V. Korten - Academia.edu (original) (raw)
Papers by V. Korten
Clinical Microbiology and Infection, 2002
Journal of Pharmacology and Pharmacotherapeutics, 2012
Gokengin, Ayse/0000-0003-0704-2302;WOS: 000494690300226[No abstract available
Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 1996
As a result of the extensive use of new generation cephalosporins, an increase in the frequency o... more As a result of the extensive use of new generation cephalosporins, an increase in the frequency of gram negative bacteria in nosocomial infections is observed in recent years. Awareness of the rate of resistance to these agents is a requirement in order to install apropriate control measured. A study was undertaken with the participation of nine hospitals in Turkey to determine the frequency of gram negative bacteria isolated in the ICU's and compare the resistance rates to selected antibiotics. 981 bacteria were collected and antibiotic susceptibilities were determined by E-test. Pseudomonas spp. was the most prevalent organism (30%) followed by Klebsiella spp. (25%) and E. coli (18%). Imipenem, amikacin and ciprofloxacin were the most active agents in vitro with slight variations according to each center. The high rate of resistance to the new generation cephalosporins suggested the Class I and extended-broad-spectrum ß-lactamases.
Journal of Medical Microbiology, 2001
ABSTRACT
Tubercle and Lung Disease, 1993
International Journal of Antimicrobial Agents, 2007
Resistance surveillance-general S517 aureus was 18.8% and the resistance of the species to erythr... more Resistance surveillance-general S517 aureus was 18.8% and the resistance of the species to erythromycin, clindamicin, gentamicin and ciprofloxacin was higher than 20%. Among the Gram-negative bacteria: the prevalence of ESBL-producing E. coli was 14.1% and among K. pneumoniae was 28.8%. Ceftazidime-resistant P. aeruginosa reached 32.9% and the resistance to ciprofloxacin among the species was similar-31.5%. Resistance to imipenem among A. baumannii was 16%. Conclusion: The aetiological structure of bloodstream infections is similar to those in most European countries and also with that in the previous years in Bulgaria. Remarkable is the stable presence of P. aeruginosa and A. baumannii among the leading pathogens causing sepsis in the country. There is a decrease in the proportion of S. aureus and E. faecalis and an increase in the proportion of Candida spp. compared with 2004. Main therapeutical problems are ESBL-positive K. pneumoniae and multiresistant P. aeruginosa and A. baumannii.
European Journal of Epidemiology, 1996
Infection with Clostridium difficile can present with various clinical pictures ranging from an a... more Infection with Clostridium difficile can present with various clinical pictures ranging from an asymptomatic carrier state to pseudomembranous colitis and plays an important part in the etiology of nosocomial diarrhoea. To identify risk factors for C. difficile colonization and diarrhoea in hospitalized subjects, patients admitted to a general medicine ward at Marmara University hospital during a one year period were entered into the study. Of the 202 patients, nosocomial diarrhoea developed in 45 (22.3%). Fourteen patients (6.9%) were colonized with C. difficile during their hospitalization period. Ten of the colonized patients (71.4%) developed diarrhoea and were found to be positive by toxin assay. Pseudomembranous colitis was confirmed endoscopically in 3 of the patients with diarrhoea. Administration of beta lactam agents such as ampicillin and cephalosporins; gastrointestinal manipulations and admission to the intensive care unit were found as major risk factors for C. diffi'cile colonization.
