Vaishali Keluskar - Academia.edu (original) (raw)

Papers by Vaishali Keluskar

Journal of Indian Academy of Oral Medicine and Radiology

The maxillary canine being the last anterior tooth to erupt in the oral cavity, is commonly impac... more The maxillary canine being the last anterior tooth to erupt in the oral cavity, is commonly impacted and the reasons for which are multifocal. It is necessary to locate the position of the impacted tooth in order to carry out a proper treatment plan. Various clinical and radiologic methods have been carried out to localize the position of the impacted tooth. The most commonly used methods include the parallax / tube shift, right angle technique, occlusal and the panoramic radiographs. This article reviews the various radiographic techniques and summarizes the current literature about the localization of impacted maxillary canine. This study confirms that the single panoramic radiograph is adequate to localize the position of the impacted maxillary canine, provided that both the magnification index and the vertical restriction criteria are used.

Journal of Indian Academy of Oral Medicine and Radiology

This site may harm your computer.

Journal of Indian Academy of Oral Medicine and Radiology

Context: Various universities have set in a wave of adapting to the newer concepts of teaching–le... more Context: Various universities have set in a wave of adapting to the newer concepts of teaching–learning to keep pace with the millennial learners. Blended learning is a new teaching–learning method that combines online activity along with face-to-face activity. Flipped classroom approach is the use of Web-enabled strategies that free up class time to allow teachers to spend more time guiding their students. Aim: To assess the impact of flipped classroom approach on the teaching–learning outcomes of dental undergraduates. Settings and Design: A prospective comparative educational intervention was conducted in the Oral Medicine and Radiology department of a private dental college in Belagavi. Methods and Materials: Forty third-year undergraduates were equally allocated into the traditional learning group (20) and flipped classroom learning group (20). A pretest/posttest format was employed with mandatory feedback. For flipped classroom approach, an audio/video lecture of 10 minutes duration was shared through learning management software. The assessment was MCQs and case-based. Statistical Analysis: Mann–Whitney U and Wilcoxon matched-pairs tests were used for intergroup and intragroup comparisons, respectively. Results: The mean posttest score was significantly higher in flipped classroom method than in the traditional method (P = 0.0001). Performance on case-based questions was highly statistically significant in the flipped classroom group with a mean rank of 29.8 (P < 0.001). Intragroup comparison between the mean pretest and posttest scores in the flipped classroom showed a high statistical significance (P = 0.0001). Conclusions: Flipped classroom teaching should be recommended as it has the advantages of providing students with a pace of learning, peer learning, instant feedback, and using classroom time effectively. Faculty have to invest time, but nothing is greater than a meaningful teaching–learning experience.

International Journal of Medical Toxicology and Legal Medicine, 2008

The aim is of the study was the difference in shape of the palatal rugae in two populations of In... more The aim is of the study was the difference in shape of the palatal rugae in two populations of India. Thirty plaster casts from two population groups i.e. Karnataka and Manipur, belonging to similar age group were examined for rugae pattern (straight, wavy, curved, converge, diverge and circular) and their incidence were recorded The average number of rugae in different patterns and association of different pattern among the two groups were compared using Chi-square test and student unpaired t-test. Significant difference was observed between rugae pattern of two populations which can be used as a parameter for forensic identification.

International Journal of Advanced Research, 2017

Age estimation, modified Kvaal"s formula, coronal pulp cavity index(CPCI), maxillary second premo... more Age estimation, modified Kvaal"s formula, coronal pulp cavity index(CPCI), maxillary second premolar, periapical digital radiographs, paralleling technique. Background: Age determination has become increasingly important in forensic science not only for the identification of corpses, but also to clarify legal queries in delineating juvenile and young adults in spheres pertaining to employment, labour acts and criminal offences. It plays a crucial role in forensic medicine, especially in connection with crimes and accidents. Aim: To estimate the accuracy of age by using modified Kvaals formula and Coronal pulp cavity index. Objectives: 1. To assess the accuracy of modified Kvaal"s formula and Coronal pulp cavity index in estimating age among Indian population. 2. To compare the standard error of estimated age among both technique. 3. To establish the standard technique in assessing age among 5 groups. Methodology: 100 individuals were selected within age group of 20-70 years. Digital intraoral periapical radiographs was taken by using KODAK 8000 RVG machine with the exposure factors of 65 KVp and 8 mA for 0.2 s for either right or left side of maxillary second premolar by paralleling technique and maximum length of tooth, root and pulp were measured based on Modified KVAAL"s method and CPCI using the KODAK Dental Imaging software. Statistical analysis: The results obtained will be analyzed by using Descriptive analysis, Chi square test and ANOVA Results: Modified kvaals formula and CPCI can be used in estimation of age among Indians. To compare SEE between both techniques, Modified Kvaals method shows lesser error when compared with CPCI.

