Vin Tangpricha - Academia.edu (original) (raw)

Papers by Vin Tangpricha

The FASEB Journal, 2014

Background: Malnutrition and lean tissue wasting are common in patients with tuberculosis (TB) di... more Background: Malnutrition and lean tissue wasting are common in patients with tuberculosis (TB) disease, yet little information is available on habitual dietary intake or links with body composition. Methods: Dietary intake was obtained in a randomized clinical trial of high-dose vitamin D (Vit D) in patients with pulmonary TB in Tbilisi, Georgia. Food intake was obtained (0, 8 and 16 weeks) using a validated, culture-specific tool. Serial body composition was by BMI and bioelectrical impedance analysis (BIA; % fat mass and % fat-free mass). Descriptive statistics and repeated measures ANOVA were used. Results: 192 subjects (mean age 35 y; 100 Vit D, 99 placebo) were studied. Mean daily intake of kcal, fat and protein were adequate at diagnosis and increased (with BMI) over time (time effect p<0.0001, treatment effect NS). There were no differences in % of fat mass or % fat-free mass between groups over time. Multi-drug resistant TB patients (n=23) had lower body weight, BMI (p=0.05) and fat-free mass vs. ...

Vitamin D, 2016

A 52-year-old female presented to the clinic for evaluation of bone pain. She presented initially... more A 52-year-old female presented to the clinic for evaluation of bone pain. She presented initially with rachitic bone changes at the age of 2 years and was diagnosed based on laboratory findings (low phosphorous) and a potential family history of rickets (maternal family members with short stature). She was placed on 50,000 IU of vitamin D daily and phosphate five times per day. The diagnosis of XLH was eventually confirmed by genetic testing. The patient received medical management until she was 18 and was determined to be finished with growth. However, at age 22 the patient began experiencing bone pain and was started on calcitriol 0.25 mg orally twice a day and elemental phosphorous two times a day. Despite this treatment, she developed multiple rib fractures and continued to experience intermittent bone pain. Her medications were eventually titrated to phosphorus three times a day and calcitriol 0.50 mcg twice a day. Though she was stable on this regimen for many years, over the year prior to this presentation, she experienced worsening bone pain. Recent laboratory results showed a serum phosphate of 2.2 mg/dL (normal range: 2.7–4.5 mg/dL), a serum calcium of 10.4 mg/dL (normal range: 8.9–10.3 mg/dL), and a serum parathyroid hormone (PTH) concentration of 136 pg/mL (normal range, 14–62 pg/mL).

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2015

Lupus science & medicine, 2014

Epidemiological associations suggest that vitamin D status may play a role in inflammation and pr... more Epidemiological associations suggest that vitamin D status may play a role in inflammation and progression of atherosclerosis. Using frozen serum, carotid intima medial thickness (CIMT) measurements and other existing data from the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, we assessed interactions between serum 25-hydroxyvitamin D (25(OH)D), atorvastatin randomisation and CIMT progression rate. Participants in the 3-year APPLE trial were randomised to placebo or atorvastatin and CIMT progression rate was measured. Baseline frozen serum was used to measure 25(OH)D concentrations. Mixed effect longitudinal models for CIMT progression at 3 years were used to evaluate interaction between vitamin D deficiency (serum 25(OH)D <20 ng/mL) at baseline and atorvastatin or placebo treatment, adjusting for key systemic lupus erythematosus disease variables and cardiovascular risk factors. 201/221 APPLE participants had available samples and were included in th...

