Umit Inceboz - Academia.edu (original) (raw)
Papers by Umit Inceboz
African Journal of Microbiology Research, Nov 13, 2012
Archives of Gynecology and Obstetrics, 2021
To investigate the histological efficacy of ranibizumab and zoledronic acid in an experimentally ... more To investigate the histological efficacy of ranibizumab and zoledronic acid in an experimentally induced endometriosis model as compared with danazol, buserelin acetate and dienogest. Endometrial implants were introduced in 52 female Wistar albino rats, which were then randomly divided into six groups. The animals were, respectively, given dienogest, danazol, buserelin acetate, zoledronic acid, ranibizumab and 0.9% NaCl. After 4 weeks, the volumes and histopathological properties of the implants were evaluated and the implants were excised completely at the third laparotomy. A histopathological scoring system was used to evaluate the preservation of epithelia. Endometrial explants were evaluated immunohistochemically. Among the groups, the histological score was significantly lower in the zoledronic acid and ranibizumab groups compared with the controls (p < 0.001). There were no significant differences regarding ellipsoidal volume levels between groups (p > 0.05). However, there was a statistically significant difference regarding cell numbers according to the degree of Bcl-2, NF-κB, and CD31 staining (p < 0.001). There was no statistically significant difference in Bcl-2, CD31, or NF-κB staining in the binary comparisons between the other groups (p > 0.05). For Bcl-2 staining, the staining rate of the group treated with zoledronic acid was significantly lower compared with the dienogest and danazol groups (p < 0.05). The staining rates of CD31 and NF-κB were significantly lower in the zoledronic acid and ranibizumab groups compared with the controls (p < 0.05). According to these results, zoledronic acid and ranibizumab may be putative candidates for the treatment of endometriosis.
American Journal of Case Reports, 2004
Bu makalede, over kanseri sonrasi sisplatin iceren kemoterapi protokolu uygulanan iki hastada gel... more Bu makalede, over kanseri sonrasi sisplatin iceren kemoterapi protokolu uygulanan iki hastada gelisen persistan hipomagnezemi ve buna sekonder tetani sunuldu. Ayrica, sisplatine bagli gelisen hipomagnezeminin klinik prezantasyonu, nedenleri, profilaksi ve tedavi secenekleri, ilgili literaturun isiginda tartisildi.
Frontiers in Global Women's Health, 2021
Endometriosis affects 10% of women worldwide and is one of the most common causes of chronic pelv... more Endometriosis affects 10% of women worldwide and is one of the most common causes of chronic pelvic pain and infertility. However, causal mechanisms of this disease remain unknown due to its heterogeneous presentation. In order to successfully study its phenotypic variation, large sample sizes are needed. Pooling of data across sites is not always feasible given the large variation in the complexity and quality of the data collected. The World Endometriosis Research Foundation (WERF) Endometriosis Phenome and Biobanking Harmonization Project (EPHect) have developed an endometriosis participant questionnaire (EPQ) to harmonize non-surgical clinical participant characteristic data relevant to endometriosis research, allowing for large-scale collaborations in English-speaking populations. Although the WERF EPHect EPQs have been translated into different languages, no study has examined the cross-cultural translation and adaptation for content and face validity. In order to investigate ...
Fertility and Sterility, 1995
ABSTRACT
Fertility and Sterility, 1995
Objective: To induce of ovulation and pregnancy in women with Kallmann's syndrome. Design: Retros... more Objective: To induce of ovulation and pregnancy in women with Kallmann's syndrome. Design: Retrospective study. Patients: Three women with hypo gonadotropic hypogonadism and anosmia with a desire for pregnancy. Interventions: Investigation of hypothalamic-pituitary-ovarian function and induction of ovulation by pulsatile GnRH or intramuscular human pituitary gonadotropins (hPG) or hMG with heG. Main Outcome Measures: Successful induction of ovulation as measured by serum P levels and successful pregnancy. Results: Ovulation was induced successfully in all three patients on more than one occasion and nine pregnancies occurred. Gonadotropin-releasing hormone was given IV by an electronically timed syringe driver. A total of 12 pulsatile GnRH cycles resulted in two pregnancies, 6 of these cycles being in one patient who did not ovulate or conceive with this therapy. Ovulation occurred in 10 of 16 hMG or hPG cycles, with conception in 7 of these. Gonadotropin usage was higher in these women compared with women with hypogonadotropic hypogonadism without anosmia (2,850 compared with 2,100 IU per treatment cycle), and the follicular phase was longer. Conclusions: All three women conceived and had children after induction of ovulation. The success rate of these therapies in Kallmann's syndrome appears to be high in spite of very few reports in the literature.
