Ujwala Maheshwari - Academia.edu (original) (raw)

Papers by Ujwala Maheshwari

International Journal of Health Sciences and Research, 2020

Epithelioid sarcoma is a rare tumour, counting for less than 1% of all soft tissue sarcomas. It i... more Epithelioid sarcoma is a rare tumour, counting for less than 1% of all soft tissue sarcomas. It is a slow growing, high grade, soft tissue malignancy of mesenchymal origin. It has marked propensity for local recurrence, regional lymph node involvement and distant metastases. Clinical diagnosis is difficult and radiological findings are nonspecific as well as inconclusive. Therefore, histopathological examination along with immunohistochemical markers are required for the confirmation of diagnosis. Here, we report a case of a 65 years old female, with retroperitoneal mass.

Indian Journal of Scientific Research

International Journal of Health Sciences and Research

Background – COVID – 19 is the latest raging pandemic that the world is facing at the moment. Fro... more Background – COVID – 19 is the latest raging pandemic that the world is facing at the moment. Frontline workers have been highly exposed to this disease and majority of them have suffered from this deadly disease too. Studying the prevalence of antibodies among frontline workers in different areas is crucial for understanding the potential risk of transmission, the prevalence of herd immunity, vaccine deployment and risk stratification in different areas of work. Materials and Methods – A prospective study was conducted in a tertiary care hospital of Navi Mumbai on 200 essential service providers, 100 HCWs and 100 police personnel, of which 2 police personnel dropped out of the study. This study was conducted over a period of 2 days, i.e, 20th and 21st May 2021 and it included answering a questionnaire and drawing blood to detect SARS COV-2 antibodies. Results – Out of the total 198 participants, there were 130 males and 68 females. Most of the participants were in the 30 – 39 years...

Journal of clinical & experimental pathology, Aug 3, 2015

C ervical cancer is one of the leading causes of cancer deaths in the world. India accounts for o... more C ervical cancer is one of the leading causes of cancer deaths in the world. India accounts for one fifth of the world's burden of cervical cancer. Cytology screening by the Papanicolaou smear remains the main stay for control of cervical carcinoma. Liquid-based cervical cytology was developed to improve the diagnostic reliability of Conventional Pap smears. The present study was undertaken to evaluate a manual liquid based cytology technique (SurePath) and to compare the sensitivity of LBC with conventional Pap smear. The aim of the study was to compare the cytomorphology of conventional pap smears and manual liquid based cytology smears and to find out whether manual liquid based cytology method can be established for routine use in our laboratory setup. In the present study cervical smears were collected by the gynaecologist using Ayre's spatula for the conventional Pap smear method and using SurePath cytobrush for manual liquid based cytology technique. 200 cases were examined for cytomorphological parameters. The details regarding cell size, cytoplasmic and nuclear details were studied for making the diagnosis. The observed results indicated that women screened with an LBC sample had significantly decreased detection rates of inadequate smears and increased detection of low-grade squamous intraepithelial lesion (LSIL)/ atypical cytology. Cells were better preserved and not obscured by blood, mucus, or inflammatory cells. The results showed increased sensitivity of LBC without loss of specificity. Liquid based cytology improves the quality of the sample and reduces the likelihood of false negative cytology results. Thus it will significantly improve early detection and treatment of cervical lesions.

International Journal of Research, 2018

Endometrial stromal sarcoma [ESS] is a rare malignant tumour of the endometrium. Usually occurs i... more Endometrial stromal sarcoma [ESS] is a rare malignant tumour of the endometrium. Usually occurs in perimenopausal women between the age group of 40-50 years. Patients come with symptoms similar to uterine leiomyoma, abnormal vaginal bleeding or abdominal pain, some patients may be asymptomatic. There is a high chance of it to be mistaken for leiomyoma clinically. Although rare, ESS should be kept in mind in women presenting with bulky uterus. A definitive diagnosis can only be made on histopathology. Surgery and postoperative radiotherapy is the most effective treatment.

Granulomatous mastitis is rare chronic inflammatory breast disease. The most common causative org... more Granulomatous mastitis is rare chronic inflammatory breast disease. The most common causative organism is Mycobacterium tuberculosis though there have been cases reported of atypical mycobacterium causing tubercular mastitis. It is a diagnostic challenge because of its similarity with carcinoma, bacterial abscess and idiopathic granulomatous mastitis. The main objective of this study was to examine the histomorphology of Granulomatous mastitis. Materials and Methods: Over a period of 2 years (2019-2021), out of 112 breast biopsies, 15 patients were diagnosed with Granulomatous mastitis. Data were collected regarding age, gender, patient’s complain, site and, any swelling in opposite breast and axilla. Histomorphological features were studied on the breast biopsies received. Results: Of the 15 patients, all were female with mean age of 34 years (25–50 years). The clinical presentation is as breast lump with or without sinus, associated lymphadenopathy. On microscopy caseating and non...