Journal of Clinical & Translational Endocrinology, 2015

Molecular vision, 2011

To assess the relationship between serum insulin-like growth factor I (IGF-I) and diabetic retino... more To assess the relationship between serum insulin-like growth factor I (IGF-I) and diabetic retinopathy. This was a clinic-based cross-sectional study conducted at the Emory Eye Center. A total of 225 subjects were classified into four groups, based on diabetes status and retinopathy findings: no diabetes mellitus (no DM; n=99), diabetes with no background diabetic retinopathy (no BDR; n=42), nonproliferative diabetic retinopathy (NPDR; n=41), and proliferative diabetic retinopathy (PDR; n=43). Key exclusion criteria included type 1 diabetes and disorders that affect serum IGF-I levels, such as acromegaly. Subjects underwent dilated fundoscopic examination and were tested for hemoglobin A1c, serum creatinine, and serum IGF-I, between December 2009 and March 2010. Serum IGF-I levels were measured using an immunoassay that was calibrated against an international standard. Between the groups, there were no statistical differences with regards to age, race, or sex. Overall, diabetic subj...

Current Opinion in Endocrinology & Diabetes and Obesity, 2014

Purpose of review-The aim of this review is to provide an update on various relevant endocrine as... more Purpose of review-The aim of this review is to provide an update on various relevant endocrine aspects of care in adolescents and adults with cystic fibrosis (CF). Recent findings-As life expectancy in CF has continuously improved, endocrine complications have become more apparent. The common endocrine complications include cystic fibrosis related diabetes (CFRD), cystic fibrosis related bone disease, vitamin D deficiency and poor growth and pubertal development. Thyroid and adrenal disorders have also been reported, although the prevalence appears to be less common. Summary-Endocrine diseases are an increasingly recognized complication that has a significant impact on the overall health of individuals with CF. This review summarizes the updated screening and management of endocrine diseases in the CF population.

A102. ADVANCES IN CYSTIC FIBROSIS, 2010

A conceptual model of the transboundary Milk River Aquifer (MRA), extending across the Canada-USA... more A conceptual model of the transboundary Milk River Aquifer (MRA), extending across the Canada-USA border, was developed based on literature, focused fieldwork and a three-dimensional geological model. The MRA corresponds to the Virgelle Member of the Milk River Formation (Eagle Formation in Montana, USA) and it is an important groundwater resource over a large area (25,000 km 2). The Virgelle outcrops near the international border and along the Sweet Grass Arch in Montana. The down-gradient limit of the MRA is the unconformity separating the Virgelle from the gasbearing sandy shale of the Alderson Member. The MRA is confined above by the Pakowki/Claggett Formations aquitards and below by the Colorado Group aquitard. The MRA contains higher transmissivity areas resulting in preferential flowpaths, confirmed by natural geochemical tracers. Tritium and 14 C delineate restricted recharge areas along the outcrops on both sides of the international border. Drastic decreases in horizontal hydraulic gradients indicate that the Milk River intercepts a large proportion of groundwater flowing to the north from the recharge area. Downgradient of the Milk River, groundwater movement is slow, as shown by 36 Cl residence times exceeding 1 Ma. These slow velocities imply that groundwater discharge downgradient of the Milk River is via vertical leakage through the Colorado Group and upward along buried valleys, which act as drains and correspond to artesian areas. When confined, the MRA contains a fossil groundwater resource, not significantly renewed by modern recharge. Groundwater exploitation thus far exceeds recharge, a situation requiring properly managed MRA groundwater depletion.

Current Rheumatology Reports, 2008

Vitamin D is known for its role in calcium homeostasis for optimal skeletal health. It was previo... more Vitamin D is known for its role in calcium homeostasis for optimal skeletal health. It was previously believed that only elderly or hospitalized patients were at risk for vitamin D insufficiency, but many people in the general US population have insufficient levels of 25-hydroxyvitamin D (25[OH]D). According to the Third National Health and Nutrition Examination Survey, 61% of white and 91% of black Americans suffer from vitamin D insufficiency (25[OH]D < 32 ng/mL). Recent studies have demonstrated that a minimum 25(OH)D level of 32 ng/mL is necessary for optimal protection from fracture and intestinal absorption of calcium. Recently, vitamin D has been recognized as important for extraskeletal functions such as immune function, cancer prevention, and hypertension prevention. We review the role of vitamin D in skeletal health and present data on vitamin D in other extraskeletal diseases, with special emphasis on the rheumatology patient.

