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Papers by VICTORIA INES VOLONTERI
El sindrome de Muir-Torre (SMT) es una variante fenotipica del cancer de colon hereditario sin po... more El sindrome de Muir-Torre (SMT) es una variante fenotipica del cancer de colon hereditario sin poliposis, en la que hay un defecto en el sistema de reparacion del acido desoxirribonucleico (ADN). Se caracteriza por asociar tumores de las glandulas sebaceas, queratoacantomas y al menos una neoplasia interna. Se presentan los resultados de un estudio retrospectivo que incluyo a los pacientes con SMT atendidos en el Hospital Italiano de Buenos Aires en el periodo enero 2005-diciembre 2010, incluyendo sus caracteristicas demograficas, clinicas, histopatologicas y geneticas
CASO CLÍNICO Se presenta una paciente de sexo femenino de 23 años, sin antecedentes patológicos d... more CASO CLÍNICO Se presenta una paciente de sexo femenino de 23 años, sin antecedentes patológicos de importancia ni consumo de medicación de forma habitual o esporádica. Concurrió a los consultorios externos del Servicio de Dermatología de la Institución por presentar lesiones cutáneas en tronco y miembro inferior izquierdo. Al examen físico presentaba pápulas redondeadas de 2-3 mm de diámetro, eritematopurpúricas, con superficie ligeramente descamativa, asintomáticas, de 1 mes de evolución. Estas lesiones se agrupaban siguiendo un trayecto lineal discontinuo de 3-4 mm de ancho y se disponían desde la región retromaleolar interna izquierda hacia el pubis y desde allí comprometían el hemiabdomen homolateral en forma de S itálica (Figs. 1 y 2). Por las características clínicas se trataba de una dermatosis adquirida inflamatoria con patrón en líneas de Blaschko. Dentro de este grupo de entidades se plantearon los siguientes diagnósticos presuntivos: liquen estriado, liquen plano lineal y...
Servicio de Dermatología (J.R.M., D.D.L., P.A.E., A.C.T., R.G.). Servicio de Anatomía Patológica ... more Servicio de Dermatología (J.R.M., D.D.L., P.A.E., A.C.T., R.G.). Servicio de Anatomía Patológica (V.I.V.). Hospital Italiano de Buenos Aires Correspondencia: johanna.rodriguez@hospitalitaliano.org.ar INTRODUCCIÓN La anetodermia primaria (AP) es una rara entidad caracterizada por áreas de piel laxa circunscriptas, causada por la pérdida de las fibras elásticas como parte de una alteración en los mecanismos de reparación cutánea, o asociada primariamente a VIH (virus de la inmunodeficiencia humana) y a enfermedades autoinmunes como el lupus eritematoso sistémico y el síndrome antifosfolípido.
El carcinosarcoma es un tumor bifasico compuesto por poblaciones de celulas malignas epiteliales... more El carcinosarcoma es un tumor bifasico compuesto por poblaciones de celulas malignas epiteliales y mesenquimaticas. Presentamos el caso de un paciente con un carcinosarcoma cutaneo primario, un tumor infrecuente cuyo diagnostico es histologico, al descartarse otros tumores fusocelulares como el carcinoma espinocelular sarcomatoide, el fibroxantoma atipico o el melanoma desmoplasico. Una histopatologia que evidencie su morfologia bifasica, junto con una inmunohistoquimica positiva para p63 y citoqueratinas AE1 y AE3, son las principales caracteristicas que confirmaron el diagnostico en este caso. El carcinosarcoma cutaneo tiene un pronostico especifico segun su diferenciacion histopatologica y su tratamiento correcto es imprescindible para obtener una evolucion favorable. Palabras clave: carcinosarcoma, inmunohistoquimica. Dermatol. Argent. 2018, 24 (3): 149-151 Primary cutaneous carcinosarcoma Abstract Carcinosarcoma is a biphasic tumor composed of malignant epithelial and m...