Indian Journal of Health Sciences and Biomedical Research (KLEU), 2017

Background and Objectives: The determination of sex in forensic investigation is an important and... more Background and Objectives: The determination of sex in forensic investigation is an important and crucial step. Unidentifiable crania are very common due to warfare, mass disasters, intentional attempt to obscure facial identity in criminal attacks, or physical injury caused by weapons, explosives, or fire. In such a situation, the determination of sex becomes extremely complicated and challenging. Aim: The present study was undertaken to provide data on foramen magnum and occipital condyle (OC) for the purpose of sex determination for establishing the identity in cases of unknown fragmentary skulls. Settings and Design: Retrospective. Subjects and Methods: The study group included computed tomography scan images of 200 patients (100 males and 100 females) in the age range of 21-80 years fulfilling the inclusion and exclusion criteria. Seven variables were used to measure the dimensions of foramen magnum and OC. Statistical Analysis Used: Descriptive statistics, discriminate analysis, and unpaired t-test. Results: Significant differences were observed in all the metric variables in male and female population. The dimensions of foramen magnum and OC were significantly larger in male population. Discriminant function analysis revealed an accuracy of 94% (91% in male and 97% in female population). Conclusion: The dimensions of foramen magnum and OC can be accurately used for sex determination thus opening avenues for new research in the field of anthropology and forensic sciences.

Lipomas represent only 1-2% of all soft tissue tumors of oral cavity. Though relatively not uncom... more Lipomas represent only 1-2% of all soft tissue tumors of oral cavity. Though relatively not uncommon, are rarely reported due to their benign nature. This article reveals the occurrence of lipomas in our departmental retrosp ective evaluation. It also emphasizes the need for the dentists to be aware of frequency of occurrence of intraoral lipoma so that it is included in the differential diagnosis of oral soft tissue swellings.

Quintessence international (Berlin, Germany : 1985), 2011

Changes in the microbial flora on the oral mucosa after cancerous alteration may lead to both loc... more Changes in the microbial flora on the oral mucosa after cancerous alteration may lead to both local and systemic infections. In this study, we assessed the microbial flora associated with the surfaces of oral squamous cell carcinoma. A comparative evaluation of these microbial contents was made with that of the contralateral healthy mucosa and control (healthy) mucosa. We also assessed the microbial flora from the saliva culture in subjects with oral squamous cell carcinoma and healthy controls. The case control study was made up of 30 subjects with oral squamous cell carcinoma as the study group; 30 healthy age-, sex-, habit-, and dentition-matched subjects served as the control group. In the study group, microbial samples were collected from the carcinoma site, contralateral healthy mucosa, and saliva, whereas in the control group, samples were collected from the healthy mucosa and saliva. These samples were stored on ice and subsequently transported to the laboratory in 2 mL of t...

Oral oncology, 2004

This study evaluates the efficacy of lycopene in the treatment of oral leukoplakia and compares t... more This study evaluates the efficacy of lycopene in the treatment of oral leukoplakia and compares two different doses with a placebo. Fifty-eight clinically and histologically diagnosed patients of oral leukoplakia were selected for the study. They were randomly divided into three groups. Group A: (n = 20; 8 mg lycopene/day), Group B: (n = 20; 4 mg lycopene/day) and Group C: (n = 18; placebo). The duration of the therapy was three months. Outcome was assessed clinically as well as histologically. Post-treatment patients were on follow-up for two months. Student's 't' test was used for statistical evaluation. Clinically the patients in Groups A, B, C had a mean response of 80%, 66.25% and 12.5% respectively. Histological evaluation too had similar results. Patients receiving lycopene in both regimes show highly significant difference in response as compared to placebo (Group C). The observed effect of lycopene suggests that it can be effectively and safely used for the mana...

