Vladimir Nesic - Academia.edu (original) (raw)
Papers by Vladimir Nesic
PubMed, 1996
We analysed 27 patients (15 women and 12 men) on CAPD treatment, between 6 months and 7 years at ... more We analysed 27 patients (15 women and 12 men) on CAPD treatment, between 6 months and 7 years at the Clinic of Nephrology, Clinical Center of Serbia, in Belgrade. Patients were between 22 and 72 years old. The main causes of pulmonary abnormalities were infections (5), hypervolaemia, hypoproteinaemia and heart failure (13). We had 11 patients (40.74%) with 18 pulmonary abnormalities: bronchopneumonia (2 pts), pleuritis sicca (1 pt), pleural effusion (10 pts): unilateral (4) and bilateral (7). Three patients had recurrent pulmonary infections and pulmonary abnormalities. All patients recovered and continued treatment with CAPD.
PubMed, 1996
In hundred patients with different stages of renal functional damage, including the controls of h... more In hundred patients with different stages of renal functional damage, including the controls of healthy persons we examined the disturbances of phosphate, calcium and magnesium ion metabolism during chronic renal failure (CRF) progression. We also determined the serum levels of regulatory substances, parathormone and 1.25 dihydroxyvitamin D3 in 43 pts. grouped according to their group, sex, age average and season (autumn-winter) distribution. We established actual renal compensatory mechanisms for all of substances we determined, which were involved in homeostasis preservation of those substances. Some characteristic changes in plasma substance concentration and renal mechanisms of their regulation during CRF progression, suggest the following conclusions. No substances have preserved body homeostasis, although renal compensatory mechanism were expressed by different size for any of them. Those disturbances very tightly correlate with the stage of renal functional deterioration, as well as the serum parathormone rising and serum 1.25 DHHC decreasing.
Srpski Arhiv Za Celokupno Lekarstvo, 2009
Iako se oèu va na re zi du al na funk ci ja bu bre ga (RFB) vr lo èe sto po i sto ve aeu je sa ve... more Iako se oèu va na re zi du al na funk ci ja bu bre ga (RFB) vr lo èe sto po i sto ve aeu je sa ve li èi nom di u re ze i sa mim tim sa kon tro lom vo lu me na, sam po jam RFB je mno go ši ri i pod ra zu me va u raz li èi tom ste penu oèu va ne broj ne fi zi o lo ške funk ci je ko je bubreg oba vqa. Oèu va na RFB je po ve za na ne sa mo sa bo qom re gu la ci jom vo lu me na i krv nog pri ti ska, veae i sa bo qom me ta bo liè kom kon tro lom, što se ogle da u sma we noj sklo no sti ka hi per fos fa te miji, hi per ka li je mi ji i hi pe ru ri ke mi ji [1, 2]. U nekim ra do vi ma je po ka za no da bo le sni ci na he modi ja li zi s oèu va nom RFB ima ju ve aee ni voe he moglo bi na ne go bo le sni ci na he mo di ja li zi ko ji su anu riè ni, što je po sle di ca da qeg stva ra wa eritro po e ti na u bu bre gu ko ji još ima iz ve stan stepen funk ci je. RFB igra zna èaj nu ulo gu i u oèu vawu nu tri ci o nog sta tu sa, što se ogle da u po ve aeanom ape ti tu i uno su mi kro nu tri je na ta [3]. Jed no od naj zna èaj ni jih is tra ži va wa ob ja vi li su Še min (She min) i sa rad ni ci [4], ko ji su po kaza li da je za stu pqe nost RFB kod bo le sni ka na hemo di ja li zi, èak i u vr lo ma lom ste pe nu, po ve za na sa ma wim mor ta li te tom. Uzi ma ju aei u ob zir po veza nost oèu va no sti RFB sa bo qim me ta bo liè kim pro fi lom, kon tro lom vo lu me na i krv nog pri tiska, kao i sa po boq ša nom nu tri ci jom, ni je te ško pret po sta vi ti da je oèu va nost RFB po ve za na i sa bo qim pre ži vqa va wem bo le sni ka.
