Vítor Devezas - Academia.edu (original) (raw)

Papers by Vítor Devezas

European journal of surgical oncology, Feb 1, 2024

Osteoporosis International, Jan 21, 2020

Autopsy and Case Reports, 2019

We describe herein an unusual cause of recurrent lower abdominal pain of the young male, which is... more We describe herein an unusual cause of recurrent lower abdominal pain of the young male, which is rare and therefore maybe misdiagnosed and scarcely reported.

Autopsy and Case Reports, 2018

Langenbeck's Archives of Surgery, Aug 6, 2022

Langenbeck's Archives of Surgery

European Journal of Sport Science

International Journal of Sports Medicine

Patients who undergo bariatric surgery (BS) have an increased risk of falls. Our aim was to deter... more Patients who undergo bariatric surgery (BS) have an increased risk of falls. Our aim was to determine if a multicomponent exercise intervention after BS improves balance. Eighty-four patients with obesity enrolled for BS were recruited and 1 month after BS randomly allocated to a control (CG; standard medical care) or exercise group (EG; exercise plus standard medical care) consisting of a supervised multicomponent training program (3d/week; 75 min/session; 5 months). Anthropometry, lower limb muscle strength (isokinetic dynamometer), vitamin D (ELISA) and balance in bipedal stance (force platform) were assessed pre-BS, 1 month and 6 months post-BS. One month post-BS, significant balance improvements were observed, namely in antero-posterior center of gravity (CoG) displacement and velocity, and medio-lateral and total CoG velocity. Between 1- and 6-months post-BS, improvements in balance were observed only in the EG, with a significant treatment effect on CoG displacement area and ...

European Journal of Surgical Oncology, 2022

Journal of Coloproctology, 2021

Tumours of the appendix are rare and tend to be diagnosed incidentally, in cases of acute appendi... more Tumours of the appendix are rare and tend to be diagnosed incidentally, in cases of acute appendicitis. For some authors, appendiceal neuroendocrine tumours (ANETs) are the most frequent neoplasm of the appendix, observed in 0.3% to 0.9% of cases acute appendicitis. The present is a unicentric retrospective study conducted between January 2005 and March 2017. Out of a total of 3,007 surgeries for appendiceal pathologies performed in the adult population at the hospital where the present study was conducted, there were 70 (2.33%) malignant cases, 20 (28.6%) of which were ANETs. The patients had a median age of 44 years (range: 18 to 85 years), and were predominantly women (there were 1.9 times more women than men). In 16 cases (80%), a simple appendicectomy was performed (1 patient was submitted to a right hemicolectomy later). The cases of ANETs had a good prognosis in our series: 85% of the patients are either alive today or were alive after 5 years of follow-up. Despite the fact t...

Medicines, 2021

Introduction: Breast cancer is the most incident cancer in the world, accounting for 25% of new c... more Introduction: Breast cancer is the most incident cancer in the world, accounting for 25% of new cancers per year in females. It is the most frequent malignancy in women, being the fifth cause of death from cancer worldwide. Approximately 5 to 10% of patients already present with metastases at diagnosis, and the liver is the site of metastases in half of these cases. Liver metastasis (LM) resection, performed after neoadjuvant systemic treatment, has been reported to increase median overall survival in this population. Aim: The aim of this analysis is to assess the outcomes of patients undergoing breast cancer liver metastasis surgical resection, including impact on survival, compared to patients where metastasectomy was not performed. Methods: retrospective review of 55 female patients with breast cancer liver metastases, diagnosed and treated in a single tertiary university hospital from January 2011 to December 2016 was performed. Results: In 32/55 patients (58.2%), multi-organ me...

