Viktorija Dragojević-simić - Academia.edu (original) (raw)
Papers by Viktorija Dragojević-simić
Vojnosanitetski Pregled, 2006
European Journal of Hospital Pharmacy
Hospital Pharmacology - International Multidisciplinary Journal
Introduction: Precision medicine is an approach that considers genetics, environment and lifestyl... more Introduction: Precision medicine is an approach that considers genetics, environment and lifestyle factors when prevent and treat diff erent diseases. The important part of precision medicine is pharmacogeneticss, a branch of clinical pharmacology that analyzes how genetic makeup aff ects the response to the drugs. Methods: Since oncology is a fi eld of particular interest in precision medicine, this article summarizes the basic principles of pharmacogenetics testing in cancer treatment. Topic: The following topics have been discussed: Samples for pharmacogenetics testing (peripheral blood, tumor biopsy, liquid biopsy), methods in pharmacogenetics testing (conventional hotspot methods and comprehensive genome profi ling), comprehensive genome profi ling (CGP) in clinical settings and oncology therapy in Serbia that depends on genetic testing. Conclusion: Pharmacogenetics testing provides the delivery of safe and effi cient therapy. The usage of CGP methods opens up the possibility for the usage of therapies directed to genetic markers across tumor types. However, this approach needs evaluation through well-designed research projects and clinical trials.
Serbian Journal of Anesthesia and Intensive Therapy
Serbian Journal of Anesthesia and Intensive Therapy
Spironolakton je kompetitivni neselektivni blokator mineralokortikoidnih receptora koji imaju vis... more Spironolakton je kompetitivni neselektivni blokator mineralokortikoidnih receptora koji imaju visok afinitet za aldosteron. Spironolakton se primenjuje u različitim stanjima zbog svog diuretskog i antihipertenzivnog efekta, u tretmanu edema kod kongestivne srčane insuficijencije, ciroze jetre sa ascitom i edemima, nefrotskog sindroma, malignog ascita, teške srčane insuficijencije i kod primarnog hiperaldosteronizma. Danas je spironolakton preporučen za terapiju rezistentne hipertenzije. Cilj narativnog revijalnog rada je da prikaže farmakodinamski i farmakokinetski profil spironolaktona i da obrazloži njegovo mesto u terapiji rezistentne hipertenzije.
Libyan Journal of Medicine
Introduction: Clostridioides difficile (C. difficile) infection (CDI) is one of the most common h... more Introduction: Clostridioides difficile (C. difficile) infection (CDI) is one of the most common healthcare-associated (HA) infections in contemporary medicine. The risk factors (RFs) for HA CDI in medical and surgical patients are poorly investigated in countries with a limited resource healthcare system. Therefore, the aim of the study was to investigate differences in patients' characteristics, factors related to healthcare and outcomes associated with HA CDI in surgical and medical patients in tertiary healthcare centre in Serbia. Materials and Methods: A prospective cohort study was conducted including adult patients diagnosed with initial episode of HA CDI, first recurrence of disease, readmission to hospital, while deaths within 30 days of CDI diagnosis and in-hospital mortality were also recorded. Patients hospitalized for any non-surgical illness, who developed initial HA CDI were assigned to medical group, whereas those who developed initial HA CDI after surgical procedures were in surgical group. The data on patients' characteristics and factors related to healthcare were collected, too. Results: During 7-year period, from 553 patients undergoing in-hospital treatment and diagnosed with CDI, 268 (48.5%) and 285 (51.5%) were surgical and medical patients, respectively. Age ≥ 65 years, use of proton pump inhibitors, chemotherapy and fluoroquinolones were positively associated with being in medical group, whereas admission to intensive care unit and use of second-and third-generation cephalosporins were positively associated with being in surgical group. Conclusions: Based on obtained results, including significant differences in 30-day mortality and in-hospital mortality, it can be concluded that medical patient were more endangered with HA CDI than surgical ones.
