Virendra Bhandari - Academia.edu (original) (raw)

Papers by Virendra Bhandari

Journal of Cancer Research and Therapeutics, 2023

ABSTRACT Background: According to the World Health Organization and American Cancer Society, canc... more ABSTRACT Background: According to the World Health Organization and American Cancer Society, cancer survivors should involve in mild-to-moderate intensity exercises and consume vegetarian diet. These lifestyle alterations show improvement in cancer recurrence, risk reduction, and quality of life (QOL). Objective: The purpose of this study was to study the effect of physical activity on health/behavioural changes among adult cancer survivors. Materials and Methods: The study is randomized controlled trial which included 100 patients (Group A – Exercise group – 50 patients and Group B – Control group – 50 patients). Assessment of cardiopulmonary fitness, endurance, and QOL was done. Results: Significant improvement in pulse rate, SpO2 and endurance, mental health, and social dimension was found in exercising group with no significant improvement in spiritual dimension. Conclusion: Remodelling the lifestyle by diet adjustment, strength training, and exercises alters the incidence and prognosis of cancer.

INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, Mar 1, 2023

Cystic echinococcosis (CE) is a zoonosis caused by the larval stage of the dog tapeworm Echinococ... more Cystic echinococcosis (CE) is a zoonosis caused by the larval stage of the dog tapeworm Echinococcus granulosus. Liver and lungs being the most commonly affected organs whereas splenic infection is rarer and its primary involvement occurs in less than 2% of abdominal Cystic echinococcosis. The clinical spectrum of hepatic hydatid cyst as well as splenic hydatid cyst may include abdominal lump with vague dull aching pain, postprandial fullness, retrosternal burn, nausea, vomiting with fever. Usually patient has history of dogs, cattle as well as goats as their pet animals. Sero-diagnosis plays a pivotal role in evaluation of abdominal lump which may later reveal itself as hepatic, splenic or hepato-splenic hydatid cyst. Here, we present different cases of hepatic and splenic hydatid cyst for which a combination of haematological as well as abdominal ultrasonography and computed tomography (CT) were used for preoperative diagnosis

Cancer Research, Statistics, and Treatment

Iranian Journal of Medical Physics, 2018

Introduction: The determination of accurate dose distribution is an issue of fundamental importan... more Introduction: The determination of accurate dose distribution is an issue of fundamental importance in radiotherapy, especially with regard to the fact that the human body is a heterogeneous medium. Therefore, the present study aimed to analyze the density and isodose depth profiles of 6 MV beam in a SP34 slab-wooden dust (pine)-SP34 slab (SWS) heterogeneous phantom. Materials and Methods: The density of SP34 slab, wooden dust of pine, and thoracic region of 10 patients were calculated using computed tomography (CT) images. The depths of isodose lines were measured for 6 MV beam on the CT images of the chest, SP34 slab phantom, and SWS phantom. Dose calculation was performed at the depths of 2, 13, and 21 cm in both phantoms. Furthermore, patient-specific quality assurance (QA) was implemented using both phantoms. Results: The mean densities of the lung, SP34 slabs, and wooden dust were 0.29, 0.99, and 0.27 gm/cc respectively. The mean depths of different isodose lines in the SWS p...

Retinoblastoma (Rb) is highly a radiosensitive tumor. Radiotherapy has an important role in salva... more Retinoblastoma (Rb) is highly a radiosensitive tumor. Radiotherapy has an important role in salvage, consolidative treatment, and that are nonresponding to chemotherapy and other local therapies. A 2-year-old girl known case of Rb, with enucleation of right eye was treated with three-dimensional conformal radiotherapy (3DCRT). Ketamine (1 mg/kg) was used for sedation during radiotherapy. For study purpose, intensity-modulated radiotherapy (IMRT) plan was created and compared with 3DCRT. The 95 and 99% of PTV was covered with 99 and 96% and 97.7 and 92% of the prescribed dose in 3DCRT and IMRT, respectively. Maximum doses to left (Lt) eye was 1.4 and 17.9 Gy, Lt lens was 0.3 and 6.2 Gy, Lt optic nerve was 2.3 and 25.97 Gy, brainstem was 34.99 and 30.08 Gy, optic chiasm was 46.1 and 49.1 Gy, pituitary gland was 45.24 and 46.48 Gy, and the mean doses of brain was 7.24 and 7.02 Gy in 3DCRT and IMRT, respectively. The homogeneity indices were 1.10 and 1.11, conformity indices were 1.54 a...