Journal of Cranio-Maxillary Diseases, 2015

Introduction: Oral submucous fibrosis is a widely prevalent disabling disease prevalent in the In... more Introduction: Oral submucous fibrosis is a widely prevalent disabling disease prevalent in the Indian subcontinent. The role of altered immune response is stated as a factor in its etiopathogenesis. The present case-control study aims at detecting changes in major immunoglobulin levels in oral submucous fibrosis patients. Materials and Methods: The study group comprised 30 patients with oral submucous fibrosis and the control group included 25 age- and sex-matched subjects. The estimation of serum immunoglobulin level was done by single radial immunodiffusion technique. Results: The serum immunoglobulin G (IgG) and immunoglobulin M (IgM) levels were significantly increased in oral submucous fibrosis patients, while no change in the levels of immunoglobulin A (Ig A) was observed. Conclusion: The serum levels of IgG and IgM were increased in oral submucous fibrosis cases, indicating altered immune response.

Contemporary Clinical Dentistry, 2015

Gorlin-Goltz syndrome or basal cell nevus syndrome is a comparatively rare syndrome characterized... more Gorlin-Goltz syndrome or basal cell nevus syndrome is a comparatively rare syndrome characterized by basal cell nevi, odontogenic keratocysts, and skeletal anomalies. Diagnosis is based on the major and minor clinical and radiographic criteria. Dentist plays a major role in the diagnosis of this disease due to the oral and maxillofacial manifestations of the syndrome. In some cases, jaw cysts are diagnosed by routine radiographs advised by the dentists. Odontogenic keratocysts in such syndromic patients will be multiple and extensive and in some cases results in cortical expansion and facial disfigurement. Thorough clinical examination and investigations prompt an early confirmation of the syndrome, which is very essential to avoid morbidity associated with the syndrome. Here, we report a case of multiple odontogenic cysts in a 16-year-old patient which later was diagnosed as a case of Gorlin Goltz syndrome.

International journal of preventive medicine, 2013

Normal salivary function is considered to be critical for the maintenance of healthy oral mucosa.... more Normal salivary function is considered to be critical for the maintenance of healthy oral mucosa. Oral fluids provide an easily available, non-invasive medium for the diagnosis of wide range of diseases and clinical situations. The objective of this study was to estimate and compare salivary nitric oxide levels in patients with oral lichen planus and healthy individuals. Saliva was collected by spitting method. Unstimulated whole saliva thus collected was refrigerated at 4°C, and processed within 24 h for the estimation of nitric oxide levels which was done using Griess reaction. The results were analyzed using Student's "t" test. There was statistically significant difference in the levels of salivary nitric oxide between the study and control groups. The present study clearly indicates a significant increase in salivary nitric oxide levels in oral lichen planus patients as compared to controls.

Journal of Indian Academy of Oral Medicine and Radiology, 2010

Journal of Indian Academy of Oral Medicine and Radiology, 2011

The World Health Organization has strongly identified prevention and early detection as one of th... more The World Health Organization has strongly identified prevention and early detection as one of the major objectives in the control of oral cancer worldwide. Population-based mass screening of oral cancer appears to be a promising health promotion strategy with significant increase in survival rate. However, the current protocol comprising conventional visual inspection and palpation of oral soft tissues for the early detection of premalignant or malignant changes appears to be deficient. 1 Neoplastic epithelial cells tend to have an altered nuclearcytoplasmic ratio. Dehydration with acetic acid highlights this nuclear density and imparts an "acetowhite" appearance to tissue. This phenomenon can be further amplified by replacing conventional lighting with diffuse blue-white chemiluminescent illumination. This article aims to review the usefulness of this screening technology in early detection of oral cancer. The oral lumenoscopy has been proposed to be a method to improve oral screening methods which assist in the identification, evaluation and monitoring of oral mucosal changes. It is a simple, inexpensive and objective method that can provide real-time result for the detection of oral neoplasia which can be used in day to day practice by general dentist.