Actas Dermo-Sifiliográficas, 2021
Pathology - Research and Practice, 2019
Nowadays, histopathological criteria for melanocytic lesions are the mainstay prognostic factors ... more Nowadays, histopathological criteria for melanocytic lesions are the mainstay prognostic factors for melanoma. However, there are cases in which these parameters fall short to predict melanoma spread. We recently demonstrated a correlation of cofilin-1 levels, a key protein for tumor invasion, with different histopathological parameters associated with melanoma malignancy as well as a negative correlation with survival. In order to broaden our previous findings, we aim to estimate the probability of a melanoma to metastasize as a function of both a conventional histopathological parameter (Breslow thickness, BT) and cofilin-1's immunohistochemical expression levels, which we propose as a potential marker for metastasis. We used a Bayesian approach to analyze clinical and cofilin-1 datasets formerly obtained from a patients' small cohort diagnosed with malignant melanocytic lesions since 2000 until 2008; classified at different tumor stages with or without detected metastasis and with at least 5 years of clinical follow-up. Low BT values exhibited wide variance to predict metastasis occurrence, while the differential diagnostic value of cofilin-1 confirmed BT diagnosis or resulted more precise to predict outcome. Particularly, the probability of metastasis estimation improved when cofilin-1 was combined with BT for specific cases, where BT displayed large uncertainties. Our analysis and the cofilin-1 determination provided statistically significant prognostic value in mid-low BT melanomas, which could complement further evaluation criteria to assist diagnosis and treatment decisionmaking. Moreover, the combined use of cofilin-1 with BT, if validated in follow-up studies, would be feasible to help patients' selection for treatment and optimize health resources.
Cancer Research, 2018
Melanoma, the deadliest type of skin cancer, derives from the transformation of melanocytes, whic... more Melanoma, the deadliest type of skin cancer, derives from the transformation of melanocytes, which protect the skin from ultraviolet radiation (UVR) through the synthesis of melanin. UVR is the major risk factor for melanoma. Intriguingly, in people with oculocutaneous albinism (OCA), who lack or have a reduction in melanin synthesis melanoma is surprisingly rare, whereas other UVR-driven skin cancers are comparatively high. Since UVR exposure and light skin complexion increase melanoma risk, it is unclear why melanoma is rare in OCA. Therefore, we evaluated how the absence of melanin impact the mutation burden in OCA and identify driver mutations by whole exome sequencing (WES) analysis of melanomas from a patient with OCA. The patient (in their 50s) presented cutaneous basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) in addition to melanoma. The histopathology of one tumor (sample A), located on the left forearm, indicated a desmoplastic nodular melanoma, Clark level I...
Anais Brasileiros de Dermatologia
International Journal of Dermatology, 2012
Background Chagas' disease is a zoonosis caused by a protozoan agent, Trypanosoma cruzi. Patients... more Background Chagas' disease is a zoonosis caused by a protozoan agent, Trypanosoma cruzi. Patients undergoing immunosuppressive treatment due to organ transplant, malignancies, infections, or chemotherapy may reactivate a preexisting chronic or indeterminate Trypanosoma cruzi infection. Methods We present two transplant patients who underwent reactivation of Chagas' disease with cutaneous manifestations after an augmentation in their immunosuppressive therapy. A 38-year-old man was hospitalized on day 69 after receiving an allogeneic bone marrow transplant; he developed multiple painful erythematous plaques with diffuse borders, confined to the right cheek, trunk, thigh, elbows, and feet. A 59-year-old woman with a 14-year history of Chagasic cardiomyopathy presented one month after heart transplantation with a painful infiltrated purpuric plaque on the back of her right leg. Results In both cases, histologic examination of skin biopsies showed dermal infiltration with intrahistiocytic amastigotes. In one of the reported cases, the Strout method detected parasitemia. Treatments with nifurtimox (600 mg/d) in case 1 and benznidazole (400 mg/d) in case 2 were started. Fever and cutaneous lesions resolved immediately after seven days of treatment. Conclusions Reactivation of Chagas' disease is a serious complication that usually occurs in immunocompromised patients. Clinical manifestations include febrile illness occasionally associated with painful skin lesions. Early diagnosis and proper treatment can significantly improve these patients' outcome.
Archivos Argentinos de Pediatria, 2013
a immunoglobulin, plasmapheresis and strict care to prevent superinfection and sequels. After 31 ... more a immunoglobulin, plasmapheresis and strict care to prevent superinfection and sequels. After 31 days of hospitalization the patient was discharged from hospital.
International Journal of Dermatology, 2014
Background All-trans retinoic acid (ATRA) is routinely associated with chemotherapy for the treat... more Background All-trans retinoic acid (ATRA) is routinely associated with chemotherapy for the treatment of acute promyelocytic leukemia (APL). Several reports of scrotal ulceration induced by this agent have been made in the recent years. Aims The aim of this article was to report the first case of a lingual ulceration associated with retinoic acid syndrome (RAS). Matherials and Methods We presented a 32-year-old man with a diagnosis of acute promyelocytic leukemia who received treatment with ATRA. He presented with febrile neutropenia and a lingual ulcer that did not respond to antibiotic and antifungal regimens. He developed weight gain, lower limb edema, polyserositis, and acute renal failure. Retinoic acid syndrome syndrome was diagnosed. Results An exhaustive attempt to exclude infectious causes was made performing repeated cultures, histologic examinations, and direct immunofluorescence for HSV. No causative agent was identified. Re-epithelialization of the ulcer was achieved with ATRA cessation and treatment with systemic steroids.
