Elena Vershinina - Academia.edu (original) (raw)
Papers by Elena Vershinina
Vestnik of Saint Petersburg University. Medicine
The high prevalence of vascular diseases of the brain (mainly as a result of atherosclerotic vasc... more The high prevalence of vascular diseases of the brain (mainly as a result of atherosclerotic vascular lesions) makes the problem of rehabilitation of patients with motor disorders, poststroke disorder of higher mental functions — one of the most relevant in modern medicine. Up to 80 % of stroke patients have persistent neurological deficits. About a quarter of these cases are profound disabilities with loss of self-care. The most complete restoration of functions lost after a stroke can be achieved within the first year after the onset of an acute cerebrovascular accident. At the same time, despite the successes of modern neurorehabilitation, up to 80 % of stroke patients remain disabled. In this regard, the timely provision of adequate emergency medical care for stroke and full-fledged rehabilitation are among the most important tasks of the healthcare system, clinical neurology and neurosurgery. In this article, for use in the system of complex rehabilitation, a biofeedback method...
Family & Community Health, 2020
Studies examining the experience of children returned from foster care can reveal its causes and ... more Studies examining the experience of children returned from foster care can reveal its causes and the severity of the psychological consequences, as well as the positive effect of psychological support on family functioning. Our research was aimed at the features of children and characteristics of foster families who refuse to continue parenting foster children. The study participants were comprised of families raising a foster child (Group One-182 families), and families who refused to continue parenting and returned the child (Group Two-19 families). The study was conducted using the "standardized interview for parents" and the "list of traumatic experiences of the child." The results show that the strongest contributor to foster family breakdown was the degree of the child's traumatic experience before placement (for Group One, 3.9 (1.15); Group Two, 6.1 (1.31), U = 395.0, p < 0.001) and the minimal participation of the family in an intervention program (the total number of program activities the family did not participate in; for Group One, 48.5 (28.27)%, Group Two, 95.5 (2.58)%, U = 67.5, p < 0.001). Our data expand ideas about the functioning of foster families who have taken children with significant traumatic experience and indicate the need to improve the quality of psychological and social support to foster families as an important factor in preventing secondary returns.
Vestnik of Saint Petersburg University. Medicine, 2020
The facial nerve is most often, as compared with other cranial nerves, damaged due to surgical in... more The facial nerve is most often, as compared with other cranial nerves, damaged due to surgical interventions. In the first place, as the cause of iatrogenic damage, is neurosurgical treatment for neoplasms of the ponto-cerebellar angle and temporal bone, brain injuries. The neuropathy of the facial nerve is the cause of neurological and cosmetic defects that have a serious traumatic effect on the patient. The psychological consequences of facial neuropathy are more important for the patient than physical damage. Paresis of mimic muscles cannot be hidden and often leads to social maladjustment, isolation and a marked reduction in the quality of life. Facial neuropathy, in most cases, is not a life-threatening condition, but it definitely changes the patient’s life. This article proposes an effective rehabilitation system, tested on 172 patients with facial nerve damage after neurosurgical treatment. The combined use of physiotherapy, massage, therapeutic gymnastics, including posture...
NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY
NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY
NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY
NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY, 2021
The results of the Akabane test, conducted in 900 healthy subjects (513 women and 387 men) aged 5... more The results of the Akabane test, conducted in 900 healthy subjects (513 women and 387 men) aged 5 to 88 years on the basis of correlation, regression and factor analysis of interchannel bonds made it possible to reveal a stable dipole structure in the form of Yin / Yang monad. At the same time, in normal, on one Yin pole of the dipole there are acupuncture channels (AС) forming the primary element of Water (KI + BL). The other, opposite, Yan pole of the dipole forms the primary element Fire, which includes 4 channels: (HT + SI + PC + TE). Between the poles of the dipole is a conditional demarcation line at the level of the first elements of the Tree, Earth and Metal. Taking into account the theoretical maximum number of open points on the channels forming the 2 poles of the dipole, a 1.6 proportion is formed close to the ratio of the "Golden Section" in 1.62, which determines the harmonious state of the organism in the norm. According to the results of the Akabane test, in...
NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY, 2021
Brain Sciences, 2021
Brain-computer interfaces (BCIs), based on motor imagery, are increasingly used in neurorehabilit... more Brain-computer interfaces (BCIs), based on motor imagery, are increasingly used in neurorehabilitation. However, some people cannot control BCI, predictors of this are the features of brain activity and personality traits. It is not known whether the success of BCI control is related to interhemispheric asymmetry. The study was conducted on 44 BCI-naive subjects and included one BCI session, EEG-analysis, 16PF Cattell Questionnaire, estimation of latent left-handedness, and of subjective complexity of real and imagery movements. The success of brain states recognition during imagination of left hand (LH) movement compared to the rest is higher in reserved, practical, skeptical, and not very sociable individuals. Extraversion, liveliness, and dominance are significant for the imagination of right hand (RH) movements in “pure” right-handers, and sensitivity in latent left-handers. Subjective complexity of real LH and of imagery RH movements correlates with the success of brain states ...
Neuroscience for Medicine and Psychology, 2019
Neuroscience for Medicine and Psychology, May 13, 2019
Journal of Diabetes & Metabolism, 2018
Background: In view of its prevalence, type 2 diabetes (T2D) is a socially significant disease, w... more Background: In view of its prevalence, type 2 diabetes (T2D) is a socially significant disease, which affects millions of patients. Despite the significant advances in modern medicine, there are problems with early diagnosis and effective treatment of this disease, especially at home. In this regard, it would be interesting to pay attention to the possibility of diagnosing and treating this disease from reverse the viewpoint of traditional Chinese medicine (TCM). Methods/Design: In order to assess patterns of heat sensitivity thresholds of acupuncture channels (AC) in patients with T2D, the Akabane test was carried out on with 116 men and 190 women. For comparison, a group of healthy subjects made up of 112 men and 277 women was also used. Results: Simple effects of paired comparisons between healthy subjects and T2D in groups of men and women, showed significant differences. The most significant differences are seen in the AC connected with the digestive system. In this case, the greatest diagnostic value is the level of asymmetry between the right and left branches of these AC, which varies in proportion to the level of glycaemia. Changes in the AC are stable and precede the manifestation of the functional and organic disorders inherent in this disease. This dependence allows for early T2D diagnostics and individual monitoring. Conclusion: The combination of the Akabane test with the use of mathematical analysis in patients with T2D makes it possible to trace the entire chain of carbohydrate metabolism at an individual level and to identify regulatory violation and the compensatory mechanisms for more effective therapeutic effects.
Journal of Acupuncture and Meridian Studies, 2018
Background: Type 2 diabetes (T2D) is a socially significant disease that affects millions of pati... more Background: Type 2 diabetes (T2D) is a socially significant disease that affects millions of patients. There were an estimated 366 million people with this disease in 2011, and, according to the forecast, approximately 552 million will be affected by this disease in 2030. It is well known that the primary diagnosis and treatment of a patient with this disease are quite expensive. What should be done to make it possible for a patient to monitor his own state and provide treatment in his own home using telemedicine? To solve this problem, an alternative concept for the diagnosis, monitoring, and treatment at the basis of traditional Chinese medicine combined with mathematical methods of data processing has been used. Methods/Design: To assess the pattern thresholds of acupuncture channels of heat sensitivity in patients with T2D, the Akabane test was performed on 160 men and 243 women (total 696 tests), including the dynamics of surveillance. For comparison, a group of healthy individuals comprising 116 men and 277 women also participated. Results: It was found that the main difference between patients with T2D and the healthy individuals is the presence of a pronounced asymmetry between the right and left branches of the canals, primarily in the digestive system. At the same time, the level of asymmetry
Journal of Acupuncture and Meridian Studies, 2018
The results of the Akabane test, conducted in 900 healthy subjects (513 women and 387 men) aged 5... more The results of the Akabane test, conducted in 900 healthy subjects (513 women and 387 men) aged 5 to 88 years on the basis of correlation, regression and factor analysis of interchannel bonds made it possible to reveal a stable dipole structure in the form of Yin / Yang monad. At the same time, in normal, on one Yin pole of the dipole there are acupuncture channels (AС) forming the primary element of Water (KI + BL). The other, opposite, Yan pole of the dipole forms the primary element Fire, which includes 4 channels: (HT + SI + PC + TE). Between the poles of the dipole is a conditional demarcation line at the level of the first elements of the Tree, Earth and Metal. Taking into account the theoretical maximum number of open points on the channels forming the 2 poles of the dipole, a 1.6 proportion is formed close to the ratio of the "Golden Section" in 1.62, which determines the harmonious state of the organism in the norm. According to the results of the Akabane test, in each specific case it is possible to calculate the ratio of the poles of a dipole and thus assess the degree of harmony in the body and its potential capabilities. When assessing the changes in the dipole pole ratios as a function of age, it was found that in the early childhood and in extreme old age, the average dipole indices are equalized to 50/50%. Regression analysis showed a lifetime relationship in men with AC-TE-r, BL, LR-r in women with AC-TE-l, BL, LR-1.
