Vignesh Kamath - Academia.edu (original) (raw)

Papers by Vignesh Kamath

Research journal of pharmacy and technology, Feb 26, 2022

Coronavirus disease 2019 (COVID-19) is a new evolving infectious disease characterized as atypica... more Coronavirus disease 2019 (COVID-19) is a new evolving infectious disease characterized as atypical pneumonia caused by severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2). It was first seen in Wuhan, China, and later spread across the globe led to a worldwide pandemic affecting millions of people. The usual manifestations of COVID-19 include cough, sore throat, fever, dyspnoea, and fatigue with exposure recently. Most of COVID-19 patients may have mild or moderate disease, whereas severe to life-threatening disease course is seen in 5–10% of the patients. Several clinical trials are presently trying to find the most effective drug or combination of the drugs for this disease. This article aims to discuss the treatment strategies in different forms of medicine that are being used for COVID-19 patients and review the literature available.

International Journal of Dentistry

Background. To evaluate and compare the shear bond strength of feldspathic porcelain to four dist... more Background. To evaluate and compare the shear bond strength of feldspathic porcelain to four distinctively surface-treated Ni-Cr and Co-Cr alloys and to assess the impact of oxidation-heat treatment on porcelain to base metal alloy bond strength. Methods. 40 specimens each of nickel-chromium alloy and cobalt-chromium alloy were cast. A total of four groups of specimens were created. Group I was surface-treated by sandblasting with 50 μm alumina particles, Group II was surface-treated by sandblasting with 110 μm alumina particles, Group III and Group IV were surface-treated with 250 μm alumina particles. In Group IV, after sandblasting initially with 250 μm alumina particles, the alloys were subjected to oxidation and resandblasting with 250 μm alumina particles. Each of the specimen was coated with opaque and body porcelain and fired to a total thickness of 2 mm porcelain. A universal measuring machine was used to assess shear bond strength at a crosshead speed of 0.5 mm/min. Result...

Research Journal of Pharmacy and Technology, 2021

Aim: To assess the knowledge and attitude of students of dental schools in Southern India towards... more Aim: To assess the knowledge and attitude of students of dental schools in Southern India towards Basic Life Support (BLS), as well as to study the retention of BLS knowledge over time. Subjects and methods: A prevalidated questionnaire was employed, which contains 12 knowledge Questions and five questions designed to assess the students perspective towards BLS. It was hosted on Google Forms, and the URL was distributed to the Students. Results: A total of 267 responses were received, of which 66 were males and 201 were female students. Out of a maximum possible score of 12, the mean knowledge score of the group was 4.54. It was found that those who attended a BLS workshop within the last 2 years scored significantly better than those who either took it more than 2 years ago or had never undergone BLS training. Almost all participants (96%) agreed that there is a need for BLS to be learned by all dental students and hence BLS training should be part of the dental curriculum. 76.8% o...

International Journal of Dentistry, 2022

Purpose. To investigate and compare the cellular host response of human gingival fibroblasts (HGF... more Purpose. To investigate and compare the cellular host response of human gingival fibroblasts (HGF) on four currently used cements. Methods and Material. 5 cement pellet samples were made for each of the 4 test cements (n = 20). The cements used for this study were zinc phosphate, zinc oxide noneugenol (ZOE), RelyX U200, and glass ionomer cement (GIC). One commercially available cell line was used to investigate the cytotoxicity of peri-implant tissues. Direct contact cell culture testing was conducted following International Organization for Standardization (ISO) methods 10993-5 and 10993-12 (MTT assay test). Cell cultures without dental cement were considered as control. Cells were allowed to grow and confluence over 48 hours after subcultivation according to standard laboratory procedures. The cells were kept in direct contact with the cement samples for 24 hours before being subjected to analysis. All specimens were tested in triplicate to validate the results. Quantitative evalu...

International Journal of Dentistry, 2022

Purpose. The purpose of this study was to evaluate and compare the strain developed in D2 and D3 ... more Purpose. The purpose of this study was to evaluate and compare the strain developed in D2 and D3 types of bones on vertical loading by platform switch implants of different diameters. Materials and Methods. Implants of diameters 3.25 mm, 4.2 mm, and 5.0 mm and of length 11.5 mm were taken and placed each on D2 and D3 bone models. Strain gauges were attached on the buccal and the lingual sides on each of these samples, and a vertical load of 190N was placed on the samples. The strain was recorded using a data logger. The data obtained was analysed using one-way ANOVA and post hoc Tukey test. Results. In D2 and D3 bone models, 3.25 mm significantly showed greater bone strain values. The buccal side strain was higher irrespective of the implant diameter and density of bone. Conclusion. Within the limitations of the study, it may be concluded that the narrow diameter implant produces greater strain than 4.2 and 5.0 mm diameter implants, respectively. The buccal side consistently produce...