Clinical Infectious Diseases, 2003
BMC Infectious Diseases, 2012
Background: Recent evidence indicates that Gram-negative bacterial pathogens, the most common of ... more Background: Recent evidence indicates that Gram-negative bacterial pathogens, the most common of which are Pseudomonas spp., Enterobacteriaceae, and Acinetobacter baumannii, are frequent causes of hospital-acquired infections. This study aims to evaluate the in vitro activity of doripenem and comparator carbapenem antibiotics against Gram-negative clinical isolates collected from COMParative Activity of Carbapenem Testing (COMPACT) study centres in Turkey. Methods: Ten centres in Turkey were invited to submit Pseudomonas aeruginosa, Enterobacteriaceae, and other Gram-negative isolates from intensive care unit (ICU)/non-ICU patients with complicated intra-abdominal infections, bloodstream infections, or nosocomial pneumonia, including ventilator-associated pneumonia, between May and October 2008. Susceptibility was determined by each centre using E-test. A central laboratory performed species confirmation as well as limited susceptibility and quality-control testing. Results: Five hundred and ninety six isolates were collected. MIC 90 values for doripenem, meropenem, and imipenem, respectively, were 32, ≥ 64, and ≥ 64 mg/L against Pseudomonas spp.; 0.12, 0.12, and 0.5 mg/L against Enterobacteriaceae; and ≥ 64 mg/L for each against other Gram-negative isolates. In determining the susceptibility of hospital isolates of selected Gram-negative pathogens to doripenem, imipenem, and meropenem, we found that against all pathogens combined, the MIC 90 for ICU compared with non-ICU isolates was higher. Conclusions: Doripenem showed similar or slightly better activity than meropenem and better activity than imipenem against the Gram-negative pathogens collected in Turkey.
American Journal of Respiratory and Critical Care Medicine, 1999
* Values are presented as mean (SD). † Severity of symptoms was based on patients' perception. * ... more * Values are presented as mean (SD). † Severity of symptoms was based on patients' perception. * Three patients showed serologic indication of recent Mycoplasma pneumoniae infection.
The Journal of Infection in Developing Countries, 2019
Introduction: Studies indicate that adherence to hand hygiene guidelines is at suboptimal levels.... more Introduction: Studies indicate that adherence to hand hygiene guidelines is at suboptimal levels. We aimed to explore the reasons for poor hand hygiene compliance. Methodology: A qualitative study based on the Theory of Planned Behavior as a framework in explaining compliance, consisting four focus group discussions and six in-depth interviews. Results: Participants mostly practiced hand hygiene depending on the sense of "dirtiness" and "cleanliness". Some of the participants indicated that on-job training delivered by the infection control team changed their perception of "emotionally" based hand hygiene to "indication" based. Direct observations and individual feedback on one-to-one basis were the core of this training. There was low social cohesiveness and a deep polarization between the professional groups that led one group accusing the other for not being compliant. Conclusions: The infection control team should continue delivering one-t...
Open Forum Infectious Diseases, 2014
The reduction of amphotericin B (AmB)-induced renal tubular apoptosis and nephrotoxicity by N-ace... more The reduction of amphotericin B (AmB)-induced renal tubular apoptosis and nephrotoxicity by N-acetylcysteine (NAC) in a murine model was evaluated. Four groups of rats were treated with AmB for 5 days, and each group concomitantly received two doses of 30, 60, or 120 mg of NAC/kg of body weight/day or sterile water for 5 days. Groups that received concomitant NAC at any dose had significantly decreased levels of apoptosis compared to that in animals receiving AmB only (48.8% versus 27.4, 23.6, or 23.5%, respectively; P < 0.001).
Mikrobiyoloji bulteni, 1988
Drug resistance patterns of shigella strains were investigated in a prospective manner in Etimesg... more Drug resistance patterns of shigella strains were investigated in a prospective manner in Etimesgut district during a period of 1 year. Thirty strains shigella were isolated, belonged to three subgroups with preponderance of Sh. flexneri (70%), followed by Sh. sonnei (27%) and Sh. boydii (3%). The resistance was highest with streptomycin (80%), followed by trimethoprim-sulfamethoxazole (TMP-SMZ) (53%) and ampicillin (43%). Only three strains (10%) were sensitive to all eight antibiotics tested. Sixteen (53%) were resistant to three or more antibiotics. The data showed an increase in resistance to the commonly used antimicrobial agents--namely IMP-SMZ and ampicillin. IMP-SMZ is no longer the drug of choice in severe shigellosis, at least in this region of Turkey.
Mikrobiyoloji bulteni, 1990
In this article, a case of group B streptococcal endocarditis in a diabetic patient, taking immun... more In this article, a case of group B streptococcal endocarditis in a diabetic patient, taking immunosuppressive therapy because of dermatomyositis is reported.