BioMed Research International, 2017
We used molecular dynamics to find the average path of the A-domainH→Bconformational transition i... more We used molecular dynamics to find the average path of the A-domainH→Bconformational transition in protein kinase A Iα. We obtained thirteen productive trajectories and processed them sequentially using factor and cross-correlation analyses. The conformational transition is presented as partly deterministic sequence of six events. Event B representsH→Btransition of the phosphate binding cassette. Main participants of this event form electrostatic switch cAMP(O6)–A202(N-H)–G199(C=O). Through this switch, cAMP transmits information about its binding to hydrophobic switch L203–Y229 and thus triggers conformational transition of A-domain. Events C and D consist in N3A-motif displacement towards phosphate binding cassette and B/C-helix rotation. Event E involves an increase in interaction energy between Y229 andβ-subdomain. Taken together, events B, E, and D correspond to the hinge movement towardsβ-barrel. Transition of B/C-helix turn (a.a. 229–234) fromα-form toπ-form accounts for even...
The Chinese Journal of Physiology, 2016
Neonatal pain and stress induce long-term changes in pain sensitivity. Therefore their interrelat... more Neonatal pain and stress induce long-term changes in pain sensitivity. Therefore their interrelation is a topical subject of clinical and basic research. The present study investigated the effects of inflammatory peripheral pain and stress of maternal deprivation (MD)-isolation in 1-2-and 7-8day-old Wistar rats (P1,2 and P7,8 respectively, ages comparable to preterm and full-term human babies) on basal pain and pain sensitivity in conditions of inflammatory pain (formalin test) during adolescence. The neonatal impacts were: pain (formalin-induced, FOR in the paw), stress (a short 60-min MD), or pain+stress combination (FOR+MD), and appropriate controls. We found that stress of short-term maternal deprivation-isolation and inflammatory pain on P1,2 and P7,8 significantly increased the vulnerability of the nociceptive system to inflammatory pain. Maternal deprivationisolation on P1,2 as compared with a similar impact on P7,8 had a greater effect on pain sensitivity of the adolescent rats, but the influence of early pain was independent of the injury age. Only adolescent rats with an early combination of pain and maternal deprivation-isolation showed hypoalgesia in the hot plate (HP) test. However licking duration (reflecting pain sensitivity) in these rats did not exceed licking duration in animals exposed only to maternal deprivation-isolation or pain. This study adds new data to the growing body of work demonstrating that early noxious impacts have long-term consequences for the functional activity of the nociceptive system. Our new findings may help to understand the impact of pain and maternal separation in the neonatal intensive care unit.
Acupuncture & Electro-Therapeutics Research, 2016
In order to assess patterns of heat sensitivity thresholds in patients with diabetes mellitus, th... more In order to assess patterns of heat sensitivity thresholds in patients with diabetes mellitus, the Akabane test was carried out on patients with insulin dependent diabetes mellitus (IDDM) (250 men and 309 women) and patients with noninsulin dependent diabetes mellitus (NIDDM) (158 men and 227 women). For comparison, a group of healthy subjects made up of 116 men and 277 women was also used. As soon as we revealed the influence of factors of pathology with a high significance level and gender and the interaction “gender*pathology”, all the results are described separately for groups of men and women and for groups with IDDM and NIDDM. Simple effects of paired comparisons between healthy subjects, IDDM and NIDDM in groups of men and women, as well as comparisons between the profiles of men and women with IDDM and NIDDM showed significant differences between ACs in healthy subjects and those with each type of diabetes. The most significant differences are seen in the AC connected with ...
Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk, 2000
Repeated nocigenic stimuli applied to the skin evoked a hyperalgesia in healthy subjects while in... more Repeated nocigenic stimuli applied to the skin evoked a hyperalgesia in healthy subjects while in patients with neurasthenia which is a natural model of a chronic psychoemotional stress, they evoked a hyperalgesia accompanied by sensitization. The differences in the nociceptive system responses show particularities in reactivity (plasticity) of a wide dynamic range of the spinal neurons under chronic psychoemotional stress that is due to disorders in supraspinal descending modulation system of plasticity in the spinal nociceptive neurons.