Hospital Pharmacology - International Multidisciplinary Journal
Metamizole is a nonsteroidal anti-infl ammatory drug, with analgesic, antipyretic, spasmolytic, a... more Metamizole is a nonsteroidal anti-infl ammatory drug, with analgesic, antipyretic, spasmolytic, and weak anti-infl ammatory properties. The analgesic eff ect of metamizole seems to be based on the inhibition of cyclooxygenase enzyme activity and stimulation of cannabinoid receptors. Its use is still controversial, mainly due to agranulocytosis, metamizole-induced serious adverse reaction. While in many countries it is withdrawn from the market, in some countries metamizole is available as a medication prescribed for strictly defi ned indications, while in the others like Mexico, Brazil and China it can be obtained as an Over-The-Counter drug. The most common adverse eff ects of metamizole are the skin and subcutaneous tissue disorders. Metamizole appears to be of similar effi cacy to analgesics which are frequently used in the treatment of moderate to severe postoperative pain.
The Journal of Infection in Developing Countries
Introduction: Healthcare-associated infections (HAIs) and irrational use of antibiotics in health... more Introduction: Healthcare-associated infections (HAIs) and irrational use of antibiotics in healthcare settings are major global public health concerns. Surveillance of HAIs in intensive care units (ICU), surgical-site infections (SSIs), and Clostridium difficile infections (CDIs), together with implementation of antibiotic stewardship, are cornerstones of hospital infection prevention programs. The aim of this study was to evaluate antibiotic consumption, especially of broad spectrum antibiotics, in relation to HAI incidence density (ID). Methodology: The study was conducted from 2011 to 2016 in a tertiary hospital, the Military Medical Academy (MMA), in Belgrade, Serbia. Through regular hospital surveillance we identified all patients with a new HAI. Data on consumption of antibacterials for systemic use were expressed as defined daily dose per 100 bed days (DDD/100 BD). Results: The highest incidence density (ID) of HAI was observed among patients in surgical ICUs (47.2 per 1000 p...
Expert opinion on drug metabolism & toxicology, 2018
The aim of the study was to evaluate the bioequivalence of two itraconazole 100 mg capsule formul... more The aim of the study was to evaluate the bioequivalence of two itraconazole 100 mg capsule formulations. The single-center, open-label, randomized, three-period, three-sequence, reference-replicated, cross-over study included 38 healthy subjects under fed conditions. In each study period (separated by a 14-day washout), a single oral dose of the test (T) or reference (R) product was administered. Blood samples were collected at pre-dose and up to 72.0 h after administration. The calculated pharmacokinetic parameters, based on the plasma concentrations of itraconazole and hydroxy itraconazole, were AUC, AUC, C, T, T and K. The 90% CI for the test/reference geometric means ratio for the parent compound, itraconazole, was in the range from 85.29% to 116.07% for AUC Since the coefficient of variation (CV) for the reference product was 44.95% for C, the 90% CI for this parameter for itraconazole was 93.49-133.78%, which was within the proposed limits of the EMA for bioequivalence of 72.1...
International journal of molecular sciences, Jan 12, 2018
Amifostine is well known cytoprotector which is efficient when administered before a wide range o... more Amifostine is well known cytoprotector which is efficient when administered before a wide range of antineoplastic agents. The aim of our study was to investigate amifostine effects on doxorubicin-induced toxic changes in rats. Amifostine (75 mg/kg ip) was given 30 min before each dose of doxorubicin (cumulatively 20 mg/kg ip, for 28 days). The animals' whole-body, liver, and kidney weight, serum biochemical examination, as well as microscopic examination of bone marrow, peripheral blood, liver, and kidney, were done on day 56 of the study. Hepatic and renal alterations were carefully quantified by semiquantitative grading scales-hepatic and renal damage score, respectively. In amifostine-pretreated rats, the number of peripheral blood leukocytes was significantly higher in comparison to doxorubicin-only treated group, preferentially protecting neutrophils. In the same group of rats, hepatic and renal alterations associated with polymorphonuclear cell infiltrates were significant...
