Usman Ghani - Academia.edu (original) (raw)

Papers by Usman Ghani

Research paper thumbnail of Design and Fabrication of High Velocity Impact Plaster Machine

The construction industry is continuously struggling to adopt methods which are most fit to meet ... more The construction industry is continuously struggling to adopt methods which are most fit to meet the competition level at construction site. As most of the construction is accomplished by men and further, lack of skilled labor, increase in labor cost, and technological advances are forcing rapid changes in building construction, which mainly consists of commercial infrastructure and residential building, where plastering work is must. As manual plastering is very time consuming and huge labor skills are required to accomplish it. So the aim of this project is to design such a method or machine which reduce labor work and working time at plastering site and intend to design a mortar spraying machine named (High Velocity Impact Plaster Machine), This machine is used to spray the mortar with a higher impact which minimize the bouncing back of the mixture from the wall and also making the surface finish good and at the same thickness. The advantages of using this machine are for saving in man power, raw material and total construction time specifically plastering time and indirectly it reduces the labor cost and hence total construction cost. Further this machine is also very easy to operate and don't require any high labor skills and is very easy to maintain. Additionally. Plastering is widely used as a finishing technology for both interior and exterior walls made from bricks. The plastering wall machine will help to save labor work ,increase productivity by many times, get professional quality finishing in less time, reduce cost, manufacture plastering wall machine in low cost.

Research paper thumbnail of Re-exploring promising α-glucosidase inhibitors for potential development into oral anti-diabetic drugs: Finding needle in the haystack

European Journal of Medicinal Chemistry, 2015

Treatment of diabetes mellitus by oral a-glucosidase inhibitors is currently confined to acarbose... more Treatment of diabetes mellitus by oral a-glucosidase inhibitors is currently confined to acarbose, miglitol and voglibose marred by efficacy problems and unwanted side effects. Since the discovery of the drugs more than three decades ago, no significant progress has been made in the drug development area of anti-diabetic a-glucosidase inhibitors. Despite existence of a wide chemical diversity of a-glucosidase inhibitors identified to date, majority of them are simply piled up in publications and reports thus creating a haystack destined to be forgotten in the scientific literature without given consideration for further development into drugs. This review finds those "needles" in that haystack and lays groundwork for highlighting promising a-glucosidase inhibitors from the literature that may potentially become suitable candidates for pre-clinical or clinical trials while drawing attention of the drug development community to consider and take already-identified promising a-glucosidase inhibitors into the next stage of drug development.

Research paper thumbnail of Impact of Vegetation Density on Flow Characteristics in a Straight Compound Channel

Vegetation exists on the floodplains of almost all natural channels. This vegetation results in a... more Vegetation exists on the floodplains of almost all natural channels. This vegetation results in a number of changes in flow features of open channel flows. Sometimes vegetation also exists within the main channel. This paper presents a numerical study in which the impact of vegetation density on different flow features has been considered. The variables investigated included velocity profiles, bed shear stresses, Reynolds stresses and side wall shear stresses. A compound channel with floodplain on both sides of the main channel has been considered. Four different vegetation densities were considered in this work. It was revealed that increase in vegetation density results in a decrease in the velocity values close to the bed and in the upper regions of the flood plains. The Reynolds stresses were also influenced considerably in the lower regions of the channel. Similar patterns were observed in case of bed shear stresses. The vertical profiles of side wall shear stresses were also investigated in this work. Such an investigation will help in enhancing the understanding and improving different conveyance and flow resistance calculation formulae.

Research paper thumbnail of Endothelial Progenitor Cells During Cerebrovascular Disease

Stroke, 2004

Background and Purpose— Endothelial progenitor cells (EPCs) are associated with endothelial repai... more Background and Purpose— Endothelial progenitor cells (EPCs) are associated with endothelial repair after ischemia in cardiac or peripheral circulation. There are no reports of EPCs with cerebrovascular disease. We present our experience with EPCs in patients with cerebrovascular disease. Summary of Report— EPC counts differed significantly ( P <0.001) between stroke patients (acute stroke: median 4.75 and range 0 to 33; stable stroke: median 7.25 and range 0 to 43) and control subjects (median 15.5 and range 4.3 to 50), independent of age. The level of EPCs was significantly correlated with the Framingham coronary risk score (FCRS) (ρ=−0.349; P =0.002). Conclusions— Similar to cardiac experience, the low EPC levels may play a role in the pathophysiology of cerebrovascular disease.

Research paper thumbnail of Forecasting Groundwater Contamination Using Artificial Neural Networks

International Conf. on Water Resources & Arid Environment, 2004

Water is one of the basic and fundamental requirements for the survival of human beings. Nearly 8... more Water is one of the basic and fundamental requirements for the survival of human beings. Nearly 80% of all the diseases arise as a result of using unsafe and contaminated water. Groundwater contamination has long been a deep concern to environmentalists due to its harmful effects on human health. The presence of different effluents in groundwater should be known as accurately as possible so that necessary arrangements can be made to provide treatment to this contaminated water. Artificial Neural Networking (ANN) model ...

