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Papers by Valentin Varlas

Research paper thumbnail of Recurrence and Carcinogenetic Rates of Colorectal Polyps

Chirurgia, 2024

Scop: de a determina rata de recurenţă a polipilor recto-colonici benigni într-un interval de 5 a... more Scop: de a determina rata de recurenţă a polipilor recto-colonici benigni într-un interval de 5 ani şi de a compara rata de dezvoltare a leziunilor carcinomatoase intrapolipoide la subiecţii polipectomizaţi faţă de subiecţii nepolipectomizaţi. Material şi Metodă: un lot de 77 de pacienţi diagnosticaţi cu leziuni polipoide recto-colonice în perioada 2014-2019 au fost supuşi colonoscopiei la momentul iniţierii studiului şi apoi anual pe un interval de cinci ani. Rezultate: Rata de recidivă a polipilor a crescut anual de la 5 la 12,5%; cea mai mare rată a fost observată în ultimii doi ani. Riscul cumulat la cinci ani de leziuni neoplazice a fost de 73% la pacienţii fără polipectomie şi de 20% la cei cu rezecţie endoscopică (p < 0,05).

Research paper thumbnail of 489 Lymphocyte to monocyte ratio as a prognostic factor in ovarian cancer

Research paper thumbnail of 488 Hemoglobin levels correlate with systemic inflammatory index in advanced stage ovarian cancer

Research paper thumbnail of Women’s Sexual Dysfunctions Following Stem Cell Transplant and the Impact on Couple Relationship

Life, Dec 24, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of Hyponatremia as a Prognostic Factor in Advanced Stage Ovarian Cancer Patients

PubMed, Sep 30, 2023

Background: hyponatremia represents one of the most commonly encountered conditions in hospitaliz... more Background: hyponatremia represents one of the most commonly encountered conditions in hospitalized patients, multiple mechanisms being cited so far, neoplastic syndromes being an important cause. The aim of the current paper is to analyse the presence and influence of the short- and long-term outcomes of hyponatremia on ovarian cancer patients submitted to surgery for advanced stage ovarian cancer. Method: 57 patients diagnosed with advanced stage ovarian cancer were submitted to surgery between 2014-2020. The patients were further classified according to the preoperative value of sodium into two groups. Results: there were 21 cases with preoperative normal values of sodium and respectively 36 cases with hyponatremia. Patients with preoperative hyponatremia associated a significantly higher rate of early postoperative complications and a significantly poorer long-term outcome. Therefore, cases with hyponatremia reported a mean disease-free survival of 10.8 months and respectively a mean overall survival of 18.5 months while cases with normal natrium levels reported a mean disease-free survival of 31.4 months and respectively a mean overall survival of 49.7 months (p=0.0001 and p 0.001). Conclusions: patients with lower preoperative values of sodium have a higher risk of developing postoperative complications and a significantly poorer outcome when compared to cases presenting normal levels of sodium preoperatively.

Research paper thumbnail of The anti-inflammatory, anti-infectious and anticancerous effects of Thymus vulgaris

Practica medicală, Aug 15, 2022

Research paper thumbnail of The correlation between the embryological development of the pancreas and the local extent of the pancreatic tumors

Practica medicală, Aug 15, 2022

Research paper thumbnail of Does the number of circulating platelets influence the postoperative evolution of endometrial cancer?

Practica medicală, Aug 15, 2022

Endometrial cancer is a frequently encountered gynecologic malignancy with increasing incidence; ... more Endometrial cancer is a frequently encountered gynecologic malignancy with increasing incidence; in order to maximize the chances to achieve a long-term survival rate, attention was focused on better identifying the patients at risk to develop more aggressive forms of the disease. The aim of the current paper is to investigate the influence of the number of circulating platelets alone or in association with other biomarkers on the perioperative outcomes of endometrial cancer patients.

