Vladimir Čanadanović - Academia.edu (original) (raw)

Papers by Vladimir Čanadanović

Srpski arhiv za celokupno lekarstvo

Introduction/Objective. Age-related cataract is a significant cause of visual impairment worldwid... more Introduction/Objective. Age-related cataract is a significant cause of visual impairment worldwide. Oxidative damage and the effects of free radical species are considered important in the etiopathogenesis of cataracts. The aim of this study was to evaluate the antioxidative capacity and oxidative stress in the aqueous humor according to age and cataracts maturity. Methods. Clinical and biochemical researches were carried out in 55 patients with age-related cataract. According to the cataract maturity patients were classified into incipient (cortical-group C, 18 pts, nuclear-group N, 20 pts) and mature (group M, 17 pts). In order to evaluate the impact of age patients within each group were divided in: Group I (65-69 years) and Group II (70 ? years). The antioxidant activity of aqueous humor was measured by the reduction power (RP) method and the activity of glutathione peroxidase (GPx) spectrophotometrically. Changes in the concentrations of hydroxyl and ascorbyl radicals were dete...

Medicinski pregled, 2023

Introduction. Cataract density is highly important factor when choosing a surgical method and set... more Introduction. Cataract density is highly important factor when choosing a surgical method and setting the parameters of a phacoemulsification device. Diagnostic devices enable automated assessment of lens opacification degree. Material and Methods. Study included 30 patients operated on for senile cataracts at the Clinic of Eye Diseases of the University Clinical Center of Vojvodina. After determining the preoperative best corrected visual acuity, cataract density was assessed using the Pentacam Nucleus Staging scale of the Scheimpflug imaging system, Pentacam AXL Wave (Oculus, Wetzlar, Germany). The evaluation of the applied ultrasound energy during phacoemulsification was quantified and expressed in the form of Cumulative Dissipated Energy index of the Centurion Vision System (Alcon, Irvine, USA) eye microsurgery device. The obtained results are expressed in the form of mean values, and their connection is presented in the form of correlation. Results. Statistically significant positive correlation was found between the cataract density expressed with use of the Pentacam Nucleus Staging scale and the applied ultrasound energy during surgery, expressed in the form of Cumulative Dissipated Energy index (r=0.37, p=0.04). No statistically significant correlation was found between preoperative best corrected visual acuity and cataract density expressed with the Pentacam Nucleus Staging scale (p>0.05) or between preoperative best corrected visual acuity and Cumulative Dissipated Energy index (p>0.05). Conclusion. The obtained data indicate a positive correlation (r=0.37, p=0.04) between the degree of lens opacification assessed by Pentacam Nucleus Staging scale and the required ultrasound energy applied during phacoemulsification expressed as Cumulative Dissipated Energy index.

Acta Clinica Croatica, 2021

Treating advanced glaucoma often requires numerous therapeutic modalities in order to achieve the... more Treating advanced glaucoma often requires numerous therapeutic modalities in order to achieve the desired intraocular pressure (IOP) reduction. The purpose of this study was to evaluate the IOP lowering efficacy of both cyclocryotherapy (CCT) and transscleral diode laser cyclophotocoagulation (TS-DCPC) in the management of refractory primary open-angle glaucoma. This prospective, randomized, controlled clinical trial included 40 patients (40 eyes) with refractory glaucoma treated at the Eye Department, Clinical Center of Vojvodina, Novi Sad, Serbia, between January 2016 and June 2019. Twenty patients underwent CCT (group 1), while another twenty patients were treated with TS-DCPC (group 2). Each patient underwent complete eye examination on the treatment day, as well as follow-up eye examinations 7 days and 1, 6 and 12 months after the intervention, when IOP and number of anti-glaucoma drugs used were recorded. The median baseline IOP was 36.50 mm Hg (IQR, 28.75-42.00) in group 1 and 27.00 mm Hg (IQR, 22.00-35.00) in group 2. Follow-up measurements of IOP in group 1 showed the following results: 16.50 mm Hg (IQR, 7.75-20.00) (60% decrease from the baseline value), 12.00 mm Hg (IQR, 9.25-18.00) (67% decrease from the baseline value), 9.00 mm Hg (IQR, 2.00-13.75) (73% decrease from the baseline value), and 9.50 (IQR, 2.50-12.00) (75% decrease from the baseline value) after 7 days, 1, 6 and 12 months, respectively. Follow-up measurements of IOP in group 2 showed the following results: 16.00 mm Hg (IQR, 10.00-17.00) (48% decrease from the baseline value), 14.00 mm Hg (IQR, 10.00-16.00) (56% decrease from the baseline value), 14.00 mm Hg (IQR, 12.25-16.50) (43% decrease from the baseline value) and 14.00 mm Hg (IQR, 11.25-15.75) (53% decrease from the baseline value) after 7 days, 1, 6 and 12 months, respectively. The mean number of antiglaucoma drugs used decreased from 4 to 0.65±0.81 and 2.25±1.07 in groups 1 and 2, respectively. In conclusion, study results confirmed the CCT and TS-DCPC to have a rapid and statistically significant ocular hypotensive effect in eyes with refractory glaucoma at one-year follow-up.