Srpski Arhiv Za Celokupno Lekarstvo, 2004
Veterinarski glasnik, 2006
U radu je prikazan slu~aj iznenadnog uginu}a ma~ke kao posledica infekcije uzrokovane parazitom D... more U radu je prikazan slu~aj iznenadnog uginu}a ma~ke kao posledica infekcije uzrokovane parazitom Dirofilaria immitis. Dirofilarioza ma~aka se kod nas retko nalazi, a frekvencija pojavljivanja u svetu je od 0,8 posto do 23 posto. Kao posledica parazitiranja odraslih oblika, usled o{te}enja endotela plu}ne arterije i njenih grana nastaje razvoj endoarteritisa sa posledi~nom tromboembolijom ili fibrozom plu}a ĩ estim iznenadnim uginu}em. Patoanatomskim pregledom u desnoj sr~anoj komori i plu}noj arteriji uo~eno je pet odraslih oblika valjkastih parazita koji prema svom mestu parazitiranja i morfolo{kom izgledu odgovaraju nalazu Dirofilaria immitis. Patohistolo{kim pregledom ise~aka tkiva plu}a ustanovljen je intenzivni edem plu}a koji se javio kao posledica parazitiranja odraslih oblika Dirofilaria immitis u desnoj sr~anoj komori, plu}noj arteriji i njenim ograncima. Na ovaj na~in potvr|eno je da je iznenadno uginu}e nastupilo kao posledica o{te}enja izazvanih parazitom Dirofilaria immitis. Klju~ne re~i: ma~ka, Dirofilaria immitis, iznenadno uginu}e, patomorfolo{ki pregled Na Dirofilaria immitis kod ma~aka se kod nas retko nailazi, a frekvencija pojavljivanja u svetu prema podacima iz literature varira u odnosu na geografski region, na~in`ivota ma~aka (ku}ne ili uli~ne) i autore koji su ispitivali rasprostranjenost i kre}e se od 0,8 posto Š8¹, 0,5-9,5 posto Š12, 4, 11¹, pa~ak do 23 posto kod ma~aka u Italiji Š4, 7¹. U desnoj sr~anoj komori razvija se naj~e{}e manje od {est adultnih oblika parazita, za razliku od pasa kod kojih ovaj broj mo`e 255 PRIKAZ SLU^AJA-REVIEW CASE Uvod / Introduction
Journal of Laryngology and Otology, Nov 1, 2016
Objective:This study aimed to compare two sampling methods for nasal nitric oxide in healthy indi... more Objective:This study aimed to compare two sampling methods for nasal nitric oxide in healthy individuals and allergic rhinitis patients, and to examine the within-subject reliability of nasal nitric oxide measurement.Methods:The study included 23 allergic rhinitis patients without concomitant asthma and 10 healthy individuals. For all participants, nitric oxide levels were measured non-invasively from the lungs through the mouth (i.e. the oral fractional exhaled nitric oxide) and the nose. Nasal nitric oxide was measured by two different methods: (1) nasal aspiration via one nostril during breath holding and (2) single-breath quiet exhalation against resistance through a tight facemask (i.e. the nasal fractional exhaled nitric oxide).Results:Compared with healthy participants, allergic rhinitis patients had significantly higher average oral and nasal nitric oxide levels. All methods of nitric oxide measurement had excellent reliability.Conclusion:Nasal nitric oxide measurement is a useful and reliable clinical tool for diagnosing allergic rhinitis in patients without asthma in an out-patient setting.
Journal of Comparative Pathology, May 1, 2023
Glasnik Antropološkog Društva Srbije, 2010
Veterinarski glasnik, 2020
Congenital spine deformation caused by vertebral malformation is reported in different brachyceph... more Congenital spine deformation caused by vertebral malformation is reported in different brachycephalic dog breeds, but also in other large dog breeds. The most severe clinical signs are due to spinal cord compression. Depending on localisation of the lesion, clinical signs can manifest differently. A five-month-old pug was brought for autopsy to the
PubMed, Jan 19, 2002
The introduction of peritoneal dialysis (PD) as a respectable modality of renal replacement thera... more The introduction of peritoneal dialysis (PD) as a respectable modality of renal replacement therapy some three decades ago, suddenly drew attention of many authors to peritoneal membrane as insufficiently investigated structure. In order to explain the pathological changes in peritoneum due to renal diseases, it became necessary to explore the normal peritoneal structure. The aim of this study was to examine the morphology of peritoneal lining cells in healthy persons. Biopsies of the peritoneum were performed on 20 volunteer kidney donors. Tissue samples were taken during renal transplantation. Special care was taken in getting appropriate samples without artificial damage because of the extreme fragility of the peritoneal tissue. The preparing procedure was standard for routine HE staining and for plastic embedded semifine and fine sections studies. Semifine sections were made on ultramicrotome, stained with Toluidin blue and studied by light microscope, while fine sections were made by ultramicrotome and studied by transmission electron microscope. One layer of cuboidal or flattened lining cells present over the lamina propria connective tissue presented mesothelium. The cells were overlapped like tiles on the roof. Lateral parts of their interdigitated membranes were interconnected with different types of cell junctions: unpermeable, adhesion and communication junctions; inhibiting intercellular transport. Cell surface was often covered with great number of microvilli and lamellar bodies. A single kinocilia was also often present on apical cell surface. Nuclei were euchromatic with well developed nucleoli. Cytoplasm was filled with a great number of ribosomes, mitochondria, cisterns of rough endoplasmatic reticulum and Golgi apparatus, lamellar bodies and lipid inclusions. Numerous pinocytic vesicles on all parts of the membrane as well as in the cytoplasm indicating active endocytosis, egsocytosis and transcytosys in the process of secretion and reabsorption of serous liquid in peritoneal cavity, were visible. Euchromatic nuclei with prominent nucleoli and numerous mitochondria indicate cells of great metabolic activity.
Acta Veterinaria-beograd, Jun 1, 2021
Nowadays, illegal traffi cking and smuggling of animals are among the greatest threats to many av... more Nowadays, illegal traffi cking and smuggling of animals are among the greatest threats to many avian species. Most commonly smuggled birds belong to parrots, song birds, raptor species and owls. All of these species are protected by national and international legislations. In order to prevent and reduce wildlife traffi cking, DNA methods have become an important forensic tool in species and sex identifi cation. In this study, CHD1R/CHD1F primer pair was used to amplify a part of the CHD1 gene from 65 birds that belong to 43 species. For 36 species this is the fi rst time that the length of CHD1 amplicons was measured for the purpose of species determination. The results were visualized using capillary electrophoresis and enabled simultaneous determination of sex and species. Based on the number of amplicons (two in females, one in males) sex was successfully determined in all species, even in cases where gel electrophoresis failed to give results. Moreover, the species was successfully determined in most bird species based on the species-specifi c sizes of CHD1 amplicon. The method used in this study is of great importance for veterinary forensic medicine and the prevention of wildlife smuggling. Still, further work is necessary to confi rm the effectiveness of the method in all bird species.