Turkiye Klinikleri Journal of Gynecology and Obstetrics Special Topics, 2013
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2004
Turkiye Klinikleri Journal of Surgical Medical Sciences, 2006
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2014
Cumhuriyet medical journal, Apr 13, 2009
... İletişim adresi: Sevgi Nehir, Ege Üniversitesi Hemşirelik Yüksekokulu, Psikiyatri Hemşireliği... more ... İletişim adresi: Sevgi Nehir, Ege Üniversitesi Hemşirelik Yüksekokulu, Psikiyatri Hemşireliği Anabilim Dalı, TR-35100 Bornova, İzmir. ... yapılan 226 kadının sosyo-demografik özellikleri incelendiğinde, yaş ortalaması 50,3±5,5, ilkokul mezunluğu %51,8, eşin ilkokul mezunluğu ...
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2001
We have been recently encountered a perplexing problem of intrahepatic cholestasis of pregnancy. ... more We have been recently encountered a perplexing problem of intrahepatic cholestasis of pregnancy. Although this is not unique to pregnancy, we wish to review this issue in the light of the literature, since the differential diagnosis and management of this enigma is important during pregnancy because of intense pruritus and the increased risk of fetal asphyxia (1). Case The case was a thirty-five year-old woman with gravida 1, para 0 had complaint of "itching" especially affecting her palms and soles at 35 weeks of gestation, so severe that she had sleep disturbances due to this terrible itching. She had no clinical findings except some scratch marks on those areas. Until that time she had completely normal pregnancy at follow-ups. Blood levels of transaminases and bilirubins were checked. Aspartate amino transferase (AST) and Alanine amino transferase (ALT) were 40 U/L and 60 U/L, respectively and bilirubins were in normal limits. These tests were checked again after 7 days. The results were slowly raising for AST and ALT as 80 U/L and 120 U/L, respectively. Complaint of itching was reported as "unbearable" by that time.
Turkiye Klinikleri Jinekoloji Obstetrik Ozel Dergisi, 2013
Se evaluaron 10 medios de cultivo para el establecimiento y la multiplicación in vitro de tomate ... more Se evaluaron 10 medios de cultivo para el establecimiento y la multiplicación in vitro de tomate de árbol partenocárpico, los cuales contenían sales de MS, BAP de 0,17 a 5,82 mg/l, y AIA de 0,19 a 2,31 mg/l y una mezcla de tres sustancias antioxidantes: cisteína, ácido ascórbico y caseína hidrolizada (100 mg/l de cada una). Los explantes utilizados fueron esquejes de nudo de 1,5 a 2,0 cm de longitud. Para el análisis estadístico se empleó un diseño central compuesto triplicado con dos repeticiones del punto central. Los resultados fueron: en el material proveniente del altiplano Norte de Antioquia, Colombia, se determinó el punto óptimo para la variable longitud de brotes con reguladores de crecimiento (0,17 mg/l de BAP y 0,19 mg/l de AIA); en el material procedente del Oriente de Antioquia-Colombia, no se pudo determinar el punto óptimo. Las sustancias antioxidantes no fueron efectivas para evitar la oxidación fenólica, la cual fue mediana a alta. Las tasas de multiplicación fueron bajas (0 % y 20 % para los genotipos del Oriente y Norte de Antioquia, respectivamente) y el desarrollo de los brotes en el material del Norte fue muy lento (cuatro meses).