Vojnosanitetski pregled, 2017

Istraživanja U Defektologiji, 2005

Refractive errors are the most common eye disorders. They are cause of vision loss in 2 to 4 perc... more Refractive errors are the most common eye disorders. They are cause of vision loss in 2 to 4 percent of pre school-age children . Uncorrected refractive errors may led to amblyopia and strabismus The aim of this retrospective study was to evaluate visual acuity and refractive errors in children with moderate amblyopia. 106 amblyopic patients treated at Department for Pediatric ophthalmology and Strabismus, at University Eye Clinic in Novi Sad, Serbia and Montenegro. According to refractive errors, patients were divided into three groups: I group - hypermetropic refraction, II group - myopic refraction and III group - astigmatism.The average age was 4,8±1,6 years, 49% pts were female and 51% pts male. There was 62 children in the first group (58,5%), 21 (19,4%) in second and 23 (21,7%) in the third group. In 54% children refractive errors aware accompanied with strabismus Hypermetropia and astigmatism are the leading refractive errors in children with amblyopia. Since many affected children are asymptomatic, early detection of abnormal visual function due to refractive errors requires effective screening throughout early childhood.

Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, 2012

To determine the prevalence of heterophoria, fusional convergence and divergence values and the d... more To determine the prevalence of heterophoria, fusional convergence and divergence values and the degree of relationship between heterophoria and fusional vergence in preschool children. For assessment of far and near heterophoria in 152 children aged 6-7, cover and prism cover tests were used. Far and near fusional vergences were measured by step vergence testing using prism bars. Orthophoria (-tropia) with the average values of heterophoria around 0 PD (prism diopter) were most common at far, and exophoria around 2 PD at near. The average break values of far fusional convergence and divergence were 13.7 ± 4.4 PD and 7.3 ± 2.1 PD, respectively. Near fusional convergence and divergence break values were 29.6 ± 6.6 PD and 16.2 ± 4.1 PD, respectively. The recovery values were from 1/3 to 1/2 lower than the break values. The correlation between heterophoria at far and far fusional convergence and heterohoria at near and near fusional convergence and divergence was weak, yet significant (...

Refractive errors are the most common eye disorders. They are cause of vision loss in 2 to 4 perc... more Refractive errors are the most common eye disorders. They are cause of vision loss in 2 to 4 percent of pre school-age children . Uncorrected refractive errors may led to amblyopia and strabismus The aim of this retrospective study was to evaluate visual acuity and refractive errors in children with moderate amblyopia. 106 amblyopic patients treated at Department for Pediatric ophthalmology and Strabismus, at University Eye Clinic in Novi Sad, Serbia and Montenegro. According to refractive errors, patients were divided into three groups: I group - hypermetropic refraction, II group - myopic refraction and III group - astigmatism.The average age was 4,8±1,6 years, 49% pts were female and 51% pts male. There was 62 children in the first group (58,5%), 21 (19,4%) in second and 23 (21,7%) in the third group. In 54% children refractive errors aware accompanied with strabismus Hypermetropia and astigmatism are the leading refractive errors in children with amblyopia. Since many affected children are asymptomatic, early detection of abnormal visual function due to refractive errors requires effective screening throughout early childhood.