Research paper thumbnail of The impact of the presence of the aberrant right hepatic artery in pancreatoduodenectomy for pancreatic head cancer

Practica medicală, Aug 15, 2022

An aberrant right hepatic artery usually originates from the superior mesenteric artery, it has a... more An aberrant right hepatic artery usually originates from the superior mesenteric artery, it has an ascendent trajectory through the head of the pancreas or behind it and represents a technical challenge in pancreatic head tumors due to the fact that it needs to be carefully dissected and preserved in order to maintain an adequate blood supply for the right hemi-liver. Meanwhile, this dissection should be performed in an oncological manner in order to obtain the premises of a radical resection with negative margins. The aim of the current paper is to discuss about the influence of this anatomical arterial particularity and the possibility of obtaining a resection with curative intent in pancreatic head adenocarcinoma.

Research paper thumbnail of The correlation between the number of platelets and endometrial pathology

Practica medicală, Jun 30, 2022

Introduction. Circulating platelets play an essential role in the immune system and furthermore i... more Introduction. Circulating platelets play an essential role in the immune system and furthermore in tumor development and proliferation. Therefore, the correlation ship between different neoplasia and the number of platelets has been widely studied. The aim of the current paper is to investigate the correlation ship between platelet number and tumoral endometrial transformation. Material and methods. Between January 2022 and June 2022 22 patients with endometrial hyperplasia or endometrial cancer were submitted to surgery. The serum levels of platelets were determined and compared to those reported in a similar group of patients in whom the endometrial lining was normal. Results. Patients diagnosed with endometrial cancer presented a significantly higher number of platelets as well as a significantly higher platelet volume when compared to patients diagnosed with endometrial hyperplasia and respectively to those in whom a normal endometrial lining was found. Conclusions. The serum number of platelets and their volume seem to be positively correlated with the aggressivity of the tumoral transformation of the endometrial lining and should be therefore considered as part of the elements which should be analyzed when discussing the best therapeutic option in such patients.

Research paper thumbnail of Debulking surgery for metastatic endometrial cancer – a case report and literature review

Revista medicală română, Jun 20, 2022

Research paper thumbnail of Total gastrectomy en bloc with total pancreatoduodenectomy, splenectomy, portal vein and celiac axis resection for isolated recurrence from epithelial ovarian cancer – A case report

Revista medicală română, Jun 20, 2022

Although the development of upper abdominal metastases in relapsed ovarian cancer has been consid... more Although the development of upper abdominal metastases in relapsed ovarian cancer has been considered as a sign of biological aggressive disease once the surgical techniques improved these extended resections have been successfully implemented in the armamentarium of cytoreductive surgery. Case: a 54 year old patient diagnosed with an isolated metastasis at the level of upper abdomen invading the pancreatic head, the portal vein and the common hepatic artery was submitted to surgery. Venous reconstruction was performed by using a Goretex patch while arterial reconstruction was performed by using a saphenous graft which was placed between the celiac trunk and the proper hepatic artery. Conclusion: extended local visceral and vascular resections might be needed in order to achieve complete cytoreduction for relapsed ovarian cancer.

Research paper thumbnail of Hepatobiliary Impairments in Patients with Inflammatory Bowel Diseases: The Current Approach

Gastroenterology Insights, Dec 27, 2022

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of Chronic Wound Management: From Gauze to Homologous Cellular Matrix

Biomedicines

Background: Chronic wounds are a significant health problem with devastating consequences for pat... more Background: Chronic wounds are a significant health problem with devastating consequences for patients’ physical, social, and mental health, increasing healthcare systems’ costs. Their prolonged healing times, economic burden, diminished quality of life, increased infection risk, and impact on patients’ mobility and functionality make them a major concern for healthcare professionals. Purpose: This review offers a multi-perspective analysis of the medical literature focusing on chronic wound management. Methods used: We evaluated 48 articles from the last 21 years registered in the MEDLINE and Global Health databases. The articles included in our study had a minimum of 20 citations, patients > 18 years old, and focused on chronic, complex, and hard-to-heal wounds. Extracted data were summarized into a narrative synthesis using the same health-related quality of life instrument. Results: We evaluated the efficacy of existing wound care therapies from classical methods to modern co...

