Vinayak Kumar - Academia.edu (original) (raw)

Papers by Vinayak Kumar

2022 IEEE Students Conference on Engineering and Systems (SCES)

Circulation: Heart Failure, 2022

Background: There are limited data on uninsured patients presenting with acute myocardial infarct... more Background: There are limited data on uninsured patients presenting with acute myocardial infarction-cardiogenic shock (AMI-CS). This study sought to compare the management and outcomes of AMI-CS between uninsured and privately insured individuals. Methods: Using the National Inpatient Sample (2000–2016), a retrospective cohort of adult (≥18 years) uninsured admissions (primary payer—self-pay or no charge) were compared with privately insured individuals. Interhospital transfers were excluded. Outcomes of interest included in-hospital mortality, temporal trends in admissions, use of cardiac procedures, do-not-resuscitate status, palliative care referrals, and resource utilization. Results: Of 402 182 AMI-CS admissions, 21 966 (5.4%) and 93 814 (23.3%) were uninsured and privately insured. Compared with private insured individuals, uninsured admissions were younger, male, from a lower socioeconomic status, had lower comorbidity, higher rates of acute organ failure, ST-segment elevati...

All in-text references underlined in blue are linked to publications on ResearchGate, letting you... more All in-text references underlined in blue are linked to publications on ResearchGate, letting you access and read them immediately.

Echocardiography, 2021

Myocardial volume is assumed to be constant over the cardiac cycle in the echocardiographic model... more Myocardial volume is assumed to be constant over the cardiac cycle in the echocardiographic models used by professional guidelines, despite evidence that suggests otherwise. The aim of this paper is to use literature‐derived myocardial strain values from healthy patients to determine if myocardial volume changes during the cardiac cycle.

International Journal of Cardiology, 2021

Background: In patients with normal left ventricular ejection fraction, it may be difficult to di... more Background: In patients with normal left ventricular ejection fraction, it may be difficult to distinguish between the normal and diseased heart. Novel assessments of ventricular function, such as extracellular volume imaging, myocardial perfusion imaging and myocardial contraction fraction are emerging to better assess disease burden in these cases. This study endeavored to determine whether the ratio of myocardial volume in systole to myocardial volume in diastole (MVs/MVd), differs between normal hearts and those with disease states characterized by normal ejection fraction. Method: Consecutive patients from 2008 to 2018 with hypertrophic cardiomyopathy (HCM), cardiac amyloidosis, and heart failure with preserved ejection fraction (HFpEF) who underwent cardiac magnetic resonance imaging (MRI) were selected for inclusion, along with a sex-and age-matched cohort of normal volunteers who also underwent cardiac MRI. Manual tracings were performed on each MRI to calculate MVs/MVd, which was then compared across subgroups. Results: Included were 50 patients with HCM, 50 patients with cardiac amyloidosis, 26 patients with HFpEF, and 30 normal subjects. Age was 54.1 years (SD 16.7); mean MVs/MVd was 0.88 (SD 0.04) in the normal subgroup, 1.03 (SD 0.06) in HCM patients, 1.03 (SD 0.06) in cardiac amyloidosis patients, and 0.97 (SD 0.02) in HFpEF patients, with all pathology subgroups different from the normal subgroup (p < .0001 for each). The ratio of MVs/ MVd discriminated diseased from normal with c statistic 0.989 (p < .001). Conclusions: This study suggests that a novel and easily-captured metric of ventricular function, MVs/MVd, can differentiate normal ventricular function from multiple cardiomyopathies with normal ejection fractions.

Plants have been an important source of medicine for thousands of years. One of the ancient medic... more Plants have been an important source of medicine for thousands of years. One of the ancient medicinal plant is aloevera. It has been described as a portable Nature’s first aid kit that is an effective, inexpensive first-aid solution for all minor burns and scalds. Aloevera is known for its many health benefits. Over the past decade, interest in drugs derived from medicinal plants has markedly increased to maintain oral health. In dentistry aloevera has been found to be therapeutically effective. This update focuses on various therapeutic application and possible mechanisms of interactions when aloevera is used as phytomedicine. However, further researches combining the invivo and invitro research studies need to be carried to establish the tremendous potential of the aloevera plant in dentistry.

