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Papers by Vikrant Gadkari
International journal of scientific research, 2019
INTRODUCTION: Laparoscopic Cholesystectomy is removal of Gall Bladder through abdominal ports whi... more INTRODUCTION: Laparoscopic Cholesystectomy is removal of Gall Bladder through abdominal ports which is appreciably associated with postoperative nausea & vomiting (PONV) resulting in increased morbidity and discomforts after the surgery in quite a number of patients. Our study was aimed to compare the efficacy of Ondansetron plus Dexamethasone and only Ondansetron as an antiemetic 30 minutes prior to elective laparoscopic Cholecystectomy. METHODS: In this randomised double blind study, 80 patients of both sexes of ASA I and II aged between 16 to 60 yrs received 4 mg Ondansetron (Group C, n = 40), Ondansetron 4 mg plus Dexamethasone 8 mg (Group T, n=40) intravenously half an hour before induction of general anaesthesia. Peri operative care was standardised in all patients. Patient was then observed for 24 hours postoperatively for any episode of PONV and any adverse effects of the study drugs. RESULTS: A complete response (defined as no PONV and no need for another antiemetic) was achieved in 62% of the patients receiving Ondansetron only and 85% of patients receiving Ondansetron plus Dexamethasone (P<0.05). The overall cumulative incidences (0-24 hrs) of PONV were 64% in Ondansetron only group, 36% in combination group (P<0.05). No difference in adverse events was observed in between group. CONCLUSION: We concluded that combination of Ondansetron plus Dexamethasone is better than Ondansetron alone as an antiemetic prophylaxis for PONV following laparoscopic cholecystectomy.
International Journal of Medical and Health Sciences, 2018
Introduction: Volatile anesthetics enhance the action of neuromuscular blockade (NMB) by various ... more Introduction: Volatile anesthetics enhance the action of neuromuscular blockade (NMB) by various degrees. The purpose of this study is to compare the muscle relaxant effects of isoflurane and sevoflurane, in the context of routinely used muscle relaxants viz. vecuronium and rocuronium. Material and methods: 80 patients were divided in a randomized manner into 4 groups of 20 each to receive a combination of an inhalational agent with a muscle relaxant. The time required for intubation and extubation were calculated using Train of Four (TOF) monitoring. Result: The group with vecuronium as muscle relaxant had significantly longer time for intubation and extubation with both inhalational agents. The group with sevoflurane as inhalational agent with vecuronium had significantly lower intubation and extubation time as compared to the group with isoflurane as inhalational agent with vecuronium as muscle relaxant. Isoflurane and sevoflurane equally affected intubation and extubation times ...
International journal of scientific research, 2019
INTRODUCTION: Laparoscopic Cholesystectomy is removal of Gall Bladder through abdominal ports whi... more INTRODUCTION: Laparoscopic Cholesystectomy is removal of Gall Bladder through abdominal ports which is appreciably associated with postoperative nausea & vomiting (PONV) resulting in increased morbidity and discomforts after the surgery in quite a number of patients. Our study was aimed to compare the efficacy of Ondansetron plus Dexamethasone and only Ondansetron as an antiemetic 30 minutes prior to elective laparoscopic Cholecystectomy. METHODS: In this randomised double blind study, 80 patients of both sexes of ASA I and II aged between 16 to 60 yrs received 4 mg Ondansetron (Group C, n = 40), Ondansetron 4 mg plus Dexamethasone 8 mg (Group T, n=40) intravenously half an hour before induction of general anaesthesia. Peri operative care was standardised in all patients. Patient was then observed for 24 hours postoperatively for any episode of PONV and any adverse effects of the study drugs. RESULTS: A complete response (defined as no PONV and no need for another antiemetic) was achieved in 62% of the patients receiving Ondansetron only and 85% of patients receiving Ondansetron plus Dexamethasone (P<0.05). The overall cumulative incidences (0-24 hrs) of PONV were 64% in Ondansetron only group, 36% in combination group (P<0.05). No difference in adverse events was observed in between group. CONCLUSION: We concluded that combination of Ondansetron plus Dexamethasone is better than Ondansetron alone as an antiemetic prophylaxis for PONV following laparoscopic cholecystectomy.
International Journal of Medical and Health Sciences, 2018
Introduction: Volatile anesthetics enhance the action of neuromuscular blockade (NMB) by various ... more Introduction: Volatile anesthetics enhance the action of neuromuscular blockade (NMB) by various degrees. The purpose of this study is to compare the muscle relaxant effects of isoflurane and sevoflurane, in the context of routinely used muscle relaxants viz. vecuronium and rocuronium. Material and methods: 80 patients were divided in a randomized manner into 4 groups of 20 each to receive a combination of an inhalational agent with a muscle relaxant. The time required for intubation and extubation were calculated using Train of Four (TOF) monitoring. Result: The group with vecuronium as muscle relaxant had significantly longer time for intubation and extubation with both inhalational agents. The group with sevoflurane as inhalational agent with vecuronium had significantly lower intubation and extubation time as compared to the group with isoflurane as inhalational agent with vecuronium as muscle relaxant. Isoflurane and sevoflurane equally affected intubation and extubation times ...