Women's Health, 2015
Endometriosis is characterized by development of the endometrial tissue outside the uterus like o... more Endometriosis is characterized by development of the endometrial tissue outside the uterus like ovary, pelvic peritoneum, pelvic organs, and affects 6-10% of reproductive-aged women. The prevalence of endometrioma is 17-44% of women with endometriosis [1-4]. Since endometriosis is mainly a disease for the women at their reproductive ages, it is important to consider ovarian reserve when managing the cases with ovarian endometriosis. There has been a long debate whether the endometrioma per se decreases the ovarian reserve and/or surgery for endometrioma-either by laparoscopy or by laparotomy-decreases it. Although the dispute for these questions is not totally settled down, in this article, we would like to give some clues for the answers in view of the literature.
Women's Health, 2015
Endometriosis is a common but an enigmatic disease in which endometrial glands and stroma are fou... more Endometriosis is a common but an enigmatic disease in which endometrial glands and stroma are found outside the uterus. Worldwide, 80 million women are affected by the disease. It has generally been accepted as a problem of reproductive ages and affects 6-10% of those women. It is more common in women with infertility. Moreover, since it is an estrogen dependent problem, it is generally believed that endometriosis connotes 'active ovarian function' and is 'healed' after the menopause. However, there are reports on endometriosis beyond the reproductive ages. In this article, endometriosis after the menopause will be discussed.
Turkish Journal of Parasitology, 2015
Echinococcus granulosus'un neden olduğu kistik ekinokokkoz hastalığı endemik bölgelerde halen öne... more Echinococcus granulosus'un neden olduğu kistik ekinokokkoz hastalığı endemik bölgelerde halen önemli bir sağlık sorunu teşkil etmektedir. Kistik ekikokkoz, en sık karaciğer ve akciğerlere olmak üzere vücutta çeşitli organ veya bölgelerde bulunabilmektedir. Pelvik tutulum bildirilmiş olmakla birlikte genellikle başka bir organdan sekonder olarak geliştiği saptanmaktadır, izole pelvik tutulum oldukça enderdir. Bu olgu sunumunda, pelvik kitle ön tanısı ile başvuran ve operasyon ve sonrasında izole pelvik kistik ekinokokkoz saptanan olguyu sunmayı ve pelvik kitlelerin ayırıcı tanısında da kistik ekinokokkozun hatırlanması üzerine dikkati çekmeyi amaçladık.
The Journal of reproductive medicine, 2007
To investigate pelvic floor muscle function and anatomy after childbirth in continent women diffe... more To investigate pelvic floor muscle function and anatomy after childbirth in continent women differing in obstetric history. Young, continent women, age range 20-40 years, were recruited into 3 groups: 1. elective, prelabor cesarean delivery (n =12); 2. vaginal delivery (n = 15); and 3. age-matched nulliparas as controls (n = 13). Pelvic floor muscle strength was measured by a perineometer and also assessed by vaginal palpation. Magnetic resonance imaging of the pelvic floor at rest and on maximal strain was performed. Statistical analysis was carried out using SPSS 10.0 (Chicago, Illinois) for Windows (Microsoft, Redmond, Washington); p < 0.05 was considered significant. Pelvic floor muscle strength was not different between the vaginal delivery and cesarean groups. The descent of the bladder and cervix on straining was greater in the subjects who delivered vaginally than in the cesarean delivery and nulliparous groups. There was a positive and significant correlation between the...
Saudi medical journal, 2006
To evaluate the relationship between vaginal douching and vaginal infections among women in early... more To evaluate the relationship between vaginal douching and vaginal infections among women in early pregnancy. We conducted this study in the Department of Gynecology and Obstetrics, Family Planning Center, Dr. E. Hayri Ustundag Hospital, Izmir, Turkey, between March 2003 and December 2004. We examined the vaginal swabs of 129 women, asking for termination of pregnancy in a family-planning center as both wet-preparations and cultures for vaginal microorganisms, and recorded the informations on women's vaginal douching habit. Among 129 women examined, 80 had at least one type of vaginal microorganisms. Of 67 vaginal douche users, 48 (71.6%) had at least one type of vaginal organisms, whereas of 62 nonusers, only 32 (51.6%) had microorganism, although age, educational status, coital frequency, age at the first intercourse were not statistically different between the vaginal douche-users and non-users. Especially, Group B Streptococcus (GBS), Enterococcus spp. and Candida spp. were f...