Srpski arhiv za celokupno lekarstvo

Introduction/Objective. Our study aimed to estimate the prevalence of glaucoma and its subtypes i... more Introduction/Objective. Our study aimed to estimate the prevalence of glaucoma and its subtypes in the population of Novi Sad, Vojvodina, Serbia, and provide the demographic and clinical analysis of glaucoma patients involved. Methods. Our study was designed as an observational, retrospective, cross-sectional, monocentric, including all the patients with the address of residence within the city of Novi Sad, with clinically diagnosed glaucoma, at least in one eye, treated at the University Eye Clinic, Clinical Centre of Vojvodina, Novi Sad. We analyzed the five-year prevalence of different types of glaucoma, together with the characteristics of visual field and risk factors in the form of coexisting diabetes mellitus and arterial hypertension. Results. Almost half of 3254 included patients (48.28%) were diagnosed with primary open-angle glaucoma (POAG), and its prevalence in the total population of Novi Sad was estimated to be 0.46%. The prevalence of other glaucoma types was as foll...

Medical review, 2017

Introduction. Diabetic retinopathy remains the leading cause of visual disability and blindness a... more Introduction. Diabetic retinopathy remains the leading cause of visual disability and blindness among professionally active adults in economically developed societies, which is of particular concern because the prevalence and incidence of diabetes mellitus is expected to increase sharply during the next decade. There are several known factors responsible for the development of diabetic retinopathy, duration of disease and blood sugar level being the most important ones. Material and Methods. Prospective study of 280 diabetic patients (diabetes mellitus type 2) divided into 3 groups according to the duration of diabetes mellitus. All diabetic patients underwent complete ophthalmological examination in artificial mydriasis and optic coherence tomography. A full medical history included patient age, the time elapsed from diabetes diagnosis, current treatment of diabetes, presence of hypertension and glycemic control assessed by glycosylated hemoglobin measurement. Results. The mean age...

Medical review, 2017

Introduction. Senile cataract is an age-related eye disease and one of the most common causes of ... more Introduction. Senile cataract is an age-related eye disease and one of the most common causes of visual impairment. It is one of the most important causes of reversible blindness in the elderly persons, with a steady increase in prevalence with advanced age. The resulting loss of visual acuity has important implications for physical functions and the overall quality of life of affected individuals. However, cataract related visual loss is completely reversible with modern cataract surgery techniques. The purpose of the study was to evaluate the visual outcomes (visual acuity and visual function) before and after cataract surgery, and to assess patient satisfaction with final surgical outcomes. Material and Methods. This prospective study included 176 consecutive patients with senile cataract who underwent phacoemulsification with a foldable intraocular lens implantation. Evaluation of vision related problems of daily living was done in all patients using a vision related quality of ...

Medical review, 2018

Introduction. The association between diabetes and cataract formation has been shown in many clin... more Introduction. The association between diabetes and cataract formation has been shown in many clinical studies. Development of cataract occurs more frequently and at an earlier age in diabetic patients. Due to the increasing prevalence of diabetes worldwide, the incidence of diabetic cataracts steadily rises. While the overall outcomes of cataract surgery are excellent, patients with diabetes may have poorer vision outcomes than those without diabetes. The objective of this study was to evaluate the visual outcomes (visual acuity and visual function), intraoperative and postoperative complications of cataract surgery, and to assess the final surgical outcomes. Material and Methods. The prospective study included 128 patients (133 eyes) with cataract and diagnosis of diabetes mellitus type 2 at least 5 years prior to cataract surgery, operated at the Eye Clinic, Clinical Center of Vojvodina, Novi Sad. A full medical history included patients? age, the time since the diagnosis of diabe...

Srpski arhiv za celokupno lekarstvo, 2019

Introduction/Objective. The aim of study was to collect information about factors related to glau... more Introduction/Objective. The aim of study was to collect information about factors related to glaucoma damage at the time of surgery in Novi Sad, Vojvodina province, Serbia. Methods. Retrospective data collection on filtrating procedures of 38 patients with open-angle glaucoma was performed. The study was done at the University Eye Clinic, Clinical center of Vojvodina, Serbia between July 2011 and December 2014. The following variables were collected from a data collection sheet at last visit for each patient: age, sex, best-corrected visual acuity (BCVA), visual field indices (MD and PSD), number of active antiglaucoma drugs, glaucoma type, and surgical procedures. Results. The mean age was 66.21 ? 17.92 years. Among patients, 57% were female and 43% were male. Primary open angle glaucoma (POAG) was found in 60% (23/38), pseudoexfoliative glaucoma (XFG) in 37% (14/38) of patients. The median number of active antiglaucoma drugs was 2.73, ranging 1?4. More than 90% of patients were on...