Clinical Microbiology and Infection, 2002
Journal of Pharmacology and Pharmacotherapeutics, 2012
Gokengin, Ayse/0000-0003-0704-2302;WOS: 000494690300226[No abstract available
Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 1996
As a result of the extensive use of new generation cephalosporins, an increase in the frequency o... more As a result of the extensive use of new generation cephalosporins, an increase in the frequency of gram negative bacteria in nosocomial infections is observed in recent years. Awareness of the rate of resistance to these agents is a requirement in order to install apropriate control measured. A study was undertaken with the participation of nine hospitals in Turkey to determine the frequency of gram negative bacteria isolated in the ICU's and compare the resistance rates to selected antibiotics. 981 bacteria were collected and antibiotic susceptibilities were determined by E-test. Pseudomonas spp. was the most prevalent organism (30%) followed by Klebsiella spp. (25%) and E. coli (18%). Imipenem, amikacin and ciprofloxacin were the most active agents in vitro with slight variations according to each center. The high rate of resistance to the new generation cephalosporins suggested the Class I and extended-broad-spectrum ß-lactamases.
Journal of Medical Microbiology, 2001
ABSTRACT
Tubercle and Lung Disease, 1993
International Journal of Antimicrobial Agents, 2007
Resistance surveillance-general S517 aureus was 18.8% and the resistance of the species to erythr... more Resistance surveillance-general S517 aureus was 18.8% and the resistance of the species to erythromycin, clindamicin, gentamicin and ciprofloxacin was higher than 20%. Among the Gram-negative bacteria: the prevalence of ESBL-producing E. coli was 14.1% and among K. pneumoniae was 28.8%. Ceftazidime-resistant P. aeruginosa reached 32.9% and the resistance to ciprofloxacin among the species was similar-31.5%. Resistance to imipenem among A. baumannii was 16%. Conclusion: The aetiological structure of bloodstream infections is similar to those in most European countries and also with that in the previous years in Bulgaria. Remarkable is the stable presence of P. aeruginosa and A. baumannii among the leading pathogens causing sepsis in the country. There is a decrease in the proportion of S. aureus and E. faecalis and an increase in the proportion of Candida spp. compared with 2004. Main therapeutical problems are ESBL-positive K. pneumoniae and multiresistant P. aeruginosa and A. baumannii.
European Journal of Epidemiology, 1996
Infection with Clostridium difficile can present with various clinical pictures ranging from an a... more Infection with Clostridium difficile can present with various clinical pictures ranging from an asymptomatic carrier state to pseudomembranous colitis and plays an important part in the etiology of nosocomial diarrhoea. To identify risk factors for C. difficile colonization and diarrhoea in hospitalized subjects, patients admitted to a general medicine ward at Marmara University hospital during a one year period were entered into the study. Of the 202 patients, nosocomial diarrhoea developed in 45 (22.3%). Fourteen patients (6.9%) were colonized with C. difficile during their hospitalization period. Ten of the colonized patients (71.4%) developed diarrhoea and were found to be positive by toxin assay. Pseudomembranous colitis was confirmed endoscopically in 3 of the patients with diarrhoea. Administration of beta lactam agents such as ampicillin and cephalosporins; gastrointestinal manipulations and admission to the intensive care unit were found as major risk factors for C. diffi'cile colonization.