Research Journal of Pharmacy and Technology, 2021

Nano technology is the science and engineering related to particles sized 10-9 of a meter. Albeit... more Nano technology is the science and engineering related to particles sized 10-9 of a meter. Albeit, the small size, they have opened up a huge array of possibilities for this world. By the inclusion of nanoparticles in various materials not only, the field of engineering but also, medical and dentistry have been benefitted largely. Researchers have manipulated the particles at a molecular and atomic level, which have opened up huge possibilities for the same material. The recent advances have helped to achieve accurate and fast diagnosis, helped to prolong the longevity of dental materials and hence helped to create a healthy oral environment. However, with all these developments, it is important that we focus on the shortcoming or the hazards too and carefully comply with the same before its long-term application. Therefore, this article focuses on the basis, all the present applications of Nano dentistry and the potential it holds for the field of dentistry in future.

Journal of Forensic Medicine, 2021

Introduction: Traumatic dental injuries are common among children owing to their developingneurom... more Introduction: Traumatic dental injuries are common among children owing to their developingneuromusculoskeletal responses. This study aims at assessment of knowledge, attitude and practice towardsmanagement of trauma to anterior teeth among faculty members and students of Medical College.Materials and Method: A cross sectional survey with pretested questionnaire was used to assess thedemographics of the participants along with their knowledge regarding dental trauma, their attitude andpractices to handle them. Total of 200 participants comprising, 150 students and 50 faculty members ofthe dental institute were part of this study. Descriptive statistics was used to represent each category. Also,inferential statistical methods were used to assess any significant differences between the groups whensignificance level is kept at 5%.Results: The findings showed that almost 40% of the participants had experienced dental trauma before,the most common trauma that they encountered was tooth f...

Objective: T o evaluate the prevalence of temporomandibular disorders (TMD) in students and to e... more Objective: T o evaluate the prevalence of temporomandibular disorders (TMD) in students and to evaluate if any relationship existed between the stress levels, salivary cortisol levels, and TMD . Material and Methods: A total of 348 students, 187 female, and 161 male students, participated in this cross-sectional study. Students were evaluated based on the Research Diagnostic Criteria for TMD. The stress levels were evaluated using the Perceived Stress Scale. The students were divided into the control and TMD groups. Salivary cortisol levels in the salivary samples were analyzed. Results: The prevalence rate of TMDs was 30.7% in the study population. Of the female students, 61% had TMD compared with 46% of male students. Muscle disorders were the most predominant disorder in 14.2% of the students with TMD. The TMD group showed significantly higher salivary cortisol and stress levels than the control group. The TMD group also showed a moderate positive correlation between cortisol...

Indian Journal of Forensic Medicine & Toxicology, 2020

Background: Toothbrushes play a significant role in disease transmission as they act as a reservo... more Background: Toothbrushes play a significant role in disease transmission as they act as a reservoir for microorganisms and aid in increasing the risk of infection in any individual. In recent years, the necessity of toothbrush disinfection has gained importance. Toothbrush disinfection should be recommended as a routine practice for all individuals. This study aimed to assess the knowledge, attitude, and practice of undergraduate students regarding toothbrush contamination and disinfection. Materials and methods: This study involved 446 undergraduate students between the age group of 18 to 23 years. A validated questionnaire was used to assess the knowledge, attitude, and practice of undergraduate students regarding toothbrush contamination and disinfection. The study showed that 24.89% of the students disinfected their toothbrushes and 75.11% did not use any disinfectant. 78.92% of the students feel that bacteria as the main mode of toothbrush contamination. 84.40% of the students feel that the disinfection of the toothbrush is necessary whereas 15.69% feel that toothbrush disinfection is not necessary. 61.29% of students did not know toothbrush disinfection. Conclusion: Fewer students have sufficient knowledge about toothbrush contamination and practice the disinfection methods, whereas the majority of the students are unaware of the contamination of toothbrushes and the use of disinfectant methods.