Journal of Indian Academy of Oral Medicine and Radiology, 2012

European Journal of General Dentistry, 2012

Increasing the consumption of fruits, vegetables, and whole grains is a practical strategy to opt... more Increasing the consumption of fruits, vegetables, and whole grains is a practical strategy to optimize good health and to reduce the risk of various chronic diseases and cancer. There are approximately 5,000 individual phytochemicals which have been identified. These interfere with multiple important cellular pathways and play an important role in maintaining balance between health and disease. This article aims to provide awareness of various additive and synergistic effects of these natural occurring chemical substances (phytochemicals) found in various fruits and vegetables. Their mechanism of action in preventing various chronic diseases and cancer is also been highlighted in this article. Grouping plant foods by color provides simplification, but it is also important as a method to help consumer′s make-wise food choices and promote health. We believe phytochemicals can be best acquired through whole-food consumption and not through the pills or an extracts.

World Journal of Dentistry, 2012

ABSTRACTOdontogenic keratocyst is a cyst of odontogenic origin that exhibits a keratinized epithe... more ABSTRACTOdontogenic keratocyst is a cyst of odontogenic origin that exhibits a keratinized epithelial lining. Odontogenic keratocyst has been the topic of numerous investigators and is known for its potentially aggressive behavior and significant rate of recurrences.1OKC cyst often occurs as a solitary lesion at the angle of the mandible, however in some instances, multiple such cysts may occur in association with a syndrome called “Nevoid basal cell syndrome”.1These patients have propensity to develop multiple neoplasm including basal cell carcinoma and medulloblastoma. Hence early diagnosis and treatment is of utmost importance in reducing the severity of long-term sequelae of this syndrome. Here we present a case of multiple odontogenic keratocysts with nevi and narrowed ribs which has profound relevance to specialist in Oral Medicine and Radiology and Oral and Maxillofacial Surgery.

Journal of Oral Science, 2011

Oral submucous fibrosis (OSMF) is a chronic, insidious and disabling condition affecting the oral... more Oral submucous fibrosis (OSMF) is a chronic, insidious and disabling condition affecting the oral cavity, being especially prevalent in India and South East Asia. However, considering its high prevalence and potential to undergo malignant transformation, OSMF has not been widely investigated with respect to levels of antioxidants, especially beta carotene. In the present study, an attempt was made to analyze serum levels of beta carotene in 45 patients with oral submucous fibrosis and 45 age-and sexmatched controls. The serum beta carotene level was estimated using the Bradley and Hornbeck method. The serum beta carotene level was significantly lower in the patients with oral submucous fibrosis than in the controls. When the values were compared between different disease stages, the maximum reduction of beta carotene was evident for Grade III OSMF, as compared with Grade I and II. From the present results, it is evident that beta carotene plays an important role in the pathogenesis of OSMF, and that its level decreases with disease progression. OSMF patients should be treated with a diet rich in beta carotene to reduce disease severity and progression towards malignancy.

Journal of Clinical Imaging Science, 2011

Gardner's syndrome is an autosomal dominant disease and is a subtype of familial adenomatous ... more Gardner's syndrome is an autosomal dominant disease and is a subtype of familial adenomatous polyposis. It is characterized by adenomatous intestinal polyps, multiple osteomas in the skull, maxillae, mandible, and multiple cutaneous and subcutaneous masses (epidermoids and desmoid). Intestinal polyps, if not treated, have 100% chance of becoming malignant. We report a case of a 25-year-old female patient with Gardner's syndrome, with clinical manifestations including impacted supernumerary teeth, odontomes, sebaceous cyst on the scalp, and osteomas. It is important for the general dental practitioners to be aware of the clinical and radiological characteristics of Gardner's syndrome.

Indian Journal of Dental Research, 2012

Angiolymphoid hyperplasia with an eosinophilia (ALHE) is a rare benign entity whose etiology and ... more Angiolymphoid hyperplasia with an eosinophilia (ALHE) is a rare benign entity whose etiology and pathogenesis is under debate. Clinically, it is characterised by cutaneous papules or nodules on the head and neck. Literature reveals very few cases of this entity in the oral mucosa. Here, we report a case of ALHE in a 25 year-old woman, who presented with a painless, 5mm x 5mm, sub mucosal erythematous nodule on left angle of mouth at lower lip. Histological examination of lip biopsy specimens revealed an increase in small vessels. The vascular walls consist of prominent endothelial cells with a histiocytoid appearance, which protruded into the lumen. Many eosinophils and lymphocytes were also seen around the vessels. The diagnosis of ALHE was made from the above findings.