El penfigoide ampollar (PA) es la dermatosis ampollar autoinmune mas frecuente. Dado que sus mani... more El penfigoide ampollar (PA) es la dermatosis ampollar autoinmune mas frecuente. Dado que sus manifestaciones cutaneas pueden tener gran polimorfismo y se han descrito multiples variantes clinicas atipicas, este trastorno puede ser dificil de diagnosticar. Material y metodos: El presente articulo describe tres casos: a) Paciente femenino de 62 anos con una ampolla tensa de contenido seroso en la zona preesternal, y una erosion mucosa, dolorosa, de 2 cm de diametro en el labio menor izquierdo. b) Paciente femenino de 88 anos con cuadro de eritrodermia de 4 meses de evolucion, quien desarrolla ampollas tensas de contenido seroso sobre placas eritematosas dispersas en los miembros inferiores. c) Paciente masculino de 62 anos con multiples vesiculas tensas y pruriginosas en el rostro y dorso de las manos. Resultados: En todos los casos, los estudios histologicos revelaron la presencia de ampollas subepidermicas con infiltrado inflamatorio predominantemente eosinofilo. Los estudios de inm...
Anais Brasileiros de Dermatologia
International Journal of Dermatology
Nodular fasciitis is a benign pseudosarcomatous, self-limited, and reactive process. Based on its... more Nodular fasciitis is a benign pseudosarcomatous, self-limited, and reactive process. Based on its clinical and histological features - a fast-growing, solitary tumor with high cellularity and mitotic count - nodular fasciitis is considered to be a benign mimic of sarcoma. We present four cases of nodular fasciitis and a review of the literature. The cases we present were initially misdiagnosed as sarcoma; two as dermatofibrosarcoma protuberans, one as atypical fibroxanthoma, and one as leiomyosarcoma. Awareness of this entity among dermatologists is important as misdiagnosis may lead to unnecessary treatments associated with increased morbidity.
International journal of dermatology, 2017
Phaeohyphomycosis is an infrequent infection in human beings. However, in recent years, its preva... more Phaeohyphomycosis is an infrequent infection in human beings. However, in recent years, its prevalence has augmented in immunosuppressed patients (mostly in solid organ transplanted patients). Infection can be mucocutaneous or disseminated. In the former, the fungus inoculation occurs mainly through traumatism. Lesions may be polymorphic and asymptomatic, isolated or multiple, and are usually localized in exposed areas of the limbs and head. Treatment is not standardized. When possible, surgical resection of the lesion is combined with systemic antifungals. We communicate three phaeohyphomycosis cases with cutaneous compromise. The cases we present show diverse clinical characteristics and varied severity and evolution. It is important for dermatologists to recognize this cutaneous fungus infection because the diagnosis using microscopic examination and mycological culture depends on the clinical suspicion.
Oncotarget, Jan 8, 2018
Melanoma is an aggressive cancer with highly metastatic ability. We propose cofilin-1, a key prot... more Melanoma is an aggressive cancer with highly metastatic ability. We propose cofilin-1, a key protein in the regulation of actin dynamics and migration, as a prognostic marker. We determined cofilin-1 levels in a retrospective cohort of patients with melanomas and benign lesions of melanocytes (nevi) by immunohistochemistry. Higher cofilin-1 levels were found in malignant melanoma (MM) with Breslow Index (BI)>2 vs MM with BI<2, melanoma (MIS) and nevi and also in MM with metastasis vs MM without detected metastasis. Kaplan-Meier survival curves were performed, clustering patients according to either the type of melanocytic lesions or cofilin-1 level. Survival curves demonstrated worse prognosis of patients with high vs low cofilin-1 levels. TCGA database analysis of melanoma also showed low survival in patients with upregulated cofilin-1 mRNA vs patients without alteration in CFL1 mRNA expression. As cofilin-1 has a dual function depending on its intracellular localization, we ...