Acta Facultatis Medicae Naissensis, Mar 1, 2013
Significant differences in speech between genders are contained in nonsegmental correlates, i.e. ... more Significant differences in speech between genders are contained in nonsegmental correlates, i.e. in the prosody and paralinguistics. Pronunciation differences between genders are more numerous than those in grammatical form. This study aims to detect temporal prosodic patterns and investigate gender differences in performing serial sevens subtraction (SSS). One hundred students of medicine (equal number of males and females) voluntarily participated in the investigation. SSS was performed by asking the participant to perform mental arithmetic consisting of repeatedly subtractions of sevens, beginning from one thousand. The students had to pronounce aloud and simultaneously write the results for five minutes. The original program for the analysis of digital signals (ADS) converted the speech signal samples into digital data. MANOVA showed significant gender differences for a group of characteristics of the SSS test: F (11, 75)=4.06, p=0.000. The number of samples per each minute and the total number of samples during five minutes was higher in males compared to females. The average length of articulation of three-digit numbers, average length of articulation and length of pauses between the linguistic units, as well as between the samples, was shorter in males for each of these five minutes and for the "average" minute. The maximum intensity of speech was higher in males for each of the five minutes. Average duration of mispronunciations, with end results being correct, was longer in women in the first, second, and fourth minute, as well as for the "average" minute. A conclusion may be drawn that shorter utterances and pauses in men suggest the advantage on the part of men in SSS task, and not greater verbal fluency in general in men.
Clinical Neurophysiology, Jul 1, 2012
(3 female and 15 male), mean age 5 years, diagnosed by DSM-IV and CARS. Subjects observed black s... more (3 female and 15 male), mean age 5 years, diagnosed by DSM-IV and CARS. Subjects observed black square (resting period), simple picture representing movement of a hand and feet, and real hand movement. Ten-second artefacts free periods were analysed offline using spectral analysis (FFT algorithm). Results: We found increasement in C3, F3, P3 region during hand movement observation when compared to resting period. No differences were found between period of picture observation and resting period. Conclusions: Children with autism showed increasement in alpha band power during movement observation, which can be one of main dysfunctions in mirror neuron system.
Clinical Neurophysiology, Jul 1, 2012
hypotony as well as secondary esophageal motility disorders such as secondary achalasia, motility... more hypotony as well as secondary esophageal motility disorders such as secondary achalasia, motility disorders in Parkinson’s disease and scleroderma. Similarly, anorectal manometry is a diagnostic procedure used in patients with anal incontinence and terminal constipation. In patients with anal incontinence we measure resting pressure of internal anal sphincter (IAS), squeezing pressure of external anal sphincter (EAS) and rectal sensibility. In patients with functional terminal constipation we determine recto-anal inhibitory reflex, rectoanal excitatory reflex, rectal sensibility and pressure changes at a level of IAS and EAS during an effort to push out an intrarectal balloon inflated with a 50 ml of air. Our experience with 338 patients with esophageal and anorectal motility disorders confirms that both methods provide a reliable diagnostic procedure in establishing a definitive diagnosis.
Clinical Neurophysiology, Sep 1, 2015
The study included 32 patients with TLE with mean age 43.47 ± 10.74 years. Most patients (59.4%) ... more The study included 32 patients with TLE with mean age 43.47 ± 10.74 years. Most patients (59.4%) were treated with two AEDs, 18.8% were on monotherapy, three AEDs were taking in 15.6% of patients, while two patients (6.25%) taking four AEDs. Most frequently used AEDs were valproate (50.00%) and lamotrigine (46.87%). Other AEDs were topiramate, carbamazepine, phenobarbital, levetiracetam, and clonazepam. We have found statistically significant correlation between the number of AEDs and number of perseverative response on the WCST. As the number of AEDs increased to the achievement of the measurements of executive function deteriorates. With the increasing number of AEDs in the treatment of patients with TLE increases the risk of developing disorder of executive function in these patients.
Veterinarski glasnik, 2016
Dirofilarioza pasa je parazitsko oboljenje izazvano vrstama Dirofilaria immitis i D. repens. D. i... more Dirofilarioza pasa je parazitsko oboljenje izazvano vrstama Dirofilaria immitis i D. repens. D. immitis parazitira u desnoj strani srca i plućnoj arteriji, dovodeći do značajnog funkcionalnog oštećenja srca, dok adultni oblici D. repens uglavnom parazitiraju u subkutanom tkivu dovodeći do manjih oštećenja kože. U ovom istraživanju ispitano je 60 pasa, različitih rasa, sa teritorije grada Beograda, u periodu od maja do novembra 2015. godine. Nakon kliničkog pregleda, krv je uzorkovana za detekciju mikrofilarija modifikovanim Knott-ovim testom, kao i za molekularnu detekciju uzročnika. Glavni klinički znaci su bili: brzo zamaranje tokom treninga, otežano disanje i suv kašalj, anoreksija, ubrzan rad srca i promene na koži. Mikrofilarije su detektovane kod 22 psa (37%) modifikovanim Knott-ovim testom. Molekularno genetskom metodom utvrđena je prevalencija D.immitis 42%, a D. repens 22 %. U sprovedenom istraživanju je bilo 7 pasa koji su bili negativni na Knott testu, dok su metodom PCR pokazali pozitivnu reakciju na prisustvo vrsta iz roda Dirofilaria. Na osnovu dobijenih rezultata primena molekularno-genetskih metoda potvrđuje svoju opravdanost u preciznoj i pouzdanoj specijskoj identifikaciji roda Dirofilaria.