Vojnosanitetski pregled, 2016
Background/Aim. Polymorphisms of genes which encode transporter P-glycoprotein and most important... more Background/Aim. Polymorphisms of genes which encode transporter P-glycoprotein and most important enzymes for tacrolimus pharmacokinetics can have significant influence reflecting on blood concentrations of this drug. The aim of this study was to examine the distribution of polymorphisms of CYP3A5, CYP3A4 and ABCB1 genes in patients subjected to renal transplantation, for the first time in our transplantation center. Methods. The research was designed as a prospective cross-sectional study which included 211 patients subjected to renal transplantation in the Centre for Solid Organ Transplantation of the university tertiary health care hospital, Military Medical Academy, Belgrade, Serbia. Patients of both genders, 22?69-year-old, Caucasians, subjected to immunosuppressive regimen, including tacrolimus, were recruited for the study. CYP3A5 6986A>G (the *3 or *1, rs776746), CYP3A4 - 392A>G (the *1 or *1B, rs2740574) and ABCB1 3435C>T (rs1045642) genotypes were determined by Ta...
Balkan Medical Journal, 2015
Background: Serbia, as the largest market of the Western Balkans, has entered socioeconomic trans... more Background: Serbia, as the largest market of the Western Balkans, has entered socioeconomic transition with substantial delay compared to most of Eastern Europe. Its health system reform efforts were bold during the past 15 years, but their results were inconsistent in various areas. The two waves of global recession that hit Balkan economies ultimately reflected to the financial situation of healthcare. Serious difficulties in providing accessible medical care to the citizens became a reality. A large part of the unbearable expenses actually belongs to the overt prescription of pharmaceuticals and various laboratory and imaging diagnostic procedures requested by physicians. Therefore, a broad national survey was conducted at all levels of the healthcare system hierarchy to distinguish the ability of cost containment strategies to reshape clinician's mindsets and decision-making in practice. Aims: Assessment of healthcare professionals' judgment on economic consequences of prescribed medical interventions and evaluation of responsiveness of healthcare professionals to policy measures targeted at increasing cost-consciousness. Study Design: Cross-sectional study. Methods: A nationwide cross-sectional survey was conducted through a hierarchy of medical facilities across diverse geographical regions before and after policy action, from January 2010 to April 2013. In the middle of the observed period, the National Health Insurance Fund (RFZO) adopted severe cost-containment measures. Independently, pharmacoeconomic guidelines targeted at prescribers were disseminated. Administration in large hospitals and community pharmacies was forced to restrict access to high budget-impact medical care. Economic Awareness of Healthcare Professionals Questionnaire-29 (EAHPQ-29), developed in Serbian language, was used in face-to-face interviews. The questionnaire documented clinician's attitudes on: Clinical-Decision-Makingbetween-Alternative-Interventions (CDMAI), Qualityof-Health-Care (QHC), and Cost-Containment-Policy (CCP). The authors randomly and anonymously recruited 2000 healthcare experts, with a total of 1487 responding; after eliminating incomplete surveys, 649 participants were considered before and 651 after policy intervention. Results: Dentists (1.195±0.560) had a higher mean CD-MAI score compared to physicians (1.017±0.453). The
Vojnosanitetski pregled, 2015
Prvi broj Vojnosanitetskog pregleda izašao je septembra meseca 1944. godine Časopis nastavlja tra... more Prvi broj Vojnosanitetskog pregleda izašao je septembra meseca 1944. godine Časopis nastavlja tradiciju Vojno-sanitetskog glasnika, koji je izlazio od 1930. do 1941. godine IZDAVAČ Uprava za vojno zdravstvo MO Srbije IZDAVAČKI SAVET prof. dr sc. med. Boris Ajdinović prof. dr sc. pharm. Mirjana Antunović prof. dr sc. med. Dragan Dinčić, puk. prof. dr sc. med. Miodrag Jevtić, general potpukovnik prof. dr sc. med. Nebojša Jović, puk. prof. dr sc. med. Đoko Maksić, puk. prof. dr sc. med. Marijan Novaković, brigadni general prof. dr sc. med. Zoran Popović, brigadni general (predsednik) prof. dr Sonja Radaković prof. dr sc. med. Zoran Šegrt, puk.