Research paper thumbnail of Design and Fabrication of High Velocity Impact Plaster Machine

The construction industry is continuously struggling to adopt methods which are most fit to meet ... more The construction industry is continuously struggling to adopt methods which are most fit to meet the competition level at construction site. As most of the construction is accomplished by men and further, lack of skilled labor, increase in labor cost, and technological advances are forcing rapid changes in building construction, which mainly consists of commercial infrastructure and residential building, where plastering work is must. As manual plastering is very time consuming and huge labor skills are required to accomplish it. So the aim of this project is to design such a method or machine which reduce labor work and working time at plastering site and intend to design a mortar spraying machine named (High Velocity Impact Plaster Machine), This machine is used to spray the mortar with a higher impact which minimize the bouncing back of the mixture from the wall and also making the surface finish good and at the same thickness. The advantages of using this machine are for saving in man power, raw material and total construction time specifically plastering time and indirectly it reduces the labor cost and hence total construction cost. Further this machine is also very easy to operate and don't require any high labor skills and is very easy to maintain. Additionally. Plastering is widely used as a finishing technology for both interior and exterior walls made from bricks. The plastering wall machine will help to save labor work ,increase productivity by many times, get professional quality finishing in less time, reduce cost, manufacture plastering wall machine in low cost.

Research paper thumbnail of Re-exploring promising α-glucosidase inhibitors for potential development into oral anti-diabetic drugs: Finding needle in the haystack

European Journal of Medicinal Chemistry, 2015

Treatment of diabetes mellitus by oral a-glucosidase inhibitors is currently confined to acarbose... more Treatment of diabetes mellitus by oral a-glucosidase inhibitors is currently confined to acarbose, miglitol and voglibose marred by efficacy problems and unwanted side effects. Since the discovery of the drugs more than three decades ago, no significant progress has been made in the drug development area of anti-diabetic a-glucosidase inhibitors. Despite existence of a wide chemical diversity of a-glucosidase inhibitors identified to date, majority of them are simply piled up in publications and reports thus creating a haystack destined to be forgotten in the scientific literature without given consideration for further development into drugs. This review finds those "needles" in that haystack and lays groundwork for highlighting promising a-glucosidase inhibitors from the literature that may potentially become suitable candidates for pre-clinical or clinical trials while drawing attention of the drug development community to consider and take already-identified promising a-glucosidase inhibitors into the next stage of drug development.

Research paper thumbnail of Impact of Vegetation Density on Flow Characteristics in a Straight Compound Channel

Vegetation exists on the floodplains of almost all natural channels. This vegetation results in a... more Vegetation exists on the floodplains of almost all natural channels. This vegetation results in a number of changes in flow features of open channel flows. Sometimes vegetation also exists within the main channel. This paper presents a numerical study in which the impact of vegetation density on different flow features has been considered. The variables investigated included velocity profiles, bed shear stresses, Reynolds stresses and side wall shear stresses. A compound channel with floodplain on both sides of the main channel has been considered. Four different vegetation densities were considered in this work. It was revealed that increase in vegetation density results in a decrease in the velocity values close to the bed and in the upper regions of the flood plains. The Reynolds stresses were also influenced considerably in the lower regions of the channel. Similar patterns were observed in case of bed shear stresses. The vertical profiles of side wall shear stresses were also investigated in this work. Such an investigation will help in enhancing the understanding and improving different conveyance and flow resistance calculation formulae.

Research paper thumbnail of Endothelial Progenitor Cells During Cerebrovascular Disease

Stroke, 2004

Background and Purpose— Endothelial progenitor cells (EPCs) are associated with endothelial repai... more Background and Purpose— Endothelial progenitor cells (EPCs) are associated with endothelial repair after ischemia in cardiac or peripheral circulation. There are no reports of EPCs with cerebrovascular disease. We present our experience with EPCs in patients with cerebrovascular disease. Summary of Report— EPC counts differed significantly ( P <0.001) between stroke patients (acute stroke: median 4.75 and range 0 to 33; stable stroke: median 7.25 and range 0 to 43) and control subjects (median 15.5 and range 4.3 to 50), independent of age. The level of EPCs was significantly correlated with the Framingham coronary risk score (FCRS) (ρ=−0.349; P =0.002). Conclusions— Similar to cardiac experience, the low EPC levels may play a role in the pathophysiology of cerebrovascular disease.

Research paper thumbnail of Forecasting Groundwater Contamination Using Artificial Neural Networks

International Conf. on Water Resources & Arid Environment, 2004

Water is one of the basic and fundamental requirements for the survival of human beings. Nearly 8... more Water is one of the basic and fundamental requirements for the survival of human beings. Nearly 80% of all the diseases arise as a result of using unsafe and contaminated water. Groundwater contamination has long been a deep concern to environmentalists due to its harmful effects on human health. The presence of different effluents in groundwater should be known as accurately as possible so that necessary arrangements can be made to provide treatment to this contaminated water. Artificial Neural Networking (ANN) model ...