svojim roditeljima koji su me naučili pravim životnim vrednostima, svakodnevno bodrili i imali ... more svojim roditeljima koji su me naučili pravim životnim vrednostima, svakodnevno bodrili i imali presudan uticaj u izradi ove teze mentoru, prof. dr Željku Petroviću, na podršci i pomoći tokom izrade doktorske disertacije komentoru, prof. dr Sandri Šipetić-Grujičić, na korisnim savetima tokom izrade ovoga rada kolegama i ostalim zaposlenim u Klinici za Otorinolaringologiju i maksilofacijalnu hirurgiju Kliničkog centra Srbije _________________________________________________________________________ V ZNAČAJ KOMORBIDITETA ZA PREŽIVLJAVANJE BOLESNIKA S PLANOCELULARNIM KARCINOMOM LARINKSA REZIME Uvod: Komorbiditeti su bolesti ili stanja koja postoje pored glavnog oboljenja. Komorbidne bolesti mogu da utiču na izbor lečenja, kao i na stopu preživljavanja. Instrumenti za procenu komorbiditeta mogu biti: opšti-mere stepen komorbiditeta kod različitih oboljenja npr. Čarlsonov indeks komorbiditeta (Charlson Comorbidity Index ili CCI) i specifični-mere stepen komorbiditeta kod određenog oboljenja npr. Procena komorbiditeta kod odraslih-27 indeks (Adult Comorbidity Evaluation-27 index ili ACE-27 index). Ciljevi rada su: Ispitati značaj komorbiditeta za preživljavanje bolesnika s planocelularnim karcinomom larinksa pomoću CCI i ACE-27 indeksa; Odrediti da li postoji razlika u učestalosti javljanja komorbiditeta i u dužini preživljavanja između bolesnika s planocelularnim karcinomom supraglotisa u odnosu na bolesnike s karcinomom glotisa; Ispitati značaj opšteg (CCI) i specifičnog (ACE-27) indeksa u proceni preživljavanja bolesnika s planocelularnim karcinomom larinksa. Materijal i metode: U studiju je uključeno 177 novoobolelih od planocelularnog karcinoma larinksa (T 1-T 4) koji su lečeni hirurški ili hirurški u kombinaciji s postoperacionom radioterapijom u Klinici za otorinolaringologiju i maksilofacijalnu hirurgiju Kliničkog centra Srbije u periodu od 1.1.2000. do 31.12.2003. godine. Podaci o bolesnicima su prikupljeni iz istorija bolesti, patohistoloških izveštaja i registra za maligna oboljenja. U statističkoj analizi podataka korišćena je krivulja preživljavanja prema Kaplanu i Mejeru (Meier), log-rank test, Koksov (Cox) proporcionalni hazardni model, Man-Vitnijev (Mann-Whitney) test i Kruskal-Volisov (Kruskal-Wallis) test. Rezultati: Prema CCI, 40,1% (71) bolesnika s planocelularnim karcinomom larinksa je imalo komorbidne bolesti od kojih su najčešće bile kardiovaskularne (40,3%), respiratorne (27,8%) i gastrointestinalne (14,4%). Međutim, prema ACE-27 indeksu, 66,7% (118) bolesnika s planocelularnim karcinomom je imalo komorbidne bolesti a _________________________________________________________________________ VI najčešće su bile kardiovaskularne (53,1%), respiratorne (15,6%) i gastrointestinalne (8,8%). Skoro svaki četvrti oboleli je imao dve ili više komorbidnih bolesti prema CCI, kao i prema ACE-27 indeksu. Težak stepen komorbiditeta je bio zastupljen kod 5,6% bolesnika s planocelularnim karcinom larinksa prema CCI i kod 9,6% prema ACE-27 indeksu. Bolesnici s karcinomom supraglotisa su imali značajno veći (p < 0,01) stepen težine komorbiditeta u odnosu na bolesnike s karcinomom glotisa. Bolesnici s karcinomom glotisa imali su značajno višu (p < 0,05) stopu petogodišnjeg ukupnog preživljavanja u odnosu na bolesnike s karcinomom supraglotisa. Bolesnici bez komorbiditeta i s blagim komorbiditetom, u odnosu na ACE-27 indeks, imali su statistički značajno bolje (p < 0,01) petogodišnje ukupno i specifično preživljavanje za bolest u odnosu na bolesnike s umerenim i teškim komorbiditetom. Prema univarijantnoj analizi, komorbiditet je imao uticaj na prognozu maligne bolesti, bez obzira koji indeks je primenjen. Prema rezultatima multivarijantne analize, značajni nezavisni prognostički faktori petogodišnjeg ukupnog i specifičnog preživljavanja za planocelularni karcinom larinksa su bili tumor-nodusmetastaza (TNM) stadijum i komorbiditet stepenovan prema ACE-27 indeksu. Zaključak: Naša studija je pokazala da su komorbiditet stepenovan pomoću ACE-27 indeksa i TNM stadijum značajni prognostički faktori za petogodišnje ukupno i specifično preživljavanje kod bolesnika s planocelularnim karcinomom larinksa. Buduće prospektivne studije trebalo bi da uključe komorbiditet kao faktor prognoze za preživljavanje bolesnika s planocelularnim karcinomom larinksa, a kao instrument izbora u cilju merenja komorbiditeta predlaže se primena ACE-27 indeksa. Štaviše, predlažemo primenu TNM-komorbiditet indeksa za petogodišnje ukupno i specifično preživljavanje kod bolesnika s planocelularnim karcinomom larinksa.