Dermato-Endocrinology, 2012

Vitamin D insufficiency and sepsis are both highly prevalent worldwide problems and this article ... more Vitamin D insufficiency and sepsis are both highly prevalent worldwide problems and this article reviews the emerging science that is defining the intersections of these conditions. The importance of vitamin D's role in skeletal health has long been understood but recent evidence is beginning to highlight its role in the functioning of other physiologic systems of the body. Basic science data reveal its integral role in local immune responses to pathogens and the systemic inflammatory pathways of sepsis. Furthermore, clinical scientists have found associations with respiratory infections, critical illness and sepsis but the causal relationship and its clinical impact have yet to be clearly defined. The article ends with speculations on the connections between racial disparities and seasonal differences in sepsis and vitamin D insufficiency.

International Journal of Endocrinology, 2012

To study the effect of puberty on the relationship between serum 25-hydroxyvitamin D (25(OH)D) an... more To study the effect of puberty on the relationship between serum 25-hydroxyvitamin D (25(OH)D) and parameters of insulin kinetics in obese Asian-Indian children. Material and Methods. The study population included 62 obese Asian-Indian children and adolescents in the age group of 6-17 years. Blood glucose, serum insulin, and serum 25(OH)D were measured. Total body fat was measured by dual energy X-ray absorptiometry. Indices of insulin resistance (HOMA-IR, AUC for insulin) and sensitivity (WBISI) were calculated after oral glucose tolerance test. Result. A total of 62 subjects (35 boys; mean age = 13.0 ± 3 years; BMI = 29.3 ± 4.8 kg/sq M; 19 subjects in Tanner stage 1, 11 in stage 2, 6 in stage 3, 3 in stage 4, and 23 subjects in Tanner stage 5) were studied. All study subjects were vitamin D deficient with a mean serum 25(OH)D of 8.5 ± 4.2 ng/mL. No significant relationship was observed between serum 25(OH)D and parameters of insulin kinetics in prepubertal children. However, a significant inverse correlation was seen between serum 25(OH)D and HOMAIR (r = −0.41, P = 0.03) in postpubertal subjects. Conclusion. The relationship between vitamin D status and parameters of insulin kinetics are affected by puberty.

International journal of endocrinology, 2010

Testosterone therapy in men and women results in decreased high-density lipoprotein cholesterol (... more Testosterone therapy in men and women results in decreased high-density lipoprotein cholesterol (HDL) and increased low-density lipoprotein cholesterol (LDL). We sought to determine whether testosterone therapy has this same effect on lipid parameters and adipocyte hormones in female-to-male (FTM) transsexuals. Twelve FTM transsexuals provided a fasting lipid profile including serum total cholesterol, HDL, LDL, and triglycerides prior to and after 1 year of testosterone therapy (testosterone enanthate or cypionate 50-125 mg IM every two weeks). Subjects experienced a significant decrease in mean serum HDL (52 +/- 11 to 40 +/- 7 mg/dL) (P < .001). The mean LDL (P = .316), triglyceride (P = .910), and total cholesterol (P = .769) levels remained unchanged. In a subset of subjects, we measured serum leptin levels which were reduced by 25% but did not reach statistical significance (P = .181) while resistin levels remained unchanged. We conclude that testosterone therapy in FTM trans...

