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Indian Journal of Pharmacy Practice, 2019
Metformin is the most frequently prescribed medication in the management of Type 2 Diabetes Melli... more Metformin is the most frequently prescribed medication in the management of Type 2 Diabetes Mellitus. It is widely approved that it suppresses hepatic glucose production and improves insulin signalling mainly in muscle, hepatic and adipose tissue. On long term use, metformin therapy leads to Vitamin B 12 deficiency and anemia. Several studies shows that long term metformin use reduce the Vitamin B 12 levels and particularly taken in a dose greater than 2000 mg/day and for a period exceeding 4 years. The prevalence is increased with increase in dose and duration of metformin use. Peripheral neuropathy may be the only clinical presentation of Vitamin B 12 deficiency, without haematological signs and symptoms. The diagnostic tests like serum Vitamin B 12 and holo-TC-11 test measure the circulating part of Vitamin while homocysteine and MMA are the biomarkers of metabolic Vitamin B 12 deficiency that show elevated levels when the Vitamin is deficient at the cellular level. Currently there are no guidelines for the supplementation and appropriate dose of Vitamin B 12 for diabetic patients on metformin but the treatment of Vitamin B 12 deficiency includes monthly injections of Vitamin B 12 or large daily therapeutic doses (1000mcg) of Vitamin B 12 , prophylactically administered calcium carbonate (1.2gms daily). This article demonstrates that regular monitoring of Vitamin B 12 should be done especially in patients receiving metformin therapy for longer duration at high dosage and Vitamin B 12 supplementation prophylactically or at least annually to prevent the complications of Vitamin B 12 deficiency.
Indian Journal of Pharmacy Practice, 2019
Metformin is the most frequently prescribed medication in the management of Type 2 Diabetes Melli... more Metformin is the most frequently prescribed medication in the management of Type 2 Diabetes Mellitus. It is widely approved that it suppresses hepatic glucose production and improves insulin signalling mainly in muscle, hepatic and adipose tissue. On long term use, metformin therapy leads to Vitamin B 12 deficiency and anemia. Several studies shows that long term metformin use reduce the Vitamin B 12 levels and particularly taken in a dose greater than 2000 mg/day and for a period exceeding 4 years. The prevalence is increased with increase in dose and duration of metformin use. Peripheral neuropathy may be the only clinical presentation of Vitamin B 12 deficiency, without haematological signs and symptoms. The diagnostic tests like serum Vitamin B 12 and holo-TC-11 test measure the circulating part of Vitamin while homocysteine and MMA are the biomarkers of metabolic Vitamin B 12 deficiency that show elevated levels when the Vitamin is deficient at the cellular level. Currently there are no guidelines for the supplementation and appropriate dose of Vitamin B 12 for diabetic patients on metformin but the treatment of Vitamin B 12 deficiency includes monthly injections of Vitamin B 12 or large daily therapeutic doses (1000mcg) of Vitamin B 12 , prophylactically administered calcium carbonate (1.2gms daily). This article demonstrates that regular monitoring of Vitamin B 12 should be done especially in patients receiving metformin therapy for longer duration at high dosage and Vitamin B 12 supplementation prophylactically or at least annually to prevent the complications of Vitamin B 12 deficiency.