PubMed, 1996
We analysed 27 patients (15 women and 12 men) on CAPD treatment, between 6 months and 7 years at ... more We analysed 27 patients (15 women and 12 men) on CAPD treatment, between 6 months and 7 years at the Clinic of Nephrology, Clinical Center of Serbia, in Belgrade. Patients were between 22 and 72 years old. The main causes of pulmonary abnormalities were infections (5), hypervolaemia, hypoproteinaemia and heart failure (13). We had 11 patients (40.74%) with 18 pulmonary abnormalities: bronchopneumonia (2 pts), pleuritis sicca (1 pt), pleural effusion (10 pts): unilateral (4) and bilateral (7). Three patients had recurrent pulmonary infections and pulmonary abnormalities. All patients recovered and continued treatment with CAPD.
PubMed, 1996
In hundred patients with different stages of renal functional damage, including the controls of h... more In hundred patients with different stages of renal functional damage, including the controls of healthy persons we examined the disturbances of phosphate, calcium and magnesium ion metabolism during chronic renal failure (CRF) progression. We also determined the serum levels of regulatory substances, parathormone and 1.25 dihydroxyvitamin D3 in 43 pts. grouped according to their group, sex, age average and season (autumn-winter) distribution. We established actual renal compensatory mechanisms for all of substances we determined, which were involved in homeostasis preservation of those substances. Some characteristic changes in plasma substance concentration and renal mechanisms of their regulation during CRF progression, suggest the following conclusions. No substances have preserved body homeostasis, although renal compensatory mechanism were expressed by different size for any of them. Those disturbances very tightly correlate with the stage of renal functional deterioration, as well as the serum parathormone rising and serum 1.25 DHHC decreasing.
Srpski Arhiv Za Celokupno Lekarstvo, 2009
Iako se oèu va na re zi du al na funk ci ja bu bre ga (RFB) vr lo èe sto po i sto ve aeu je sa ve... more Iako se oèu va na re zi du al na funk ci ja bu bre ga (RFB) vr lo èe sto po i sto ve aeu je sa ve li èi nom di u re ze i sa mim tim sa kon tro lom vo lu me na, sam po jam RFB je mno go ši ri i pod ra zu me va u raz li èi tom ste penu oèu va ne broj ne fi zi o lo ške funk ci je ko je bubreg oba vqa. Oèu va na RFB je po ve za na ne sa mo sa bo qom re gu la ci jom vo lu me na i krv nog pri ti ska, veae i sa bo qom me ta bo liè kom kon tro lom, što se ogle da u sma we noj sklo no sti ka hi per fos fa te miji, hi per ka li je mi ji i hi pe ru ri ke mi ji [1, 2]. U nekim ra do vi ma je po ka za no da bo le sni ci na he modi ja li zi s oèu va nom RFB ima ju ve aee ni voe he moglo bi na ne go bo le sni ci na he mo di ja li zi ko ji su anu riè ni, što je po sle di ca da qeg stva ra wa eritro po e ti na u bu bre gu ko ji još ima iz ve stan stepen funk ci je. RFB igra zna èaj nu ulo gu i u oèu vawu nu tri ci o nog sta tu sa, što se ogle da u po ve aeanom ape ti tu i uno su mi kro nu tri je na ta [3]. Jed no od naj zna èaj ni jih is tra ži va wa ob ja vi li su Še min (She min) i sa rad ni ci [4], ko ji su po kaza li da je za stu pqe nost RFB kod bo le sni ka na hemo di ja li zi, èak i u vr lo ma lom ste pe nu, po ve za na sa ma wim mor ta li te tom. Uzi ma ju aei u ob zir po veza nost oèu va no sti RFB sa bo qim me ta bo liè kim pro fi lom, kon tro lom vo lu me na i krv nog pri tiska, kao i sa po boq ša nom nu tri ci jom, ni je te ško pret po sta vi ti da je oèu va nost RFB po ve za na i sa bo qim pre ži vqa va wem bo le sni ka.
