V. Resanovic - Academia.edu (original) (raw)
Papers by V. Resanovic
World journal of surgery, Jul 4, 2018
Given the conflicting nature of reported risk factors for post-discharge venous thromboembolism (... more Given the conflicting nature of reported risk factors for post-discharge venous thromboembolism (VTE) and unclear guidelines for post-discharge pharmacoprophylaxis, we sought to determine risk factors for 30-day post-discharge VTE after colectomy to predict which patients will benefit from post-discharge pharmacoprophylaxis. Patients who underwent colectomy in the American College of Surgeons National Surgical Quality Improvement Project Participant Use Files from 2011 to 2015 were identified. Logistic regression modeling was used. Receiver-operating characteristic curves were used and the best cut-points were determined using Youden's J index (sensitivity + specificity - 1). Hosmer-Lemeshow goodness-of-fit test was used to test model calibration. A random sample of 30% of the cohort was used as a validation set. Among 77,823 cases, the overall incidence of VTE after colectomy was 1.9%, with 0.7% of VTE events occurring in the post-discharge setting. Factors associated with post...
Acta chirurgica iugoslavica, 2007
Peptic ulcer bleeding has overall incidence of 50 to 150 on 100.000 grown-ups per year and repres... more Peptic ulcer bleeding has overall incidence of 50 to 150 on 100.000 grown-ups per year and represents cause for over 1% of all urgent hospitalization today. Despite of the evolution of the endoscopic diagnostics and haemostasis, improved intensive care and surgical treatment, overall mortality is still over 10% (operative treatment over 20%), and it almost hasn?t changed over past 40 years. For more than 100 years surgery had major role in treatment of peptic bleeding ulcers, whereas nowadays it is limited to treatment of its complications. Adequate surgical treatment demands properly timed operation, safest but appropriate operation and trained surgeon. Early surgery is much better compared to the last minute surgery. At high risk rebleeding ulcer, early delayed surgery appears to be adequate, since the complications and lethal outcome are more frequent in this group.
Acta chirurgica iugoslavica, 2010
Injury-induced anergy is one of the key factors contributing to trauma victims&am... more Injury-induced anergy is one of the key factors contributing to trauma victims' high susceptibility to sepsis. This group of patients is mostly of young age and it is therefore essential to be able to predict as accurately as possible the development of septic complications, so appropriate treatment could be provided. The aim of this study was to assess kinetics of interleukin (IL)-6 and -10, phospholipase A2-II and C-reactive protein (CRP) in severely traumatized patients and explore the possibilities for early detection of potentially septic patients. This prospective study included 65 traumatized patients with injury severity score (ISS) > 18, requiring treatment at surgical intensive care units, divided into two groups: 24 patients without sepsis and 41 patients with sepsis. C-reactive protein, IL-6 and -10 and phospholipase A2 group II, were determined within the first 24 hours, and on the second, third and seventh day of hospitalization. Mean values of IL-6 and phospholipase A2-II in the patients with and without sepsis did not show a statistically significant difference on any assessed time points. In the septic patients with ISS 29-35 and > 35 on the days two and seven a statistically significantly lower level of IL-10 was found, compared with those without sepsis and with the same ISS. C-reactive protein levels were significantly higher in septic patients with ISS 18-28 on the first day. On the second, third and seventh day CRP levels were significantly lower in the groups of septic patients with ISS 29-35 and > 35, than in those with the same ISS but without sepsis. Mean levels of CRP on the first day after the injury may be useful predictor of sepsis development in traumatized patients with ISS score 18-28. Mean levels of CRP on the days two, three and seven after the injury may be a useful predictor of sepsis development in traumatized patients with ISS score more than 28. Mean levels of IL-10 on the second and seventh day after the injury may be a useful predictor of sepsis development in traumatized patients with ISS score > 28.
Acta chirurgica iugoslavica, 2010
Acta chirurgica iugoslavica, 2010
... Predicting outcome after multiple trauma: which scoring system? Injury. 2004;35(4):347-58. 6.... more ... Predicting outcome after multiple trauma: which scoring system? Injury. 2004;35(4):347-58. 6. Gortzis LG, Sakellaropoulos F, Ilias I, Stamoulis K, Dimopoulou I. Predicting ICU survival: a meta-level ap-proach. BMC Health Serv Res. 2008; 26 (8):157. 7. Champion HR. ...