African Journal of Microbiology Research, Nov 13, 2012
Archives of Gynecology and Obstetrics, 2021
To investigate the histological efficacy of ranibizumab and zoledronic acid in an experimentally ... more To investigate the histological efficacy of ranibizumab and zoledronic acid in an experimentally induced endometriosis model as compared with danazol, buserelin acetate and dienogest. Endometrial implants were introduced in 52 female Wistar albino rats, which were then randomly divided into six groups. The animals were, respectively, given dienogest, danazol, buserelin acetate, zoledronic acid, ranibizumab and 0.9% NaCl. After 4 weeks, the volumes and histopathological properties of the implants were evaluated and the implants were excised completely at the third laparotomy. A histopathological scoring system was used to evaluate the preservation of epithelia. Endometrial explants were evaluated immunohistochemically. Among the groups, the histological score was significantly lower in the zoledronic acid and ranibizumab groups compared with the controls (p < 0.001). There were no significant differences regarding ellipsoidal volume levels between groups (p > 0.05). However, there was a statistically significant difference regarding cell numbers according to the degree of Bcl-2, NF-κB, and CD31 staining (p < 0.001). There was no statistically significant difference in Bcl-2, CD31, or NF-κB staining in the binary comparisons between the other groups (p > 0.05). For Bcl-2 staining, the staining rate of the group treated with zoledronic acid was significantly lower compared with the dienogest and danazol groups (p < 0.05). The staining rates of CD31 and NF-κB were significantly lower in the zoledronic acid and ranibizumab groups compared with the controls (p < 0.05). According to these results, zoledronic acid and ranibizumab may be putative candidates for the treatment of endometriosis.
American Journal of Case Reports, 2004
Bu makalede, over kanseri sonrasi sisplatin iceren kemoterapi protokolu uygulanan iki hastada gel... more Bu makalede, over kanseri sonrasi sisplatin iceren kemoterapi protokolu uygulanan iki hastada gelisen persistan hipomagnezemi ve buna sekonder tetani sunuldu. Ayrica, sisplatine bagli gelisen hipomagnezeminin klinik prezantasyonu, nedenleri, profilaksi ve tedavi secenekleri, ilgili literaturun isiginda tartisildi.
Frontiers in Global Women's Health, 2021
Endometriosis affects 10% of women worldwide and is one of the most common causes of chronic pelv... more Endometriosis affects 10% of women worldwide and is one of the most common causes of chronic pelvic pain and infertility. However, causal mechanisms of this disease remain unknown due to its heterogeneous presentation. In order to successfully study its phenotypic variation, large sample sizes are needed. Pooling of data across sites is not always feasible given the large variation in the complexity and quality of the data collected. The World Endometriosis Research Foundation (WERF) Endometriosis Phenome and Biobanking Harmonization Project (EPHect) have developed an endometriosis participant questionnaire (EPQ) to harmonize non-surgical clinical participant characteristic data relevant to endometriosis research, allowing for large-scale collaborations in English-speaking populations. Although the WERF EPHect EPQs have been translated into different languages, no study has examined the cross-cultural translation and adaptation for content and face validity. In order to investigate ...
Fertility and Sterility, 1995
ABSTRACT
Fertility and Sterility, 1995
Objective: To induce of ovulation and pregnancy in women with Kallmann's syndrome. Design: Retros... more Objective: To induce of ovulation and pregnancy in women with Kallmann's syndrome. Design: Retrospective study. Patients: Three women with hypo gonadotropic hypogonadism and anosmia with a desire for pregnancy. Interventions: Investigation of hypothalamic-pituitary-ovarian function and induction of ovulation by pulsatile GnRH or intramuscular human pituitary gonadotropins (hPG) or hMG with heG. Main Outcome Measures: Successful induction of ovulation as measured by serum P levels and successful pregnancy. Results: Ovulation was induced successfully in all three patients on more than one occasion and nine pregnancies occurred. Gonadotropin-releasing hormone was given IV by an electronically timed syringe driver. A total of 12 pulsatile GnRH cycles resulted in two pregnancies, 6 of these cycles being in one patient who did not ovulate or conceive with this therapy. Ovulation occurred in 10 of 16 hMG or hPG cycles, with conception in 7 of these. Gonadotropin usage was higher in these women compared with women with hypogonadotropic hypogonadism without anosmia (2,850 compared with 2,100 IU per treatment cycle), and the follicular phase was longer. Conclusions: All three women conceived and had children after induction of ovulation. The success rate of these therapies in Kallmann's syndrome appears to be high in spite of very few reports in the literature.