Translational Research, 2006

The objective of this article is to evaluate the pharmacokinetics of serum estrone and estradiol ... more The objective of this article is to evaluate the pharmacokinetics of serum estrone and estradiol levels in women who were taking either 17beta-estradiol-3beta-glucoside (E(2)-3beta-glucoside) or 17beta-estradiol (E(2)) daily and to examine the effects of E(2)-3beta-glucoside and E(2) on postmenopausal symptoms, gonadotropins, hepatic metabolism, and coagulation factors. Healthy postmenopausal women on estrogen who had undergone a hysterectomy were recruited. Subjects were randomly assigned to receive equivalent doses of either E(2)-3beta-glucoside or micronized E(2) for 28 days. Pharmacokinetic studies of estrone and estradiol were performed on days 1, 2, 28, and 29. Gonadotropin levels and Kupperman Index (KI) scores were determined at baseline and on treatment day 28. Mean serum estradiol and estrone concentrations in those taking E(2)-3beta-glucoside were comparable with those taking E(2). Mean baseline follicle stimulating hormone (FSH) levels were 84 +/- 27 mIU/mL and 71 +/- 24 mIU/mL in the E(2)-3beta-glucoside and E(2) groups, respectively, with significant decreases (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01) of 54 +/- 21 mIU/mL and 38 +/-18 mIU/mL, respectively, by treatment day 28. Baseline KI scores in the E(2)-3beta-glucoside group were 10 +/- 6 compared with 5 +/- 4 on treatment day 28, which is equivalent to a 50% reduction in menopausal symptoms (P = 0.003). The change in KI scores in the E(2) group was not statistically significant. Total serum estradiol and estrone levels in women taking E(2)-3beta-glucoside are comparable with those in women taking E(2). E(2)-3beta-glucoside reduces serum gonadotropin levels to the premenopausal range and is effective at reducing postmenopausal symptoms. E(2)-3beta-glucoside is a novel synthetic estrogen that is well tolerated and has promise as a hormone replacement therapy.

International Journal of Endocrinology, 2010

Thyroid, 2011

Ridgway delivered the first Lewis E. Braverman Distinguished Award Lectureship at the 81st Annual... more Ridgway delivered the first Lewis E. Braverman Distinguished Award Lectureship at the 81st Annual Meeting of the American Thyroid Association (ATA). Dr. Ridgway was introduced by Dr. Alan Farwell, who noted his long record of service to the ATA and Endocrine Society, stressing that ''Dr Ridgway truly excels at the essential requirement for the Braverman lectureship-a demonstrated excellence and passion for being a mentor.'' Pertinent to this is not only the extensive list of fellows he co-authored papers with, but also his leadership in developing and sustaining programs for fellows at the ATA's annual meeting. As Dr. Farwell remarked, Dr. Ridgway's mentorship was not only for those he wrote papers with, and not only for his fellows, but for all he came in contact with. Dr. Ridgway began his lecture with a portrait of Dr. Braverman then, using the magic of Power Point, added two images of Braverman's mentor, Dr. Sidney H. Ingbar, shown in his early years and as a senior investigator. The collage was completed by adding five mentees; some were former fellows, others were former members of his faculty, but all were only a tiny fraction of the many whose lives and careers he influenced. Keeping the slide in place, Ridgway expanded the scope of Braverman's mentorship, explaining that although he had not been one of his mentees, it was his privilege to have Lew as a mentor's mentor. Dr. Ridgway's topic of ''Mentors and Thyroidology'' focused on three of the most dynamic aspects of the 2011 ATA meeting and the previous year's literature: thyroid hormone transporters, the role of deiodinases in the regulation of triiodothyronine and thyroxine in cellular compartments, and small molecule thyrotropin receptor agonists and antagonists. Each topic was succinctly reviewed. When speaking of thyroid hormone transporters and deiodinases, Dr. Ridgway stressed the discrepancies that can occur between plasma thyroid hormone concentrations and the ''true'' state of thyroid function within cells. He illustrated this with a description of the Allan-Herndon-Dudley syndrome of psychomotor retardation, now attributed to defects in the X chromosome