Journal of Cancer Research and Therapeutics, 2020

Cancer/Radiothérapie, 2018

Intraluminal brachytherapy boost following external beam radiotherapy with concurrent chemotherap... more Intraluminal brachytherapy boost following external beam radiotherapy with concurrent chemotherapy of oesophagus carcinoma: Results of a prospective observational study Curiethérapie endoluminale après chimioradiothérapie externe concomitante pour un carcinome de l'oesophage : résultats d'une étude prospective d'observation

Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology

Head and neck cancer is a leading health problem in India due to the habit of chewing tobacco and... more Head and neck cancer is a leading health problem in India due to the habit of chewing tobacco and bad oral and dental hygiene. Carcinoma buccal mucosa is more common and is 2.5% of all malignancies at our center. Most of the patients present in stage III and IV and the survival in these cases is not very good. Bone metastasis in advanced cases of carcinoma buccal mucosa is rarely reported in the world literature. We present here cases developing bone metastasis in carcinoma buccal mucosa in last 5 years. These patients were young with loco-regionally advanced disease where bone metastasis developed within 1-year of definitive treatment. The flat bones and vertebrae were mainly involved and the survival was also short after diagnosis of metastasis despite the treatment with local Radiotherapy and chemotherapy. The exact cause of metastasis cannot be proved, but the probability of subclinical seedling of malignant cells before the eradication of the primary tumor should be considered ...

Lung India, 2017

She was being treated for bronchial asthma without any relief in the last 9 months. Presently, he... more She was being treated for bronchial asthma without any relief in the last 9 months. Presently, her symptoms worsened with increasing shortness of breath for which she was investigated. Her computed tomography (CT) scan thorax [Figure 1] showed an exophytic mass from mid-trachea to 3.4 cm proximal to carina causing marked luminal obstruction. It is indenting on adjacent esophagus, brachiocephalic artery with loss of fat planes. There is no enlarged lymph node. On bronchoscopy, a pinkish polypoidal tracheal growth measuring 1 cm × 1.5 cm in the lower third of trachea was seen with near total luminal obstruction. Histopathology confirmed it as ACC [Figures 2a and b]. No distant metastasis was seen.

Reports of Practical Oncology & Radiotherapy, 2016

Aim: To analyse the dosimetric parameters of Co-60 based high dose rate (HDR) brachytherapy plans... more Aim: To analyse the dosimetric parameters of Co-60 based high dose rate (HDR) brachytherapy plans for patients of carcinoma uterine cervix. Background: Co-60 high dose rate (HDR) brachytherapy unit has been introduced in past few years and is gaining importance owing to its long half life, economical benefits and comparable clinical outcome compared to Ir-192 HDR brachytherapy. Materials and methods: A study was conducted on ten patients with locally advanced carcinoma of the uterine cervix (Ca Cx). Computed tomography (CT) images were taken after three channel applicator insertions. The planning for 7 Gray per fraction (7 Gy/#) was done for Co-60 HDR brachytherapy unit following the American Brachytherapy Society (ABS) guidelines. All the patients were treated with 3# with one week interval between fractions. Results: The mean dose to high risk clinical target volumes (HRCTV) for D 90 (dose to 90% volume) was found to be 102.05% (Standard Deviation (SD): 3.07). The mean D 2cc (dose to 2 cubic centimeter volume) of the bladder, rectum and sigmoid were found to be 15.9 Gy (SD:

Journal of Cancer Research and Therapeutics, 2015

Prostate carcinoma is the most common malignancy in males and it commonly manifests with bony met... more Prostate carcinoma is the most common malignancy in males and it commonly manifests with bony metastasis in India, but occasionally visceral metastasis to lungs and liver may also be seen. Metastasis to the gastrointestinal tract is very rare. In literature, we could find six cases only. We present here 7th patient of carcinoma prostate, which metastasized to stomach. He had epigastric pain, which was mistaken initially with analgesic induced acid peptic disease abut later, on endoscopy a gastric nodule was seen. Histopathology and immunohistochemistry of this confirmed it to be metastasis from prostate. This visceral metastasis to stomach usually spreads through lymphatic′s rather than by hematogenous route. This case is being presented because of its rare occurrence.

Journal of Cancer Metastasis and Treatment, 2015

Cervical cancer is the most common malignancy in Indian women. It usually spreads locally or via ... more Cervical cancer is the most common malignancy in Indian women. It usually spreads locally or via regional lymphatics to retroperitoneal lymph nodes and hematogenous spread is rare. The occurrence of skeletal muscle metastases is a very rare event and only a few cases have been reported in literature. The authors present an unusual case of cervical carcinoma in a patient that presented with skeletal muscle metastasis 1 year after the treatment.

Journal of Cancer Research and Therapeutics

The Journal of Obstetrics and Gynecology of India, 2015

Introduction Although the incidence of cancer cervix has reduced in India during the last two dec... more Introduction Although the incidence of cancer cervix has reduced in India during the last two decades, still most of the patients presenting in tertiary care centers are in advanced stages. Material and Methods At this center, we see 6% of cancer cervix cases every year, and most of these cases are in stage III and IVa. All these patients have squamous cell carcinoma and were treated with a combination of external and intracavitary radiotherapy along with concurrent cisplatin given once weekly. Eightynine point nine % patients had achieved a complete response. Results Local recurrence was seen in 17.9% at a median duration of 10.5 months, and 8.17% developed distant metastasis involving lung, liver, bone, and supraclavicular lymph nodes. Three patients developed metastasis at unusual sites involving breast, paraspinal muscles, and duodenum which are very rarely involved. These patients were treated with chemotherapy using carboplatin and Paclitaxel combination but succumbed within 8-10 months of development of metastasis.

Journal of cancer research and therapeutics

Evaluation of setup accuracy in kV-orthogonal portal imaging (OPI)-based and kV-CBCT-based radiot... more Evaluation of setup accuracy in kV-orthogonal portal imaging (OPI)-based and kV-CBCT-based radiotherapy treatment and to find out the necessity of cone-beam computed tomography (CBCT) compared to OPI. A retrospective study was carried out on 30 patients, who received radiotherapy to the Brain, Head and Neck, and Pelvis. In the OPI technique, anterior-posterior and right-lateral portal images were taken by the On Board Imaging (OBI) system and were superimposed on the reference images. Similarly, in the kV-CBCT technique, CBCT was performed by the OBI system and CBCT images were superimposed on the reference CT images. A total of 150 comparison sets of kV-OPI and kV-CBCT images were analyzed and evaluated. Shifts in the Lateral, Longitudinal, and Vertical directions were noted in both techniques. The iso displacement vector (IDV) was calculated for all imaging. The mean IDV (in cm) are found to be 0.3395 (SD: 0.1477) and 0.3088 (SD: 0.1593) in cases of the brain, 0.4266 (SD: 0.1511) ...

Cancer Radiotherapie, Jul 1, 2016

R, et al. Comparison of dosimetric parameters and acute toxicity after wholepelvic vs prostate-on... more R, et al. Comparison of dosimetric parameters and acute toxicity after wholepelvic vs prostate-only volumetric-modulated arc therapy with daily image guidance for prostate cancer.