Clinical Infectious Diseases, 2003
BMC Infectious Diseases, 2012
Background: Recent evidence indicates that Gram-negative bacterial pathogens, the most common of ... more Background: Recent evidence indicates that Gram-negative bacterial pathogens, the most common of which are Pseudomonas spp., Enterobacteriaceae, and Acinetobacter baumannii, are frequent causes of hospital-acquired infections. This study aims to evaluate the in vitro activity of doripenem and comparator carbapenem antibiotics against Gram-negative clinical isolates collected from COMParative Activity of Carbapenem Testing (COMPACT) study centres in Turkey. Methods: Ten centres in Turkey were invited to submit Pseudomonas aeruginosa, Enterobacteriaceae, and other Gram-negative isolates from intensive care unit (ICU)/non-ICU patients with complicated intra-abdominal infections, bloodstream infections, or nosocomial pneumonia, including ventilator-associated pneumonia, between May and October 2008. Susceptibility was determined by each centre using E-test. A central laboratory performed species confirmation as well as limited susceptibility and quality-control testing. Results: Five hundred and ninety six isolates were collected. MIC 90 values for doripenem, meropenem, and imipenem, respectively, were 32, ≥ 64, and ≥ 64 mg/L against Pseudomonas spp.; 0.12, 0.12, and 0.5 mg/L against Enterobacteriaceae; and ≥ 64 mg/L for each against other Gram-negative isolates. In determining the susceptibility of hospital isolates of selected Gram-negative pathogens to doripenem, imipenem, and meropenem, we found that against all pathogens combined, the MIC 90 for ICU compared with non-ICU isolates was higher. Conclusions: Doripenem showed similar or slightly better activity than meropenem and better activity than imipenem against the Gram-negative pathogens collected in Turkey.
American Journal of Respiratory and Critical Care Medicine, 1999
* Values are presented as mean (SD). † Severity of symptoms was based on patients' perception. * ... more * Values are presented as mean (SD). † Severity of symptoms was based on patients' perception. * Three patients showed serologic indication of recent Mycoplasma pneumoniae infection.
The Journal of Infection in Developing Countries, 2019
Introduction: Studies indicate that adherence to hand hygiene guidelines is at suboptimal levels.... more Introduction: Studies indicate that adherence to hand hygiene guidelines is at suboptimal levels. We aimed to explore the reasons for poor hand hygiene compliance. Methodology: A qualitative study based on the Theory of Planned Behavior as a framework in explaining compliance, consisting four focus group discussions and six in-depth interviews. Results: Participants mostly practiced hand hygiene depending on the sense of "dirtiness" and "cleanliness". Some of the participants indicated that on-job training delivered by the infection control team changed their perception of "emotionally" based hand hygiene to "indication" based. Direct observations and individual feedback on one-to-one basis were the core of this training. There was low social cohesiveness and a deep polarization between the professional groups that led one group accusing the other for not being compliant. Conclusions: The infection control team should continue delivering one-t...
Open Forum Infectious Diseases, 2014
The reduction of amphotericin B (AmB)-induced renal tubular apoptosis and nephrotoxicity by N-ace... more The reduction of amphotericin B (AmB)-induced renal tubular apoptosis and nephrotoxicity by N-acetylcysteine (NAC) in a murine model was evaluated. Four groups of rats were treated with AmB for 5 days, and each group concomitantly received two doses of 30, 60, or 120 mg of NAC/kg of body weight/day or sterile water for 5 days. Groups that received concomitant NAC at any dose had significantly decreased levels of apoptosis compared to that in animals receiving AmB only (48.8% versus 27.4, 23.6, or 23.5%, respectively; P < 0.001).
Mikrobiyoloji bulteni, 1988
Drug resistance patterns of shigella strains were investigated in a prospective manner in Etimesg... more Drug resistance patterns of shigella strains were investigated in a prospective manner in Etimesgut district during a period of 1 year. Thirty strains shigella were isolated, belonged to three subgroups with preponderance of Sh. flexneri (70%), followed by Sh. sonnei (27%) and Sh. boydii (3%). The resistance was highest with streptomycin (80%), followed by trimethoprim-sulfamethoxazole (TMP-SMZ) (53%) and ampicillin (43%). Only three strains (10%) were sensitive to all eight antibiotics tested. Sixteen (53%) were resistant to three or more antibiotics. The data showed an increase in resistance to the commonly used antimicrobial agents--namely IMP-SMZ and ampicillin. IMP-SMZ is no longer the drug of choice in severe shigellosis, at least in this region of Turkey.
Mikrobiyoloji bulteni, 1990
In this article, a case of group B streptococcal endocarditis in a diabetic patient, taking immun... more In this article, a case of group B streptococcal endocarditis in a diabetic patient, taking immunosuppressive therapy because of dermatomyositis is reported.