Vojnosanitetski pregled. Military-medical and pharmaceutical review, 2006
Digest Journal of Nanomaterials and Biostructures
Water soluble fullerene (C60) derivative fullerenol C60(OH)24 nano-particles (FNP) are a promisin... more Water soluble fullerene (C60) derivative fullerenol C60(OH)24 nano-particles (FNP) are a promising candidate for many biomedical applications due to, besides other properties, strong free-radical scavenging and antioxidative potential. Using the carrageenan-induced rat footpad oedema test, the anti-inflammatory effect of FNP have been estimated in comparison with those of amifostine (AMI) and indomethacin (IND). FNP and IND, dissolved in dimethylsulfoxide, and AMI, dissolved in saline, were intraperitoneally injected to rats in a dose range 12.5 - 75 mg/kg, 3 - 10 mg/kg, and 50 - 300 mg/kg, respectively. The control groups were given corresponding vehicles. The drugs or vehicles were given 30 min before carrageenan injection. Footpad swelling was measured 3 hours after carrageenan application. Calculation of a per cent of inhibition derived through comparison with the control groups was done. Histopathological examination of the inflamed foot skin biopsies was also performed. FNP do...
Vojnosanitetski pregled, 2007
Vojnosanitetski pregled, 2015
Background/Aim. A combination of tacrolimus and other drugs such as corticosteroids has been comm... more Background/Aim. A combination of tacrolimus and other drugs such as corticosteroids has been commonly used immunosuppresive regimens. On the other hand, there is a growing body of evidence that male and female may differ in their response to the equal drug treatment. The aim of the study was to estimated the use of tacrolimus concentration/dose (C/D) ratio for the assessment of the influence of gender differences and comedication on tacrolimus exposure in renal transplant recipients. Methods. This prospective case series study included 54 patients, in which the unit of monitoring was outpatient examination (1,872) of the renal transplant patients. The patients were monitored in the period 2010-2014, starting one month after the transplantation. Tacrolimus trough concentrations (TTC) were measured by chemiluminescence microparticles immunoassay. Results. TTC and the tacrolimus C/D ratio were significantly lower in the females comparing with the males. Contrary to the males, in the fe...
Vojnosanitetski Pregled, 2006
European Journal of Hospital Pharmacy
Hospital Pharmacology - International Multidisciplinary Journal
Introduction: Precision medicine is an approach that considers genetics, environment and lifestyl... more Introduction: Precision medicine is an approach that considers genetics, environment and lifestyle factors when prevent and treat diff erent diseases. The important part of precision medicine is pharmacogeneticss, a branch of clinical pharmacology that analyzes how genetic makeup aff ects the response to the drugs. Methods: Since oncology is a fi eld of particular interest in precision medicine, this article summarizes the basic principles of pharmacogenetics testing in cancer treatment. Topic: The following topics have been discussed: Samples for pharmacogenetics testing (peripheral blood, tumor biopsy, liquid biopsy), methods in pharmacogenetics testing (conventional hotspot methods and comprehensive genome profi ling), comprehensive genome profi ling (CGP) in clinical settings and oncology therapy in Serbia that depends on genetic testing. Conclusion: Pharmacogenetics testing provides the delivery of safe and effi cient therapy. The usage of CGP methods opens up the possibility for the usage of therapies directed to genetic markers across tumor types. However, this approach needs evaluation through well-designed research projects and clinical trials.
Serbian Journal of Anesthesia and Intensive Therapy
Serbian Journal of Anesthesia and Intensive Therapy
Spironolakton je kompetitivni neselektivni blokator mineralokortikoidnih receptora koji imaju vis... more Spironolakton je kompetitivni neselektivni blokator mineralokortikoidnih receptora koji imaju visok afinitet za aldosteron. Spironolakton se primenjuje u različitim stanjima zbog svog diuretskog i antihipertenzivnog efekta, u tretmanu edema kod kongestivne srčane insuficijencije, ciroze jetre sa ascitom i edemima, nefrotskog sindroma, malignog ascita, teške srčane insuficijencije i kod primarnog hiperaldosteronizma. Danas je spironolakton preporučen za terapiju rezistentne hipertenzije. Cilj narativnog revijalnog rada je da prikaže farmakodinamski i farmakokinetski profil spironolaktona i da obrazloži njegovo mesto u terapiji rezistentne hipertenzije.
