V. Y. Srinivas - Academia.edu (original) (raw)

Papers by V. Y. Srinivas

Indian Journal of Clinical Anaesthesia

Background: Tracheal extubation process evokes stress response which causes autonomic variations ... more Background: Tracheal extubation process evokes stress response which causes autonomic variations such as tachycardia, rise in systolic arterial blood pressure and diastolic arterial blood pressure which is potentially lethal in high risk patients. Thus this study is conducted to compare the efficacy between 0.15mg/kg and 0.25mg/kg of iv Labetalol in the suppression of haemodynamic response to Extubation. Materials and Methods: 60 participants aged between 18-55 yrs belonging to ASA 1 or 2 were randomly allocated into 2 groups. Group Lb received injection Labetalol 0.15mg/kg and Group Lt received injection Labetalol 0.25mg/kg. Heart rate, systolic arterial blood pressure and diastolic arterial blood pressure were recorded at basal, two, five, eight minutes after drug infusion, at extubation and one, three, five, eight, ten and fifteen minutes post extubation. Results: Group Lt showed a better lowering values in heart rate, systolic arterial blood pressure and diastolic arterial blood pressure after drug infusion, at Extubation, and fifteen minutes post Extubation compared to Group Lb. Conclusion: Injection Labetalol 0.25mg/kg showed a effective suppression of haemodynamic response to Extubation compared to injection Labetalol 0.15mg/kg.

IP innovative publication pvt. ltd, 2019

anaesthesia cause noxious stimuli and are associated with laryngo- sympathetic stimulation manife... more anaesthesia cause noxious stimuli and are associated with laryngo- sympathetic stimulation manifested by hypertension, tachycardia and arrhythmias. This study compares the efficacy of dexmedetomidine and fentanyl in attenuating haemodynamic stress responses to laryngoscopic endo-tracheal intubation in adult patients undergoing surgeries under general anaesthesia. Materials and Methods: 90 adult participants of any sex aged between 18-55yrs undergoing elective surgeries under general endo-tracheal anaesthesia were divided into 3 groups of 30 patients in each group. Group C: Control group – received 10ml of normal saline (NS) intravenously (IV) over 10 minutes (min), 10min before induction. Group D: Dexmedetomidine group - received IV Dexmedetomidine 0.6mg/kg body weight diluted to 1 0ml of NS IV over 10min using a syringe pump and 3ml of NS IV 2min before induction. Group F: Fentanyl group - received 10ml of NS IV over 10min using a syringe pump and IV Fentanyl 2mg/kg body weight dil...

MedPulse International Journal of Anesthesology

MedPulse International Journal of Anesthesology

Annals of African Medicine, 2009

Background: Nephrotic syndrome is a common childhood renal disorder; the prevalence of Urinary tr... more Background: Nephrotic syndrome is a common childhood renal disorder; the prevalence of Urinary tract infection (UTI) in these patients is high. The increased prevalence of UTI are due to immunoglobulin loss, defective T cell function, presence of ascites and relative malnutrition. Objective: The study is to evaluate the prevalence of UTI , its etiological agents, antibiotics, sensitivity pattern and the outcome in children with nephrotic syndrome. Methods: A prospective study of all patients with diagnosis of nephrotic syndrome from January 2003 to December 2006. Urine specimen were routinely obtained by clean catch method following careful preparation urethral orifices. The specimens were processed immediately. Five millimeters (5mml) loopful of the sample were inoculated on a blood agar and CLED agar plates. Identification of the organism to species level was by using stokes disc diffusion technique. Results: Forty two patients were studied. The mean age and SEM for males was 8.2 + 0.5years and females with 7.9 + 0.8years. The age range was two to fifteen years UTI was caused predominantly by Staphylococcus aureus in 67.9%, Klebsiella species (17.9%) and Pseudomonas (14.2%). There was high invitro resistance of these organisms to nalidixic acid and ampicillin but sensitive to cefotaxime, ceftriazone and ciprofloxacin. Conclusion: It is recommend that UTI should be sought for in patients with nephrotic syndrome and treatment should be prompt and appropriate.