Dermatologia Argentina, Feb 12, 2013
Dermatologia Argentina, May 8, 2013
Dermatol Pediatr Latinoam, May 1, 2008
El sindrome de Muir-Torre (SMT) es una variante fenotipica del cancer de colon hereditario sin po... more El sindrome de Muir-Torre (SMT) es una variante fenotipica del cancer de colon hereditario sin poliposis, en la que hay un defecto en el sistema de reparacion del acido desoxirribonucleico (ADN). Se caracteriza por asociar tumores de las glandulas sebaceas, queratoacantomas y al menos una neoplasia interna. Se presentan los resultados de un estudio retrospectivo que incluyo a los pacientes con SMT atendidos en el Hospital Italiano de Buenos Aires en el periodo enero 2005-diciembre 2010, incluyendo sus caracteristicas demograficas, clinicas, histopatologicas y geneticas
CASO CLÍNICO Se presenta una paciente de sexo femenino de 23 años, sin antecedentes patológicos d... more CASO CLÍNICO Se presenta una paciente de sexo femenino de 23 años, sin antecedentes patológicos de importancia ni consumo de medicación de forma habitual o esporádica. Concurrió a los consultorios externos del Servicio de Dermatología de la Institución por presentar lesiones cutáneas en tronco y miembro inferior izquierdo. Al examen físico presentaba pápulas redondeadas de 2-3 mm de diámetro, eritematopurpúricas, con superficie ligeramente descamativa, asintomáticas, de 1 mes de evolución. Estas lesiones se agrupaban siguiendo un trayecto lineal discontinuo de 3-4 mm de ancho y se disponían desde la región retromaleolar interna izquierda hacia el pubis y desde allí comprometían el hemiabdomen homolateral en forma de S itálica (Figs. 1 y 2). Por las características clínicas se trataba de una dermatosis adquirida inflamatoria con patrón en líneas de Blaschko. Dentro de este grupo de entidades se plantearon los siguientes diagnósticos presuntivos: liquen estriado, liquen plano lineal y...
Servicio de Dermatología (J.R.M., D.D.L., P.A.E., A.C.T., R.G.). Servicio de Anatomía Patológica ... more Servicio de Dermatología (J.R.M., D.D.L., P.A.E., A.C.T., R.G.). Servicio de Anatomía Patológica (V.I.V.). Hospital Italiano de Buenos Aires Correspondencia: johanna.rodriguez@hospitalitaliano.org.ar INTRODUCCIÓN La anetodermia primaria (AP) es una rara entidad caracterizada por áreas de piel laxa circunscriptas, causada por la pérdida de las fibras elásticas como parte de una alteración en los mecanismos de reparación cutánea, o asociada primariamente a VIH (virus de la inmunodeficiencia humana) y a enfermedades autoinmunes como el lupus eritematoso sistémico y el síndrome antifosfolípido.
El carcinosarcoma es un tumor bifasico compuesto por poblaciones de celulas malignas epiteliales... more El carcinosarcoma es un tumor bifasico compuesto por poblaciones de celulas malignas epiteliales y mesenquimaticas. Presentamos el caso de un paciente con un carcinosarcoma cutaneo primario, un tumor infrecuente cuyo diagnostico es histologico, al descartarse otros tumores fusocelulares como el carcinoma espinocelular sarcomatoide, el fibroxantoma atipico o el melanoma desmoplasico. Una histopatologia que evidencie su morfologia bifasica, junto con una inmunohistoquimica positiva para p63 y citoqueratinas AE1 y AE3, son las principales caracteristicas que confirmaron el diagnostico en este caso. El carcinosarcoma cutaneo tiene un pronostico especifico segun su diferenciacion histopatologica y su tratamiento correcto es imprescindible para obtener una evolucion favorable. Palabras clave: carcinosarcoma, inmunohistoquimica. Dermatol. Argent. 2018, 24 (3): 149-151 Primary cutaneous carcinosarcoma Abstract Carcinosarcoma is a biphasic tumor composed of malignant epithelial and m...