Libyan Journal of Medicine
Introduction: Clostridioides difficile (C. difficile) infection (CDI) is one of the most common h... more Introduction: Clostridioides difficile (C. difficile) infection (CDI) is one of the most common healthcare-associated (HA) infections in contemporary medicine. The risk factors (RFs) for HA CDI in medical and surgical patients are poorly investigated in countries with a limited resource healthcare system. Therefore, the aim of the study was to investigate differences in patients' characteristics, factors related to healthcare and outcomes associated with HA CDI in surgical and medical patients in tertiary healthcare centre in Serbia. Materials and Methods: A prospective cohort study was conducted including adult patients diagnosed with initial episode of HA CDI, first recurrence of disease, readmission to hospital, while deaths within 30 days of CDI diagnosis and in-hospital mortality were also recorded. Patients hospitalized for any non-surgical illness, who developed initial HA CDI were assigned to medical group, whereas those who developed initial HA CDI after surgical procedures were in surgical group. The data on patients' characteristics and factors related to healthcare were collected, too. Results: During 7-year period, from 553 patients undergoing in-hospital treatment and diagnosed with CDI, 268 (48.5%) and 285 (51.5%) were surgical and medical patients, respectively. Age ≥ 65 years, use of proton pump inhibitors, chemotherapy and fluoroquinolones were positively associated with being in medical group, whereas admission to intensive care unit and use of second-and third-generation cephalosporins were positively associated with being in surgical group. Conclusions: Based on obtained results, including significant differences in 30-day mortality and in-hospital mortality, it can be concluded that medical patient were more endangered with HA CDI than surgical ones.
Hospital Pharmacology - International Multidisciplinary Journal
Metamizole is a nonsteroidal anti-infl ammatory drug, with analgesic, antipyretic, spasmolytic, a... more Metamizole is a nonsteroidal anti-infl ammatory drug, with analgesic, antipyretic, spasmolytic, and weak anti-infl ammatory properties. The analgesic eff ect of metamizole seems to be based on the inhibition of cyclooxygenase enzyme activity and stimulation of cannabinoid receptors. Its use is still controversial, mainly due to agranulocytosis, metamizole-induced serious adverse reaction. While in many countries it is withdrawn from the market, in some countries metamizole is available as a medication prescribed for strictly defi ned indications, while in the others like Mexico, Brazil and China it can be obtained as an Over-The-Counter drug. The most common adverse eff ects of metamizole are the skin and subcutaneous tissue disorders. Metamizole appears to be of similar effi cacy to analgesics which are frequently used in the treatment of moderate to severe postoperative pain.
The Journal of Infection in Developing Countries
Introduction: Healthcare-associated infections (HAIs) and irrational use of antibiotics in health... more Introduction: Healthcare-associated infections (HAIs) and irrational use of antibiotics in healthcare settings are major global public health concerns. Surveillance of HAIs in intensive care units (ICU), surgical-site infections (SSIs), and Clostridium difficile infections (CDIs), together with implementation of antibiotic stewardship, are cornerstones of hospital infection prevention programs. The aim of this study was to evaluate antibiotic consumption, especially of broad spectrum antibiotics, in relation to HAI incidence density (ID). Methodology: The study was conducted from 2011 to 2016 in a tertiary hospital, the Military Medical Academy (MMA), in Belgrade, Serbia. Through regular hospital surveillance we identified all patients with a new HAI. Data on consumption of antibacterials for systemic use were expressed as defined daily dose per 100 bed days (DDD/100 BD). Results: The highest incidence density (ID) of HAI was observed among patients in surgical ICUs (47.2 per 1000 p...