Research paper thumbnail of COVID-19 in pregnancy – a possible risk factor for the poor neurological outcome of the infant

Revista română de pediatrie, Nov 30, 2022

Research paper thumbnail of Bilateral ovarian metastases from pulmonary neuroendocrine tumor. A case report and literature review

Romanian Medical Journal

Pulmonary cancer is commonly associated with the development of distant metastases at the level o... more Pulmonary cancer is commonly associated with the development of distant metastases at the level of liver, bones, adrenal glands and even brain. However, in certain cases other metastatic sites might be encountered such as the ovaries; however, these situations have been rarely encountered. The aim of the current paper is to present the case of a 39 year old patient with previous history of pulmonary neuroendocrine tumor, submitted to palliative radio-chemotherapy who was diagnosed with two large ovarian tumors and high volume of ascites which impaired even more the respiratory function. The patient was submitted to hysterectomy and bilateral adnexectomy, the histopathological studies demonstrating the metastatic origin of the tumors.

Research paper thumbnail of Surgical strategies in uterine adenomyosis

Romanian Journal of Medical Practice

Uterine adenomyosis is defined by the presence of heterotopic endometrial glands and stroma at th... more Uterine adenomyosis is defined by the presence of heterotopic endometrial glands and stroma at the myometrial level. Although imagistic studies improved, the incidence of adenomyosis is still underestimated, in a significant number of cases the final diagnostic of adenomyosis being established on the histopathological specimen of hysterectomy. The aim of the current paper is to discuss about the most efficient therapeutic strategies in adenomyosis.

Research paper thumbnail of 486 Platelet count as a prognostic marker in advanced stage and relapsed ovarian cancer

Research paper thumbnail of Inteligenţa artificială în tehnicile de reproducere asistată

Obstetrică şi ginecologie, 2023

Research paper thumbnail of Oligohydramnios: A review of etiology and management options

Practica medicală, Dec 31, 2022

Oligohydramnios is both a consequence of fetal malformations and of uteroplacental insufficiency.... more Oligohydramnios is both a consequence of fetal malformations and of uteroplacental insufficiency. Its existence is associated with a high rate of both antepartum and intrapartum complications. It is vital that its occurrence is detected as early as possible so that we can manage it correctly. The main causes of its occurrence are identified and described in this review. The management of oligohydramnios is most often expectant, the timing of delivery also being determined by Doppler examination and changes in parameters measuring fetal growth and development.

Research paper thumbnail of Recurrence and Carcinogenetic Rates of Colorectal Polyps

Chirurgia, 2024

Scop: de a determina rata de recurenţă a polipilor recto-colonici benigni într-un interval de 5 a... more Scop: de a determina rata de recurenţă a polipilor recto-colonici benigni într-un interval de 5 ani şi de a compara rata de dezvoltare a leziunilor carcinomatoase intrapolipoide la subiecţii polipectomizaţi faţă de subiecţii nepolipectomizaţi. Material şi Metodă: un lot de 77 de pacienţi diagnosticaţi cu leziuni polipoide recto-colonice în perioada 2014-2019 au fost supuşi colonoscopiei la momentul iniţierii studiului şi apoi anual pe un interval de cinci ani. Rezultate: Rata de recidivă a polipilor a crescut anual de la 5 la 12,5%; cea mai mare rată a fost observată în ultimii doi ani. Riscul cumulat la cinci ani de leziuni neoplazice a fost de 73% la pacienţii fără polipectomie şi de 20% la cei cu rezecţie endoscopică (p < 0,05).

Research paper thumbnail of 489 Lymphocyte to monocyte ratio as a prognostic factor in ovarian cancer

Research paper thumbnail of 488 Hemoglobin levels correlate with systemic inflammatory index in advanced stage ovarian cancer

Research paper thumbnail of Women’s Sexual Dysfunctions Following Stem Cell Transplant and the Impact on Couple Relationship

Life, Dec 24, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of Hyponatremia as a Prognostic Factor in Advanced Stage Ovarian Cancer Patients