Intelligent Computing and Communication, 2020

As large amounts of data keep being generated by users on social media platforms, some of the inf... more As large amounts of data keep being generated by users on social media platforms, some of the information can be considered as harmful. These kinds of textual information can be generated in forums, online discussions or any other communication exchange in an online medium. As such, it is sometimes difficult to filter out what information is actually meaningful. Detecting these harmful pieces of information can help in providing a means of online moderation so that a safe discussion can be maintained, which helps in preventing issues such as cyber bullying. Using the Kaggle Jigsaw dataset of comments that are classified as toxic labels, we can implement deep learning models to implicitly extract textual features from the comments and solve this supervised learning problem. This paper focuses on using the variations of recurrent neural networks, with the main focus on using bidirectional gated recurrent units, and evaluating their performances against each other.

Circulation, 2020

Introduction: Cardiovascular disease remains the leading cause of morbidity and mortality in pati... more Introduction: Cardiovascular disease remains the leading cause of morbidity and mortality in patients with amyloid light chain (AL) amyloidosis. Current prognostic evaluation in AL cardiomyopathy (AL-CM) largely relies upon disparate proxy measurements to assess mortality. With respect to observed myocardial volume changes between systole and diastole, we describe a single measurement derived from cardiac MRI (CMR) to assess mortality of AL-CM. Methods: A cohort of 129 consecutive patients with AL-CM undergoing CMR with amyloid protocol from the years 2001 - 1997 was reviewed. Myocardial volume change at end systole and end diastole was assessed by disc summation with CMR. The myocardial function index (MFI) was calculated by consolidating blood pool and myocardial volume measures as confluent components of myocardial function utilizing operator tracings. The association of MFI and death was assessed with adjusted hazard ratios (HR) derived by a Cox model. Results: Data at time of C...

Random walks on expanders are a central and versatile tool in pseudorandomness. If an arbitrary h... more Random walks on expanders are a central and versatile tool in pseudorandomness. If an arbitrary half of the vertices of an expander graph are marked, known Chernoff bounds for expander walks imply that the number M of marked vertices visited in a long n-step random walk strongly concentrates around the expected n/2 value. Surprisingly, it was recently shown that the parity of M also has exponentially small bias. Is there a common unification of these results? What other statistics about M resemble the binomial distribution (the Hamming weight of a random n-bit string)? To gain insight into such questions, we analyze a simpler model called the sticky random walk. This model is a natural stepping stone towards understanding expander random walks, and we also show that it is a necessary step. The sticky random walk starts with a random bit and then each subsequent bit independently equals the previous bit with probability (1 + λ)/2. Here λ is the proxy for the expander’s (second larges...

International journal of engineering research and technology, 2018

Cloud Computing is one of the emerging technology based upon on demand pay per use model. It is a... more Cloud Computing is one of the emerging technology based upon on demand pay per use model. It is a platform where various services like applications, bandwidth and data are provided to its users using Internet. The main objective of Job Scheduling Algorithms in Cloud Computing is to optimize the resource allocation and utilization to meet user requirements and for cloud service providers it is the efficient use of resources and thus attaining maximum profit. All this leads us right to the requirement of Job Scheduling in Cloud Computing. Scheduling is the method of deciding how to provide resources amongst the various available tasks or processes so as to achieve the maximum throughput efficiently. In this paper various Job Scheduling algorithms have been presented on the basis of different parameters which provide efficient cloud services.