Expert opinion on drug metabolism & toxicology, 2018
The aim of the study was to evaluate the bioequivalence of two itraconazole 100 mg capsule formul... more The aim of the study was to evaluate the bioequivalence of two itraconazole 100 mg capsule formulations. The single-center, open-label, randomized, three-period, three-sequence, reference-replicated, cross-over study included 38 healthy subjects under fed conditions. In each study period (separated by a 14-day washout), a single oral dose of the test (T) or reference (R) product was administered. Blood samples were collected at pre-dose and up to 72.0 h after administration. The calculated pharmacokinetic parameters, based on the plasma concentrations of itraconazole and hydroxy itraconazole, were AUC, AUC, C, T, T and K. The 90% CI for the test/reference geometric means ratio for the parent compound, itraconazole, was in the range from 85.29% to 116.07% for AUC Since the coefficient of variation (CV) for the reference product was 44.95% for C, the 90% CI for this parameter for itraconazole was 93.49-133.78%, which was within the proposed limits of the EMA for bioequivalence of 72.1...
International journal of molecular sciences, Jan 12, 2018
Amifostine is well known cytoprotector which is efficient when administered before a wide range o... more Amifostine is well known cytoprotector which is efficient when administered before a wide range of antineoplastic agents. The aim of our study was to investigate amifostine effects on doxorubicin-induced toxic changes in rats. Amifostine (75 mg/kg ip) was given 30 min before each dose of doxorubicin (cumulatively 20 mg/kg ip, for 28 days). The animals' whole-body, liver, and kidney weight, serum biochemical examination, as well as microscopic examination of bone marrow, peripheral blood, liver, and kidney, were done on day 56 of the study. Hepatic and renal alterations were carefully quantified by semiquantitative grading scales-hepatic and renal damage score, respectively. In amifostine-pretreated rats, the number of peripheral blood leukocytes was significantly higher in comparison to doxorubicin-only treated group, preferentially protecting neutrophils. In the same group of rats, hepatic and renal alterations associated with polymorphonuclear cell infiltrates were significant...
Vojnosanitetski pregled, 2016
Background/Aim. Polymorphisms of genes which encode transporter P-glycoprotein and most important... more Background/Aim. Polymorphisms of genes which encode transporter P-glycoprotein and most important enzymes for tacrolimus pharmacokinetics can have significant influence reflecting on blood concentrations of this drug. The aim of this study was to examine the distribution of polymorphisms of CYP3A5, CYP3A4 and ABCB1 genes in patients subjected to renal transplantation, for the first time in our transplantation center. Methods. The research was designed as a prospective cross-sectional study which included 211 patients subjected to renal transplantation in the Centre for Solid Organ Transplantation of the university tertiary health care hospital, Military Medical Academy, Belgrade, Serbia. Patients of both genders, 22?69-year-old, Caucasians, subjected to immunosuppressive regimen, including tacrolimus, were recruited for the study. CYP3A5 6986A>G (the *3 or *1, rs776746), CYP3A4 - 392A>G (the *1 or *1B, rs2740574) and ABCB1 3435C>T (rs1045642) genotypes were determined by Ta...
Balkan Medical Journal, 2015
Background: Serbia, as the largest market of the Western Balkans, has entered socioeconomic trans... more Background: Serbia, as the largest market of the Western Balkans, has entered socioeconomic transition with substantial delay compared to most of Eastern Europe. Its health system reform efforts were bold during the past 15 years, but their results were inconsistent in various areas. The two waves of global recession that hit Balkan economies ultimately reflected to the financial situation of healthcare. Serious difficulties in providing accessible medical care to the citizens became a reality. A large part of the unbearable expenses actually belongs to the overt prescription of pharmaceuticals and various laboratory and imaging diagnostic procedures requested by physicians. Therefore, a broad national survey was conducted at all levels of the healthcare system hierarchy to distinguish the ability of cost containment strategies to reshape clinician's mindsets and decision-making in practice. Aims: Assessment of healthcare professionals' judgment on economic consequences