Cystic hygromas are congenital lymphatic malformations of pediatric age group commonly in head an... more Cystic hygromas are congenital lymphatic malformations of pediatric age group commonly in head and neck region. These arise from developmental defects in the lymphatic system. In this article we report a case of 15 years old male patient who presented with right supraclavicular swelling. Initial physical examination was followed by Ultrasonography which reported differential diagnosis as lymphatic malformation, cystic thyroid lesion. The histopathological examination of the surgically excised specimen confirmed it to be Cystic hygroma. Hence, histopathology plays an important role in confirming the diagnosis required for optimal management and better prognosis.

Journal of Medical Science And Clinical Research, 2017

More than one million deaths amongst worlds women population every year are attributed to carcino... more More than one million deaths amongst worlds women population every year are attributed to carcinoma cervix. In India over a lakh women are diagnosed with cervical cancers each year of which nearly 50 % succumb to death. Cervical cancer is the second most common carcinoma seen in 15-44 years age group which if diagnosed early and treated the morbidity can be reduced by 70% and mortality by 80%. Cervical smear is a sensitive, simple, safe, noninvasive and effective method for detection of pre-cancerous and non-cancerous changes. Aim: The objective is to study the role of pap smear in diagnosing premalignant and malignant as well as nonneoplastic lesion of the cervix and to determine the incidence of various lesions. Material and Method: A retrospective study of six months on Pap smears examination was carried out in cytopathology section in Central Laboratory of MGM Medical College Kamothe. Around 701 smears were studied ranging from 18-90 age group. The smears were taken with sterile Ayers spatula. Materials were smeared on a pre labelled glass slides to form a monolayer thick smear. Slides were fixed with methanol, which after drying were stained by rapid pap method. Result: A total of 701 cases were screened there were 582 abnormal pap smears with 119 normal pap cases 24 cases were inadequate for opinion, 468 showed inflammation 29 cases of atrophic smear 2 cases of HSIL and 3 of LSIL, 4 cases of CIN 1, 22 of candida, 3 suspected cases Chlamydia trachomatis, 4 of AGUS,16 of bacterial vaginosis and 6cases of trichomoniasis were seen in the smears studied. Conclusion: Incidence of malignancy can be prevented by pap screening programmes. Pap smear helps in early detection and management of malignancies hence reducing mortality and morbidity. Pap smear studies are cost effective, doesn't need experts and specialists for collection. Therefore, till today it is the most useful screening procedure for malignant and pre-malignant conditions.

Indian journal of scientific research, 2014

Motion control incorporates a range of challenges when it comes to the control of mechanical syst... more Motion control incorporates a range of challenges when it comes to the control of mechanical systems. In rotary motion; position, velocity and acceleration control are the tasks required most often for robotics. The achievement of velocity control is one of the popular technical issues in motion control and industrial applications. The traditional approach for velocity control is PID based feedback controllers. PID controllers are not suitable for the applications subjected to higher external disturbances. This paper proposes a Disturbance Observer (DOB) based velocity controller. DOB together with the tuned PID controller can make the system robust. To validate the proposed method, stability analysis and experiments were carried out with and without DOB. The velocity responses of the experiments were analyzed for different modes of disturbances with different observer gains. The performance of the proposed controller shows enhanced results compared to the traditional velocity contr...

Objective: The aim of this study was to investigate the effect of malarial parasites, on differen... more Objective: The aim of this study was to investigate the effect of malarial parasites, on different biochemical liver and renal parameters. This was a retrospective and hospital-based study, which was carried out at Department of Microbiology and Central Clinical Laboratory, MGM Medical College and Hospital, Navi Mumbai, is an endemic malaria transmission. Methods: A total of 60 samples were included in this study out of which 30 samples with peripheral blood film evidence of falciparum malaria and 30 samples of vivax malaria. Liver function tests and renal function tests were estimated by standard method. Results: the results showed an increased level in Plasmodium falciparum than Plasmodium vivax which is statistically significant. In our study we found that Plasmodium falciparum altered more biochemical parameters than Plasmodium vivax. Conclusions: The biochemical markers can be used as biomarkers for the confirmation of malaria.

Blood is the most easily accessible diagnostic tissue. Changes in haematological parameters are l... more Blood is the most easily accessible diagnostic tissue. Changes in haematological parameters are likely to be influenced by any disease condition which affects the haemopoetic physiology at any level. This is likely to happen with an endemic disease such as malaria that affects the host homeostasis at various fronts resulting in a myriad of clinical presentation. Malaria is a major cause of morbidity in the tropics. Two hundred and forty seven million cases were reported worldwide in 2006 [3]. Haematological changes are some of the most common complications in malaria and they play a major role in malaria pathology. These changes involve the major cell lines such as red blood cells, leucocytes and thrombocytes. In Western Kenya, severe anaemia is the predominant severe malaria syndrome peaking in the first two years of life and is attributed to Plasmodium falciparum [4].