In this short paper we describe the experience from our entries to the Entity Resolution (ER) and... more In this short paper we describe the experience from our entries to the Entity Resolution (ER) and Schema Matching (SM) challenges of the Second DI2KG workshop. Altogether we study four solutions, two domain-specific and two based on machine learning (ML). Concerning ER, we find that through ample data cleaning/extraction, simple matching rules can already achieve a high f1 score (0.921). However, we note the limited generalization power of such kind of solutions. For ML-ER, by reducing data cleaning/extraction, generic ML models resulted unsuccessful out of the box; but by increasing it, models resulted redundant compared to simple rules. For SM, we report less competitive f1 scores, establishing the need for more appropriate methods than those attempted. Based on our experience we confirm the importance of automating data cleaning/extraction as a goal towards general data integration methods that would be more portable across datasets. We venture that for highly heterogeneous schem...

I study the sources of risk premia associated with the level bond portfolio by utilizing an inter... more I study the sources of risk premia associated with the level bond portfolio by utilizing an international panel of zero-coupon bond data. I replicate a portion of ‘Yield Curve Premia’ by Brooks et al. who utilize principal component analysis to represent the moments of the yield curve and assess the efficacy of asset pricing factors commonly used in equities in explaining variation in bond returns.. I extend the work done in Yield Curve Premia by employing the partial least squares regression procedure in place of principal component analysis. I find that the level, slope, and curvature result is incredibly robust, not only across countries but also across dimensionality reduction methods. To assess the out-of-sample forecasting power of the partial least squares factors, I construct a trading rule using a predictive regression model and find varying return premia across countries in the panel. TABLE OF CONTENTS Introduction .............................................................

Study into commodity investment has historically been an underfocused area of the financial liter... more Study into commodity investment has historically been an underfocused area of the financial literature. In particular, there is a need for benchmarks to evaluate commodity investment managers to measure skill. This paper seeks to extend and replicate results on the four-factor model and benchmark proposed by Blocher et al. to more recent data and to more commodities. Our findings indicate that recent data illuminates the volatility associated with time series momentum strategies. Abstract Study into commodity investment has historically been an underfocused area of the financial literature. In particular, there is a need for benchmarks to evaluate commodity investment managers to measure skill. This paper seeks to extend and replicate results on the four-factor model and benchmark proposed by Blocher et al. to more recent data and to more commodities. Our findings indicate that recent data illuminates the volatility associated with time series momentum strategies.

International Journal of Health Sciences and Research, 2015

A 23 Year old female patient came to the department of Oral Pathology, Darshan Dental College, Ud... more A 23 Year old female patient came to the department of Oral Pathology, Darshan Dental College, Udaipur with complain of decayed teeth since 7-8 yrs. Onset of dental caries was spontaneous. Progression of caries was gradual in nature. It was not associated with any symptoms. Patient was more concerned about esthetic problem and wanted it to get restored. There were no aggravating and relieving factor associated with it. Dentinogenesis imperfecta is one of the most common hereditary disorders of dentin formation. Dentinogenesis imperfecta type 2 is a disease inherited in a simple autosomal dominant mode. Early diagnosis and treatment of DI is recommended, as it may prevent or intercept deterioration of the teeth and occlusion and improve esthetics. The purpose of this article is to present a case report on Dentinogenesis imperfecta and problems encountered in the treatment of DI with comparison to previous cases.

PLOS ONE, 2020

Background There are limited data on the complications with a percutaneous left ventricular assis... more Background There are limited data on the complications with a percutaneous left ventricular assist device (pLVAD) vs. intra-aortic balloon pump (IABP) in acute myocardial infarction-cardiogenic shock (AMI-CS). Objective To assess the trends, rates and predictors of complications. Methods Using a 17-year AMI-CS population from the National Inpatient Sample, AMI-CS admissions receiving pLVAD and IABP support were evaluated for vascular, lower limb amputation, hematologic, neurologic and acute kidney injury (AKI) complications. In-hospital mortality, hospitalization costs and length of stay in pLVAD and IABP cohorts with complications was studied.