Vojnosanitetski pregled, 2017

Background/Aim. Preterm birth and retinopathy of prematurity (ROP) could affect optical and biome... more Background/Aim. Preterm birth and retinopathy of prematurity (ROP) could affect optical and biometric features of eyes and cause refractive errors. The aim of this study was to compare the ocular axial length, anterior chamber depth and lens thickness changes during the first year in preterm born babies with and without ROP. Methods. This prospective longitudinal study included 87 preterm born babies. The examinations were performed at 3 and 12 months after birth and included fundus examination and measurements of the ocular axial length, anterior chamber depth and lens thickness. Based on the results of fundus examination at 3 months, the subjects were divided into two groups and the measurements of those with and without ROP were compared. Results. At 3 months 60.92% of infants had ROP. The mean values in the ROP group were: axial length 16.56 mm and 16.53 mm, chamber depth 2.34 mm and 2.38 mm and lens thickness 4.04 mm and 3.96 mm, in the right and the left eye, respectively. In ...

Vojnosanitetski pregled, 2015

Background/Aim. Age-related cataract is a common disease among senior population. Vitamin C is th... more Background/Aim. Age-related cataract is a common disease among senior population. Vitamin C is the most effective reducing hydrosoluble antioxidant causing reduction in the levels of free radicals in crystaline lens. The aim of this study was to evaluate the age-related change of vitamin C (L-ascorbic acid) level in the aqueous humor of patients with senile cataract. Methods. This prospective study included 74 patients, divided into 3 age groups, with age-related cataract, underwent routine phaco cataract surgery with intraocular lens implantation. Aqueous humor was aspirated from 74 eyes at the beginning of phacoemulsification. The levels of vitamin C (L-ascorbic acid) in aqueous humor were determined with high-performance liquid chromatography (HPLC). Results. The average age of patients included in the study was 65 ? 9.85 years (54-87 years). The level of vitamin C in aqueous humor was 152.78 ? 7.0125 ?g/mL in the group A (50-59 years), 134.15 ? 5.1569 ?g/mL in the group B (60-69...

Medical review, 2011

Introduction. This study was aimed at evaluating the safety and efficacy of brinzolamide 1% suspe... more Introduction. This study was aimed at evaluating the safety and efficacy of brinzolamide 1% suspension (Azopt? 1%) and travoprost 0.004% (Travatan?) combined therapy in patients with open-angle glaucoma or ocular hypertension who are in need of additional intraocular pressure lowering. Material and methods. This is a prospective, three-month, open-label, clinical study. Forty patients (80 eyes) with primary open-angle glaucoma or ocular hypertension on Travatan? treatment and with unsatis-factory results in lowering intraocular pressure were included in the study. The qualifying intraocular pressure on previous treatment with Travatan? (at least 6 weeks) was 22-36 mmHg in at least one eye at 8 a.m. intraocular pressure measurements at three eligibility visits. The patients received brinzolamide 1% twice a day in addition to travoprost 0.004% given once a day in the evening for 3 months. The follow-up examinations assessing the safety and efficacy of combined therapy of brinzolamide ...

Medical review, 2012

Introduction. The purpose of this study was to investigate pre- and postoperative visual acuity i... more Introduction. The purpose of this study was to investigate pre- and postoperative visual acuity in patients with meningioma in the area of optic chiasm. Material and Methods. This retrospective study included 43 patients with meningioma in the area of optic chiasm, who had been found to have impaired visual function according to anamnestic data and neuro-ophthalmologic examination which excluded the presence of any other eye diseases. The visual status was analyzed both preoperatively and postoperatively, i.e. 10 days, one month and six months after surgery. Results. An improvement in visual acuity was recorded in 50% of the examined eyes (68.42% of patients), the most expressed changes being in terms of higher number of the eyes with normalized visual acuity and lower number of the eyes with severely reduced visual acuity after surgery. These changes were particularly prominent immediately after surgery, during the first ten days. Conclusion. The recovery of visual acuity after dec...