of prescribed medical interventions and evaluation of responsiveness of healthcare professionals to policy measures targeted at increasing cost-consciousness. Study Design: Cross-sectional study. Methods: A nationwide cross-sectional survey was conducted through a hierarchy of medical facilities across diverse geographical regions before and after policy action, from January 2010 to April 2013. In the middle of the observed period, the National Health Insurance Fund (RFZO) adopted severe cost-containment measures. Independently, pharmacoeconomic guidelines targeted at prescribers were disseminated. Administration in large hospitals and community pharmacies was forced to restrict access to high budget-impact medical care. Economic Awareness of Healthcare Professionals Questionnaire-29 (EAHPQ-29), developed in Serbian language, was used in face-to-face interviews. The questionnaire documented clinician's attitudes on: Clinical-Decision-Makingbetween-Alternative-Interventions (CDMAI), Qualityof-Health-Care (QHC), and Cost-Containment-Policy (CCP). The authors randomly and anonymously recruited 2000 healthcare experts, with a total of 1487 responding; after eliminating incomplete surveys, 649 participants were considered before and 651 after policy intervention. Results: Dentists (1.195±0.560) had a higher mean CD-MAI score compared to physicians (1.017±0.453). The
Vojnosanitetski pregled, 2015
Prvi broj Vojnosanitetskog pregleda izašao je septembra meseca 1944. godine Časopis nastavlja tra... more Prvi broj Vojnosanitetskog pregleda izašao je septembra meseca 1944. godine Časopis nastavlja tradiciju Vojno-sanitetskog glasnika, koji je izlazio od 1930. do 1941. godine IZDAVAČ Uprava za vojno zdravstvo MO Srbije IZDAVAČKI SAVET prof. dr sc. med. Boris Ajdinović prof. dr sc. pharm. Mirjana Antunović prof. dr sc. med. Dragan Dinčić, puk. prof. dr sc. med. Miodrag Jevtić, general potpukovnik prof. dr sc. med. Nebojša Jović, puk. prof. dr sc. med. Đoko Maksić, puk. prof. dr sc. med. Marijan Novaković, brigadni general prof. dr sc. med. Zoran Popović, brigadni general (predsednik) prof. dr Sonja Radaković prof. dr sc. med. Zoran Šegrt, puk.
Vojnosanitetski pregled. Military-medical and pharmaceutical review, 2006
Digest Journal of Nanomaterials and Biostructures
Water soluble fullerene (C60) derivative fullerenol C60(OH)24 nano-particles (FNP) are a promisin... more Water soluble fullerene (C60) derivative fullerenol C60(OH)24 nano-particles (FNP) are a promising candidate for many biomedical applications due to, besides other properties, strong free-radical scavenging and antioxidative potential. Using the carrageenan-induced rat footpad oedema test, the anti-inflammatory effect of FNP have been estimated in comparison with those of amifostine (AMI) and indomethacin (IND). FNP and IND, dissolved in dimethylsulfoxide, and AMI, dissolved in saline, were intraperitoneally injected to rats in a dose range 12.5 - 75 mg/kg, 3 - 10 mg/kg, and 50 - 300 mg/kg, respectively. The control groups were given corresponding vehicles. The drugs or vehicles were given 30 min before carrageenan injection. Footpad swelling was measured 3 hours after carrageenan application. Calculation of a per cent of inhibition derived through comparison with the control groups was done. Histopathological examination of the inflamed foot skin biopsies was also performed. FNP do...
Vojnosanitetski pregled, 2007
Vojnosanitetski pregled, 2015
Background/Aim. A combination of tacrolimus and other drugs such as corticosteroids has been comm... more Background/Aim. A combination of tacrolimus and other drugs such as corticosteroids has been commonly used immunosuppresive regimens. On the other hand, there is a growing body of evidence that male and female may differ in their response to the equal drug treatment. The aim of the study was to estimated the use of tacrolimus concentration/dose (C/D) ratio for the assessment of the influence of gender differences and comedication on tacrolimus exposure in renal transplant recipients. Methods. This prospective case series study included 54 patients, in which the unit of monitoring was outpatient examination (1,872) of the renal transplant patients. The patients were monitored in the period 2010-2014, starting one month after the transplantation. Tacrolimus trough concentrations (TTC) were measured by chemiluminescence microparticles immunoassay. Results. TTC and the tacrolimus C/D ratio were significantly lower in the females comparing with the males. Contrary to the males, in the fe...