Ulrike Herberg - Academia.edu (original) (raw)

Papers by Ulrike Herberg

Fragestellung: Die Reanimation im Kindesalter stellt eine besondere Herausforderung an Ärzte und ... more Fragestellung: Die Reanimation im Kindesalter stellt eine besondere Herausforderung an Ärzte und Pflegekräfte dar. Die Leitlinien des European Resuscitation Council von 2005 bieten allgemeingültige und gut verständliche Algorithmen zur Wiederbelebung im Kindesalter an. Leider mangelt[for full text, please go to the a.m. URL]

50th Annual Meeting of the German Society for Pediatric Cardiology (DGPK), 2018

The Thoracic and Cardiovascular Surgeon, 2017

Ultraschall in der Medizin - European Journal of Ultrasound, 2006

Ultraschall in der Medizin - European Journal of Ultrasound, 2004

The Thoracic and Cardiovascular Surgeon, 2015

Background: Pressure-volume relations (PVR) provide vital information regarding ventricular perfo... more Background: Pressure-volume relations (PVR) provide vital information regarding ventricular performance and cardiac pathophysiology. However, in children acquisition of PVR by conductance-technology is - due to catheter size and invasiveness - restricted to an older age. Objectives: The aim of the study was to validate the accuracy of minimal invasive assessment of PVR in small hearts using volume data obtained by real-time three-dimensional echocardiography (3D) and simultaneously acquired pressure data. Methods: In 17 piglets (mean weight:5 0.9 ± 1.3 [range 3.6–8.0] kg) left ventricular PVR were generated by 3D in conjunction with simultaneously recording of left ventricular pressure using a mini pressure wire (PVR3D). PVR3D were compared with conductance catheter measurements (PVRCond) under various hemodynamic conditions: baseline, adrenergic stimulation (phenylephrine) and β-adrenoreceptor blockage (esmolol). In another 8 pigles, the accuracy of 3D volumetric data including volume changes over time was validated by cardiac magnetic resonance imaging (CMR) . Results: Computation of PVR3D was feasible, reproducible and comparable to results obtained by conductance technology . Bland-Altman analysis showed a low bias between PVR3D and PVRCond for systolic (systolic myocardial elastance, arterial elastance dp/dtmax) and diastolic parameters (Tau, enddiastolic PVR, dp/dtmin). The dynamic changes under different hemodynamics conditions correlated well between the two methods (Fig. 1). Comparision of CMR and 3DE revealed excellent correlation (r = 0.8829). Inter- and intraobserver- coefficients of variation were below 5% for all parameters . Conclusions: 3D echocardiography generated PVR represent a novel, feasible and reliable method to assess different conditions of cardiac function in small hearts. Due to its minimal invasive character this methodology may be implemented into daily practice and contribute to clinical decision making in this crucial age group.

Figure S1. Representative picture of Complex I assembly in fibroblasts of individual 1 (A, upper ... more Figure S1. Representative picture of Complex I assembly in fibroblasts of individual 1 (A, upper panels) Two-dimensional BN/SDS-PAGE separation and quantification of fluorescent-labelled mitochondrial complexes from 10 mg patient (left) and control fibroblasts (right) are shown. (A, lower panels) show silver stained 2 D gels. (B) Quantified Supercomplexes in 2D gels from control and patient fibroblast with and without bezafibrate treatment for 72 h. (C) Panoramaplots of 2D gels with assignment of signals used for quantification of complexes. Assignment of complexes: O, OGDC, oxoglutarate dehydrogenase complex; V, complex V or ATP synthase; III, complex III or cytochrome c reductase; IV, complex IV or cytochrome c oxidase; S, supercomplexes composed of respiratory chain complexes I, III, and IV. 2-D gels were scanned side by side for direct comparison and are shown as pseudocolors. (pdf). (PDF 1109 kb)

Table S2. Calculation of European incidence of ACAD9 deficiency (DOCX 36Â kb)

Table S1. Compound heterozygous and homozygous ACAD9 variants identified in 67 patients present i... more Table S1. Compound heterozygous and homozygous ACAD9 variants identified in 67 patients present in this study (DOCX 75Â kb)

Additional data. (DOCX 38Â kb)

Journal of Medical Genetics, 2012

Abstracts zum 19. Kongress der Deutschen Gesellschaft für Pränatal- und Geburtsmedizin e. V., 2020

Journal of the American Society of Echocardiography

Cardiovascular Engineering and Technology, 2021

Purpose Patients with a functionally univentricular heart represent one of the most common severe... more Purpose Patients with a functionally univentricular heart represent one of the most common severe cardiac lesions with a prevalence of 3 per 10,000 live births. Hemodynamics of the singular ventricle is a major research topic in cardiology and there exists a relationship between fluid dynamical features and cardiac behavior in health and disease. The aim of the present work was to compare intraventricular flow in single right ventricle (SRV) patients and subjects with healthy left hearts (LV) through patient-specific CFD simulations. Methods Three-dimensional real-time echocardiographic images were obtained for five SRV patients and two healthy subjects and CFD simulations with a moving mesh methodology were performed. Intraventricular vortex formation and vortex formation time (VFT) as well as the turbulent kinetic energy (TKE) and ventricular washout were evaluated. Results The results show significantly lower values for the VFT and the TKE in SRV patients compared with healthy LV...

Archives of Disease in Childhood, 1993

Journal of Clinical Medicine, 2022

Scimitar syndrome is a rare disease characterized by hypoplasia of the right lung and partial ano... more Scimitar syndrome is a rare disease characterized by hypoplasia of the right lung and partial anomalous pulmonary venous drainage to the inferior vena cava. All cases with a prenatal diagnosis of scimitar syndrome with or without associated malformations in an 18-year period (2000–2018) in two large tertiary referral centers (University of Bonn and University of Cologne, Germany) were retrospectively reviewed for the intrauterine course and postnatal outcome. Six cases were diagnosed in the study period. All presented with hypoplasia of the right lung, right-sided mediastinal shift, and abnormal pulmonary venous drainage to the inferior vena cava. Systemic arterial blood supply to the right lung, albeit postnatally present in all cases, could not be detected prenatally. Major associated anomalies were present in all cases and included atrial septal defect (n = 5), coarctation (n = 3), diaphragmatic hernia (n = 2), and VACTERL association (n = 1). Half of the cohort died within 6 mon...

Zeitschrift für Geburtshilfe und Neonatologie, 2012