Journal of critical reviews, 2020

Digital technologies have advanced rapidly in the last few years. New technological innovations h... more Digital technologies have advanced rapidly in the last few years. New technological innovations have emerged in dentistry, resulting in clinical procedures becoming easier for the clinician, and more precise. As technology advances, the up-gradation of earlier versions is also evolving. Intraoral scanners have a broad application in Prosthodontics and have gained a lot of popularity since its introduction. This article provides an insight into clinical applications of digital impression in Prosthodontics.

Journal of critical reviews, 2020

Dating back to the last universal common ancestor (LUCA), the P-loop NTPases and Rossmanns now co... more Dating back to the last universal common ancestor (LUCA), the P-loop NTPases and Rossmanns now comprise the most ubiquitous and diverse enzyme lineages. Intriguing similarities in their overall architecture and phosphate binding motifs suggest common ancestry; however, due to a lack of sequence identity and some fundamental structural differences, these families are considered independent emergences. To address this longstanding dichotomy, we systematically searched for 'bridge proteins' with structure and sequence elements shared by both lineages. We detected homologous segments that span the first βαβ segment of both lineages and include two key functional motifs: (i) a phosphate binding loop-the 'Walker A' motif of P-loop NTPases or the Rossmann equivalent, both residing at the N-terminus of α 1; and (ii) an Asp at the tip of β 2. The latter comprises the 'Walker B' aspartate that chelates the catalytic metal in P-loop NTPases, or the canonical Rossmann β 2-Asp that binds the cofactor's ribose moiety. Tubulin, a Rossmann GTPase, demonstrates the potential of the β 2-Asp to take either one of these two roles. We conclude that common P-loops/Rossmann ancestry is plausible, although convergence cannot be completely ruled out. Regardless, both lineages most likely emerged from a polypeptide comprising a βαβ segment carrying the above two functional motifs, a segment that comprises the core of both enzyme families to this very day.

Shiraz E-Medical Journal, 2019

Indian Journal of Public Health Research & Development, 2019

Indian Journal of Public Health Research & Development, 2019

The Journal of Indian Prosthodontic Society, 2018

Research Journal of Pharmacy and Technology, 2020

A clinician should have complete information about the drugs being prescribed as the vital aspect... more A clinician should have complete information about the drugs being prescribed as the vital aspect of the treatment. It is necessary to know about the indications and possible interactions of the drug to provide a correct and safe treatment to the patients. This article aims to provide useful information about the common medications used in Prosthodontics, to make proper assessment while prescribing them to the patients.

Research journal of pharmacy and technology, Feb 26, 2022

Coronavirus disease 2019 (COVID-19) is a new evolving infectious disease characterized as atypica... more Coronavirus disease 2019 (COVID-19) is a new evolving infectious disease characterized as atypical pneumonia caused by severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2). It was first seen in Wuhan, China, and later spread across the globe led to a worldwide pandemic affecting millions of people. The usual manifestations of COVID-19 include cough, sore throat, fever, dyspnoea, and fatigue with exposure recently. Most of COVID-19 patients may have mild or moderate disease, whereas severe to life-threatening disease course is seen in 5–10% of the patients. Several clinical trials are presently trying to find the most effective drug or combination of the drugs for this disease. This article aims to discuss the treatment strategies in different forms of medicine that are being used for COVID-19 patients and review the literature available.

International Journal of Dentistry

Background. To evaluate and compare the shear bond strength of feldspathic porcelain to four dist... more Background. To evaluate and compare the shear bond strength of feldspathic porcelain to four distinctively surface-treated Ni-Cr and Co-Cr alloys and to assess the impact of oxidation-heat treatment on porcelain to base metal alloy bond strength. Methods. 40 specimens each of nickel-chromium alloy and cobalt-chromium alloy were cast. A total of four groups of specimens were created. Group I was surface-treated by sandblasting with 50 μm alumina particles, Group II was surface-treated by sandblasting with 110 μm alumina particles, Group III and Group IV were surface-treated with 250 μm alumina particles. In Group IV, after sandblasting initially with 250 μm alumina particles, the alloys were subjected to oxidation and resandblasting with 250 μm alumina particles. Each of the specimen was coated with opaque and body porcelain and fired to a total thickness of 2 mm porcelain. A universal measuring machine was used to assess shear bond strength at a crosshead speed of 0.5 mm/min. Result...

