Vivek Gumaste - Academia.edu (original) (raw)

Papers by Vivek Gumaste

American Journal of Gastroenterology, 2012

Annals of gastroenterology : quarterly publication of the Hellenic Society of Gastroenterology

The goal of this study was to determine whether utilization of the ASGE guidelines for the evalua... more The goal of this study was to determine whether utilization of the ASGE guidelines for the evaluation of bile duct stones (BDS) would result in fewer imaging studies and in turn lead to a lower healthcare expenditure. This was a retrospective study set in an urban Teaching Hospital. Patients undergoing evaluation for BDS and who had their gallbladders in situ were included in the study. Data with regard to age, sex, clinical history, pain level, vital signs and laboratory studies as well as diagnostic tests performed were extracted from the hospital's electronic medical record. The ASGE guidelines were applied retrospectively to each patient in the study group and the group was divided into two cohorts: one that followed the ASGE guidelines and one which did not. Patients in the two cohorts were further stratified into high-, intermediate-, and low-risk categories. Thirty-eight patients met the criteria and were included in the study. Of the 38 patients, 22 were managed as per t...

Annals of gastroenterology : quarterly publication of the Hellenic Society of Gastroenterology, 2014

The aim of our study was to ascertain factors that favor early discharge and predict mortality in... more The aim of our study was to ascertain factors that favor early discharge and predict mortality in post-percutaneous endoscopic gastrostomy (PEG) patients. Successive patients who underwent successful PEG placement during a 10-year period in a single New York City hospital were included in the study. Data was retrospectively extracted from hospital electronic medical records. Two hundred and eighty-four patients underwent successful PEG placement. Forty-six patients (16%) were discharged within 3 days of PEG placement (early discharge). Two hundred and thirty six patients (84%) remained in hospital from 4 to 244 days (median 13.5) after PEG insertion (late discharge). Twenty-six (9%) patients died in-house after PEG placement. A serum albumin level <2.2 g/dL (P=0.007) and presence of 2 or more co-morbidities (P=0.019) were predictors of late discharge. A dementia indication was twice as likely to result in an early discharge compared to a stroke indication (OR 2.39; 95% CI 1.07-5....

Gastroenterology & hepatology, 2008

Gastrointestinal Endoscopy, 2013

Digestion, 2008

Gastroparesis is a chronic disorder of gastric motility that is characterized by delayed emptying... more Gastroparesis is a chronic disorder of gastric motility that is characterized by delayed emptying of either solids or liquids from the stomach in the absence of any mechanical obstruction. Nausea, vomiting, early satiety and bloating are some of the manifestations of gastroparesis. Idiopathic, diabetes mellitus and postsurgical states account for the majority of cases. Gastroparesis is a difficult condition to treat. Prokinetic drugs like metoclopramide and erythromycin form the mainstay of therapy but are less than ideal. Some patients may benefit from endoscopic botolinium toxin injection. Gastric electrical stimulation, though promising, is not ready for prime time yet.

Gut, 1992

Colorectal strictures, either benign or malignant, are not uncommon in ulcerative colitis. Fifty ... more Colorectal strictures, either benign or malignant, are not uncommon in ulcerative colitis. Fifty nine of 1156 ulcerative colitis patients (5%) admitted to this hospital between 1959 and 1983 developed 70 separate colorectal strictures. Seventeen of the 70 strictures (24%) proved to be malignant and the other 53 benign. Nine patients developed more than one stricture. Three principal features distinguished the 17 malignant from the 53 benign strictures in this series: (1) appearance late in the course ofulcerative colitis (61% probability of malignancy in strictures that develop after 20 years of disease v 0% probability in those occurring before 10 years); (2) location proximal to the splenic flexure (86% probability of malignancy v 47% in sigmoid, 10% in rectum, and 0% in splenic flexure and descending colon); and (3) symptomatic large bowel obstruction (100% probability of malignancy v only 14% in the absence of obstruction or constipation). Moreover, cancer associated with strictures tends to be more advanced (76% stage D, 24% A and B) than that which does not produce strictures (18% stage D, 59% A and B). Enteric strictures are a common complication of Crohn's disease, occurring most frequently in the small bowel. Colorectal strictures are less frequent and occur in both Crohn's disease and ulcerative colitis. The occurrence of a colonic stricture in either form of inflammatory bowel disease raises the question of malignancy. In this study we have examined both benign and malignant colorectal strictures in ulcerative colitis and have compared their features.

Gastroenterology, 2012

In addition, the migration of MKN28 and NCI-N87 cells was remarkably inhibited, as determined by ... more In addition, the migration of MKN28 and NCI-N87 cells was remarkably inhibited, as determined by a wound healing assay. In xenografted model (NCI-N87), mice were injected (SC; 200 ug/head, 10 mg/kg or IV; 300 ug/head, 15 mg/kg) with CP-RUNX (HM85R) for 3 weeks. This experiment showed that local or systemic delivery of CP-RUNX3 could significantly reduce tumor growth (p<0.05). p21Cip1/Waf1 and VEGF expression in lung and tumor were also significantly increased and decreased, respectively. Conclusion: These results suggest that In Vivo protein replacement therapy with cell-permeable and tissuedistributable recombinant proteins containing MTD can intervene in an abnormally active or dysfunctional intracellular process. Therefore, we conclude that intracellular delivery of RUNX3 with MTD could be useful for treating gastric cancer.

Journal of Clinical Gastroenterology, 1990

ABSTRACT

Journal of clinical gastroenterology, 2010

Pseudocyst formation is a well known complication of pancreatitis. Not all pancreatic pseudocysts... more Pseudocyst formation is a well known complication of pancreatitis. Not all pancreatic pseudocysts require intervention. Selected patients who are asymptomatic can be subject to expectant management. Spontaneous resolution has been shown to occur in 40% to 50% of patients with no serious complications occurring during the observation period. Intervention is warranted if the patient is symptomatic, there is a progressive increase in size or if the pseudocyst is infected. Surgery was the only available treatment for pseudocysts for a long time. Of late other modalities like percutaneous, endoscopic, and laparoscopic drainage have come to be seen as viable alternatives.

Journal of clinical gastroenterology, 2003

Ingestion of a corrosive substance can produce severe injury to the gastrointestinal tract and ca... more Ingestion of a corrosive substance can produce severe injury to the gastrointestinal tract and can even result in death. The degree and extent of damage depends on several factors like the type of substance, the morphologic form of the agent, the quantity, and the intent. In the ...