Journal of Indian Academy of Oral Medicine and Radiology

The maxillary canine being the last anterior tooth to erupt in the oral cavity, is commonly impac... more The maxillary canine being the last anterior tooth to erupt in the oral cavity, is commonly impacted and the reasons for which are multifocal. It is necessary to locate the position of the impacted tooth in order to carry out a proper treatment plan. Various clinical and radiologic methods have been carried out to localize the position of the impacted tooth. The most commonly used methods include the parallax / tube shift, right angle technique, occlusal and the panoramic radiographs. This article reviews the various radiographic techniques and summarizes the current literature about the localization of impacted maxillary canine. This study confirms that the single panoramic radiograph is adequate to localize the position of the impacted maxillary canine, provided that both the magnification index and the vertical restriction criteria are used.

Journal of Indian Academy of Oral Medicine and Radiology

This site may harm your computer.

Journal of Indian Academy of Oral Medicine and Radiology

Context: Various universities have set in a wave of adapting to the newer concepts of teaching–le... more Context: Various universities have set in a wave of adapting to the newer concepts of teaching–learning to keep pace with the millennial learners. Blended learning is a new teaching–learning method that combines online activity along with face-to-face activity. Flipped classroom approach is the use of Web-enabled strategies that free up class time to allow teachers to spend more time guiding their students. Aim: To assess the impact of flipped classroom approach on the teaching–learning outcomes of dental undergraduates. Settings and Design: A prospective comparative educational intervention was conducted in the Oral Medicine and Radiology department of a private dental college in Belagavi. Methods and Materials: Forty third-year undergraduates were equally allocated into the traditional learning group (20) and flipped classroom learning group (20). A pretest/posttest format was employed with mandatory feedback. For flipped classroom approach, an audio/video lecture of 10 minutes duration was shared through learning management software. The assessment was MCQs and case-based. Statistical Analysis: Mann–Whitney U and Wilcoxon matched-pairs tests were used for intergroup and intragroup comparisons, respectively. Results: The mean posttest score was significantly higher in flipped classroom method than in the traditional method (P = 0.0001). Performance on case-based questions was highly statistically significant in the flipped classroom group with a mean rank of 29.8 (P < 0.001). Intragroup comparison between the mean pretest and posttest scores in the flipped classroom showed a high statistical significance (P = 0.0001). Conclusions: Flipped classroom teaching should be recommended as it has the advantages of providing students with a pace of learning, peer learning, instant feedback, and using classroom time effectively. Faculty have to invest time, but nothing is greater than a meaningful teaching–learning experience.

International Journal of Medical Toxicology and Legal Medicine, 2008

The aim is of the study was the difference in shape of the palatal rugae in two populations of In... more The aim is of the study was the difference in shape of the palatal rugae in two populations of India. Thirty plaster casts from two population groups i.e. Karnataka and Manipur, belonging to similar age group were examined for rugae pattern (straight, wavy, curved, converge, diverge and circular) and their incidence were recorded The average number of rugae in different patterns and association of different pattern among the two groups were compared using Chi-square test and student unpaired t-test. Significant difference was observed between rugae pattern of two populations which can be used as a parameter for forensic identification.

International Journal of Advanced Research, 2017

Age estimation, modified Kvaal"s formula, coronal pulp cavity index(CPCI), maxillary second premo... more Age estimation, modified Kvaal"s formula, coronal pulp cavity index(CPCI), maxillary second premolar, periapical digital radiographs, paralleling technique. Background: Age determination has become increasingly important in forensic science not only for the identification of corpses, but also to clarify legal queries in delineating juvenile and young adults in spheres pertaining to employment, labour acts and criminal offences. It plays a crucial role in forensic medicine, especially in connection with crimes and accidents. Aim: To estimate the accuracy of age by using modified Kvaals formula and Coronal pulp cavity index. Objectives: 1. To assess the accuracy of modified Kvaal"s formula and Coronal pulp cavity index in estimating age among Indian population. 2. To compare the standard error of estimated age among both technique. 3. To establish the standard technique in assessing age among 5 groups. Methodology: 100 individuals were selected within age group of 20-70 years. Digital intraoral periapical radiographs was taken by using KODAK 8000 RVG machine with the exposure factors of 65 KVp and 8 mA for 0.2 s for either right or left side of maxillary second premolar by paralleling technique and maximum length of tooth, root and pulp were measured based on Modified KVAAL"s method and CPCI using the KODAK Dental Imaging software. Statistical analysis: The results obtained will be analyzed by using Descriptive analysis, Chi square test and ANOVA Results: Modified kvaals formula and CPCI can be used in estimation of age among Indians. To compare SEE between both techniques, Modified Kvaals method shows lesser error when compared with CPCI.