Acta chirurgica iugoslavica, 2007
Gastrointestinal hemorrhage is one of the most frequent complications that occurs in 15 20% patie... more Gastrointestinal hemorrhage is one of the most frequent complications that occurs in 15 20% patients with peptic ulcer disease. Recurrent ulcer haemorrhage presents in the first 72 hours after initial bleeding: they are the most im portant cause of death. The aim of our study was to show the possibility of ulcer recurrent haemorrhage combined with risk factors: age 60, high risk lesion (active arterial bleeding, visible blood vessel, adherent coagulum), the size, ulcer base and localization (posterior duodenal wall. lesser curvature or high gastric ulcer), commorbidities ( cardiovascular and liver diseases) and haemodynamic instabilities. The combination of these risk-factor, unproportionally increases the risk: presence of two risk factors gives the possibility of recurrent bleeding of 16.67%, three risk factors 58.82%, four 93.33%, while the presence of five risk factors shows 100% posibility. Probability of death is 8.27 times greater if ulcer haemorrhage occurs.
Injury-induced anergy is one of the key factors contributing to trauma victims&am... more Injury-induced anergy is one of the key factors contributing to trauma victims' high susceptibility to sepsis. This group of patients is mostly of young age and it is therefore essential to be able to predict as accurately as possible the development of septic complications, so appropriate treatment could be provided. The aim of this study was to assess kinetics of interleukin (IL)-6 and -10, phospholipase A2-II and C-reactive protein (CRP) in severely traumatized patients and explore the possibilities for early detection of potentially septic patients. This prospective study included 65 traumatized patients with injury severity score (ISS) > 18, requiring treatment at surgical intensive care units, divided into two groups: 24 patients without sepsis and 41 patients with sepsis. C-reactive protein, IL-6 and -10 and phospholipase A2 group II, were determined within the first 24 hours, and on the second, third and seventh day of hospitalization. Mean values of IL-6 and phospholipase A2-II in the patients with and without sepsis did not show a statistically significant difference on any assessed time points. In the septic patients with ISS 29-35 and > 35 on the days two and seven a statistically significantly lower level of IL-10 was found, compared with those without sepsis and with the same ISS. C-reactive protein levels were significantly higher in septic patients with ISS 18-28 on the first day. On the second, third and seventh day CRP levels were significantly lower in the groups of septic patients with ISS 29-35 and > 35, than in those with the same ISS but without sepsis. Mean levels of CRP on the first day after the injury may be useful predictor of sepsis development in traumatized patients with ISS score 18-28. Mean levels of CRP on the days two, three and seven after the injury may be a useful predictor of sepsis development in traumatized patients with ISS score more than 28. Mean levels of IL-10 on the second and seventh day after the injury may be a useful predictor of sepsis development in traumatized patients with ISS score > 28.
Acta chirurgica iugoslavica, 2007
Krvarenje iz pepti~nog ulkusa ima incidencu od 50-150 na 100.000 odraslih godi{nje i predstavlja ... more Krvarenje iz pepti~nog ulkusa ima incidencu od 50-150 na 100.000 odraslih godi{nje i predstavlja razlog za vi{e od 1 % svih urgentnih hospitalizacija danas. Kod ulkusnog krvarenja uprkos napretku endoskopske dijagnostike i hemostaze, unapredjenog intenzivnog i hirur{kog tretmana, ukupan mortalitet iznosi preko 10%, (operativni i preko 20%) i gotovo da se nije promenio u poslednjih etrdeset godina. Vi{e od sto godina hirurgija je imala najva'niju ulogu u le~enju ulkusne bolesti, dok je danas njena uloga svedena na le~enje najte'ih komplikacija. Kvalitetno hirur{ko le~enje ulkusnog krvarenja zahteva preduzimanje operacije u pravo vreme, izvodjenje najbezbednije a ipak adekvatne operacije i naravno visoko obu~enog hirurga. Rana hirurgija je u svakom slu~aju bolja u odnosu na "hirurgiju poslednjeg trenutka". Kod visokog rizika za rekrvarenje hitna odlo'ena operacija se ~ini logi~nim re{enjem, po{to su komplikacije i smrtni ishod mnogo ~e{}i kod ove grupe bolesnika. Klju~ne re~i: ulkusno krvarenje, hirurgija, perspektive UVOD K rvarenje iz gornjih partija digestivnog trakta (GPDT) @. Lau{evi} i sar. ACI Vol. LIV
World journal of surgery, Jul 4, 2018
Given the conflicting nature of reported risk factors for post-discharge venous thromboembolism (... more Given the conflicting nature of reported risk factors for post-discharge venous thromboembolism (VTE) and unclear guidelines for post-discharge pharmacoprophylaxis, we sought to determine risk factors for 30-day post-discharge VTE after colectomy to predict which patients will benefit from post-discharge pharmacoprophylaxis. Patients who underwent colectomy in the American College of Surgeons National Surgical Quality Improvement Project Participant Use Files from 2011 to 2015 were identified. Logistic regression modeling was used. Receiver-operating characteristic curves were used and the best cut-points were determined using Youden's J index (sensitivity + specificity - 1). Hosmer-Lemeshow goodness-of-fit test was used to test model calibration. A random sample of 30% of the cohort was used as a validation set. Among 77,823 cases, the overall incidence of VTE after colectomy was 1.9%, with 0.7% of VTE events occurring in the post-discharge setting. Factors associated with post...