PubMed, Sep 30, 2023

Background: hyponatremia represents one of the most commonly encountered conditions in hospitaliz... more Background: hyponatremia represents one of the most commonly encountered conditions in hospitalized patients, multiple mechanisms being cited so far, neoplastic syndromes being an important cause. The aim of the current paper is to analyse the presence and influence of the short- and long-term outcomes of hyponatremia on ovarian cancer patients submitted to surgery for advanced stage ovarian cancer. Method: 57 patients diagnosed with advanced stage ovarian cancer were submitted to surgery between 2014-2020. The patients were further classified according to the preoperative value of sodium into two groups. Results: there were 21 cases with preoperative normal values of sodium and respectively 36 cases with hyponatremia. Patients with preoperative hyponatremia associated a significantly higher rate of early postoperative complications and a significantly poorer long-term outcome. Therefore, cases with hyponatremia reported a mean disease-free survival of 10.8 months and respectively a mean overall survival of 18.5 months while cases with normal natrium levels reported a mean disease-free survival of 31.4 months and respectively a mean overall survival of 49.7 months (p=0.0001 and p 0.001). Conclusions: patients with lower preoperative values of sodium have a higher risk of developing postoperative complications and a significantly poorer outcome when compared to cases presenting normal levels of sodium preoperatively.

Research paper thumbnail of The anti-inflammatory, anti-infectious and anticancerous effects of Thymus vulgaris

Practica medicală, Aug 15, 2022

Research paper thumbnail of The correlation between the embryological development of the pancreas and the local extent of the pancreatic tumors

Practica medicală, Aug 15, 2022

Research paper thumbnail of Does the number of circulating platelets influence the postoperative evolution of endometrial cancer?

Practica medicală, Aug 15, 2022

Endometrial cancer is a frequently encountered gynecologic malignancy with increasing incidence; ... more Endometrial cancer is a frequently encountered gynecologic malignancy with increasing incidence; in order to maximize the chances to achieve a long-term survival rate, attention was focused on better identifying the patients at risk to develop more aggressive forms of the disease. The aim of the current paper is to investigate the influence of the number of circulating platelets alone or in association with other biomarkers on the perioperative outcomes of endometrial cancer patients.

Research paper thumbnail of The impact of the presence of the aberrant right hepatic artery in pancreatoduodenectomy for pancreatic head cancer

Practica medicală, Aug 15, 2022

An aberrant right hepatic artery usually originates from the superior mesenteric artery, it has a... more An aberrant right hepatic artery usually originates from the superior mesenteric artery, it has an ascendent trajectory through the head of the pancreas or behind it and represents a technical challenge in pancreatic head tumors due to the fact that it needs to be carefully dissected and preserved in order to maintain an adequate blood supply for the right hemi-liver. Meanwhile, this dissection should be performed in an oncological manner in order to obtain the premises of a radical resection with negative margins. The aim of the current paper is to discuss about the influence of this anatomical arterial particularity and the possibility of obtaining a resection with curative intent in pancreatic head adenocarcinoma.

Research paper thumbnail of The correlation between the number of platelets and endometrial pathology

Practica medicală, Jun 30, 2022

Introduction. Circulating platelets play an essential role in the immune system and furthermore i... more Introduction. Circulating platelets play an essential role in the immune system and furthermore in tumor development and proliferation. Therefore, the correlation ship between different neoplasia and the number of platelets has been widely studied. The aim of the current paper is to investigate the correlation ship between platelet number and tumoral endometrial transformation. Material and methods. Between January 2022 and June 2022 22 patients with endometrial hyperplasia or endometrial cancer were submitted to surgery. The serum levels of platelets were determined and compared to those reported in a similar group of patients in whom the endometrial lining was normal. Results. Patients diagnosed with endometrial cancer presented a significantly higher number of platelets as well as a significantly higher platelet volume when compared to patients diagnosed with endometrial hyperplasia and respectively to those in whom a normal endometrial lining was found. Conclusions. The serum number of platelets and their volume seem to be positively correlated with the aggressivity of the tumoral transformation of the endometrial lining and should be therefore considered as part of the elements which should be analyzed when discussing the best therapeutic option in such patients.