Vestnik of Saint Petersburg University. Medicine
The high prevalence of vascular diseases of the brain (mainly as a result of atherosclerotic vasc... more The high prevalence of vascular diseases of the brain (mainly as a result of atherosclerotic vascular lesions) makes the problem of rehabilitation of patients with motor disorders, poststroke disorder of higher mental functions — one of the most relevant in modern medicine. Up to 80 % of stroke patients have persistent neurological deficits. About a quarter of these cases are profound disabilities with loss of self-care. The most complete restoration of functions lost after a stroke can be achieved within the first year after the onset of an acute cerebrovascular accident. At the same time, despite the successes of modern neurorehabilitation, up to 80 % of stroke patients remain disabled. In this regard, the timely provision of adequate emergency medical care for stroke and full-fledged rehabilitation are among the most important tasks of the healthcare system, clinical neurology and neurosurgery. In this article, for use in the system of complex rehabilitation, a biofeedback method...
Family & Community Health, 2020
Studies examining the experience of children returned from foster care can reveal its causes and ... more Studies examining the experience of children returned from foster care can reveal its causes and the severity of the psychological consequences, as well as the positive effect of psychological support on family functioning. Our research was aimed at the features of children and characteristics of foster families who refuse to continue parenting foster children. The study participants were comprised of families raising a foster child (Group One-182 families), and families who refused to continue parenting and returned the child (Group Two-19 families). The study was conducted using the "standardized interview for parents" and the "list of traumatic experiences of the child." The results show that the strongest contributor to foster family breakdown was the degree of the child's traumatic experience before placement (for Group One, 3.9 (1.15); Group Two, 6.1 (1.31), U = 395.0, p < 0.001) and the minimal participation of the family in an intervention program (the total number of program activities the family did not participate in; for Group One, 48.5 (28.27)%, Group Two, 95.5 (2.58)%, U = 67.5, p < 0.001). Our data expand ideas about the functioning of foster families who have taken children with significant traumatic experience and indicate the need to improve the quality of psychological and social support to foster families as an important factor in preventing secondary returns.
Vestnik of Saint Petersburg University. Medicine, 2020
The facial nerve is most often, as compared with other cranial nerves, damaged due to surgical in... more The facial nerve is most often, as compared with other cranial nerves, damaged due to surgical interventions. In the first place, as the cause of iatrogenic damage, is neurosurgical treatment for neoplasms of the ponto-cerebellar angle and temporal bone, brain injuries. The neuropathy of the facial nerve is the cause of neurological and cosmetic defects that have a serious traumatic effect on the patient. The psychological consequences of facial neuropathy are more important for the patient than physical damage. Paresis of mimic muscles cannot be hidden and often leads to social maladjustment, isolation and a marked reduction in the quality of life. Facial neuropathy, in most cases, is not a life-threatening condition, but it definitely changes the patient’s life. This article proposes an effective rehabilitation system, tested on 172 patients with facial nerve damage after neurosurgical treatment. The combined use of physiotherapy, massage, therapeutic gymnastics, including posture...
NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY
NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY
NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY
NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY, 2021
The results of the Akabane test, conducted in 900 healthy subjects (513 women and 387 men) aged 5... more The results of the Akabane test, conducted in 900 healthy subjects (513 women and 387 men) aged 5 to 88 years on the basis of correlation, regression and factor analysis of interchannel bonds made it possible to reveal a stable dipole structure in the form of Yin / Yang monad. At the same time, in normal, on one Yin pole of the dipole there are acupuncture channels (AС) forming the primary element of Water (KI + BL). The other, opposite, Yan pole of the dipole forms the primary element Fire, which includes 4 channels: (HT + SI + PC + TE). Between the poles of the dipole is a conditional demarcation line at the level of the first elements of the Tree, Earth and Metal. Taking into account the theoretical maximum number of open points on the channels forming the 2 poles of the dipole, a 1.6 proportion is formed close to the ratio of the "Golden Section" in 1.62, which determines the harmonious state of the organism in the norm. According to the results of the Akabane test, in...
NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY, 2021
Brain Sciences, 2021
Brain-computer interfaces (BCIs), based on motor imagery, are increasingly used in neurorehabilit... more Brain-computer interfaces (BCIs), based on motor imagery, are increasingly used in neurorehabilitation. However, some people cannot control BCI, predictors of this are the features of brain activity and personality traits. It is not known whether the success of BCI control is related to interhemispheric asymmetry. The study was conducted on 44 BCI-naive subjects and included one BCI session, EEG-analysis, 16PF Cattell Questionnaire, estimation of latent left-handedness, and of subjective complexity of real and imagery movements. The success of brain states recognition during imagination of left hand (LH) movement compared to the rest is higher in reserved, practical, skeptical, and not very sociable individuals. Extraversion, liveliness, and dominance are significant for the imagination of right hand (RH) movements in “pure” right-handers, and sensitivity in latent left-handers. Subjective complexity of real LH and of imagery RH movements correlates with the success of brain states ...
Neuroscience for Medicine and Psychology, 2019
Neuroscience for Medicine and Psychology, May 13, 2019
Journal of Diabetes & Metabolism, 2018
Background: In view of its prevalence, type 2 diabetes (T2D) is a socially significant disease, w... more Background: In view of its prevalence, type 2 diabetes (T2D) is a socially significant disease, which affects millions of patients. Despite the significant advances in modern medicine, there are problems with early diagnosis and effective treatment of this disease, especially at home. In this regard, it would be interesting to pay attention to the possibility of diagnosing and treating this disease from reverse the viewpoint of traditional Chinese medicine (TCM). Methods/Design: In order to assess patterns of heat sensitivity thresholds of acupuncture channels (AC) in patients with T2D, the Akabane test was carried out on with 116 men and 190 women. For comparison, a group of healthy subjects made up of 112 men and 277 women was also used. Results: Simple effects of paired comparisons between healthy subjects and T2D in groups of men and women, showed significant differences. The most significant differences are seen in the AC connected with the digestive system. In this case, the greatest diagnostic value is the level of asymmetry between the right and left branches of these AC, which varies in proportion to the level of glycaemia. Changes in the AC are stable and precede the manifestation of the functional and organic disorders inherent in this disease. This dependence allows for early T2D diagnostics and individual monitoring. Conclusion: The combination of the Akabane test with the use of mathematical analysis in patients with T2D makes it possible to trace the entire chain of carbohydrate metabolism at an individual level and to identify regulatory violation and the compensatory mechanisms for more effective therapeutic effects.
Journal of Acupuncture and Meridian Studies, 2018
Background: Type 2 diabetes (T2D) is a socially significant disease that affects millions of pati... more Background: Type 2 diabetes (T2D) is a socially significant disease that affects millions of patients. There were an estimated 366 million people with this disease in 2011, and, according to the forecast, approximately 552 million will be affected by this disease in 2030. It is well known that the primary diagnosis and treatment of a patient with this disease are quite expensive. What should be done to make it possible for a patient to monitor his own state and provide treatment in his own home using telemedicine? To solve this problem, an alternative concept for the diagnosis, monitoring, and treatment at the basis of traditional Chinese medicine combined with mathematical methods of data processing has been used. Methods/Design: To assess the pattern thresholds of acupuncture channels of heat sensitivity in patients with T2D, the Akabane test was performed on 160 men and 243 women (total 696 tests), including the dynamics of surveillance. For comparison, a group of healthy individuals comprising 116 men and 277 women also participated. Results: It was found that the main difference between patients with T2D and the healthy individuals is the presence of a pronounced asymmetry between the right and left branches of the canals, primarily in the digestive system. At the same time, the level of asymmetry
Journal of Acupuncture and Meridian Studies, 2018
The results of the Akabane test, conducted in 900 healthy subjects (513 women and 387 men) aged 5... more The results of the Akabane test, conducted in 900 healthy subjects (513 women and 387 men) aged 5 to 88 years on the basis of correlation, regression and factor analysis of interchannel bonds made it possible to reveal a stable dipole structure in the form of Yin / Yang monad. At the same time, in normal, on one Yin pole of the dipole there are acupuncture channels (AС) forming the primary element of Water (KI + BL). The other, opposite, Yan pole of the dipole forms the primary element Fire, which includes 4 channels: (HT + SI + PC + TE). Between the poles of the dipole is a conditional demarcation line at the level of the first elements of the Tree, Earth and Metal. Taking into account the theoretical maximum number of open points on the channels forming the 2 poles of the dipole, a 1.6 proportion is formed close to the ratio of the "Golden Section" in 1.62, which determines the harmonious state of the organism in the norm. According to the results of the Akabane test, in each specific case it is possible to calculate the ratio of the poles of a dipole and thus assess the degree of harmony in the body and its potential capabilities. When assessing the changes in the dipole pole ratios as a function of age, it was found that in the early childhood and in extreme old age, the average dipole indices are equalized to 50/50%. Regression analysis showed a lifetime relationship in men with AC-TE-r, BL, LR-r in women with AC-TE-l, BL, LR-1.