Acta chirurgica iugoslavica, 2007
Peptic ulcer bleeding has overall incidence of 50 to 150 on 100.000 grown-ups per year and repres... more Peptic ulcer bleeding has overall incidence of 50 to 150 on 100.000 grown-ups per year and represents cause for over 1% of all urgent hospitalization today. Despite of the evolution of the endoscopic diagnostics and haemostasis, improved intensive care and surgical treatment, overall mortality is still over 10% (operative treatment over 20%), and it almost hasn?t changed over past 40 years. For more than 100 years surgery had major role in treatment of peptic bleeding ulcers, whereas nowadays it is limited to treatment of its complications. Adequate surgical treatment demands properly timed operation, safest but appropriate operation and trained surgeon. Early surgery is much better compared to the last minute surgery. At high risk rebleeding ulcer, early delayed surgery appears to be adequate, since the complications and lethal outcome are more frequent in this group.
Acta chirurgica iugoslavica, 2010
Injury-induced anergy is one of the key factors contributing to trauma victims&am... more Injury-induced anergy is one of the key factors contributing to trauma victims' high susceptibility to sepsis. This group of patients is mostly of young age and it is therefore essential to be able to predict as accurately as possible the development of septic complications, so appropriate treatment could be provided. The aim of this study was to assess kinetics of interleukin (IL)-6 and -10, phospholipase A2-II and C-reactive protein (CRP) in severely traumatized patients and explore the possibilities for early detection of potentially septic patients. This prospective study included 65 traumatized patients with injury severity score (ISS) > 18, requiring treatment at surgical intensive care units, divided into two groups: 24 patients without sepsis and 41 patients with sepsis. C-reactive protein, IL-6 and -10 and phospholipase A2 group II, were determined within the first 24 hours, and on the second, third and seventh day of hospitalization. Mean values of IL-6 and phospholipase A2-II in the patients with and without sepsis did not show a statistically significant difference on any assessed time points. In the septic patients with ISS 29-35 and > 35 on the days two and seven a statistically significantly lower level of IL-10 was found, compared with those without sepsis and with the same ISS. C-reactive protein levels were significantly higher in septic patients with ISS 18-28 on the first day. On the second, third and seventh day CRP levels were significantly lower in the groups of septic patients with ISS 29-35 and > 35, than in those with the same ISS but without sepsis. Mean levels of CRP on the first day after the injury may be useful predictor of sepsis development in traumatized patients with ISS score 18-28. Mean levels of CRP on the days two, three and seven after the injury may be a useful predictor of sepsis development in traumatized patients with ISS score more than 28. Mean levels of IL-10 on the second and seventh day after the injury may be a useful predictor of sepsis development in traumatized patients with ISS score > 28.
Acta chirurgica iugoslavica, 2010
Acta chirurgica iugoslavica, 2010
... Predicting outcome after multiple trauma: which scoring system? Injury. 2004;35(4):347-58. 6.... more ... Predicting outcome after multiple trauma: which scoring system? Injury. 2004;35(4):347-58. 6. Gortzis LG, Sakellaropoulos F, Ilias I, Stamoulis K, Dimopoulou I. Predicting ICU survival: a meta-level ap-proach. BMC Health Serv Res. 2008; 26 (8):157. 7. Champion HR. ...