Turkiye Klinikleri Journal of Gynecology and Obstetrics Special Topics, 2013
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2004
Turkiye Klinikleri Journal of Surgical Medical Sciences, 2006
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2014
Cumhuriyet medical journal, Apr 13, 2009
... İletişim adresi: Sevgi Nehir, Ege Üniversitesi Hemşirelik Yüksekokulu, Psikiyatri Hemşireliği... more ... İletişim adresi: Sevgi Nehir, Ege Üniversitesi Hemşirelik Yüksekokulu, Psikiyatri Hemşireliği Anabilim Dalı, TR-35100 Bornova, İzmir. ... yapılan 226 kadının sosyo-demografik özellikleri incelendiğinde, yaş ortalaması 50,3±5,5, ilkokul mezunluğu %51,8, eşin ilkokul mezunluğu ...
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2001
We have been recently encountered a perplexing problem of intrahepatic cholestasis of pregnancy. ... more We have been recently encountered a perplexing problem of intrahepatic cholestasis of pregnancy. Although this is not unique to pregnancy, we wish to review this issue in the light of the literature, since the differential diagnosis and management of this enigma is important during pregnancy because of intense pruritus and the increased risk of fetal asphyxia (1). Case The case was a thirty-five year-old woman with gravida 1, para 0 had complaint of "itching" especially affecting her palms and soles at 35 weeks of gestation, so severe that she had sleep disturbances due to this terrible itching. She had no clinical findings except some scratch marks on those areas. Until that time she had completely normal pregnancy at follow-ups. Blood levels of transaminases and bilirubins were checked. Aspartate amino transferase (AST) and Alanine amino transferase (ALT) were 40 U/L and 60 U/L, respectively and bilirubins were in normal limits. These tests were checked again after 7 days. The results were slowly raising for AST and ALT as 80 U/L and 120 U/L, respectively. Complaint of itching was reported as "unbearable" by that time.
Turkiye Klinikleri Jinekoloji Obstetrik Ozel Dergisi, 2013
Se evaluaron 10 medios de cultivo para el establecimiento y la multiplicación in vitro de tomate ... more Se evaluaron 10 medios de cultivo para el establecimiento y la multiplicación in vitro de tomate de árbol partenocárpico, los cuales contenían sales de MS, BAP de 0,17 a 5,82 mg/l, y AIA de 0,19 a 2,31 mg/l y una mezcla de tres sustancias antioxidantes: cisteína, ácido ascórbico y caseína hidrolizada (100 mg/l de cada una). Los explantes utilizados fueron esquejes de nudo de 1,5 a 2,0 cm de longitud. Para el análisis estadístico se empleó un diseño central compuesto triplicado con dos repeticiones del punto central. Los resultados fueron: en el material proveniente del altiplano Norte de Antioquia, Colombia, se determinó el punto óptimo para la variable longitud de brotes con reguladores de crecimiento (0,17 mg/l de BAP y 0,19 mg/l de AIA); en el material procedente del Oriente de Antioquia-Colombia, no se pudo determinar el punto óptimo. Las sustancias antioxidantes no fueron efectivas para evitar la oxidación fenólica, la cual fue mediana a alta. Las tasas de multiplicación fueron bajas (0 % y 20 % para los genotipos del Oriente y Norte de Antioquia, respectivamente) y el desarrollo de los brotes en el material del Norte fue muy lento (cuatro meses).