Srpski Arhiv Za Celokupno Lekarstvo, 2004
Veterinarski glasnik, 2006
U radu je prikazan slu~aj iznenadnog uginu}a ma~ke kao posledica infekcije uzrokovane parazitom D... more U radu je prikazan slu~aj iznenadnog uginu}a ma~ke kao posledica infekcije uzrokovane parazitom Dirofilaria immitis. Dirofilarioza ma~aka se kod nas retko nalazi, a frekvencija pojavljivanja u svetu je od 0,8 posto do 23 posto. Kao posledica parazitiranja odraslih oblika, usled o{te}enja endotela plu}ne arterije i njenih grana nastaje razvoj endoarteritisa sa posledi~nom tromboembolijom ili fibrozom plu}a ĩ estim iznenadnim uginu}em. Patoanatomskim pregledom u desnoj sr~anoj komori i plu}noj arteriji uo~eno je pet odraslih oblika valjkastih parazita koji prema svom mestu parazitiranja i morfolo{kom izgledu odgovaraju nalazu Dirofilaria immitis. Patohistolo{kim pregledom ise~aka tkiva plu}a ustanovljen je intenzivni edem plu}a koji se javio kao posledica parazitiranja odraslih oblika Dirofilaria immitis u desnoj sr~anoj komori, plu}noj arteriji i njenim ograncima. Na ovaj na~in potvr|eno je da je iznenadno uginu}e nastupilo kao posledica o{te}enja izazvanih parazitom Dirofilaria immitis. Klju~ne re~i: ma~ka, Dirofilaria immitis, iznenadno uginu}e, patomorfolo{ki pregled Na Dirofilaria immitis kod ma~aka se kod nas retko nailazi, a frekvencija pojavljivanja u svetu prema podacima iz literature varira u odnosu na geografski region, na~in`ivota ma~aka (ku}ne ili uli~ne) i autore koji su ispitivali rasprostranjenost i kre}e se od 0,8 posto Š8¹, 0,5-9,5 posto Š12, 4, 11¹, pa~ak do 23 posto kod ma~aka u Italiji Š4, 7¹. U desnoj sr~anoj komori razvija se naj~e{}e manje od {est adultnih oblika parazita, za razliku od pasa kod kojih ovaj broj mo`e 255 PRIKAZ SLU^AJA-REVIEW CASE Uvod / Introduction
Journal of Laryngology and Otology, Nov 1, 2016
Objective:This study aimed to compare two sampling methods for nasal nitric oxide in healthy indi... more Objective:This study aimed to compare two sampling methods for nasal nitric oxide in healthy individuals and allergic rhinitis patients, and to examine the within-subject reliability of nasal nitric oxide measurement.Methods:The study included 23 allergic rhinitis patients without concomitant asthma and 10 healthy individuals. For all participants, nitric oxide levels were measured non-invasively from the lungs through the mouth (i.e. the oral fractional exhaled nitric oxide) and the nose. Nasal nitric oxide was measured by two different methods: (1) nasal aspiration via one nostril during breath holding and (2) single-breath quiet exhalation against resistance through a tight facemask (i.e. the nasal fractional exhaled nitric oxide).Results:Compared with healthy participants, allergic rhinitis patients had significantly higher average oral and nasal nitric oxide levels. All methods of nitric oxide measurement had excellent reliability.Conclusion:Nasal nitric oxide measurement is a useful and reliable clinical tool for diagnosing allergic rhinitis in patients without asthma in an out-patient setting.
Journal of Comparative Pathology, May 1, 2023
Glasnik Antropološkog Društva Srbije, 2010
Veterinarski glasnik, 2020
Congenital spine deformation caused by vertebral malformation is reported in different brachyceph... more Congenital spine deformation caused by vertebral malformation is reported in different brachycephalic dog breeds, but also in other large dog breeds. The most severe clinical signs are due to spinal cord compression. Depending on localisation of the lesion, clinical signs can manifest differently. A five-month-old pug was brought for autopsy to the
PubMed, Jan 19, 2002
The introduction of peritoneal dialysis (PD) as a respectable modality of renal replacement thera... more The introduction of peritoneal dialysis (PD) as a respectable modality of renal replacement therapy some three decades ago, suddenly drew attention of many authors to peritoneal membrane as insufficiently investigated structure. In order to explain the pathological changes in peritoneum due to renal diseases, it became necessary to explore the normal peritoneal structure. The aim of this study was to examine the morphology of peritoneal lining cells in healthy persons. Biopsies of the peritoneum were performed on 20 volunteer kidney donors. Tissue samples were taken during renal transplantation. Special care was taken in getting appropriate samples without artificial damage because of the extreme fragility of the peritoneal tissue. The preparing procedure was standard for routine HE staining and for plastic embedded semifine and fine sections studies. Semifine sections were made on ultramicrotome, stained with Toluidin blue and studied by light microscope, while fine sections were made by ultramicrotome and studied by transmission electron microscope. One layer of cuboidal or flattened lining cells present over the lamina propria connective tissue presented mesothelium. The cells were overlapped like tiles on the roof. Lateral parts of their interdigitated membranes were interconnected with different types of cell junctions: unpermeable, adhesion and communication junctions; inhibiting intercellular transport. Cell surface was often covered with great number of microvilli and lamellar bodies. A single kinocilia was also often present on apical cell surface. Nuclei were euchromatic with well developed nucleoli. Cytoplasm was filled with a great number of ribosomes, mitochondria, cisterns of rough endoplasmatic reticulum and Golgi apparatus, lamellar bodies and lipid inclusions. Numerous pinocytic vesicles on all parts of the membrane as well as in the cytoplasm indicating active endocytosis, egsocytosis and transcytosys in the process of secretion and reabsorption of serous liquid in peritoneal cavity, were visible. Euchromatic nuclei with prominent nucleoli and numerous mitochondria indicate cells of great metabolic activity.
Acta Veterinaria-beograd, Jun 1, 2021
Nowadays, illegal traffi cking and smuggling of animals are among the greatest threats to many av... more Nowadays, illegal traffi cking and smuggling of animals are among the greatest threats to many avian species. Most commonly smuggled birds belong to parrots, song birds, raptor species and owls. All of these species are protected by national and international legislations. In order to prevent and reduce wildlife traffi cking, DNA methods have become an important forensic tool in species and sex identifi cation. In this study, CHD1R/CHD1F primer pair was used to amplify a part of the CHD1 gene from 65 birds that belong to 43 species. For 36 species this is the fi rst time that the length of CHD1 amplicons was measured for the purpose of species determination. The results were visualized using capillary electrophoresis and enabled simultaneous determination of sex and species. Based on the number of amplicons (two in females, one in males) sex was successfully determined in all species, even in cases where gel electrophoresis failed to give results. Moreover, the species was successfully determined in most bird species based on the species-specifi c sizes of CHD1 amplicon. The method used in this study is of great importance for veterinary forensic medicine and the prevention of wildlife smuggling. Still, further work is necessary to confi rm the effectiveness of the method in all bird species.