Actas Dermo-Sifiliográficas, 2021
Pathology - Research and Practice, 2019
Nowadays, histopathological criteria for melanocytic lesions are the mainstay prognostic factors ... more Nowadays, histopathological criteria for melanocytic lesions are the mainstay prognostic factors for melanoma. However, there are cases in which these parameters fall short to predict melanoma spread. We recently demonstrated a correlation of cofilin-1 levels, a key protein for tumor invasion, with different histopathological parameters associated with melanoma malignancy as well as a negative correlation with survival. In order to broaden our previous findings, we aim to estimate the probability of a melanoma to metastasize as a function of both a conventional histopathological parameter (Breslow thickness, BT) and cofilin-1's immunohistochemical expression levels, which we propose as a potential marker for metastasis. We used a Bayesian approach to analyze clinical and cofilin-1 datasets formerly obtained from a patients' small cohort diagnosed with malignant melanocytic lesions since 2000 until 2008; classified at different tumor stages with or without detected metastasis and with at least 5 years of clinical follow-up. Low BT values exhibited wide variance to predict metastasis occurrence, while the differential diagnostic value of cofilin-1 confirmed BT diagnosis or resulted more precise to predict outcome. Particularly, the probability of metastasis estimation improved when cofilin-1 was combined with BT for specific cases, where BT displayed large uncertainties. Our analysis and the cofilin-1 determination provided statistically significant prognostic value in mid-low BT melanomas, which could complement further evaluation criteria to assist diagnosis and treatment decisionmaking. Moreover, the combined use of cofilin-1 with BT, if validated in follow-up studies, would be feasible to help patients' selection for treatment and optimize health resources.
Cancer Research, 2018
Melanoma, the deadliest type of skin cancer, derives from the transformation of melanocytes, whic... more Melanoma, the deadliest type of skin cancer, derives from the transformation of melanocytes, which protect the skin from ultraviolet radiation (UVR) through the synthesis of melanin. UVR is the major risk factor for melanoma. Intriguingly, in people with oculocutaneous albinism (OCA), who lack or have a reduction in melanin synthesis melanoma is surprisingly rare, whereas other UVR-driven skin cancers are comparatively high. Since UVR exposure and light skin complexion increase melanoma risk, it is unclear why melanoma is rare in OCA. Therefore, we evaluated how the absence of melanin impact the mutation burden in OCA and identify driver mutations by whole exome sequencing (WES) analysis of melanomas from a patient with OCA. The patient (in their 50s) presented cutaneous basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) in addition to melanoma. The histopathology of one tumor (sample A), located on the left forearm, indicated a desmoplastic nodular melanoma, Clark level I...
Anais Brasileiros de Dermatologia
International Journal of Dermatology, 2012
Background Chagas' disease is a zoonosis caused by a protozoan agent, Trypanosoma cruzi. Patients... more Background Chagas' disease is a zoonosis caused by a protozoan agent, Trypanosoma cruzi. Patients undergoing immunosuppressive treatment due to organ transplant, malignancies, infections, or chemotherapy may reactivate a preexisting chronic or indeterminate Trypanosoma cruzi infection. Methods We present two transplant patients who underwent reactivation of Chagas' disease with cutaneous manifestations after an augmentation in their immunosuppressive therapy. A 38-year-old man was hospitalized on day 69 after receiving an allogeneic bone marrow transplant; he developed multiple painful erythematous plaques with diffuse borders, confined to the right cheek, trunk, thigh, elbows, and feet. A 59-year-old woman with a 14-year history of Chagasic cardiomyopathy presented one month after heart transplantation with a painful infiltrated purpuric plaque on the back of her right leg. Results In both cases, histologic examination of skin biopsies showed dermal infiltration with intrahistiocytic amastigotes. In one of the reported cases, the Strout method detected parasitemia. Treatments with nifurtimox (600 mg/d) in case 1 and benznidazole (400 mg/d) in case 2 were started. Fever and cutaneous lesions resolved immediately after seven days of treatment. Conclusions Reactivation of Chagas' disease is a serious complication that usually occurs in immunocompromised patients. Clinical manifestations include febrile illness occasionally associated with painful skin lesions. Early diagnosis and proper treatment can significantly improve these patients' outcome.
Archivos Argentinos de Pediatria, 2013
a immunoglobulin, plasmapheresis and strict care to prevent superinfection and sequels. After 31 ... more a immunoglobulin, plasmapheresis and strict care to prevent superinfection and sequels. After 31 days of hospitalization the patient was discharged from hospital.
International Journal of Dermatology, 2014
Background All-trans retinoic acid (ATRA) is routinely associated with chemotherapy for the treat... more Background All-trans retinoic acid (ATRA) is routinely associated with chemotherapy for the treatment of acute promyelocytic leukemia (APL). Several reports of scrotal ulceration induced by this agent have been made in the recent years. Aims The aim of this article was to report the first case of a lingual ulceration associated with retinoic acid syndrome (RAS). Matherials and Methods We presented a 32-year-old man with a diagnosis of acute promyelocytic leukemia who received treatment with ATRA. He presented with febrile neutropenia and a lingual ulcer that did not respond to antibiotic and antifungal regimens. He developed weight gain, lower limb edema, polyserositis, and acute renal failure. Retinoic acid syndrome syndrome was diagnosed. Results An exhaustive attempt to exclude infectious causes was made performing repeated cultures, histologic examinations, and direct immunofluorescence for HSV. No causative agent was identified. Re-epithelialization of the ulcer was achieved with ATRA cessation and treatment with systemic steroids.
