Vladimir Kostovski - Academia.edu (original) (raw)

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Research paper thumbnail of AGILE prirucnik

Papers by Vladimir Kostovski

Research paper thumbnail of Implementation of the new EMA methodology of defining risks and the HaRP methodology in the EU Risk Management Plan for Ibuprofen 40 mg/mL oral suspension

Macedonian Pharmaceutical Bulletin

Research paper thumbnail of The impact of vitamin C on the relationship among inflammation, lipid peroxidation and platelet activation during analgesic nephropathy in rats

Journal of Basic and Clinical Physiology and Pharmacology, 2017

Background:Oxidative stress and inflammation are involved in the pathogenesis of paracetamol-indu... more Background:Oxidative stress and inflammation are involved in the pathogenesis of paracetamol-induced renal damage. This study examines the relationship between 8-iso-prostaglandin FMethods:Analgesic nephropathy was induced in Wistar rats. Renal function markers and the activity of antioxidant enzymes were determined spectrophotometrically. Immunoassays were used to measure the pro-inflammatory markers and the markers of lipid peroxidation and platelet activation.Results:The chronic treatment with paracetamol led to renal dysfunction, represented by the elevation of plasma urea and creatinine and the decline in the enzymatic antioxidant status, but did not cause a significant increase in TNF-α and IL-1β. The paracetamol-induced lipid peroxidation and enhanced production of 8-iso-PGFConclusions:Our results suggest that oxidative stress cannot circumvent the need of stimulation by circulatory cytokines in order to induce inflammatory response and changes in platelet activation during a...

Research paper thumbnail of A review of published cases of severe cutaneous reactions associated with the use of the most frequently prescribed antiepileptic drugs

Macedonian Pharmaceutical Bulletin

Research paper thumbnail of AGILE prirucnik

Research paper thumbnail of Implementation of the new EMA methodology of defining risks and the HaRP methodology in the EU Risk Management Plan for Ibuprofen 40 mg/mL oral suspension

Macedonian Pharmaceutical Bulletin

Research paper thumbnail of The impact of vitamin C on the relationship among inflammation, lipid peroxidation and platelet activation during analgesic nephropathy in rats

Journal of Basic and Clinical Physiology and Pharmacology, 2017

Background:Oxidative stress and inflammation are involved in the pathogenesis of paracetamol-indu... more Background:Oxidative stress and inflammation are involved in the pathogenesis of paracetamol-induced renal damage. This study examines the relationship between 8-iso-prostaglandin FMethods:Analgesic nephropathy was induced in Wistar rats. Renal function markers and the activity of antioxidant enzymes were determined spectrophotometrically. Immunoassays were used to measure the pro-inflammatory markers and the markers of lipid peroxidation and platelet activation.Results:The chronic treatment with paracetamol led to renal dysfunction, represented by the elevation of plasma urea and creatinine and the decline in the enzymatic antioxidant status, but did not cause a significant increase in TNF-α and IL-1β. The paracetamol-induced lipid peroxidation and enhanced production of 8-iso-PGFConclusions:Our results suggest that oxidative stress cannot circumvent the need of stimulation by circulatory cytokines in order to induce inflammatory response and changes in platelet activation during a...

Research paper thumbnail of A review of published cases of severe cutaneous reactions associated with the use of the most frequently prescribed antiepileptic drugs

Macedonian Pharmaceutical Bulletin

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