IP innovative publication pvt. ltd, 2019

Background and Objective: To reduces the intraoperative blood loss and to provide better visibili... more Background and Objective: To reduces the intraoperative blood loss and to provide better visibility of
the surgical field controlled hypotension is used. Aim of this study is to compare dexmedetomidine and
nitroglycerine as hypotensive agents for inducing controlled hypotension in patients undergoing elective
spine surgeries.
Materials and Methods: 60 ASA class I or II adult patients undergoing elective spine surgeries were
randomly alloca ted into 2 groups of 30 participant in each group DX and group NG . Group DX received
dexmeditomidine bolus 1 microgram/kg over 10 minutes before induction and intraoperative infusion of
0.2 - 0.7 microgram per kg per hour, while group NG received nitroglycerine intraoperative infusion at
0.5 to 10 microgram/kg/ min titrated to a mean arterial pressure (MAP) of 70 - 75 mmHg. In both groups
the surgical field quality assessed using Fromme - Boezaart grading. Hemodynamic variable and adverse
events were noted. Post operative sedation was also assessed using Ramsay sedation score.
Results: The mean heart rate was significantly lower in group DX compared to group NG throughout the
procedure. (p<0.001). Mean arterial pressure were found to be significantly lower in group DX than in
group NG after induction, after intubation, end of surgery, after extubation, and post operatively (p<0.001),
but average intraoperative values were comparable in both groups. Significantly better Fromme - BoezaarT
surgical field score was noted in group DX compared to group NG during the intraoperative period.
Conclusion: Controlled hypotension using dexmeditomidine as bolus dose 1 microgram per kg intravenous
over 10 minutes prior to induction followed by continous intravenous infusion at 0.2 - 0.7 microgram per kg
per hour, provided more stable hemodynamics and better surgical field quality compared to nitroglycerine
intraoperative infusion at 0.5 to 10 microgram/kg/min.

IP innovative publication pvt ltd, 2020

Introduction and Objective: Axillary block is most commonly used regional anaesthetic technique f... more Introduction and Objective: Axillary block is most commonly used regional anaesthetic technique for
surgeries of forearm, wrist and hand surgeries. Various local anaesthetic been used for axillary block,
among them levobupivacaine has gained more interest as it prolong the duration of analgesia with reduced
cardiovascular and central nervous system toxicity. This study is done to compare the effects of 1.5%
lignocaine with 1:300000 adrenaline with the 0.333% levobupivacaine in axillary brachial plexus block
and the quality of postoperative analgesia.
Materials and Methods: After obtaining ethical committee clearance and written informed consent, 60
patients of ASA class I and II, aged between 18-60 years, posted for elective upper limb surgeries, were
randomly assigned to 2 groups of 30 in each group A and group B. Group A to receive 30ml of 1.5%
lidocaine with adrenaline 1 in 300000 and group B to receive 30ml of 0.333% levobupivacaine. Through
perivascular approach axillary brachial plexus block given using peripheral nerve stimulator. Onset and
duration of sensory and motor block, quality of block, duration of analgesia and adverse effects if any we
re evaluated.
Result: Levobupivacaine had slower onset of actions but statistically significant increased duration of
sensory and motor blockade, prolonged duration of analgesia were obtained in levobupivacaine group,
with no haemodynamic variations and adverse effects in both groups.
Conclusion: Levobupivacaine produced prolonged duration of analgesia with reduced toxic potential thus
providing greater margin of clinical safety.

Indian Journal of Clinical Anaesthesia

Background: Tracheal extubation process evokes stress response which causes autonomic variations ... more Background: Tracheal extubation process evokes stress response which causes autonomic variations such as tachycardia, rise in systolic arterial blood pressure and diastolic arterial blood pressure which is potentially lethal in high risk patients. Thus this study is conducted to compare the efficacy between 0.15mg/kg and 0.25mg/kg of iv Labetalol in the suppression of haemodynamic response to Extubation. Materials and Methods: 60 participants aged between 18-55 yrs belonging to ASA 1 or 2 were randomly allocated into 2 groups. Group Lb received injection Labetalol 0.15mg/kg and Group Lt received injection Labetalol 0.25mg/kg. Heart rate, systolic arterial blood pressure and diastolic arterial blood pressure were recorded at basal, two, five, eight minutes after drug infusion, at extubation and one, three, five, eight, ten and fifteen minutes post extubation. Results: Group Lt showed a better lowering values in heart rate, systolic arterial blood pressure and diastolic arterial blood pressure after drug infusion, at Extubation, and fifteen minutes post Extubation compared to Group Lb. Conclusion: Injection Labetalol 0.25mg/kg showed a effective suppression of haemodynamic response to Extubation compared to injection Labetalol 0.15mg/kg.

IP innovative publication pvt. ltd, 2019

anaesthesia cause noxious stimuli and are associated with laryngo- sympathetic stimulation manife... more anaesthesia cause noxious stimuli and are associated with laryngo- sympathetic stimulation manifested by hypertension, tachycardia and arrhythmias. This study compares the efficacy of dexmedetomidine and fentanyl in attenuating haemodynamic stress responses to laryngoscopic endo-tracheal intubation in adult patients undergoing surgeries under general anaesthesia. Materials and Methods: 90 adult participants of any sex aged between 18-55yrs undergoing elective surgeries under general endo-tracheal anaesthesia were divided into 3 groups of 30 patients in each group. Group C: Control group – received 10ml of normal saline (NS) intravenously (IV) over 10 minutes (min), 10min before induction. Group D: Dexmedetomidine group - received IV Dexmedetomidine 0.6mg/kg body weight diluted to 1 0ml of NS IV over 10min using a syringe pump and 3ml of NS IV 2min before induction. Group F: Fentanyl group - received 10ml of NS IV over 10min using a syringe pump and IV Fentanyl 2mg/kg body weight dil...