Women's Health, 2015
Endometriosis is characterized by development of the endometrial tissue outside the uterus like o... more Endometriosis is characterized by development of the endometrial tissue outside the uterus like ovary, pelvic peritoneum, pelvic organs, and affects 6-10% of reproductive-aged women. The prevalence of endometrioma is 17-44% of women with endometriosis [1-4]. Since endometriosis is mainly a disease for the women at their reproductive ages, it is important to consider ovarian reserve when managing the cases with ovarian endometriosis. There has been a long debate whether the endometrioma per se decreases the ovarian reserve and/or surgery for endometrioma-either by laparoscopy or by laparotomy-decreases it. Although the dispute for these questions is not totally settled down, in this article, we would like to give some clues for the answers in view of the literature.
Women's Health, 2015
Endometriosis is a common but an enigmatic disease in which endometrial glands and stroma are fou... more Endometriosis is a common but an enigmatic disease in which endometrial glands and stroma are found outside the uterus. Worldwide, 80 million women are affected by the disease. It has generally been accepted as a problem of reproductive ages and affects 6-10% of those women. It is more common in women with infertility. Moreover, since it is an estrogen dependent problem, it is generally believed that endometriosis connotes 'active ovarian function' and is 'healed' after the menopause. However, there are reports on endometriosis beyond the reproductive ages. In this article, endometriosis after the menopause will be discussed.
Turkish Journal of Parasitology, 2015
Echinococcus granulosus'un neden olduğu kistik ekinokokkoz hastalığı endemik bölgelerde halen öne... more Echinococcus granulosus'un neden olduğu kistik ekinokokkoz hastalığı endemik bölgelerde halen önemli bir sağlık sorunu teşkil etmektedir. Kistik ekikokkoz, en sık karaciğer ve akciğerlere olmak üzere vücutta çeşitli organ veya bölgelerde bulunabilmektedir. Pelvik tutulum bildirilmiş olmakla birlikte genellikle başka bir organdan sekonder olarak geliştiği saptanmaktadır, izole pelvik tutulum oldukça enderdir. Bu olgu sunumunda, pelvik kitle ön tanısı ile başvuran ve operasyon ve sonrasında izole pelvik kistik ekinokokkoz saptanan olguyu sunmayı ve pelvik kitlelerin ayırıcı tanısında da kistik ekinokokkozun hatırlanması üzerine dikkati çekmeyi amaçladık.
The Journal of reproductive medicine, 2007
To investigate pelvic floor muscle function and anatomy after childbirth in continent women diffe... more To investigate pelvic floor muscle function and anatomy after childbirth in continent women differing in obstetric history. Young, continent women, age range 20-40 years, were recruited into 3 groups: 1. elective, prelabor cesarean delivery (n =12); 2. vaginal delivery (n = 15); and 3. age-matched nulliparas as controls (n = 13). Pelvic floor muscle strength was measured by a perineometer and also assessed by vaginal palpation. Magnetic resonance imaging of the pelvic floor at rest and on maximal strain was performed. Statistical analysis was carried out using SPSS 10.0 (Chicago, Illinois) for Windows (Microsoft, Redmond, Washington); p < 0.05 was considered significant. Pelvic floor muscle strength was not different between the vaginal delivery and cesarean groups. The descent of the bladder and cervix on straining was greater in the subjects who delivered vaginally than in the cesarean delivery and nulliparous groups. There was a positive and significant correlation between the...
Saudi medical journal, 2006
To evaluate the relationship between vaginal douching and vaginal infections among women in early... more To evaluate the relationship between vaginal douching and vaginal infections among women in early pregnancy. We conducted this study in the Department of Gynecology and Obstetrics, Family Planning Center, Dr. E. Hayri Ustundag Hospital, Izmir, Turkey, between March 2003 and December 2004. We examined the vaginal swabs of 129 women, asking for termination of pregnancy in a family-planning center as both wet-preparations and cultures for vaginal microorganisms, and recorded the informations on women's vaginal douching habit. Among 129 women examined, 80 had at least one type of vaginal microorganisms. Of 67 vaginal douche users, 48 (71.6%) had at least one type of vaginal organisms, whereas of 62 nonusers, only 32 (51.6%) had microorganism, although age, educational status, coital frequency, age at the first intercourse were not statistically different between the vaginal douche-users and non-users. Especially, Group B Streptococcus (GBS), Enterococcus spp. and Candida spp. were f...