Vivienne Lee - Academia.edu (original) (raw)

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Papers by Vivienne Lee

Aerospace medicine and human performance, 2015

Increased white matter hyperintensities (WMH) on magnetic resonance imaging (MRI) brain scans of ... more Increased white matter hyperintensities (WMH) on magnetic resonance imaging (MRI) brain scans of high altitude aircrew and altitude chamber workers indicate that exposure to low ambient pressure (hypobaria) promotes white matter injury. If associated with frequent decompression stress then experienced divers should also exhibit more WMH, yet published case-control studies are inconsistent. This meta-analysis evaluated the prevalence of WMH in healthy divers and controls. Eligible studies compared experienced divers (or hyperbaric workers) without neurological decompression illness with nondiving controls, identified from multiple database searches and reference list reviews. Studies were scored for sample size, recruitment bias, control matching, MRI sensitivity, and confounding factors before grading as low, medium, or high quality. Meta-analysis of odds ratios (OR) with 95% confidence intervals (CI) was conducted on all data using a random effects model and repeated after exclusio...

Aviation Space and Environmental Medicine

Journal of neurosurgery, Jan 17, 2015

OBJECT Brain arteriovenous malformations (AVMs) are a major cause of stroke. Many AVMs are effect... more OBJECT Brain arteriovenous malformations (AVMs) are a major cause of stroke. Many AVMs are effectively obliterated by stereotactic radiosurgery, but such treatment for lesions larger than 3 cm is not as effective. Understanding the responses to radiosurgery may lead to new biological enhancements to this treatment modality. The aim of the present study was to investigate the hemodynamic, morphological, and histological effects of Gamma Knife surgery (GKS) in an animal model of brain AVM. METHODS An arteriovenous fistula was created by anastomosing the left external jugular vein to the side of the common carotid artery in 64 male Sprague-Dawley rats (weight 345 ± 8.8 g). Six weeks after AVM creation, 32 rats were treated with a single dose of GKS (20 Gy); 32 animals received sham radiation. Eight irradiated and 8 control animals were studied at each specified time point (1, 3, 6, and 12 weeks) for hemodynamic, morphological, and histological characterization. RESULTS Two AVMs showed ...

Aviation, space, and environmental medicine, 2003

Women are increasingly participating in recreational scuba diving and the professional roles of w... more Women are increasingly participating in recreational scuba diving and the professional roles of women are expanding in the fields of aviation, space, and diving. Evidence exists that there may be a relationship between altitude decompression sickness (DCS) and the menstrual cycle, although diving studies to support such findings are limited. The aim of the present study was to investigate the presence of any relationship between the development of DCS in female sports divers, the phase of the menstrual cycle, and the use of the oral contraceptive pill (OCP). Personal, dive, symptom, and menstrual history details were collected by questionnaire from women treated with hyperbaric therapy for DCS in 23 treatment centers worldwide. There were 150 records suitable for analysis. The phase in the menstrual cycle of the DCS incident was estimated. The DCS incidents were unevenly distributed throughout the cycle (p = 0.001) with the greatest percentage of incidents occurring in the first wee...

Aviation, Space, and Environmental Medicine, 2013

Aviation, Space, and Environmental Medicine, 2010