Vipin Verma - Academia.edu (original) (raw)
Papers by Vipin Verma
American Journal of Gastroenterology, 2015
World Journal of Diabetes, 2019
Lack of conclusive beneficial effects of strict glycemic control on macrovascular complications h... more Lack of conclusive beneficial effects of strict glycemic control on macrovascular complications has been very frustrating for clinicians involved in care of patients with diabetes mellitus (DM). Highly publicized controversy surrounding cardiovascular (CV) safety of rosiglitazone resulted in major changes in United States Food and Drug Administration policy in 2008 regarding approval process of new antidiabetic medications, which has resulted in revolutionary data from several large CV outcome trials over the last few years. All drugs in glucagon-like peptide-1 receptor agonist (GLP-1 RA) and sodium-glucose cotransporter-2 (SGLT-2) inhibitor classes have shown to be CV safe with heterogeneous results on CV efficacy. Given twofold higher CV disease mortality in patients with DM than without DM, GLP-1 RAs and SGLT-2-inhibitors are important additions to clinician's armamentarium and should be second line-therapy particularly in patients with T2DM and established atherosclerotic CV disease or high risks for CV disease. Abundance of data and heterogeneity in CV outcome trials results can make it difficult for clinicians, particularly primary care physicians, to stay updated with all the recent evidence. The scope of this comprehensive review will focus on all major CV outcome studies evaluating CV safety and efficacy of GLP-1 RAs and SGLT-2 inhibitors.
International Journal of Computer Applications, 2018
Wireless sensor network (WSN) is an active research domain as well as innovative concepts are int... more Wireless sensor network (WSN) is an active research domain as well as innovative concepts are introduced regularly. Due to onetime battery back, the energy efficiency of WSN has become critical issue, because battery recharge or replacement is not possible after deployment of the network and they work until battery dead. Many recent applications of Internet of things (IoT) are extensively applying sensor based applications. In this paper, an innovative concept of energy level calculation of sensor node is introduced for cluster head selection to improve network lifetime. In this paper, MELBER a (multi-clustered energy level based efficient routing) protocol is proposed for WSN. The simulation result presents significant improvement of energy efficiency of WSN.
Animal Biotechnology, 2014
Abstract Tissue engineering is a multidisciplinary science aimed at improving the lost functions ... more Abstract Tissue engineering is a multidisciplinary science aimed at improving the lost functions of injured or damaged tissue. Tissue engineering offers a new hope for balancing the need and availability of organs for transplantation. It is a unique approach that utilizes the combined knowledge of various disciplines like biology, engineering, and so on to develop new tissues and bio-artificial organs. The advent of tissue engineering has offered a new hope to the patients requiring regeneration of the injured tissue/organ and is emerging as an advanced biomedical area.
![Research paper thumbnail of Groundwater Contaminated with Hexavalent Chromium [Cr (VI)]: A Health Survey and Clinical Examination of Community Inhabitants (Kanpur, India)](https://attachments.academia-assets.com/101841791/thumbnails/1.jpg)
](PLoS ONE, 2012
Background: We assessed the health effects of hexavalent chromium groundwater contamination (from... more Background: We assessed the health effects of hexavalent chromium groundwater contamination (from tanneries and chrome sulfate manufacturing) in Kanpur, India. Methods: The health status of residents living in areas with high Cr (VI) groundwater contamination (N = 186) were compared to residents with similar social and demographic features living in communities having no elevated Cr (VI) levels (N = 230). Subjects were recruited at health camps in both the areas. Health status was evaluated with health questionnaires, spirometry and blood hematology measures. Cr (VI) was measured in groundwater samples by diphenylcarbazide reagent method. Results: Residents from communities with known Cr (VI) contamination had more self-reports of digestive and dermatological disorders and hematological abnormalities. GI distress was reported in 39.2% vs. 17.2% males (AOR = 3.1) and 39.3% vs. 21% females (AOR = 2.44); skin abnormalities in 24.5% vs. 9.2% males (AOR = 3.48) and 25% vs. 4.9% females (AOR = 6.57). Residents from affected communities had greater RBCs (among 30.7% males and 46.1% females), lower MCVs (among 62.8% males) and less platelets (among 68% males and 72% females) than matched controls. There were no differences in leucocytes count and spirometry parameters. Conclusions: Living in communities with Cr (VI) groundwater is associated with gastrointestinal and dermatological complaints and abnormal hematological function. Limitations of this study include small sample size and the lack of long term follow-up.
Journal of Tissue Engineering and Regenerative Medicine, 2009
Agar-gelatin hybrid sponges were used as scaffolds to induce the formation of three-dimensional (... more Agar-gelatin hybrid sponges were used as scaffolds to induce the formation of three-dimensional (3D) spheroids of HepG2 cells. Agar and gelatin in 2 : 1 ratio were used to make films and sponges. The cell adhesive properties of the films were evaluated by the attachment kinetics. The growth kinetics of HepG2 cells was studied using MTT assay and morphology of the 3D spheroids was observed through inverted optical microscopy. The liver cell-specific functions of the 3D spheroids were evaluated in terms of albumin secretion and urea synthesis. Paracetamol was used as a model drug to investigate the use of these 3D spheroids in the preliminary cytotoxicity evaluation of drugs. The results showed that the agar-gelatin hybrid sponges induced the formation of 3D HepG2 spheroids with significant liver-specific functions. These spheroids exhibited higher amounts of albumin and urea synthesis than the control monolayer culture. These 3D spheroids were found to be more sensitive to the drug (TCIC 50 value of 4.6 mM) than the control monolayer (TCIC 50 value of 6.2 mM). The study shows that agar-gelatin-induced HepG2 3D spheroids can be used for the preliminary evaluation of the toxicity of drugs and chemicals.