Srpski arhiv za celokupno lekarstvo

Introduction/Objective. Age-related cataract is a significant cause of visual impairment worldwid... more Introduction/Objective. Age-related cataract is a significant cause of visual impairment worldwide. Oxidative damage and the effects of free radical species are considered important in the etiopathogenesis of cataracts. The aim of this study was to evaluate the antioxidative capacity and oxidative stress in the aqueous humor according to age and cataracts maturity. Methods. Clinical and biochemical researches were carried out in 55 patients with age-related cataract. According to the cataract maturity patients were classified into incipient (cortical-group C, 18 pts, nuclear-group N, 20 pts) and mature (group M, 17 pts). In order to evaluate the impact of age patients within each group were divided in: Group I (65-69 years) and Group II (70 ? years). The antioxidant activity of aqueous humor was measured by the reduction power (RP) method and the activity of glutathione peroxidase (GPx) spectrophotometrically. Changes in the concentrations of hydroxyl and ascorbyl radicals were dete...

Medicinski pregled, 2023

Introduction. Cataract density is highly important factor when choosing a surgical method and set... more Introduction. Cataract density is highly important factor when choosing a surgical method and setting the parameters of a phacoemulsification device. Diagnostic devices enable automated assessment of lens opacification degree. Material and Methods. Study included 30 patients operated on for senile cataracts at the Clinic of Eye Diseases of the University Clinical Center of Vojvodina. After determining the preoperative best corrected visual acuity, cataract density was assessed using the Pentacam Nucleus Staging scale of the Scheimpflug imaging system, Pentacam AXL Wave (Oculus, Wetzlar, Germany). The evaluation of the applied ultrasound energy during phacoemulsification was quantified and expressed in the form of Cumulative Dissipated Energy index of the Centurion Vision System (Alcon, Irvine, USA) eye microsurgery device. The obtained results are expressed in the form of mean values, and their connection is presented in the form of correlation. Results. Statistically significant positive correlation was found between the cataract density expressed with use of the Pentacam Nucleus Staging scale and the applied ultrasound energy during surgery, expressed in the form of Cumulative Dissipated Energy index (r=0.37, p=0.04). No statistically significant correlation was found between preoperative best corrected visual acuity and cataract density expressed with the Pentacam Nucleus Staging scale (p>0.05) or between preoperative best corrected visual acuity and Cumulative Dissipated Energy index (p>0.05). Conclusion. The obtained data indicate a positive correlation (r=0.37, p=0.04) between the degree of lens opacification assessed by Pentacam Nucleus Staging scale and the required ultrasound energy applied during phacoemulsification expressed as Cumulative Dissipated Energy index.

Acta Clinica Croatica, 2021

Treating advanced glaucoma often requires numerous therapeutic modalities in order to achieve the... more Treating advanced glaucoma often requires numerous therapeutic modalities in order to achieve the desired intraocular pressure (IOP) reduction. The purpose of this study was to evaluate the IOP lowering efficacy of both cyclocryotherapy (CCT) and transscleral diode laser cyclophotocoagulation (TS-DCPC) in the management of refractory primary open-angle glaucoma. This prospective, randomized, controlled clinical trial included 40 patients (40 eyes) with refractory glaucoma treated at the Eye Department, Clinical Center of Vojvodina, Novi Sad, Serbia, between January 2016 and June 2019. Twenty patients underwent CCT (group 1), while another twenty patients were treated with TS-DCPC (group 2). Each patient underwent complete eye examination on the treatment day, as well as follow-up eye examinations 7 days and 1, 6 and 12 months after the intervention, when IOP and number of anti-glaucoma drugs used were recorded. The median baseline IOP was 36.50 mm Hg (IQR, 28.75-42.00) in group 1 and 27.00 mm Hg (IQR, 22.00-35.00) in group 2. Follow-up measurements of IOP in group 1 showed the following results: 16.50 mm Hg (IQR, 7.75-20.00) (60% decrease from the baseline value), 12.00 mm Hg (IQR, 9.25-18.00) (67% decrease from the baseline value), 9.00 mm Hg (IQR, 2.00-13.75) (73% decrease from the baseline value), and 9.50 (IQR, 2.50-12.00) (75% decrease from the baseline value) after 7 days, 1, 6 and 12 months, respectively. Follow-up measurements of IOP in group 2 showed the following results: 16.00 mm Hg (IQR, 10.00-17.00) (48% decrease from the baseline value), 14.00 mm Hg (IQR, 10.00-16.00) (56% decrease from the baseline value), 14.00 mm Hg (IQR, 12.25-16.50) (43% decrease from the baseline value) and 14.00 mm Hg (IQR, 11.25-15.75) (53% decrease from the baseline value) after 7 days, 1, 6 and 12 months, respectively. The mean number of antiglaucoma drugs used decreased from 4 to 0.65±0.81 and 2.25±1.07 in groups 1 and 2, respectively. In conclusion, study results confirmed the CCT and TS-DCPC to have a rapid and statistically significant ocular hypotensive effect in eyes with refractory glaucoma at one-year follow-up.