Indian Journal of Health Sciences and Biomedical Research (KLEU), 2017

Background and Objectives: The determination of sex in forensic investigation is an important and... more Background and Objectives: The determination of sex in forensic investigation is an important and crucial step. Unidentifiable crania are very common due to warfare, mass disasters, intentional attempt to obscure facial identity in criminal attacks, or physical injury caused by weapons, explosives, or fire. In such a situation, the determination of sex becomes extremely complicated and challenging. Aim: The present study was undertaken to provide data on foramen magnum and occipital condyle (OC) for the purpose of sex determination for establishing the identity in cases of unknown fragmentary skulls. Settings and Design: Retrospective. Subjects and Methods: The study group included computed tomography scan images of 200 patients (100 males and 100 females) in the age range of 21-80 years fulfilling the inclusion and exclusion criteria. Seven variables were used to measure the dimensions of foramen magnum and OC. Statistical Analysis Used: Descriptive statistics, discriminate analysis, and unpaired t-test. Results: Significant differences were observed in all the metric variables in male and female population. The dimensions of foramen magnum and OC were significantly larger in male population. Discriminant function analysis revealed an accuracy of 94% (91% in male and 97% in female population). Conclusion: The dimensions of foramen magnum and OC can be accurately used for sex determination thus opening avenues for new research in the field of anthropology and forensic sciences.

Lipomas represent only 1-2% of all soft tissue tumors of oral cavity. Though relatively not uncom... more Lipomas represent only 1-2% of all soft tissue tumors of oral cavity. Though relatively not uncommon, are rarely reported due to their benign nature. This article reveals the occurrence of lipomas in our departmental retrosp ective evaluation. It also emphasizes the need for the dentists to be aware of frequency of occurrence of intraoral lipoma so that it is included in the differential diagnosis of oral soft tissue swellings.

Quintessence international (Berlin, Germany : 1985), 2011

Changes in the microbial flora on the oral mucosa after cancerous alteration may lead to both loc... more Changes in the microbial flora on the oral mucosa after cancerous alteration may lead to both local and systemic infections. In this study, we assessed the microbial flora associated with the surfaces of oral squamous cell carcinoma. A comparative evaluation of these microbial contents was made with that of the contralateral healthy mucosa and control (healthy) mucosa. We also assessed the microbial flora from the saliva culture in subjects with oral squamous cell carcinoma and healthy controls. The case control study was made up of 30 subjects with oral squamous cell carcinoma as the study group; 30 healthy age-, sex-, habit-, and dentition-matched subjects served as the control group. In the study group, microbial samples were collected from the carcinoma site, contralateral healthy mucosa, and saliva, whereas in the control group, samples were collected from the healthy mucosa and saliva. These samples were stored on ice and subsequently transported to the laboratory in 2 mL of t...

Oral oncology, 2004

This study evaluates the efficacy of lycopene in the treatment of oral leukoplakia and compares t... more This study evaluates the efficacy of lycopene in the treatment of oral leukoplakia and compares two different doses with a placebo. Fifty-eight clinically and histologically diagnosed patients of oral leukoplakia were selected for the study. They were randomly divided into three groups. Group A: (n = 20; 8 mg lycopene/day), Group B: (n = 20; 4 mg lycopene/day) and Group C: (n = 18; placebo). The duration of the therapy was three months. Outcome was assessed clinically as well as histologically. Post-treatment patients were on follow-up for two months. Student's 't' test was used for statistical evaluation. Clinically the patients in Groups A, B, C had a mean response of 80%, 66.25% and 12.5% respectively. Histological evaluation too had similar results. Patients receiving lycopene in both regimes show highly significant difference in response as compared to placebo (Group C). The observed effect of lycopene suggests that it can be effectively and safely used for the mana...