The Journal of Steroid Biochemistry and Molecular Biology, 2010

Vitamin D has been reported to lower blood pressure in vivo by regulating the renin-angiotensin s... more Vitamin D has been reported to lower blood pressure in vivo by regulating the renin-angiotensin system; however, there are limited clinical studies to support this finding in humans. We investigated the effect of vitamin D treatment on hypertension in a three-arm randomized placebo controlled pilot and feasibility study. We tested placebo with two forms of vitamin D: cholecalciferol (vitamin D 3) and the active form of vitamin D, calcitriol. Subjects were recruited from the Atlanta Veterans Affairs Medical Center in Decatur, GA between April and August 2008. Subjects received 200,000 IU of vitamin D 3 (n = 3) weekly for 3 weeks or matching placebo (n = 3) weekly for 3 weeks (n = 3) or 0.5 μg calcitriol (n = 2) taken twice daily for one week. Our primary endpoint was blood pressure measured by 24 h ambulatory blood pressure monitor. Subjects receiving calcitriol experienced a 9% decrease in mean systolic blood pressure (SBP) compared placebo (p < 0.001). One week after conclusion of calcitriol therapy SBP returned to pre-treatment levels. There was no reduction in blood pressure in the placebo or vitamin D 3 groups. Results from this pilot study suggests that active vitamin D therapy may be an effective short-term intervention for reducing blood pressure and needs to be explored further in larger controlled studies.

Southern Medical Journal, 2007

Vitamin D is an essential nutrient for optimal calcium homeostasis for the body. Vitamin D is a s... more Vitamin D is an essential nutrient for optimal calcium homeostasis for the body. Vitamin D is a secosteroid hormone ("seco" meaning "cut") with two forms: D 2 found in the diet, and D 3 , which is either found in the diet or made in the skin from 7-dehydrocholesterol (7-DHC) upon exposure to ultraviolet B radiation (UVB) between wavelengths of 290 and 315 nm. Upon entering the circulation, vitamin D (D without subscripts refers to either D 2 or D 3) undergoes two sequential hydroxylations. The first hydroxylation occurs in the liver in the 25 position to form 25-hydroxyvitamin D (25(OH)D), the major circulating form of vitamin D with a half-life of 2-3 weeks. The second hydroxylation happens in the kidney in the 1 position to create 1,25(OH) 2 D, the active form. The major role of vitamin D is to maintain adequate serum calcium and phosphorus levels for proper mineralization of bone by increased intestinal efficacy of calcium and phosphorus absorption from the small intestine.

Photodermatology, Photoimmunology & Photomedicine, 2007

The Pediatric Infectious Disease Journal, 2013

Background-In HIV-infected adults, we and others have shown that vitamin D deficiency is independ... more Background-In HIV-infected adults, we and others have shown that vitamin D deficiency is independently associated with increased carotid intima-media thickness (cIMT), a surrogate marker for cardiovascular disease (CVD). This study explored for the first time the relationship between vitamin D and CVD risk in HIV-infected youth. Methods-This is a cross-sectional assessment of cIMT, inflammation, metabolic markers and vitamin D status in HIV-infected youth and healthy controls. We measured serum 25hydroxyvitamin D (25(OH)D), fasting lipids, insulin, glucose, inflammatory markers, and cIMT. Results-30 HIV-infected subjects and 31 controls were included. Among HIV-infected subjects, median age was 11 years (37% males; 73% black; similar to controls). HIV-infected subjects' mean (standard deviation) serum 25(OH)D was 24 (35) ng/mL; 70% had 25(OH)D <20 ng/mL (deficient), 23% between 20-30 ng/mL (insufficient), and 7% >30 ng/mL (sufficient); proportions were similar to controls (P=0.17). After adjusting for season, sex and race, there was no difference in serum 25(OH)D between groups (P=0.11). Serum 25(OH)D was not significantly correlated with cIMT, inflammatory markers, or lipids. Serum 25(OH)D was negatively correlated with body mass index, insulin resistance, HIV duration, and cumulative use of antiretroviral therapy, non-and nucleoside reverse transcriptase inhibitors. Conclusions-Most HIV-infected youth have vitamin D deficiency or insufficiency. Despite no direct association between serum 25(OH)D and cIMT, there were notable associations with some CVD risk factors, particularly inverse correlation with insulin resistance. Studies are needed to determine whether CVD risk, including insulin resistance, could be improved with vitamin D supplementation.