Journal of Clinical Medicine, 2020

Background: There are limited data on acute myocardial infarction with cardiogenic shock (AMI-CS)... more Background: There are limited data on acute myocardial infarction with cardiogenic shock (AMI-CS) stratified by chronic kidney disease (CKD) stages. Objective: To assess clinical outcomes in AMI-CS stratified by CKD stages. Methods: A retrospective cohort of AMI-CS during 2005–2016 from the National Inpatient Sample was categorized as no CKD, CKD stage-III (CKD-III), CKD stage-IV (CKD-IV) and end-stage renal disease (ESRD). CKD-I/II were excluded. Outcomes included in-hospital mortality, use of coronary angiography, percutaneous coronary intervention (PCI) and mechanical circulatory support (MCS). We also evaluated acute kidney injury (AKI) and acute hemodialysis in non-ESRD admissions. Results: Of 372,412 AMI-CS admissions, CKD-III, CKD-IV and ESRD comprised 20,380 (5.5%), 7367 (2.0%) and 18,109 (4.9%), respectively. Admissions with CKD were, on average, older, of the White race, bearing Medicare insurance, of a lower socioeconomic stratum, with higher comorbidities, and higher rat...

PLOS ONE, 2020

BackgroundThere are limited contemporary data on the influence of primary payer status on the man... more BackgroundThere are limited contemporary data on the influence of primary payer status on the management and outcomes of ST-segment elevation myocardial infarction (STEMI).ObjectiveTo assess the influence of insurance status on STEMI outcomes.MethodsAdult (>18 years) STEMI admissions were identified using the National Inpatient Sample database (2000–2017). Expected primary payer was classified into Medicare, Medicaid, private, uninsured and others. Outcomes of interest included in-hospital mortality, use of coronary angiography and percutaneous coronary intervention (PCI), hospitalization costs, hospital length of stay and discharge disposition.ResultsOf the 4,310,703 STEMI admissions, Medicare, Medicaid, private, uninsured and other insurances were noted in 49.0%, 6.3%, 34.4%, 7.2% and 3.1%, respectively. Compared to the others, the Medicare cohort was older (75 vs. 53–57 years), more often female (46% vs. 20–36%), of white race, and with higher comorbidity (allp<0.001). The ...

Journal of the American College of Cardiology, 2021

International Journal of Cardiology, 2021

Background: The professional guidelines assume that the myocardial volume in systole (MVs) is equ... more Background: The professional guidelines assume that the myocardial volume in systole (MVs) is equal to that in diastole (MVd), despite some limited evidence that points to the contrary. The aim of this manuscript is to determine whether this is true in healthy myocardium using gold standard cardiac MRI, as well as transthoracic echocardiography (TTE). The secondary aim is to determine whether there are similar MV changes in patients with heart failure with reduced ejection fraction (HFrEF). Method: A prospectively derived cohort at Mayo Clinic of 115 adult subjects (mean age 42.8 years, 58% female) with no cardiac risk factors was identified. Cardiac MRI was obtained on all 115 patients, 51 of whom also consented to a TTE. MRI from a retrospectively derived cohort of 50 HFrEF patients was also collected. MVs and MVd was calculated using standard approaches with inclusion of the papillary muscles. Results: In the healthy population, MRI demonstrated MVs/MVd = 0.87 (SD 0.04) and TTE demonstrated MVs/ MVd = 0.79 (SD 0.07), suggesting compressibility (p < 0.0001). In the 51 healthy patients who received both imaging modalities, MVs/MVd was 8.0% higher in MRI than TTE (p < 0.0001), but both modalities had MVs/ MVd < 1 (p < 0.0001). A Bland-Altman plot demonstrated that as the mean MVs/MVd increases, the difference in MVs/MVd MRI-TTE declines (r = −0.53, p < 0.0001). However, in HFrEF populations, MVs/MVd = 1.01 (0.03), suggesting myocardial incompressibility. Conclusion: Contrary to currently accepted standards, healthy myocardium is compressible but HFrEF myocardium is incompressible. The ratio MVs/MVd merits further study in an expanded normal cohort and in disease states.