Journal of Cranio-Maxillary Diseases, 2015

Introduction: Oral submucous fibrosis is a widely prevalent disabling disease prevalent in the In... more Introduction: Oral submucous fibrosis is a widely prevalent disabling disease prevalent in the Indian subcontinent. The role of altered immune response is stated as a factor in its etiopathogenesis. The present case-control study aims at detecting changes in major immunoglobulin levels in oral submucous fibrosis patients. Materials and Methods: The study group comprised 30 patients with oral submucous fibrosis and the control group included 25 age- and sex-matched subjects. The estimation of serum immunoglobulin level was done by single radial immunodiffusion technique. Results: The serum immunoglobulin G (IgG) and immunoglobulin M (IgM) levels were significantly increased in oral submucous fibrosis patients, while no change in the levels of immunoglobulin A (Ig A) was observed. Conclusion: The serum levels of IgG and IgM were increased in oral submucous fibrosis cases, indicating altered immune response.

Contemporary Clinical Dentistry, 2015

Gorlin-Goltz syndrome or basal cell nevus syndrome is a comparatively rare syndrome characterized... more Gorlin-Goltz syndrome or basal cell nevus syndrome is a comparatively rare syndrome characterized by basal cell nevi, odontogenic keratocysts, and skeletal anomalies. Diagnosis is based on the major and minor clinical and radiographic criteria. Dentist plays a major role in the diagnosis of this disease due to the oral and maxillofacial manifestations of the syndrome. In some cases, jaw cysts are diagnosed by routine radiographs advised by the dentists. Odontogenic keratocysts in such syndromic patients will be multiple and extensive and in some cases results in cortical expansion and facial disfigurement. Thorough clinical examination and investigations prompt an early confirmation of the syndrome, which is very essential to avoid morbidity associated with the syndrome. Here, we report a case of multiple odontogenic cysts in a 16-year-old patient which later was diagnosed as a case of Gorlin Goltz syndrome.

International journal of preventive medicine, 2013

Normal salivary function is considered to be critical for the maintenance of healthy oral mucosa.... more Normal salivary function is considered to be critical for the maintenance of healthy oral mucosa. Oral fluids provide an easily available, non-invasive medium for the diagnosis of wide range of diseases and clinical situations. The objective of this study was to estimate and compare salivary nitric oxide levels in patients with oral lichen planus and healthy individuals. Saliva was collected by spitting method. Unstimulated whole saliva thus collected was refrigerated at 4°C, and processed within 24 h for the estimation of nitric oxide levels which was done using Griess reaction. The results were analyzed using Student's "t" test. There was statistically significant difference in the levels of salivary nitric oxide between the study and control groups. The present study clearly indicates a significant increase in salivary nitric oxide levels in oral lichen planus patients as compared to controls.

Journal of Indian Academy of Oral Medicine and Radiology, 2010

Journal of Indian Academy of Oral Medicine and Radiology, 2011

The World Health Organization has strongly identified prevention and early detection as one of th... more The World Health Organization has strongly identified prevention and early detection as one of the major objectives in the control of oral cancer worldwide. Population-based mass screening of oral cancer appears to be a promising health promotion strategy with significant increase in survival rate. However, the current protocol comprising conventional visual inspection and palpation of oral soft tissues for the early detection of premalignant or malignant changes appears to be deficient. 1 Neoplastic epithelial cells tend to have an altered nuclearcytoplasmic ratio. Dehydration with acetic acid highlights this nuclear density and imparts an "acetowhite" appearance to tissue. This phenomenon can be further amplified by replacing conventional lighting with diffuse blue-white chemiluminescent illumination. This article aims to review the usefulness of this screening technology in early detection of oral cancer. The oral lumenoscopy has been proposed to be a method to improve oral screening methods which assist in the identification, evaluation and monitoring of oral mucosal changes. It is a simple, inexpensive and objective method that can provide real-time result for the detection of oral neoplasia which can be used in day to day practice by general dentist.