MedPulse International Journal of Anesthesology

MedPulse International Journal of Anesthesology

Annals of African Medicine, 2009

Background: Nephrotic syndrome is a common childhood renal disorder; the prevalence of Urinary tr... more Background: Nephrotic syndrome is a common childhood renal disorder; the prevalence of Urinary tract infection (UTI) in these patients is high. The increased prevalence of UTI are due to immunoglobulin loss, defective T cell function, presence of ascites and relative malnutrition. Objective: The study is to evaluate the prevalence of UTI , its etiological agents, antibiotics, sensitivity pattern and the outcome in children with nephrotic syndrome. Methods: A prospective study of all patients with diagnosis of nephrotic syndrome from January 2003 to December 2006. Urine specimen were routinely obtained by clean catch method following careful preparation urethral orifices. The specimens were processed immediately. Five millimeters (5mml) loopful of the sample were inoculated on a blood agar and CLED agar plates. Identification of the organism to species level was by using stokes disc diffusion technique. Results: Forty two patients were studied. The mean age and SEM for males was 8.2 + 0.5years and females with 7.9 + 0.8years. The age range was two to fifteen years UTI was caused predominantly by Staphylococcus aureus in 67.9%, Klebsiella species (17.9%) and Pseudomonas (14.2%). There was high invitro resistance of these organisms to nalidixic acid and ampicillin but sensitive to cefotaxime, ceftriazone and ciprofloxacin. Conclusion: It is recommend that UTI should be sought for in patients with nephrotic syndrome and treatment should be prompt and appropriate.

IP innovative publication pvt. ltd, 2019

Background and Objective: To reduces the intraoperative blood loss and to provide better visibili... more Background and Objective: To reduces the intraoperative blood loss and to provide better visibility of
the surgical field controlled hypotension is used. Aim of this study is to compare dexmedetomidine and
nitroglycerine as hypotensive agents for inducing controlled hypotension in patients undergoing elective
spine surgeries.
Materials and Methods: 60 ASA class I or II adult patients undergoing elective spine surgeries were
randomly alloca ted into 2 groups of 30 participant in each group DX and group NG . Group DX received
dexmeditomidine bolus 1 microgram/kg over 10 minutes before induction and intraoperative infusion of
0.2 - 0.7 microgram per kg per hour, while group NG received nitroglycerine intraoperative infusion at
0.5 to 10 microgram/kg/ min titrated to a mean arterial pressure (MAP) of 70 - 75 mmHg. In both groups
the surgical field quality assessed using Fromme - Boezaart grading. Hemodynamic variable and adverse
events were noted. Post operative sedation was also assessed using Ramsay sedation score.
Results: The mean heart rate was significantly lower in group DX compared to group NG throughout the
procedure. (p<0.001). Mean arterial pressure were found to be significantly lower in group DX than in
group NG after induction, after intubation, end of surgery, after extubation, and post operatively (p<0.001),
but average intraoperative values were comparable in both groups. Significantly better Fromme - BoezaarT
surgical field score was noted in group DX compared to group NG during the intraoperative period.
Conclusion: Controlled hypotension using dexmeditomidine as bolus dose 1 microgram per kg intravenous
over 10 minutes prior to induction followed by continous intravenous infusion at 0.2 - 0.7 microgram per kg
per hour, provided more stable hemodynamics and better surgical field quality compared to nitroglycerine
intraoperative infusion at 0.5 to 10 microgram/kg/min.

IP innovative publication pvt ltd, 2020

Introduction and Objective: Axillary block is most commonly used regional anaesthetic technique f... more Introduction and Objective: Axillary block is most commonly used regional anaesthetic technique for
surgeries of forearm, wrist and hand surgeries. Various local anaesthetic been used for axillary block,
among them levobupivacaine has gained more interest as it prolong the duration of analgesia with reduced
cardiovascular and central nervous system toxicity. This study is done to compare the effects of 1.5%
lignocaine with 1:300000 adrenaline with the 0.333% levobupivacaine in axillary brachial plexus block
and the quality of postoperative analgesia.
Materials and Methods: After obtaining ethical committee clearance and written informed consent, 60
patients of ASA class I and II, aged between 18-60 years, posted for elective upper limb surgeries, were
randomly assigned to 2 groups of 30 in each group A and group B. Group A to receive 30ml of 1.5%
lidocaine with adrenaline 1 in 300000 and group B to receive 30ml of 0.333% levobupivacaine. Through
perivascular approach axillary brachial plexus block given using peripheral nerve stimulator. Onset and
duration of sensory and motor block, quality of block, duration of analgesia and adverse effects if any we
re evaluated.
Result: Levobupivacaine had slower onset of actions but statistically significant increased duration of
sensory and motor blockade, prolonged duration of analgesia were obtained in levobupivacaine group,
with no haemodynamic variations and adverse effects in both groups.
Conclusion: Levobupivacaine produced prolonged duration of analgesia with reduced toxic potential thus
providing greater margin of clinical safety.