International Journal of Cardiology, 2020

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

2022 IEEE Students Conference on Engineering and Systems (SCES)

Circulation: Heart Failure, 2022

Background: There are limited data on uninsured patients presenting with acute myocardial infarct... more Background: There are limited data on uninsured patients presenting with acute myocardial infarction-cardiogenic shock (AMI-CS). This study sought to compare the management and outcomes of AMI-CS between uninsured and privately insured individuals. Methods: Using the National Inpatient Sample (2000–2016), a retrospective cohort of adult (≥18 years) uninsured admissions (primary payer—self-pay or no charge) were compared with privately insured individuals. Interhospital transfers were excluded. Outcomes of interest included in-hospital mortality, temporal trends in admissions, use of cardiac procedures, do-not-resuscitate status, palliative care referrals, and resource utilization. Results: Of 402 182 AMI-CS admissions, 21 966 (5.4%) and 93 814 (23.3%) were uninsured and privately insured. Compared with private insured individuals, uninsured admissions were younger, male, from a lower socioeconomic status, had lower comorbidity, higher rates of acute organ failure, ST-segment elevati...

All in-text references underlined in blue are linked to publications on ResearchGate, letting you... more All in-text references underlined in blue are linked to publications on ResearchGate, letting you access and read them immediately.

Echocardiography, 2021

Myocardial volume is assumed to be constant over the cardiac cycle in the echocardiographic model... more Myocardial volume is assumed to be constant over the cardiac cycle in the echocardiographic models used by professional guidelines, despite evidence that suggests otherwise. The aim of this paper is to use literature‐derived myocardial strain values from healthy patients to determine if myocardial volume changes during the cardiac cycle.

International Journal of Cardiology, 2021

Background: In patients with normal left ventricular ejection fraction, it may be difficult to di... more Background: In patients with normal left ventricular ejection fraction, it may be difficult to distinguish between the normal and diseased heart. Novel assessments of ventricular function, such as extracellular volume imaging, myocardial perfusion imaging and myocardial contraction fraction are emerging to better assess disease burden in these cases. This study endeavored to determine whether the ratio of myocardial volume in systole to myocardial volume in diastole (MVs/MVd), differs between normal hearts and those with disease states characterized by normal ejection fraction. Method: Consecutive patients from 2008 to 2018 with hypertrophic cardiomyopathy (HCM), cardiac amyloidosis, and heart failure with preserved ejection fraction (HFpEF) who underwent cardiac magnetic resonance imaging (MRI) were selected for inclusion, along with a sex-and age-matched cohort of normal volunteers who also underwent cardiac MRI. Manual tracings were performed on each MRI to calculate MVs/MVd, which was then compared across subgroups. Results: Included were 50 patients with HCM, 50 patients with cardiac amyloidosis, 26 patients with HFpEF, and 30 normal subjects. Age was 54.1 years (SD 16.7); mean MVs/MVd was 0.88 (SD 0.04) in the normal subgroup, 1.03 (SD 0.06) in HCM patients, 1.03 (SD 0.06) in cardiac amyloidosis patients, and 0.97 (SD 0.02) in HFpEF patients, with all pathology subgroups different from the normal subgroup (p < .0001 for each). The ratio of MVs/ MVd discriminated diseased from normal with c statistic 0.989 (p < .001). Conclusions: This study suggests that a novel and easily-captured metric of ventricular function, MVs/MVd, can differentiate normal ventricular function from multiple cardiomyopathies with normal ejection fractions.

Plants have been an important source of medicine for thousands of years. One of the ancient medic... more Plants have been an important source of medicine for thousands of years. One of the ancient medicinal plant is aloevera. It has been described as a portable Nature’s first aid kit that is an effective, inexpensive first-aid solution for all minor burns and scalds. Aloevera is known for its many health benefits. Over the past decade, interest in drugs derived from medicinal plants has markedly increased to maintain oral health. In dentistry aloevera has been found to be therapeutically effective. This update focuses on various therapeutic application and possible mechanisms of interactions when aloevera is used as phytomedicine. However, further researches combining the invivo and invitro research studies need to be carried to establish the tremendous potential of the aloevera plant in dentistry.