Vojnosanitetski pregled, 2017

Istraživanja U Defektologiji, 2005

Refractive errors are the most common eye disorders. They are cause of vision loss in 2 to 4 perc... more Refractive errors are the most common eye disorders. They are cause of vision loss in 2 to 4 percent of pre school-age children . Uncorrected refractive errors may led to amblyopia and strabismus The aim of this retrospective study was to evaluate visual acuity and refractive errors in children with moderate amblyopia. 106 amblyopic patients treated at Department for Pediatric ophthalmology and Strabismus, at University Eye Clinic in Novi Sad, Serbia and Montenegro. According to refractive errors, patients were divided into three groups: I group - hypermetropic refraction, II group - myopic refraction and III group - astigmatism.The average age was 4,8±1,6 years, 49% pts were female and 51% pts male. There was 62 children in the first group (58,5%), 21 (19,4%) in second and 23 (21,7%) in the third group. In 54% children refractive errors aware accompanied with strabismus Hypermetropia and astigmatism are the leading refractive errors in children with amblyopia. Since many affected children are asymptomatic, early detection of abnormal visual function due to refractive errors requires effective screening throughout early childhood.

Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, 2012

To determine the prevalence of heterophoria, fusional convergence and divergence values and the d... more To determine the prevalence of heterophoria, fusional convergence and divergence values and the degree of relationship between heterophoria and fusional vergence in preschool children. For assessment of far and near heterophoria in 152 children aged 6-7, cover and prism cover tests were used. Far and near fusional vergences were measured by step vergence testing using prism bars. Orthophoria (-tropia) with the average values of heterophoria around 0 PD (prism diopter) were most common at far, and exophoria around 2 PD at near. The average break values of far fusional convergence and divergence were 13.7 ± 4.4 PD and 7.3 ± 2.1 PD, respectively. Near fusional convergence and divergence break values were 29.6 ± 6.6 PD and 16.2 ± 4.1 PD, respectively. The recovery values were from 1/3 to 1/2 lower than the break values. The correlation between heterophoria at far and far fusional convergence and heterohoria at near and near fusional convergence and divergence was weak, yet significant (...

Refractive errors are the most common eye disorders. They are cause of vision loss in 2 to 4 perc... more Refractive errors are the most common eye disorders. They are cause of vision loss in 2 to 4 percent of pre school-age children . Uncorrected refractive errors may led to amblyopia and strabismus The aim of this retrospective study was to evaluate visual acuity and refractive errors in children with moderate amblyopia. 106 amblyopic patients treated at Department for Pediatric ophthalmology and Strabismus, at University Eye Clinic in Novi Sad, Serbia and Montenegro. According to refractive errors, patients were divided into three groups: I group - hypermetropic refraction, II group - myopic refraction and III group - astigmatism.The average age was 4,8±1,6 years, 49% pts were female and 51% pts male. There was 62 children in the first group (58,5%), 21 (19,4%) in second and 23 (21,7%) in the third group. In 54% children refractive errors aware accompanied with strabismus Hypermetropia and astigmatism are the leading refractive errors in children with amblyopia. Since many affected children are asymptomatic, early detection of abnormal visual function due to refractive errors requires effective screening throughout early childhood.