Acta Facultatis Medicae Naissensis, Mar 1, 2013
Significant differences in speech between genders are contained in nonsegmental correlates, i.e. ... more Significant differences in speech between genders are contained in nonsegmental correlates, i.e. in the prosody and paralinguistics. Pronunciation differences between genders are more numerous than those in grammatical form. This study aims to detect temporal prosodic patterns and investigate gender differences in performing serial sevens subtraction (SSS). One hundred students of medicine (equal number of males and females) voluntarily participated in the investigation. SSS was performed by asking the participant to perform mental arithmetic consisting of repeatedly subtractions of sevens, beginning from one thousand. The students had to pronounce aloud and simultaneously write the results for five minutes. The original program for the analysis of digital signals (ADS) converted the speech signal samples into digital data. MANOVA showed significant gender differences for a group of characteristics of the SSS test: F (11, 75)=4.06, p=0.000. The number of samples per each minute and the total number of samples during five minutes was higher in males compared to females. The average length of articulation of three-digit numbers, average length of articulation and length of pauses between the linguistic units, as well as between the samples, was shorter in males for each of these five minutes and for the "average" minute. The maximum intensity of speech was higher in males for each of the five minutes. Average duration of mispronunciations, with end results being correct, was longer in women in the first, second, and fourth minute, as well as for the "average" minute. A conclusion may be drawn that shorter utterances and pauses in men suggest the advantage on the part of men in SSS task, and not greater verbal fluency in general in men.
Clinical Neurophysiology, Jul 1, 2012
(3 female and 15 male), mean age 5 years, diagnosed by DSM-IV and CARS. Subjects observed black s... more (3 female and 15 male), mean age 5 years, diagnosed by DSM-IV and CARS. Subjects observed black square (resting period), simple picture representing movement of a hand and feet, and real hand movement. Ten-second artefacts free periods were analysed offline using spectral analysis (FFT algorithm). Results: We found increasement in C3, F3, P3 region during hand movement observation when compared to resting period. No differences were found between period of picture observation and resting period. Conclusions: Children with autism showed increasement in alpha band power during movement observation, which can be one of main dysfunctions in mirror neuron system.
Clinical Neurophysiology, Jul 1, 2012
hypotony as well as secondary esophageal motility disorders such as secondary achalasia, motility... more hypotony as well as secondary esophageal motility disorders such as secondary achalasia, motility disorders in Parkinson’s disease and scleroderma. Similarly, anorectal manometry is a diagnostic procedure used in patients with anal incontinence and terminal constipation. In patients with anal incontinence we measure resting pressure of internal anal sphincter (IAS), squeezing pressure of external anal sphincter (EAS) and rectal sensibility. In patients with functional terminal constipation we determine recto-anal inhibitory reflex, rectoanal excitatory reflex, rectal sensibility and pressure changes at a level of IAS and EAS during an effort to push out an intrarectal balloon inflated with a 50 ml of air. Our experience with 338 patients with esophageal and anorectal motility disorders confirms that both methods provide a reliable diagnostic procedure in establishing a definitive diagnosis.
Clinical Neurophysiology, Sep 1, 2015
The study included 32 patients with TLE with mean age 43.47 ± 10.74 years. Most patients (59.4%) ... more The study included 32 patients with TLE with mean age 43.47 ± 10.74 years. Most patients (59.4%) were treated with two AEDs, 18.8% were on monotherapy, three AEDs were taking in 15.6% of patients, while two patients (6.25%) taking four AEDs. Most frequently used AEDs were valproate (50.00%) and lamotrigine (46.87%). Other AEDs were topiramate, carbamazepine, phenobarbital, levetiracetam, and clonazepam. We have found statistically significant correlation between the number of AEDs and number of perseverative response on the WCST. As the number of AEDs increased to the achievement of the measurements of executive function deteriorates. With the increasing number of AEDs in the treatment of patients with TLE increases the risk of developing disorder of executive function in these patients.
Veterinarski glasnik, 2016
Dirofilarioza pasa je parazitsko oboljenje izazvano vrstama Dirofilaria immitis i D. repens. D. i... more Dirofilarioza pasa je parazitsko oboljenje izazvano vrstama Dirofilaria immitis i D. repens. D. immitis parazitira u desnoj strani srca i plućnoj arteriji, dovodeći do značajnog funkcionalnog oštećenja srca, dok adultni oblici D. repens uglavnom parazitiraju u subkutanom tkivu dovodeći do manjih oštećenja kože. U ovom istraživanju ispitano je 60 pasa, različitih rasa, sa teritorije grada Beograda, u periodu od maja do novembra 2015. godine. Nakon kliničkog pregleda, krv je uzorkovana za detekciju mikrofilarija modifikovanim Knott-ovim testom, kao i za molekularnu detekciju uzročnika. Glavni klinički znaci su bili: brzo zamaranje tokom treninga, otežano disanje i suv kašalj, anoreksija, ubrzan rad srca i promene na koži. Mikrofilarije su detektovane kod 22 psa (37%) modifikovanim Knott-ovim testom. Molekularno genetskom metodom utvrđena je prevalencija D.immitis 42%, a D. repens 22 %. U sprovedenom istraživanju je bilo 7 pasa koji su bili negativni na Knott testu, dok su metodom PCR pokazali pozitivnu reakciju na prisustvo vrsta iz roda Dirofilaria. Na osnovu dobijenih rezultata primena molekularno-genetskih metoda potvrđuje svoju opravdanost u preciznoj i pouzdanoj specijskoj identifikaciji roda Dirofilaria.