Bone, 2021

INTRODUCTION Mechanical unloading associated with weight loss might be one of the main causes for... more INTRODUCTION Mechanical unloading associated with weight loss might be one of the main causes for bariatric surgery (BS) induced bone loss. However, no study has tested this hypothesis through objectively measured accelerometry-derived gravitational loading. We aimed to assess how gravitational loading changes following BS and how this correlates with bone mass loss. METHODS Twenty-one patients submitted to gastric bypass were assessed before, 1, 6 and 12 months after BS on areal bone mineral density (BMD), calciotropic hormones, sclerostin, body composition and daily physical activity. Gravitational loading was determined as the sum of ground reaction forces assessed by accelerometer which considered the interaction between weight and daily ambulation. RESULTS Mechanical stimuli promoted through the significant increase in steps number counterbalanced the gravitational loading decreases derived from the significant weight loss after BS. Gravitational loading volume decreased between pre-BS and 1 month post-BS (-2215 kN∙d-1; p = .023), but remained stable between 6 and 12 months post-BS, despite decreases on hip (-7.0%; p < .001), femoral neck (-8.8%; p < .001) and lumbar spine (-5.2%; p < .001) BMD. Serum sclerostin increased from pre-BS to 1 month post-BS (+0.118 ng∙mL-1; p = .021), returning to pre-BS levels 6 months after surgery. Neither vitamin D nor parathyroid hormone were affected by BS. Weight variation was a predictor of BMD decreases at total hip (R2 = 0.06; p = .026) and femoral neck (R2 = 0.12; p = .022), whereas daily gravitational loading volume was not. Fat and lean mass changes were also predictors of BMD decrease at total hip (R2 = 0.05; p = .031) and femoral neck (R2 = 0.14; p = .010), respectively. CONCLUSION Our findings suggest that gravitational loading only decreased during the first month after surgery remaining stable thereafter, and these changes do not seem to explain BS-induced bone loss. The association between weight and bone loss seems to result from other physiological aspects, fat and lean mass loss, rather than from gravitational loading decrease.

Surgery, Gastroenterology and Oncology, 2020

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the human gastro... more Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the human gastrointestinal tract. They are derived from transformed neoplastic precursors of the interstitial cells of Cajal. They account for 0.1% to 3% of all gastrointestinal cancers. Up to 20% of cancers of the small bowel are GISTs. Less than 5% of cases are associated with hereditary predisposition, like Neurofibromatosis type I, Carney syndrome, and Familial GIST syndrome. The latter, is a rare autosomal dominant genetic disorder originated by germline gain-of-function mutations of KIT or PDGFRA. The study objectives were: to update the response to imatinib of family of our institution and review the families cases published in the literature with this syndrome. Review of the cases of Familial GIST syndrome published in literature and update of the only portuguese family be consultation of clinical processes. In the literature, we found 35 cases of unrelated families with this syndrome. This report is also an update on the only portuguese family with this syndrome and a good response to imatinib. The role of imatinib was not established in cases of familial GIST syndrome. In our opinion, it seems wise to use 400 mg/day for an indefinite period. The objective is disease control and hindering the development of additional lesions.

Osteoporosis International, 2020

Surgery, Gastroenterology and Oncology, 2018

Introduction: Pancreatic intraductal papillary mucinous neoplasms (IPMN) are recognized as pre-ma... more Introduction: Pancreatic intraductal papillary mucinous neoplasms (IPMN) are recognized as pre-malignant lesions, corresponding to less than 3% of all pancreatic exocrine neoplasms. The study objectives were: to evaluate the surgical results of our institution, to identify factors predicting malignancy in IPMN and to assess the validity of recently introduced IPMN guidelines in our population. Methods: A single center, retrospective study in patients submitted to surgical resection for IPMN was conducted, between 1/2008-6/2016, to identify predictive factors for malignancy, and to evaluate the surgical results. Results: Thirty-nine patients were submitted to a surgical resection. The median age was 68 years (61.5% females). Adenocarcinoma and high-grade dysplasia were present, in 7 and 4 patients, respectively. A significant association was identified with the phenotype and the degree of atypia (p = 0.001), and duct origin and degree of atypia (p = 0.026). Malignant transformation was associated with intestinal or pancreatic-biliary subtypes. Discussion and Conclusions: Applying the European guidelines, all adenocarcinoma would have undergone surgical resection, but 1 with high-grade dysplasia would not be resected. If we applied the American guidelines, 1 patient with adenocarcinoma and 3 with high-grade dysplasia wouldn´t be submitted to resection. The decision in patients with these lesions requires multidisciplinary teams and a tailored based approach.

European Surgery, 2020

Background Hereditary diffuse gastric cancer is an autosomal dominant cancer susceptibility syndr... more Background Hereditary diffuse gastric cancer is an autosomal dominant cancer susceptibility syndrome characterized by increased risk for gastric cancer and lobular breast cancer and mainly caused by germline alterations in the CDH1 gene. Methods This was an observational, retrospective, and unicentric study. Clinical data from patients with