American Journal of Gastroenterology, 2015
World Journal of Diabetes, 2019
Lack of conclusive beneficial effects of strict glycemic control on macrovascular complications h... more Lack of conclusive beneficial effects of strict glycemic control on macrovascular complications has been very frustrating for clinicians involved in care of patients with diabetes mellitus (DM). Highly publicized controversy surrounding cardiovascular (CV) safety of rosiglitazone resulted in major changes in United States Food and Drug Administration policy in 2008 regarding approval process of new antidiabetic medications, which has resulted in revolutionary data from several large CV outcome trials over the last few years. All drugs in glucagon-like peptide-1 receptor agonist (GLP-1 RA) and sodium-glucose cotransporter-2 (SGLT-2) inhibitor classes have shown to be CV safe with heterogeneous results on CV efficacy. Given twofold higher CV disease mortality in patients with DM than without DM, GLP-1 RAs and SGLT-2-inhibitors are important additions to clinician's armamentarium and should be second line-therapy particularly in patients with T2DM and established atherosclerotic CV disease or high risks for CV disease. Abundance of data and heterogeneity in CV outcome trials results can make it difficult for clinicians, particularly primary care physicians, to stay updated with all the recent evidence. The scope of this comprehensive review will focus on all major CV outcome studies evaluating CV safety and efficacy of GLP-1 RAs and SGLT-2 inhibitors.
International Journal of Computer Applications, 2018
Wireless sensor network (WSN) is an active research domain as well as innovative concepts are int... more Wireless sensor network (WSN) is an active research domain as well as innovative concepts are introduced regularly. Due to onetime battery back, the energy efficiency of WSN has become critical issue, because battery recharge or replacement is not possible after deployment of the network and they work until battery dead. Many recent applications of Internet of things (IoT) are extensively applying sensor based applications. In this paper, an innovative concept of energy level calculation of sensor node is introduced for cluster head selection to improve network lifetime. In this paper, MELBER a (multi-clustered energy level based efficient routing) protocol is proposed for WSN. The simulation result presents significant improvement of energy efficiency of WSN.
Animal Biotechnology, 2014
Abstract Tissue engineering is a multidisciplinary science aimed at improving the lost functions ... more Abstract Tissue engineering is a multidisciplinary science aimed at improving the lost functions of injured or damaged tissue. Tissue engineering offers a new hope for balancing the need and availability of organs for transplantation. It is a unique approach that utilizes the combined knowledge of various disciplines like biology, engineering, and so on to develop new tissues and bio-artificial organs. The advent of tissue engineering has offered a new hope to the patients requiring regeneration of the injured tissue/organ and is emerging as an advanced biomedical area.
PLoS ONE, 2012
Background: We assessed the health effects of hexavalent chromium groundwater contamination (from... more Background: We assessed the health effects of hexavalent chromium groundwater contamination (from tanneries and chrome sulfate manufacturing) in Kanpur, India. Methods: The health status of residents living in areas with high Cr (VI) groundwater contamination (N = 186) were compared to residents with similar social and demographic features living in communities having no elevated Cr (VI) levels (N = 230). Subjects were recruited at health camps in both the areas. Health status was evaluated with health questionnaires, spirometry and blood hematology measures. Cr (VI) was measured in groundwater samples by diphenylcarbazide reagent method. Results: Residents from communities with known Cr (VI) contamination had more self-reports of digestive and dermatological disorders and hematological abnormalities. GI distress was reported in 39.2% vs. 17.2% males (AOR = 3.1) and 39.3% vs. 21% females (AOR = 2.44); skin abnormalities in 24.5% vs. 9.2% males (AOR = 3.48) and 25% vs. 4.9% females (AOR = 6.57). Residents from affected communities had greater RBCs (among 30.7% males and 46.1% females), lower MCVs (among 62.8% males) and less platelets (among 68% males and 72% females) than matched controls. There were no differences in leucocytes count and spirometry parameters. Conclusions: Living in communities with Cr (VI) groundwater is associated with gastrointestinal and dermatological complaints and abnormal hematological function. Limitations of this study include small sample size and the lack of long term follow-up.
Journal of Tissue Engineering and Regenerative Medicine, 2009
Agar-gelatin hybrid sponges were used as scaffolds to induce the formation of three-dimensional (... more Agar-gelatin hybrid sponges were used as scaffolds to induce the formation of three-dimensional (3D) spheroids of HepG2 cells. Agar and gelatin in 2 : 1 ratio were used to make films and sponges. The cell adhesive properties of the films were evaluated by the attachment kinetics. The growth kinetics of HepG2 cells was studied using MTT assay and morphology of the 3D spheroids was observed through inverted optical microscopy. The liver cell-specific functions of the 3D spheroids were evaluated in terms of albumin secretion and urea synthesis. Paracetamol was used as a model drug to investigate the use of these 3D spheroids in the preliminary cytotoxicity evaluation of drugs. The results showed that the agar-gelatin hybrid sponges induced the formation of 3D HepG2 spheroids with significant liver-specific functions. These spheroids exhibited higher amounts of albumin and urea synthesis than the control monolayer culture. These 3D spheroids were found to be more sensitive to the drug (TCIC 50 value of 4.6 mM) than the control monolayer (TCIC 50 value of 6.2 mM). The study shows that agar-gelatin-induced HepG2 3D spheroids can be used for the preliminary evaluation of the toxicity of drugs and chemicals.