Research paper thumbnail of Debulking surgery for metastatic endometrial cancer – a case report and literature review

Revista medicală română, Jun 20, 2022

Research paper thumbnail of Total gastrectomy en bloc with total pancreatoduodenectomy, splenectomy, portal vein and celiac axis resection for isolated recurrence from epithelial ovarian cancer – A case report

Revista medicală română, Jun 20, 2022

Although the development of upper abdominal metastases in relapsed ovarian cancer has been consid... more Although the development of upper abdominal metastases in relapsed ovarian cancer has been considered as a sign of biological aggressive disease once the surgical techniques improved these extended resections have been successfully implemented in the armamentarium of cytoreductive surgery. Case: a 54 year old patient diagnosed with an isolated metastasis at the level of upper abdomen invading the pancreatic head, the portal vein and the common hepatic artery was submitted to surgery. Venous reconstruction was performed by using a Goretex patch while arterial reconstruction was performed by using a saphenous graft which was placed between the celiac trunk and the proper hepatic artery. Conclusion: extended local visceral and vascular resections might be needed in order to achieve complete cytoreduction for relapsed ovarian cancer.

Research paper thumbnail of Hepatobiliary Impairments in Patients with Inflammatory Bowel Diseases: The Current Approach

Gastroenterology Insights, Dec 27, 2022

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of Chronic Wound Management: From Gauze to Homologous Cellular Matrix

Biomedicines

Background: Chronic wounds are a significant health problem with devastating consequences for pat... more Background: Chronic wounds are a significant health problem with devastating consequences for patients’ physical, social, and mental health, increasing healthcare systems’ costs. Their prolonged healing times, economic burden, diminished quality of life, increased infection risk, and impact on patients’ mobility and functionality make them a major concern for healthcare professionals. Purpose: This review offers a multi-perspective analysis of the medical literature focusing on chronic wound management. Methods used: We evaluated 48 articles from the last 21 years registered in the MEDLINE and Global Health databases. The articles included in our study had a minimum of 20 citations, patients > 18 years old, and focused on chronic, complex, and hard-to-heal wounds. Extracted data were summarized into a narrative synthesis using the same health-related quality of life instrument. Results: We evaluated the efficacy of existing wound care therapies from classical methods to modern co...

Research paper thumbnail of COVID-19 in pregnancy – a possible risk factor for the poor neurological outcome of the infant

Revista română de pediatrie, Nov 30, 2022

Research paper thumbnail of Bilateral ovarian metastases from pulmonary neuroendocrine tumor. A case report and literature review

Romanian Medical Journal

Pulmonary cancer is commonly associated with the development of distant metastases at the level o... more Pulmonary cancer is commonly associated with the development of distant metastases at the level of liver, bones, adrenal glands and even brain. However, in certain cases other metastatic sites might be encountered such as the ovaries; however, these situations have been rarely encountered. The aim of the current paper is to present the case of a 39 year old patient with previous history of pulmonary neuroendocrine tumor, submitted to palliative radio-chemotherapy who was diagnosed with two large ovarian tumors and high volume of ascites which impaired even more the respiratory function. The patient was submitted to hysterectomy and bilateral adnexectomy, the histopathological studies demonstrating the metastatic origin of the tumors.

Research paper thumbnail of Surgical strategies in uterine adenomyosis

Romanian Journal of Medical Practice

Uterine adenomyosis is defined by the presence of heterotopic endometrial glands and stroma at th... more Uterine adenomyosis is defined by the presence of heterotopic endometrial glands and stroma at the myometrial level. Although imagistic studies improved, the incidence of adenomyosis is still underestimated, in a significant number of cases the final diagnostic of adenomyosis being established on the histopathological specimen of hysterectomy. The aim of the current paper is to discuss about the most efficient therapeutic strategies in adenomyosis.

Research paper thumbnail of 486 Platelet count as a prognostic marker in advanced stage and relapsed ovarian cancer

Research paper thumbnail of Inteligenţa artificială în tehnicile de reproducere asistată

Obstetrică şi ginecologie, 2023

Research paper thumbnail of Oligohydramnios: A review of etiology and management options

Practica medicală, Dec 31, 2022

Oligohydramnios is both a consequence of fetal malformations and of uteroplacental insufficiency.... more Oligohydramnios is both a consequence of fetal malformations and of uteroplacental insufficiency. Its existence is associated with a high rate of both antepartum and intrapartum complications. It is vital that its occurrence is detected as early as possible so that we can manage it correctly. The main causes of its occurrence are identified and described in this review. The management of oligohydramnios is most often expectant, the timing of delivery also being determined by Doppler examination and changes in parameters measuring fetal growth and development.