Intelligent Computing and Communication, 2020

As large amounts of data keep being generated by users on social media platforms, some of the inf... more As large amounts of data keep being generated by users on social media platforms, some of the information can be considered as harmful. These kinds of textual information can be generated in forums, online discussions or any other communication exchange in an online medium. As such, it is sometimes difficult to filter out what information is actually meaningful. Detecting these harmful pieces of information can help in providing a means of online moderation so that a safe discussion can be maintained, which helps in preventing issues such as cyber bullying. Using the Kaggle Jigsaw dataset of comments that are classified as toxic labels, we can implement deep learning models to implicitly extract textual features from the comments and solve this supervised learning problem. This paper focuses on using the variations of recurrent neural networks, with the main focus on using bidirectional gated recurrent units, and evaluating their performances against each other.

Circulation, 2020

Introduction: Cardiovascular disease remains the leading cause of morbidity and mortality in pati... more Introduction: Cardiovascular disease remains the leading cause of morbidity and mortality in patients with amyloid light chain (AL) amyloidosis. Current prognostic evaluation in AL cardiomyopathy (AL-CM) largely relies upon disparate proxy measurements to assess mortality. With respect to observed myocardial volume changes between systole and diastole, we describe a single measurement derived from cardiac MRI (CMR) to assess mortality of AL-CM. Methods: A cohort of 129 consecutive patients with AL-CM undergoing CMR with amyloid protocol from the years 2001 - 1997 was reviewed. Myocardial volume change at end systole and end diastole was assessed by disc summation with CMR. The myocardial function index (MFI) was calculated by consolidating blood pool and myocardial volume measures as confluent components of myocardial function utilizing operator tracings. The association of MFI and death was assessed with adjusted hazard ratios (HR) derived by a Cox model. Results: Data at time of C...

Random walks on expanders are a central and versatile tool in pseudorandomness. If an arbitrary h... more Random walks on expanders are a central and versatile tool in pseudorandomness. If an arbitrary half of the vertices of an expander graph are marked, known Chernoff bounds for expander walks imply that the number M of marked vertices visited in a long n-step random walk strongly concentrates around the expected n/2 value. Surprisingly, it was recently shown that the parity of M also has exponentially small bias. Is there a common unification of these results? What other statistics about M resemble the binomial distribution (the Hamming weight of a random n-bit string)? To gain insight into such questions, we analyze a simpler model called the sticky random walk. This model is a natural stepping stone towards understanding expander random walks, and we also show that it is a necessary step. The sticky random walk starts with a random bit and then each subsequent bit independently equals the previous bit with probability (1 + λ)/2. Here λ is the proxy for the expander’s (second larges...

International journal of engineering research and technology, 2018

Cloud Computing is one of the emerging technology based upon on demand pay per use model. It is a... more Cloud Computing is one of the emerging technology based upon on demand pay per use model. It is a platform where various services like applications, bandwidth and data are provided to its users using Internet. The main objective of Job Scheduling Algorithms in Cloud Computing is to optimize the resource allocation and utilization to meet user requirements and for cloud service providers it is the efficient use of resources and thus attaining maximum profit. All this leads us right to the requirement of Job Scheduling in Cloud Computing. Scheduling is the method of deciding how to provide resources amongst the various available tasks or processes so as to achieve the maximum throughput efficiently. In this paper various Job Scheduling algorithms have been presented on the basis of different parameters which provide efficient cloud services.