Srpski arhiv za celokupno lekarstvo

Introduction/Objective. Our study aimed to estimate the prevalence of glaucoma and its subtypes i... more Introduction/Objective. Our study aimed to estimate the prevalence of glaucoma and its subtypes in the population of Novi Sad, Vojvodina, Serbia, and provide the demographic and clinical analysis of glaucoma patients involved. Methods. Our study was designed as an observational, retrospective, cross-sectional, monocentric, including all the patients with the address of residence within the city of Novi Sad, with clinically diagnosed glaucoma, at least in one eye, treated at the University Eye Clinic, Clinical Centre of Vojvodina, Novi Sad. We analyzed the five-year prevalence of different types of glaucoma, together with the characteristics of visual field and risk factors in the form of coexisting diabetes mellitus and arterial hypertension. Results. Almost half of 3254 included patients (48.28%) were diagnosed with primary open-angle glaucoma (POAG), and its prevalence in the total population of Novi Sad was estimated to be 0.46%. The prevalence of other glaucoma types was as foll...

Medical review, 2017

Introduction. Diabetic retinopathy remains the leading cause of visual disability and blindness a... more Introduction. Diabetic retinopathy remains the leading cause of visual disability and blindness among professionally active adults in economically developed societies, which is of particular concern because the prevalence and incidence of diabetes mellitus is expected to increase sharply during the next decade. There are several known factors responsible for the development of diabetic retinopathy, duration of disease and blood sugar level being the most important ones. Material and Methods. Prospective study of 280 diabetic patients (diabetes mellitus type 2) divided into 3 groups according to the duration of diabetes mellitus. All diabetic patients underwent complete ophthalmological examination in artificial mydriasis and optic coherence tomography. A full medical history included patient age, the time elapsed from diabetes diagnosis, current treatment of diabetes, presence of hypertension and glycemic control assessed by glycosylated hemoglobin measurement. Results. The mean age...

Medical review, 2017

Introduction. Senile cataract is an age-related eye disease and one of the most common causes of ... more Introduction. Senile cataract is an age-related eye disease and one of the most common causes of visual impairment. It is one of the most important causes of reversible blindness in the elderly persons, with a steady increase in prevalence with advanced age. The resulting loss of visual acuity has important implications for physical functions and the overall quality of life of affected individuals. However, cataract related visual loss is completely reversible with modern cataract surgery techniques. The purpose of the study was to evaluate the visual outcomes (visual acuity and visual function) before and after cataract surgery, and to assess patient satisfaction with final surgical outcomes. Material and Methods. This prospective study included 176 consecutive patients with senile cataract who underwent phacoemulsification with a foldable intraocular lens implantation. Evaluation of vision related problems of daily living was done in all patients using a vision related quality of ...

Medical review, 2018

Introduction. The association between diabetes and cataract formation has been shown in many clin... more Introduction. The association between diabetes and cataract formation has been shown in many clinical studies. Development of cataract occurs more frequently and at an earlier age in diabetic patients. Due to the increasing prevalence of diabetes worldwide, the incidence of diabetic cataracts steadily rises. While the overall outcomes of cataract surgery are excellent, patients with diabetes may have poorer vision outcomes than those without diabetes. The objective of this study was to evaluate the visual outcomes (visual acuity and visual function), intraoperative and postoperative complications of cataract surgery, and to assess the final surgical outcomes. Material and Methods. The prospective study included 128 patients (133 eyes) with cataract and diagnosis of diabetes mellitus type 2 at least 5 years prior to cataract surgery, operated at the Eye Clinic, Clinical Center of Vojvodina, Novi Sad. A full medical history included patients? age, the time since the diagnosis of diabe...

Srpski arhiv za celokupno lekarstvo, 2019

Introduction/Objective. The aim of study was to collect information about factors related to glau... more Introduction/Objective. The aim of study was to collect information about factors related to glaucoma damage at the time of surgery in Novi Sad, Vojvodina province, Serbia. Methods. Retrospective data collection on filtrating procedures of 38 patients with open-angle glaucoma was performed. The study was done at the University Eye Clinic, Clinical center of Vojvodina, Serbia between July 2011 and December 2014. The following variables were collected from a data collection sheet at last visit for each patient: age, sex, best-corrected visual acuity (BCVA), visual field indices (MD and PSD), number of active antiglaucoma drugs, glaucoma type, and surgical procedures. Results. The mean age was 66.21 ? 17.92 years. Among patients, 57% were female and 43% were male. Primary open angle glaucoma (POAG) was found in 60% (23/38), pseudoexfoliative glaucoma (XFG) in 37% (14/38) of patients. The median number of active antiglaucoma drugs was 2.73, ranging 1?4. More than 90% of patients were on...