Research Journal of Pharmacy and Technology, 2021

Aim: To assess the knowledge and attitude of students of dental schools in Southern India towards... more Aim: To assess the knowledge and attitude of students of dental schools in Southern India towards Basic Life Support (BLS), as well as to study the retention of BLS knowledge over time. Subjects and methods: A prevalidated questionnaire was employed, which contains 12 knowledge Questions and five questions designed to assess the students perspective towards BLS. It was hosted on Google Forms, and the URL was distributed to the Students. Results: A total of 267 responses were received, of which 66 were males and 201 were female students. Out of a maximum possible score of 12, the mean knowledge score of the group was 4.54. It was found that those who attended a BLS workshop within the last 2 years scored significantly better than those who either took it more than 2 years ago or had never undergone BLS training. Almost all participants (96%) agreed that there is a need for BLS to be learned by all dental students and hence BLS training should be part of the dental curriculum. 76.8% o...

International Journal of Dentistry, 2022

Purpose. To investigate and compare the cellular host response of human gingival fibroblasts (HGF... more Purpose. To investigate and compare the cellular host response of human gingival fibroblasts (HGF) on four currently used cements. Methods and Material. 5 cement pellet samples were made for each of the 4 test cements (n = 20). The cements used for this study were zinc phosphate, zinc oxide noneugenol (ZOE), RelyX U200, and glass ionomer cement (GIC). One commercially available cell line was used to investigate the cytotoxicity of peri-implant tissues. Direct contact cell culture testing was conducted following International Organization for Standardization (ISO) methods 10993-5 and 10993-12 (MTT assay test). Cell cultures without dental cement were considered as control. Cells were allowed to grow and confluence over 48 hours after subcultivation according to standard laboratory procedures. The cells were kept in direct contact with the cement samples for 24 hours before being subjected to analysis. All specimens were tested in triplicate to validate the results. Quantitative evalu...

International Journal of Dentistry, 2022

Purpose. The purpose of this study was to evaluate and compare the strain developed in D2 and D3 ... more Purpose. The purpose of this study was to evaluate and compare the strain developed in D2 and D3 types of bones on vertical loading by platform switch implants of different diameters. Materials and Methods. Implants of diameters 3.25 mm, 4.2 mm, and 5.0 mm and of length 11.5 mm were taken and placed each on D2 and D3 bone models. Strain gauges were attached on the buccal and the lingual sides on each of these samples, and a vertical load of 190N was placed on the samples. The strain was recorded using a data logger. The data obtained was analysed using one-way ANOVA and post hoc Tukey test. Results. In D2 and D3 bone models, 3.25 mm significantly showed greater bone strain values. The buccal side strain was higher irrespective of the implant diameter and density of bone. Conclusion. Within the limitations of the study, it may be concluded that the narrow diameter implant produces greater strain than 4.2 and 5.0 mm diameter implants, respectively. The buccal side consistently produce...

Research Journal of Pharmacy and Technology, 2021

Nano technology is the science and engineering related to particles sized 10-9 of a meter. Albeit... more Nano technology is the science and engineering related to particles sized 10-9 of a meter. Albeit, the small size, they have opened up a huge array of possibilities for this world. By the inclusion of nanoparticles in various materials not only, the field of engineering but also, medical and dentistry have been benefitted largely. Researchers have manipulated the particles at a molecular and atomic level, which have opened up huge possibilities for the same material. The recent advances have helped to achieve accurate and fast diagnosis, helped to prolong the longevity of dental materials and hence helped to create a healthy oral environment. However, with all these developments, it is important that we focus on the shortcoming or the hazards too and carefully comply with the same before its long-term application. Therefore, this article focuses on the basis, all the present applications of Nano dentistry and the potential it holds for the field of dentistry in future.

Journal of Forensic Medicine, 2021

Introduction: Traumatic dental injuries are common among children owing to their developingneurom... more Introduction: Traumatic dental injuries are common among children owing to their developingneuromusculoskeletal responses. This study aims at assessment of knowledge, attitude and practice towardsmanagement of trauma to anterior teeth among faculty members and students of Medical College.Materials and Method: A cross sectional survey with pretested questionnaire was used to assess thedemographics of the participants along with their knowledge regarding dental trauma, their attitude andpractices to handle them. Total of 200 participants comprising, 150 students and 50 faculty members ofthe dental institute were part of this study. Descriptive statistics was used to represent each category. Also,inferential statistical methods were used to assess any significant differences between the groups whensignificance level is kept at 5%.Results: The findings showed that almost 40% of the participants had experienced dental trauma before,the most common trauma that they encountered was tooth f...