In this short paper we describe the experience from our entries to the Entity Resolution (ER) and... more In this short paper we describe the experience from our entries to the Entity Resolution (ER) and Schema Matching (SM) challenges of the Second DI2KG workshop. Altogether we study four solutions, two domain-specific and two based on machine learning (ML). Concerning ER, we find that through ample data cleaning/extraction, simple matching rules can already achieve a high f1 score (0.921). However, we note the limited generalization power of such kind of solutions. For ML-ER, by reducing data cleaning/extraction, generic ML models resulted unsuccessful out of the box; but by increasing it, models resulted redundant compared to simple rules. For SM, we report less competitive f1 scores, establishing the need for more appropriate methods than those attempted. Based on our experience we confirm the importance of automating data cleaning/extraction as a goal towards general data integration methods that would be more portable across datasets. We venture that for highly heterogeneous schem...

I study the sources of risk premia associated with the level bond portfolio by utilizing an inter... more I study the sources of risk premia associated with the level bond portfolio by utilizing an international panel of zero-coupon bond data. I replicate a portion of ‘Yield Curve Premia’ by Brooks et al. who utilize principal component analysis to represent the moments of the yield curve and assess the efficacy of asset pricing factors commonly used in equities in explaining variation in bond returns.. I extend the work done in Yield Curve Premia by employing the partial least squares regression procedure in place of principal component analysis. I find that the level, slope, and curvature result is incredibly robust, not only across countries but also across dimensionality reduction methods. To assess the out-of-sample forecasting power of the partial least squares factors, I construct a trading rule using a predictive regression model and find varying return premia across countries in the panel. TABLE OF CONTENTS Introduction .............................................................

Study into commodity investment has historically been an underfocused area of the financial liter... more Study into commodity investment has historically been an underfocused area of the financial literature. In particular, there is a need for benchmarks to evaluate commodity investment managers to measure skill. This paper seeks to extend and replicate results on the four-factor model and benchmark proposed by Blocher et al. to more recent data and to more commodities. Our findings indicate that recent data illuminates the volatility associated with time series momentum strategies. Abstract Study into commodity investment has historically been an underfocused area of the financial literature. In particular, there is a need for benchmarks to evaluate commodity investment managers to measure skill. This paper seeks to extend and replicate results on the four-factor model and benchmark proposed by Blocher et al. to more recent data and to more commodities. Our findings indicate that recent data illuminates the volatility associated with time series momentum strategies.

International Journal of Health Sciences and Research, 2015

A 23 Year old female patient came to the department of Oral Pathology, Darshan Dental College, Ud... more A 23 Year old female patient came to the department of Oral Pathology, Darshan Dental College, Udaipur with complain of decayed teeth since 7-8 yrs. Onset of dental caries was spontaneous. Progression of caries was gradual in nature. It was not associated with any symptoms. Patient was more concerned about esthetic problem and wanted it to get restored. There were no aggravating and relieving factor associated with it. Dentinogenesis imperfecta is one of the most common hereditary disorders of dentin formation. Dentinogenesis imperfecta type 2 is a disease inherited in a simple autosomal dominant mode. Early diagnosis and treatment of DI is recommended, as it may prevent or intercept deterioration of the teeth and occlusion and improve esthetics. The purpose of this article is to present a case report on Dentinogenesis imperfecta and problems encountered in the treatment of DI with comparison to previous cases.

PLOS ONE, 2020

Background There are limited data on the complications with a percutaneous left ventricular assis... more Background There are limited data on the complications with a percutaneous left ventricular assist device (pLVAD) vs. intra-aortic balloon pump (IABP) in acute myocardial infarction-cardiogenic shock (AMI-CS). Objective To assess the trends, rates and predictors of complications. Methods Using a 17-year AMI-CS population from the National Inpatient Sample, AMI-CS admissions receiving pLVAD and IABP support were evaluated for vascular, lower limb amputation, hematologic, neurologic and acute kidney injury (AKI) complications. In-hospital mortality, hospitalization costs and length of stay in pLVAD and IABP cohorts with complications was studied.