Journal of Indian Academy of Oral Medicine and Radiology, 2012

European Journal of General Dentistry, 2012

Increasing the consumption of fruits, vegetables, and whole grains is a practical strategy to opt... more Increasing the consumption of fruits, vegetables, and whole grains is a practical strategy to optimize good health and to reduce the risk of various chronic diseases and cancer. There are approximately 5,000 individual phytochemicals which have been identified. These interfere with multiple important cellular pathways and play an important role in maintaining balance between health and disease. This article aims to provide awareness of various additive and synergistic effects of these natural occurring chemical substances (phytochemicals) found in various fruits and vegetables. Their mechanism of action in preventing various chronic diseases and cancer is also been highlighted in this article. Grouping plant foods by color provides simplification, but it is also important as a method to help consumer′s make-wise food choices and promote health. We believe phytochemicals can be best acquired through whole-food consumption and not through the pills or an extracts.

World Journal of Dentistry, 2012

ABSTRACTOdontogenic keratocyst is a cyst of odontogenic origin that exhibits a keratinized epithe... more ABSTRACTOdontogenic keratocyst is a cyst of odontogenic origin that exhibits a keratinized epithelial lining. Odontogenic keratocyst has been the topic of numerous investigators and is known for its potentially aggressive behavior and significant rate of recurrences.1OKC cyst often occurs as a solitary lesion at the angle of the mandible, however in some instances, multiple such cysts may occur in association with a syndrome called “Nevoid basal cell syndrome”.1These patients have propensity to develop multiple neoplasm including basal cell carcinoma and medulloblastoma. Hence early diagnosis and treatment is of utmost importance in reducing the severity of long-term sequelae of this syndrome. Here we present a case of multiple odontogenic keratocysts with nevi and narrowed ribs which has profound relevance to specialist in Oral Medicine and Radiology and Oral and Maxillofacial Surgery.

Journal of Oral Science, 2011

Oral submucous fibrosis (OSMF) is a chronic, insidious and disabling condition affecting the oral... more Oral submucous fibrosis (OSMF) is a chronic, insidious and disabling condition affecting the oral cavity, being especially prevalent in India and South East Asia. However, considering its high prevalence and potential to undergo malignant transformation, OSMF has not been widely investigated with respect to levels of antioxidants, especially beta carotene. In the present study, an attempt was made to analyze serum levels of beta carotene in 45 patients with oral submucous fibrosis and 45 age-and sexmatched controls. The serum beta carotene level was estimated using the Bradley and Hornbeck method. The serum beta carotene level was significantly lower in the patients with oral submucous fibrosis than in the controls. When the values were compared between different disease stages, the maximum reduction of beta carotene was evident for Grade III OSMF, as compared with Grade I and II. From the present results, it is evident that beta carotene plays an important role in the pathogenesis of OSMF, and that its level decreases with disease progression. OSMF patients should be treated with a diet rich in beta carotene to reduce disease severity and progression towards malignancy.

Journal of Clinical Imaging Science, 2011

Gardner's syndrome is an autosomal dominant disease and is a subtype of familial adenomatous ... more Gardner's syndrome is an autosomal dominant disease and is a subtype of familial adenomatous polyposis. It is characterized by adenomatous intestinal polyps, multiple osteomas in the skull, maxillae, mandible, and multiple cutaneous and subcutaneous masses (epidermoids and desmoid). Intestinal polyps, if not treated, have 100% chance of becoming malignant. We report a case of a 25-year-old female patient with Gardner's syndrome, with clinical manifestations including impacted supernumerary teeth, odontomes, sebaceous cyst on the scalp, and osteomas. It is important for the general dental practitioners to be aware of the clinical and radiological characteristics of Gardner's syndrome.

Indian Journal of Dental Research, 2012

Angiolymphoid hyperplasia with an eosinophilia (ALHE) is a rare benign entity whose etiology and ... more Angiolymphoid hyperplasia with an eosinophilia (ALHE) is a rare benign entity whose etiology and pathogenesis is under debate. Clinically, it is characterised by cutaneous papules or nodules on the head and neck. Literature reveals very few cases of this entity in the oral mucosa. Here, we report a case of ALHE in a 25 year-old woman, who presented with a painless, 5mm x 5mm, sub mucosal erythematous nodule on left angle of mouth at lower lip. Histological examination of lip biopsy specimens revealed an increase in small vessels. The vascular walls consist of prominent endothelial cells with a histiocytoid appearance, which protruded into the lumen. Many eosinophils and lymphocytes were also seen around the vessels. The diagnosis of ALHE was made from the above findings.