Acta chirurgica iugoslavica, 2007
Gastrointestinal hemorrhage is one of the most frequent complications that occurs in 15 20% patie... more Gastrointestinal hemorrhage is one of the most frequent complications that occurs in 15 20% patients with peptic ulcer disease. Recurrent ulcer haemorrhage presents in the first 72 hours after initial bleeding: they are the most im portant cause of death. The aim of our study was to show the possibility of ulcer recurrent haemorrhage combined with risk factors: age 60, high risk lesion (active arterial bleeding, visible blood vessel, adherent coagulum), the size, ulcer base and localization (posterior duodenal wall. lesser curvature or high gastric ulcer), commorbidities ( cardiovascular and liver diseases) and haemodynamic instabilities. The combination of these risk-factor, unproportionally increases the risk: presence of two risk factors gives the possibility of recurrent bleeding of 16.67%, three risk factors 58.82%, four 93.33%, while the presence of five risk factors shows 100% posibility. Probability of death is 8.27 times greater if ulcer haemorrhage occurs.
Injury-induced anergy is one of the key factors contributing to trauma victims&am... more Injury-induced anergy is one of the key factors contributing to trauma victims' high susceptibility to sepsis. This group of patients is mostly of young age and it is therefore essential to be able to predict as accurately as possible the development of septic complications, so appropriate treatment could be provided. The aim of this study was to assess kinetics of interleukin (IL)-6 and -10, phospholipase A2-II and C-reactive protein (CRP) in severely traumatized patients and explore the possibilities for early detection of potentially septic patients. This prospective study included 65 traumatized patients with injury severity score (ISS) > 18, requiring treatment at surgical intensive care units, divided into two groups: 24 patients without sepsis and 41 patients with sepsis. C-reactive protein, IL-6 and -10 and phospholipase A2 group II, were determined within the first 24 hours, and on the second, third and seventh day of hospitalization. Mean values of IL-6 and phospholipase A2-II in the patients with and without sepsis did not show a statistically significant difference on any assessed time points. In the septic patients with ISS 29-35 and > 35 on the days two and seven a statistically significantly lower level of IL-10 was found, compared with those without sepsis and with the same ISS. C-reactive protein levels were significantly higher in septic patients with ISS 18-28 on the first day. On the second, third and seventh day CRP levels were significantly lower in the groups of septic patients with ISS 29-35 and > 35, than in those with the same ISS but without sepsis. Mean levels of CRP on the first day after the injury may be useful predictor of sepsis development in traumatized patients with ISS score 18-28. Mean levels of CRP on the days two, three and seven after the injury may be a useful predictor of sepsis development in traumatized patients with ISS score more than 28. Mean levels of IL-10 on the second and seventh day after the injury may be a useful predictor of sepsis development in traumatized patients with ISS score > 28.
Acta chirurgica iugoslavica, 2007
Krvarenje iz pepti~nog ulkusa ima incidencu od 50-150 na 100.000 odraslih godi{nje i predstavlja ... more Krvarenje iz pepti~nog ulkusa ima incidencu od 50-150 na 100.000 odraslih godi{nje i predstavlja razlog za vi{e od 1 % svih urgentnih hospitalizacija danas. Kod ulkusnog krvarenja uprkos napretku endoskopske dijagnostike i hemostaze, unapredjenog intenzivnog i hirur{kog tretmana, ukupan mortalitet iznosi preko 10%, (operativni i preko 20%) i gotovo da se nije promenio u poslednjih etrdeset godina. Vi{e od sto godina hirurgija je imala najva'niju ulogu u le~enju ulkusne bolesti, dok je danas njena uloga svedena na le~enje najte'ih komplikacija. Kvalitetno hirur{ko le~enje ulkusnog krvarenja zahteva preduzimanje operacije u pravo vreme, izvodjenje najbezbednije a ipak adekvatne operacije i naravno visoko obu~enog hirurga. Rana hirurgija je u svakom slu~aju bolja u odnosu na "hirurgiju poslednjeg trenutka". Kod visokog rizika za rekrvarenje hitna odlo'ena operacija se ~ini logi~nim re{enjem, po{to su komplikacije i smrtni ishod mnogo ~e{}i kod ove grupe bolesnika. Klju~ne re~i: ulkusno krvarenje, hirurgija, perspektive UVOD K rvarenje iz gornjih partija digestivnog trakta (GPDT) @. Lau{evi} i sar. ACI Vol. LIV