International journal of scientific research, 2016

INTRODUCTION: Immune thrombocytopenic purpura (ITP) is a relatively uncommon disorder of acquired... more INTRODUCTION: Immune thrombocytopenic purpura (ITP) is a relatively uncommon disorder of acquired immune mechanism. Due to lack of adequate relevant data in India pertaining to incidence of immune thrombocytopenic purpura, designing of suitable clinical models and health resource allocation has becomea little abstract and demanding. Knowledge of epidemiology and pattern of immune thrombocytopenia purpura is essential for devising new clinical trials and management of the condition. OBJECTIVES: The objective of the present study is to determine the incidence, pattern and characterization by analyzing the data of routine haematological investigations in haematology laboratory of a tertiary care hospital. METHODS: The present study is to determine the incidence and pattern of immune thrombocytopenic purpura by analyzing data of routine haematological investigations on the blood samples received in haematology laboratory of a tertiary care hospital located in peripheral area of Navi Mum...

Global journal for research analysis, 2018

Background: Anaemia, being an important global health problem, affects both underdeveloped and af... more Background: Anaemia, being an important global health problem, affects both underdeveloped and affluent countries leading to severe impact on human health and social and economic development. The present study is to analyze the data present in the haematology laboratory of a tertiary care hospital to determine the overall incidence and pattern of anaemia, which is a novel exercise, first of its kind in Navi Mumbai region in Maharashtra, India, that would essentially facilitate devising of clinical trials for its management and establishing comprehensive mechanisms to improve health care at community level for its prevention. Objectives: The objective of the present study is to assess the incidence and pattern of anaemia by analyzing the haematology data available in the haematology laboratory of a tertiary care hospital. Methods: The design of the present study is to analyze the available data in the haematology laboratory of a tertiary care hospital to determine incidence and patte...

Journal of evolution of medical and dental sciences, Jan 31, 2013

Umbilical polyps, containing vestigial remnants of the omphalomesentric duct, are a rare cause of... more Umbilical polyps, containing vestigial remnants of the omphalomesentric duct, are a rare cause of persistent umbilical discharge in the paediatric age group, as compared to omphalitis or umbilical granulomas. However, umbilical polyps need to be investigated thoroughly to ensure complete resection and to rule out extension into the abdominal cavity. Further, such umbilical polyps may cause complications due to the presence of ectopic tissues inside them. The present case is the first reported case of three tissue types, viz. Pancreatic, Gastric, and Small Intestinal tissues, being present ectopically in an umbilical polyp, which had caused persistent umbilical discharge with severe local excoriation and ulceration in a 2 year old child. CONCLUSION Umbilical polyps with ectopic tissues can lead to severe complications if not treated properly, and should be ruled out in all cases of persistent umbilical discharge in the paediatric age group.

Journal of Bacteriology & Parasitology, 2015

The aim of this study was to determine the prevalence of malarial infections among the patients a... more The aim of this study was to determine the prevalence of malarial infections among the patients attending at tertiary care hospital, Navi Mumbai, India, between January and December 2013. 4878 blood samples of suspected malaria cases were examined out of which 809 (16.58%) were positive for malaria. The types of malarial parasites were Plasmodium vivax (54.76%), Plasmodium falciparum (17.80%), and mixed species (27.44%). The prevalence of malarial infection exhibited seasonal pattern with many cases in the month of July to November with peak in October. Infection prevalence in male patients was 2-fold higher than in female patients. Age group ranged from 11-50 years with 21-30 years had greatest risk. These findings compared with other findings of malaria endemic populations in India that a hospital-based diagnosis and surveillance for malaria reflects seasonal malaria transmission underlying demographic and geographic distribution.

Indian Journal of Pathology and Microbiology, 2011

Bombay Hospital Journal, 2009

Page 1. 380 Bombay Hospital Journal, Vol. 51, No. 3, 2009 An Unusual Presentation of Neurofibroma... more Page 1. 380 Bombay Hospital Journal, Vol. 51, No. 3, 2009 An Unusual Presentation of Neurofibromatosis with Breast Carcinoma Ujwala M Maheshwari*, Shilpi S Sahu**, Dharamdas B Borkar**, Benzy Paul*** Abstract We ...

Acta Cytologica, 2006

UNLABELLED BACKGROUND The diagnosis of gout can be problematic when the presentation is atypical ... more UNLABELLED BACKGROUND The diagnosis of gout can be problematic when the presentation is atypical and serum uric acid is borderline elevated. Demonstration of monosodium urate (MSU) crystals in fine needle aspiration (FNA) smears from nodular masses clinically suspected to be tophi establishes the diagnosis unequivocally. CASES Of the 7 cases in this study, 4 were suspected clinically to have gouty tophi. Giant cell tumor of tendon sheath, giant cell tumor of bone and metastatic tumor with multicentric involvement of bone were the clinical diagnoses in 1 case each. Serum uric acid levels high enough to be in the diagnostic range for gout were reported in 3 cases, within normal limits in 3 cases and low in 1 chronic alcoholic patient. Bright field microscopy of FNA smears revealed singly scattered or stacks of MSU crystals with variable number of inflammatory cells, with or without foreign body giant cells in 6 cases. In 1 patient, FNA showed stacks of MSU crystals only. Characteristic birefringence of MSU crystals was observed on polarizing microscopy. CONCLUSION FNA demonstration of MSU crystals on polarizing microscopy can easily establish the nature of the nodules in and around the joints and in soft tissue as gouty tophi and is thus an investigation differentiating this lesion from other masses clinically simulating it.