El penfigoide ampollar (PA) es la dermatosis ampollar autoinmune mas frecuente. Dado que sus mani... more El penfigoide ampollar (PA) es la dermatosis ampollar autoinmune mas frecuente. Dado que sus manifestaciones cutaneas pueden tener gran polimorfismo y se han descrito multiples variantes clinicas atipicas, este trastorno puede ser dificil de diagnosticar. Material y metodos: El presente articulo describe tres casos: a) Paciente femenino de 62 anos con una ampolla tensa de contenido seroso en la zona preesternal, y una erosion mucosa, dolorosa, de 2 cm de diametro en el labio menor izquierdo. b) Paciente femenino de 88 anos con cuadro de eritrodermia de 4 meses de evolucion, quien desarrolla ampollas tensas de contenido seroso sobre placas eritematosas dispersas en los miembros inferiores. c) Paciente masculino de 62 anos con multiples vesiculas tensas y pruriginosas en el rostro y dorso de las manos. Resultados: En todos los casos, los estudios histologicos revelaron la presencia de ampollas subepidermicas con infiltrado inflamatorio predominantemente eosinofilo. Los estudios de inm...
Anais Brasileiros de Dermatologia
International Journal of Dermatology
Nodular fasciitis is a benign pseudosarcomatous, self-limited, and reactive process. Based on its... more Nodular fasciitis is a benign pseudosarcomatous, self-limited, and reactive process. Based on its clinical and histological features - a fast-growing, solitary tumor with high cellularity and mitotic count - nodular fasciitis is considered to be a benign mimic of sarcoma. We present four cases of nodular fasciitis and a review of the literature. The cases we present were initially misdiagnosed as sarcoma; two as dermatofibrosarcoma protuberans, one as atypical fibroxanthoma, and one as leiomyosarcoma. Awareness of this entity among dermatologists is important as misdiagnosis may lead to unnecessary treatments associated with increased morbidity.
International journal of dermatology, 2017
Phaeohyphomycosis is an infrequent infection in human beings. However, in recent years, its preva... more Phaeohyphomycosis is an infrequent infection in human beings. However, in recent years, its prevalence has augmented in immunosuppressed patients (mostly in solid organ transplanted patients). Infection can be mucocutaneous or disseminated. In the former, the fungus inoculation occurs mainly through traumatism. Lesions may be polymorphic and asymptomatic, isolated or multiple, and are usually localized in exposed areas of the limbs and head. Treatment is not standardized. When possible, surgical resection of the lesion is combined with systemic antifungals. We communicate three phaeohyphomycosis cases with cutaneous compromise. The cases we present show diverse clinical characteristics and varied severity and evolution. It is important for dermatologists to recognize this cutaneous fungus infection because the diagnosis using microscopic examination and mycological culture depends on the clinical suspicion.
Oncotarget, Jan 8, 2018
Melanoma is an aggressive cancer with highly metastatic ability. We propose cofilin-1, a key prot... more Melanoma is an aggressive cancer with highly metastatic ability. We propose cofilin-1, a key protein in the regulation of actin dynamics and migration, as a prognostic marker. We determined cofilin-1 levels in a retrospective cohort of patients with melanomas and benign lesions of melanocytes (nevi) by immunohistochemistry. Higher cofilin-1 levels were found in malignant melanoma (MM) with Breslow Index (BI)>2 vs MM with BI<2, melanoma (MIS) and nevi and also in MM with metastasis vs MM without detected metastasis. Kaplan-Meier survival curves were performed, clustering patients according to either the type of melanocytic lesions or cofilin-1 level. Survival curves demonstrated worse prognosis of patients with high vs low cofilin-1 levels. TCGA database analysis of melanoma also showed low survival in patients with upregulated cofilin-1 mRNA vs patients without alteration in CFL1 mRNA expression. As cofilin-1 has a dual function depending on its intracellular localization, we ...
Dermatologia Argentina, Feb 12, 2013
Dermatologia Argentina, May 8, 2013
Dermatol Pediatr Latinoam, May 1, 2008