Umer Ejaz - Academia.edu (original) (raw)

Umer Ejaz

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Papers by Umer Ejaz

Research paper thumbnail of Comparison of Incidence of Postoperative Sternotomy Surgical Site Infections and Impact of Suture Type (Absorbable or Non-Absorbable) on Its Frequency

Journal of Population and Therapeutics and Clinical Pharmacology

Research paper thumbnail of Incidence of Neurological Complications in Coronary Artery Bypass Grafting Versus Valve Surgery (Aortic, Mitral, Tricuspid); Single Centre Study

Journal of Population and Therapeutics and Clinical Pharmacology

Research paper thumbnail of Review: Inhibitory potential of low molecular weight Heparin in cell adhesion; emphasis on tumor metastasis

European Journal of Pharmacology, 2021

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Research paper thumbnail of Phosphorylation of CENP-R by Aurora B regulates kinetochore–microtubule attachment for accurate chromosome segregation

Journal of Molecular Cell Biology

Error-free mitosis depends on accurate chromosome attachment to spindle microtubules via a fine s... more Error-free mitosis depends on accurate chromosome attachment to spindle microtubules via a fine structure called the centromere that is epigenetically specified by the enrichment of CENP-A nucleosomes. Centromere maintenance during mitosis requires CENP-A-mediated deposition of constitutive centromere-associated network that establishes the inner kinetochore and connects centromeric chromatin to spindle microtubules during mitosis. Although previously proposed to be an adaptor of retinoic acid receptor, here, we show that CENP-R synergizes with CENP-OPQU to regulate kinetochore–microtubule attachment stability and ensure accurate chromosome segregation in mitosis. We found that a phospho-mimicking mutation of CENP-R weakened its localization to the kinetochore, suggesting that phosphorylation may regulate its localization. Perturbation of CENP-R phosphorylation is shown to prevent proper kinetochore–microtubule attachment at metaphase. Mechanistically, CENP-R phosphorylation disrupt...

Research paper thumbnail of Comparison of Incidence of Postoperative Sternotomy Surgical Site Infections and Impact of Suture Type (Absorbable or Non-Absorbable) on Its Frequency

Journal of Population and Therapeutics and Clinical Pharmacology

Research paper thumbnail of Incidence of Neurological Complications in Coronary Artery Bypass Grafting Versus Valve Surgery (Aortic, Mitral, Tricuspid); Single Centre Study

Journal of Population and Therapeutics and Clinical Pharmacology

Research paper thumbnail of Review: Inhibitory potential of low molecular weight Heparin in cell adhesion; emphasis on tumor metastasis

European Journal of Pharmacology, 2021

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Research paper thumbnail of Phosphorylation of CENP-R by Aurora B regulates kinetochore–microtubule attachment for accurate chromosome segregation

Journal of Molecular Cell Biology

Error-free mitosis depends on accurate chromosome attachment to spindle microtubules via a fine s... more Error-free mitosis depends on accurate chromosome attachment to spindle microtubules via a fine structure called the centromere that is epigenetically specified by the enrichment of CENP-A nucleosomes. Centromere maintenance during mitosis requires CENP-A-mediated deposition of constitutive centromere-associated network that establishes the inner kinetochore and connects centromeric chromatin to spindle microtubules during mitosis. Although previously proposed to be an adaptor of retinoic acid receptor, here, we show that CENP-R synergizes with CENP-OPQU to regulate kinetochore–microtubule attachment stability and ensure accurate chromosome segregation in mitosis. We found that a phospho-mimicking mutation of CENP-R weakened its localization to the kinetochore, suggesting that phosphorylation may regulate its localization. Perturbation of CENP-R phosphorylation is shown to prevent proper kinetochore–microtubule attachment at metaphase. Mechanistically, CENP-R phosphorylation disrupt...

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