svojim roditeljima koji su me naučili pravim životnim vrednostima, svakodnevno bodrili i imali ... more svojim roditeljima koji su me naučili pravim životnim vrednostima, svakodnevno bodrili i imali presudan uticaj u izradi ove teze mentoru, prof. dr Željku Petroviću, na podršci i pomoći tokom izrade doktorske disertacije komentoru, prof. dr Sandri Šipetić-Grujičić, na korisnim savetima tokom izrade ovoga rada kolegama i ostalim zaposlenim u Klinici za Otorinolaringologiju i maksilofacijalnu hirurgiju Kliničkog centra Srbije _________________________________________________________________________ V ZNAČAJ KOMORBIDITETA ZA PREŽIVLJAVANJE BOLESNIKA S PLANOCELULARNIM KARCINOMOM LARINKSA REZIME Uvod: Komorbiditeti su bolesti ili stanja koja postoje pored glavnog oboljenja. Komorbidne bolesti mogu da utiču na izbor lečenja, kao i na stopu preživljavanja. Instrumenti za procenu komorbiditeta mogu biti: opšti-mere stepen komorbiditeta kod različitih oboljenja npr. Čarlsonov indeks komorbiditeta (Charlson Comorbidity Index ili CCI) i specifični-mere stepen komorbiditeta kod određenog oboljenja npr. Procena komorbiditeta kod odraslih-27 indeks (Adult Comorbidity Evaluation-27 index ili ACE-27 index). Ciljevi rada su: Ispitati značaj komorbiditeta za preživljavanje bolesnika s planocelularnim karcinomom larinksa pomoću CCI i ACE-27 indeksa; Odrediti da li postoji razlika u učestalosti javljanja komorbiditeta i u dužini preživljavanja između bolesnika s planocelularnim karcinomom supraglotisa u odnosu na bolesnike s karcinomom glotisa; Ispitati značaj opšteg (CCI) i specifičnog (ACE-27) indeksa u proceni preživljavanja bolesnika s planocelularnim karcinomom larinksa. Materijal i metode: U studiju je uključeno 177 novoobolelih od planocelularnog karcinoma larinksa (T 1-T 4) koji su lečeni hirurški ili hirurški u kombinaciji s postoperacionom radioterapijom u Klinici za otorinolaringologiju i maksilofacijalnu hirurgiju Kliničkog centra Srbije u periodu od 1.1.2000. do 31.12.2003. godine. Podaci o bolesnicima su prikupljeni iz istorija bolesti, patohistoloških izveštaja i registra za maligna oboljenja. U statističkoj analizi podataka korišćena je krivulja preživljavanja prema Kaplanu i Mejeru (Meier), log-rank test, Koksov (Cox) proporcionalni hazardni model, Man-Vitnijev (Mann-Whitney) test i Kruskal-Volisov (Kruskal-Wallis) test. Rezultati: Prema CCI, 40,1% (71) bolesnika s planocelularnim karcinomom larinksa je imalo komorbidne bolesti od kojih su najčešće bile kardiovaskularne (40,3%), respiratorne (27,8%) i gastrointestinalne (14,4%). Međutim, prema ACE-27 indeksu, 66,7% (118) bolesnika s planocelularnim karcinomom je imalo komorbidne bolesti a _________________________________________________________________________ VI najčešće su bile kardiovaskularne (53,1%), respiratorne (15,6%) i gastrointestinalne (8,8%). Skoro svaki četvrti oboleli je imao dve ili više komorbidnih bolesti prema CCI, kao i prema ACE-27 indeksu. Težak stepen komorbiditeta je bio zastupljen kod 5,6% bolesnika s planocelularnim karcinom larinksa prema CCI i kod 9,6% prema ACE-27 indeksu. Bolesnici s karcinomom supraglotisa su imali značajno veći (p < 0,01) stepen težine komorbiditeta u odnosu na bolesnike s karcinomom glotisa. Bolesnici s karcinomom glotisa imali su značajno višu (p < 0,05) stopu petogodišnjeg ukupnog preživljavanja u odnosu na bolesnike s karcinomom supraglotisa. Bolesnici bez komorbiditeta i s blagim komorbiditetom, u odnosu na ACE-27 indeks, imali su statistički značajno bolje (p < 0,01) petogodišnje ukupno i specifično preživljavanje za bolest u odnosu na bolesnike s umerenim i teškim komorbiditetom. Prema univarijantnoj analizi, komorbiditet je imao uticaj na prognozu maligne bolesti, bez obzira koji indeks je primenjen. Prema rezultatima multivarijantne analize, značajni nezavisni prognostički faktori petogodišnjeg ukupnog i specifičnog preživljavanja za planocelularni karcinom larinksa su bili tumor-nodusmetastaza (TNM) stadijum i komorbiditet stepenovan prema ACE-27 indeksu. Zaključak: Naša studija je pokazala da su komorbiditet stepenovan pomoću ACE-27 indeksa i TNM stadijum značajni prognostički faktori za petogodišnje ukupno i specifično preživljavanje kod bolesnika s planocelularnim karcinomom larinksa. Buduće prospektivne studije trebalo bi da uključe komorbiditet kao faktor prognoze za preživljavanje bolesnika s planocelularnim karcinomom larinksa, a kao instrument izbora u cilju merenja komorbiditeta predlaže se primena ACE-27 indeksa. Štaviše, predlažemo primenu TNM-komorbiditet indeksa za petogodišnje ukupno i specifično preživljavanje kod bolesnika s planocelularnim karcinomom larinksa.