited amount of water to generate a reactive organotin species. The target alcohols are formed by simultaneous epoxide rearrangement and carbonyl addition with exclusive γ-regioselectivity.-(ROY, U. K.;
Medicolegal Aspects in Obstetrics and Gynecology, 2008
Encyclopedia of Reagents for Organic Synthesis, 2001
Encyclopedia of Reagents for Organic Synthesis, 2001
The Analyst, 2012
The synthesis of sensor S is shown in Scheme 1. This is synthesized simply by condensation of 4-c... more The synthesis of sensor S is shown in Scheme 1. This is synthesized simply by condensation of 4-chlorobenzaldehyd and indole. A mixuture of 4-chlorobenzaldehyde (1 mmol), indole (2 mmol) and I 2 (0.2 mmol) in acetonitrile (10 ml) was stirred at room temperature for one minute. After completion of the reaction (TLC, <1 min), the mixture treated with aq. Na 2 S 2 O 3 solution (5%, 10 ml) and the product was extracted with ethyl acetate (3×5 ml). The combined organic layer was dried with anhydrous sodium sulphate, concentrated in vacuo and purified by column chromatography (ethyl acetate:petroleum ether=1:9) to afford the pure product. Product was characterized by NMR and elemental analysis data.
Tetrahedron Letters, 2007
The 3-C 3 strategy involves (i) Pd(0)/SnX 2 (X = Cl, Br) mediated generation of allyltin(IV) from... more The 3-C 3 strategy involves (i) Pd(0)/SnX 2 (X = Cl, Br) mediated generation of allyltin(IV) from allyl bromide in anhydrous DCM, (ii) formation of homoallyloxytin(IV) intermediate I from allyltin(IV) and an aldehyde, and (iii) coupling of I with an aldehyde, an aryl epoxide or an arene as the third partner to afford tetrahydropyrans, benzyl tetrahydropyrans or 4,4-diarylbut-1-enes, respectively.
Tetrahedron Letters, 2007
A one-pot Barbier protocol is described for the facile formation of homoallyl sulfonamides from s... more A one-pot Barbier protocol is described for the facile formation of homoallyl sulfonamides from sulfonimines and allyl or crotyl bromide in the presence of SnCl 2 , and catalytic Pd 2 (dba) 3 AECHCl 3 at room temperature.