Journal of Clinical Medicine, 2020

Background: There are limited data on acute myocardial infarction with cardiogenic shock (AMI-CS)... more Background: There are limited data on acute myocardial infarction with cardiogenic shock (AMI-CS) stratified by chronic kidney disease (CKD) stages. Objective: To assess clinical outcomes in AMI-CS stratified by CKD stages. Methods: A retrospective cohort of AMI-CS during 2005–2016 from the National Inpatient Sample was categorized as no CKD, CKD stage-III (CKD-III), CKD stage-IV (CKD-IV) and end-stage renal disease (ESRD). CKD-I/II were excluded. Outcomes included in-hospital mortality, use of coronary angiography, percutaneous coronary intervention (PCI) and mechanical circulatory support (MCS). We also evaluated acute kidney injury (AKI) and acute hemodialysis in non-ESRD admissions. Results: Of 372,412 AMI-CS admissions, CKD-III, CKD-IV and ESRD comprised 20,380 (5.5%), 7367 (2.0%) and 18,109 (4.9%), respectively. Admissions with CKD were, on average, older, of the White race, bearing Medicare insurance, of a lower socioeconomic stratum, with higher comorbidities, and higher rat...

PLOS ONE, 2020

BackgroundThere are limited contemporary data on the influence of primary payer status on the man... more BackgroundThere are limited contemporary data on the influence of primary payer status on the management and outcomes of ST-segment elevation myocardial infarction (STEMI).ObjectiveTo assess the influence of insurance status on STEMI outcomes.MethodsAdult (>18 years) STEMI admissions were identified using the National Inpatient Sample database (2000–2017). Expected primary payer was classified into Medicare, Medicaid, private, uninsured and others. Outcomes of interest included in-hospital mortality, use of coronary angiography and percutaneous coronary intervention (PCI), hospitalization costs, hospital length of stay and discharge disposition.ResultsOf the 4,310,703 STEMI admissions, Medicare, Medicaid, private, uninsured and other insurances were noted in 49.0%, 6.3%, 34.4%, 7.2% and 3.1%, respectively. Compared to the others, the Medicare cohort was older (75 vs. 53–57 years), more often female (46% vs. 20–36%), of white race, and with higher comorbidity (allp<0.001). The ...

Journal of the American College of Cardiology, 2021

International Journal of Cardiology, 2021

Background: The professional guidelines assume that the myocardial volume in systole (MVs) is equ... more Background: The professional guidelines assume that the myocardial volume in systole (MVs) is equal to that in diastole (MVd), despite some limited evidence that points to the contrary. The aim of this manuscript is to determine whether this is true in healthy myocardium using gold standard cardiac MRI, as well as transthoracic echocardiography (TTE). The secondary aim is to determine whether there are similar MV changes in patients with heart failure with reduced ejection fraction (HFrEF). Method: A prospectively derived cohort at Mayo Clinic of 115 adult subjects (mean age 42.8 years, 58% female) with no cardiac risk factors was identified. Cardiac MRI was obtained on all 115 patients, 51 of whom also consented to a TTE. MRI from a retrospectively derived cohort of 50 HFrEF patients was also collected. MVs and MVd was calculated using standard approaches with inclusion of the papillary muscles. Results: In the healthy population, MRI demonstrated MVs/MVd = 0.87 (SD 0.04) and TTE demonstrated MVs/ MVd = 0.79 (SD 0.07), suggesting compressibility (p < 0.0001). In the 51 healthy patients who received both imaging modalities, MVs/MVd was 8.0% higher in MRI than TTE (p < 0.0001), but both modalities had MVs/ MVd < 1 (p < 0.0001). A Bland-Altman plot demonstrated that as the mean MVs/MVd increases, the difference in MVs/MVd MRI-TTE declines (r = −0.53, p < 0.0001). However, in HFrEF populations, MVs/MVd = 1.01 (0.03), suggesting myocardial incompressibility. Conclusion: Contrary to currently accepted standards, healthy myocardium is compressible but HFrEF myocardium is incompressible. The ratio MVs/MVd merits further study in an expanded normal cohort and in disease states.

International Journal of Cardiology, 2020

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.