Objective: T o evaluate the prevalence of temporomandibular disorders (TMD) in students and to e... more Objective: T o evaluate the prevalence of temporomandibular disorders (TMD) in students and to evaluate if any relationship existed between the stress levels, salivary cortisol levels, and TMD . Material and Methods: A total of 348 students, 187 female, and 161 male students, participated in this cross-sectional study. Students were evaluated based on the Research Diagnostic Criteria for TMD. The stress levels were evaluated using the Perceived Stress Scale. The students were divided into the control and TMD groups. Salivary cortisol levels in the salivary samples were analyzed. Results: The prevalence rate of TMDs was 30.7% in the study population. Of the female students, 61% had TMD compared with 46% of male students. Muscle disorders were the most predominant disorder in 14.2% of the students with TMD. The TMD group showed significantly higher salivary cortisol and stress levels than the control group. The TMD group also showed a moderate positive correlation between cortisol...

Indian Journal of Forensic Medicine & Toxicology, 2020

Background: Toothbrushes play a significant role in disease transmission as they act as a reservo... more Background: Toothbrushes play a significant role in disease transmission as they act as a reservoir for microorganisms and aid in increasing the risk of infection in any individual. In recent years, the necessity of toothbrush disinfection has gained importance. Toothbrush disinfection should be recommended as a routine practice for all individuals. This study aimed to assess the knowledge, attitude, and practice of undergraduate students regarding toothbrush contamination and disinfection. Materials and methods: This study involved 446 undergraduate students between the age group of 18 to 23 years. A validated questionnaire was used to assess the knowledge, attitude, and practice of undergraduate students regarding toothbrush contamination and disinfection. The study showed that 24.89% of the students disinfected their toothbrushes and 75.11% did not use any disinfectant. 78.92% of the students feel that bacteria as the main mode of toothbrush contamination. 84.40% of the students feel that the disinfection of the toothbrush is necessary whereas 15.69% feel that toothbrush disinfection is not necessary. 61.29% of students did not know toothbrush disinfection. Conclusion: Fewer students have sufficient knowledge about toothbrush contamination and practice the disinfection methods, whereas the majority of the students are unaware of the contamination of toothbrushes and the use of disinfectant methods.

Journal of critical reviews, 2020

Digital technologies have advanced rapidly in the last few years. New technological innovations h... more Digital technologies have advanced rapidly in the last few years. New technological innovations have emerged in dentistry, resulting in clinical procedures becoming easier for the clinician, and more precise. As technology advances, the up-gradation of earlier versions is also evolving. Intraoral scanners have a broad application in Prosthodontics and have gained a lot of popularity since its introduction. This article provides an insight into clinical applications of digital impression in Prosthodontics.

Journal of critical reviews, 2020

Dating back to the last universal common ancestor (LUCA), the P-loop NTPases and Rossmanns now co... more Dating back to the last universal common ancestor (LUCA), the P-loop NTPases and Rossmanns now comprise the most ubiquitous and diverse enzyme lineages. Intriguing similarities in their overall architecture and phosphate binding motifs suggest common ancestry; however, due to a lack of sequence identity and some fundamental structural differences, these families are considered independent emergences. To address this longstanding dichotomy, we systematically searched for 'bridge proteins' with structure and sequence elements shared by both lineages. We detected homologous segments that span the first βαβ segment of both lineages and include two key functional motifs: (i) a phosphate binding loop-the 'Walker A' motif of P-loop NTPases or the Rossmann equivalent, both residing at the N-terminus of α 1; and (ii) an Asp at the tip of β 2. The latter comprises the 'Walker B' aspartate that chelates the catalytic metal in P-loop NTPases, or the canonical Rossmann β 2-Asp that binds the cofactor's ribose moiety. Tubulin, a Rossmann GTPase, demonstrates the potential of the β 2-Asp to take either one of these two roles. We conclude that common P-loops/Rossmann ancestry is plausible, although convergence cannot be completely ruled out. Regardless, both lineages most likely emerged from a polypeptide comprising a βαβ segment carrying the above two functional motifs, a segment that comprises the core of both enzyme families to this very day.

Shiraz E-Medical Journal, 2019

Indian Journal of Public Health Research & Development, 2019

Indian Journal of Public Health Research & Development, 2019

The Journal of Indian Prosthodontic Society, 2018

Research Journal of Pharmacy and Technology, 2020

A clinician should have complete information about the drugs being prescribed as the vital aspect... more A clinician should have complete information about the drugs being prescribed as the vital aspect of the treatment. It is necessary to know about the indications and possible interactions of the drug to provide a correct and safe treatment to the patients. This article aims to provide useful information about the common medications used in Prosthodontics, to make proper assessment while prescribing them to the patients.