Umut Safer - Academia.edu (original) (raw)
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UERJ - Universidade do Estado do Rio de Janeiro / Rio de Janeiro State University
UFF - Universidade Federal Fluminense
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Papers by Umut Safer
Journal of Surgical Oncology, 2015
Journal of the American Geriatrics Society, 2014
Geriatrics & Gerontology International, 2015
American journal of obstetrics and gynecology, 2015
Experimental gerontology, 2014
Geriatrics & gerontology international, 2013
Saudi Journal of Gastroenterology, 2014
The Journal of Arthroplasty, 2014
Obesity Research & Clinical Practice, 2014
JAMA, 2014
IMPORTANCE For many older people, long-term functional limitations persist after a hip fracture. ... more IMPORTANCE For many older people, long-term functional limitations persist after a hip fracture. The efficacy of a home exercise program with minimal supervision after formal hip fracture rehabilitation ends has not been established. OBJECTIVE To determine whether a home exercise program with minimal contact with a physical therapist improved function after formal hip fracture rehabilitation ended.
Journal of the American Geriatrics Society, 2014
commenting on the methodology used to measure body fat percentage in our recent study. 2 The vali... more commenting on the methodology used to measure body fat percentage in our recent study. 2 The validity of bioelectrical impedance analysis (BIA) for assessing body composition in older adults is important.
European Journal of Nutrition, 2013
Endocrine, 2010
The enzyme chitotriosidase (ChT) is secreted by activated macrophages and play active role in hum... more The enzyme chitotriosidase (ChT) is secreted by activated macrophages and play active role in human immune response. ChT activity is increased in atherosclerosis in association to the extent of the disease. We investigated the relevance of ChT to endothelial functions and insulin resistance in patients with T2DM. Forty newly diagnosed and untreated patients with T2DM (male 17; age 47.0 ± 6.2 years) and 50 healthy volunteers (male 21; age 50.2 ± 8.8 years) were enrolled. Plasma asymmetric dimethyl arginine (ADMA) levels were determined by ELISA. ChT activity was measured by the fluorescence method. Insulin resistance was calculated by the HOMA-IR formula. The patients had higher systolic blood pressures, HOMA-IR, ADMA levels, and ChT activities (P < 0.001 for all) and lower HDL cholesterol levels (P = 0.03) than the control group. The ChT activities of the total group were significantly correlated to the age (r = 0.031, p = 0.003), ADMA (r = 0.22, p = 0.04), and plasma glucose levels (r = 0.27, p = 0.01). ChT was the independent determinant of the plasma ADMA levels (r = 0.26, p = 0.02). The results of this study show that serum ChT activity is increased in patients with newly diagnosed, untreated, and uncomplicated patients with T2DM. The results also imply that increased ChT activity may be a predictor of endothelial dysfunction.
Turkish Nephrology Dialysis Transplantation, 2014
Journal of Surgical Oncology, 2015
Journal of the American Geriatrics Society, 2014
Geriatrics & Gerontology International, 2015
American journal of obstetrics and gynecology, 2015
Experimental gerontology, 2014
Geriatrics & gerontology international, 2013
Saudi Journal of Gastroenterology, 2014
The Journal of Arthroplasty, 2014
Obesity Research & Clinical Practice, 2014
JAMA, 2014
IMPORTANCE For many older people, long-term functional limitations persist after a hip fracture. ... more IMPORTANCE For many older people, long-term functional limitations persist after a hip fracture. The efficacy of a home exercise program with minimal supervision after formal hip fracture rehabilitation ends has not been established. OBJECTIVE To determine whether a home exercise program with minimal contact with a physical therapist improved function after formal hip fracture rehabilitation ended.
Journal of the American Geriatrics Society, 2014
commenting on the methodology used to measure body fat percentage in our recent study. 2 The vali... more commenting on the methodology used to measure body fat percentage in our recent study. 2 The validity of bioelectrical impedance analysis (BIA) for assessing body composition in older adults is important.
European Journal of Nutrition, 2013
Endocrine, 2010
The enzyme chitotriosidase (ChT) is secreted by activated macrophages and play active role in hum... more The enzyme chitotriosidase (ChT) is secreted by activated macrophages and play active role in human immune response. ChT activity is increased in atherosclerosis in association to the extent of the disease. We investigated the relevance of ChT to endothelial functions and insulin resistance in patients with T2DM. Forty newly diagnosed and untreated patients with T2DM (male 17; age 47.0 ± 6.2 years) and 50 healthy volunteers (male 21; age 50.2 ± 8.8 years) were enrolled. Plasma asymmetric dimethyl arginine (ADMA) levels were determined by ELISA. ChT activity was measured by the fluorescence method. Insulin resistance was calculated by the HOMA-IR formula. The patients had higher systolic blood pressures, HOMA-IR, ADMA levels, and ChT activities (P < 0.001 for all) and lower HDL cholesterol levels (P = 0.03) than the control group. The ChT activities of the total group were significantly correlated to the age (r = 0.031, p = 0.003), ADMA (r = 0.22, p = 0.04), and plasma glucose levels (r = 0.27, p = 0.01). ChT was the independent determinant of the plasma ADMA levels (r = 0.26, p = 0.02). The results of this study show that serum ChT activity is increased in patients with newly diagnosed, untreated, and uncomplicated patients with T2DM. The results also imply that increased ChT activity may be a predictor of endothelial dysfunction.
Turkish Nephrology Dialysis Transplantation, 2014