BioMed Research International, 2017
We used molecular dynamics to find the average path of the A-domainH→Bconformational transition i... more We used molecular dynamics to find the average path of the A-domainH→Bconformational transition in protein kinase A Iα. We obtained thirteen productive trajectories and processed them sequentially using factor and cross-correlation analyses. The conformational transition is presented as partly deterministic sequence of six events. Event B representsH→Btransition of the phosphate binding cassette. Main participants of this event form electrostatic switch cAMP(O6)–A202(N-H)–G199(C=O). Through this switch, cAMP transmits information about its binding to hydrophobic switch L203–Y229 and thus triggers conformational transition of A-domain. Events C and D consist in N3A-motif displacement towards phosphate binding cassette and B/C-helix rotation. Event E involves an increase in interaction energy between Y229 andβ-subdomain. Taken together, events B, E, and D correspond to the hinge movement towardsβ-barrel. Transition of B/C-helix turn (a.a. 229–234) fromα-form toπ-form accounts for even...
The Chinese Journal of Physiology, 2016
Neonatal pain and stress induce long-term changes in pain sensitivity. Therefore their interrelat... more Neonatal pain and stress induce long-term changes in pain sensitivity. Therefore their interrelation is a topical subject of clinical and basic research. The present study investigated the effects of inflammatory peripheral pain and stress of maternal deprivation (MD)-isolation in 1-2-and 7-8day-old Wistar rats (P1,2 and P7,8 respectively, ages comparable to preterm and full-term human babies) on basal pain and pain sensitivity in conditions of inflammatory pain (formalin test) during adolescence. The neonatal impacts were: pain (formalin-induced, FOR in the paw), stress (a short 60-min MD), or pain+stress combination (FOR+MD), and appropriate controls. We found that stress of short-term maternal deprivation-isolation and inflammatory pain on P1,2 and P7,8 significantly increased the vulnerability of the nociceptive system to inflammatory pain. Maternal deprivationisolation on P1,2 as compared with a similar impact on P7,8 had a greater effect on pain sensitivity of the adolescent rats, but the influence of early pain was independent of the injury age. Only adolescent rats with an early combination of pain and maternal deprivation-isolation showed hypoalgesia in the hot plate (HP) test. However licking duration (reflecting pain sensitivity) in these rats did not exceed licking duration in animals exposed only to maternal deprivation-isolation or pain. This study adds new data to the growing body of work demonstrating that early noxious impacts have long-term consequences for the functional activity of the nociceptive system. Our new findings may help to understand the impact of pain and maternal separation in the neonatal intensive care unit.
Acupuncture & Electro-Therapeutics Research, 2016
In order to assess patterns of heat sensitivity thresholds in patients with diabetes mellitus, th... more In order to assess patterns of heat sensitivity thresholds in patients with diabetes mellitus, the Akabane test was carried out on patients with insulin dependent diabetes mellitus (IDDM) (250 men and 309 women) and patients with noninsulin dependent diabetes mellitus (NIDDM) (158 men and 227 women). For comparison, a group of healthy subjects made up of 116 men and 277 women was also used. As soon as we revealed the influence of factors of pathology with a high significance level and gender and the interaction “gender*pathology”, all the results are described separately for groups of men and women and for groups with IDDM and NIDDM. Simple effects of paired comparisons between healthy subjects, IDDM and NIDDM in groups of men and women, as well as comparisons between the profiles of men and women with IDDM and NIDDM showed significant differences between ACs in healthy subjects and those with each type of diabetes. The most significant differences are seen in the AC connected with ...
Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk, 2000
Repeated nocigenic stimuli applied to the skin evoked a hyperalgesia in healthy subjects while in... more Repeated nocigenic stimuli applied to the skin evoked a hyperalgesia in healthy subjects while in patients with neurasthenia which is a natural model of a chronic psychoemotional stress, they evoked a hyperalgesia accompanied by sensitization. The differences in the nociceptive system responses show particularities in reactivity (plasticity) of a wide dynamic range of the spinal neurons under chronic psychoemotional stress that is due to disorders in supraspinal descending modulation system of plasticity in the spinal nociceptive neurons.