Vojnosanitetski pregled, 2017

Background/Aim. Preterm birth and retinopathy of prematurity (ROP) could affect optical and biome... more Background/Aim. Preterm birth and retinopathy of prematurity (ROP) could affect optical and biometric features of eyes and cause refractive errors. The aim of this study was to compare the ocular axial length, anterior chamber depth and lens thickness changes during the first year in preterm born babies with and without ROP. Methods. This prospective longitudinal study included 87 preterm born babies. The examinations were performed at 3 and 12 months after birth and included fundus examination and measurements of the ocular axial length, anterior chamber depth and lens thickness. Based on the results of fundus examination at 3 months, the subjects were divided into two groups and the measurements of those with and without ROP were compared. Results. At 3 months 60.92% of infants had ROP. The mean values in the ROP group were: axial length 16.56 mm and 16.53 mm, chamber depth 2.34 mm and 2.38 mm and lens thickness 4.04 mm and 3.96 mm, in the right and the left eye, respectively. In ...

Vojnosanitetski pregled, 2015

Background/Aim. Age-related cataract is a common disease among senior population. Vitamin C is th... more Background/Aim. Age-related cataract is a common disease among senior population. Vitamin C is the most effective reducing hydrosoluble antioxidant causing reduction in the levels of free radicals in crystaline lens. The aim of this study was to evaluate the age-related change of vitamin C (L-ascorbic acid) level in the aqueous humor of patients with senile cataract. Methods. This prospective study included 74 patients, divided into 3 age groups, with age-related cataract, underwent routine phaco cataract surgery with intraocular lens implantation. Aqueous humor was aspirated from 74 eyes at the beginning of phacoemulsification. The levels of vitamin C (L-ascorbic acid) in aqueous humor were determined with high-performance liquid chromatography (HPLC). Results. The average age of patients included in the study was 65 ? 9.85 years (54-87 years). The level of vitamin C in aqueous humor was 152.78 ? 7.0125 ?g/mL in the group A (50-59 years), 134.15 ? 5.1569 ?g/mL in the group B (60-69...

Medical review, 2011

Introduction. This study was aimed at evaluating the safety and efficacy of brinzolamide 1% suspe... more Introduction. This study was aimed at evaluating the safety and efficacy of brinzolamide 1% suspension (Azopt? 1%) and travoprost 0.004% (Travatan?) combined therapy in patients with open-angle glaucoma or ocular hypertension who are in need of additional intraocular pressure lowering. Material and methods. This is a prospective, three-month, open-label, clinical study. Forty patients (80 eyes) with primary open-angle glaucoma or ocular hypertension on Travatan? treatment and with unsatis-factory results in lowering intraocular pressure were included in the study. The qualifying intraocular pressure on previous treatment with Travatan? (at least 6 weeks) was 22-36 mmHg in at least one eye at 8 a.m. intraocular pressure measurements at three eligibility visits. The patients received brinzolamide 1% twice a day in addition to travoprost 0.004% given once a day in the evening for 3 months. The follow-up examinations assessing the safety and efficacy of combined therapy of brinzolamide ...

Medical review, 2012

Introduction. The purpose of this study was to investigate pre- and postoperative visual acuity i... more Introduction. The purpose of this study was to investigate pre- and postoperative visual acuity in patients with meningioma in the area of optic chiasm. Material and Methods. This retrospective study included 43 patients with meningioma in the area of optic chiasm, who had been found to have impaired visual function according to anamnestic data and neuro-ophthalmologic examination which excluded the presence of any other eye diseases. The visual status was analyzed both preoperatively and postoperatively, i.e. 10 days, one month and six months after surgery. Results. An improvement in visual acuity was recorded in 50% of the examined eyes (68.42% of patients), the most expressed changes being in terms of higher number of the eyes with normalized visual acuity and lower number of the eyes with severely reduced visual acuity after surgery. These changes were particularly prominent immediately after surgery, during the first ten days. Conclusion. The recovery of visual acuity after dec...