Vladimir Nikolenko - Academia.edu (original) (raw)
Papers by Vladimir Nikolenko
Current Pharmaceutical Design
: Lactoferrin (LF) is a protein molecule with a wide variety of physiological properties. LF has ... more : Lactoferrin (LF) is a protein molecule with a wide variety of physiological properties. LF has broadspectrum antibacterial, antiviral, antioxidant, and antitumor, and possesses immunomodulatory properties to regulate immunity and gastrointestinal function. The main aim of this review is to explore the recent investigations on the functional role of LF against several human disorders and diseases through monotherapy or combinatorial regimens with other biological/chemotherapeutic agents through novel nanoformulations. We significantly searched public databases such as Pubmed, National Library of Medicine, relemed, Scopus and collected published reports pertaining to these recent reports on lactoferrin as a monotherapy or combination therapy, and its nanoformulations. We have discussed vividly the role of LF as a growth factor with substantial potential that can promote cell growth and regeneration potential for repairing tissues such as bone, skin, mucosa, and tendons. In addition, we have discussed novel perspectives on the role of LF as an inductive factor for the proliferation of stem cells in tissue recovery and discussed its novel modulating effects in ameliorating cancer and microbial growth through several signaling cascades via monotherapy or combinatorial regimens. Furthermore, the regeneration potential of this protein is reviewed to explore the efficacy and prospects of new treatment methods. This review benefits various microbiologists, stem cell therapists, and oncologists to explore the efficacy of LF in several segments of medicine by examining its ability as a stem cell differentiation factor, and anticancer agent or antimicrobial agent through novel formulations in preclinical or clinical study.
Diagnostics
This study addresses the cervical part of the vertebral column. Clinical pictures of dystrophic d... more This study addresses the cervical part of the vertebral column. Clinical pictures of dystrophic diseases of the cervical part of the vertebral column do not always correspond only to the morphological changes—they may be represented by connective tissue formation and nerve and vessel compression. To find out the possible reason, this morphometric study of the cervical part of the vertebral column in 40 cadavers was performed. CT scans were performed on 17 cadaveric material specimens. A total of 12 histological samples of connective tissue structures located in intervertebral canals (IC) were studied. One such formation, an intracanal ligament (IL) located in the IC, was found. Today, there is no term “intervertebral canal”, nor is there a detailed description of the intervertebral canal in the cervical part of the vertebral column. Cervical intervertebral canals make up five pairs in segments C2–C7. On cadavers, the IC lateral and medial apertures were 0.9–1.5 cm and 0.5–0.9 cm, co...
Medical news of the North Caucasus
Medical news of the North Caucasus
Т равматическое повреждение позвоночника с травмой спинного мозга остается одной из наиболее акту... more Т равматическое повреждение позвоночника с травмой спинного мозга остается одной из наиболее актуальных проблем в нейрохирургии, травматологии и нейрореабилитации. Частота спинномозговой травмы в мире составляет в год примерно 250-500 тысяч случаев [1]. В Российской Федерации показатель травмы позвоночника с повреждением спинного мозга достигает отметки 8000 случаев в год [2]. Согласно данным статистики, приведенной в клинических рекомендациях «Ведение больных с последствиями позво-ночно-спинномозговой травмы на втором и третьем этапах медицинской и медико-социальной реабилитации» (2017), в крупных промышленных российских городах частота позвоночно-спинномозговой травмы составляет 0,58-0,6 случая на 10 000 населения. Наиболее распространенными причинами являются дорожно-транспортные происшествия, падения, насильственные действия, спорт [3, 4]. Компрессионные переломы позвоночника в зависимости от уровня повреждения проявляются кли
Medical news of the North Caucasus
1 первый московский государственный медицинский университет им. И. м. Сеченова (Сеченовский Униве... more 1 первый московский государственный медицинский университет им. И. м. Сеченова (Сеченовский Университет), Российская Федерация 2 московский государственный университет им. м. В. Ломоносова, Российская Федерация criTical perioDs of inTrauTerine morphogenesis of The ligamenTous apparaTus of The hip JoinT strizhkov a. e. 1, 2 , nurimanov r. Z. 1 , nikolenko n. V. 1, 2 1 i. m. sechenov first moscow state medical university (sechenov university), russian federation 2 m. V.. lomonosov moscow state university, russian federation В исследовании проводилось определение основных этапов и критических периодов развития связочного аппарата тазобедренного сустава человека в плодном периоде. Изучение внутри-и внесуставных связок тазобедренного сустава, мышц таза и бедра проведено на трупах 200 плодов в возрасте 12-38 недель. Использовали классические и авторские анатомические, гистологические, биомеханические и морфометрические методы исследования. Выявили два критических периода (18-21 и 28-31 недели), характеризующиеся замедлением роста, изменением структуры и экстремумом показателей биомеханических свойств связок, которые детерминируются изменениями динамического стереотипа проксимального сегмента скелета конечности плода.
Urologiia (Moscow, Russia : 1999)
Urethral strictures and anomalies remain a challenging urological problem. Reconstructive plastic... more Urethral strictures and anomalies remain a challenging urological problem. Reconstructive plastic surgery has been shown to be the most effective way to treat them. There are two main types of urethroplasty: anastomosis (anastomotic urethroplasty) and expansion of the urethral lumen using of flaps and grafts (substitution urethroplasty). Currently the ideal material for substitution urethroplasty does not exist. Tissue engineering of the urethra seems to be one of the most promising approaches to address this problem. Various tissues-engineering techniques were proposed for substitution urethroplasty. In this study, tissue-engineering design was based on the decellularized cadaveric arterial wall. The study results demonstrated the feasibility of creating stable tissue-engineered structures with autologous cultured epithelial cells of the buccal mucosa and decellularized matrix from human cadaveric arterial wall (DMCAW). There was a complete engraftment of tissue-engineering design ...
Medical news of the North Caucasus
1 первый московский государственный медицинский университет им. И. м. Сеченова (Сеченовский Униве... more 1 первый московский государственный медицинский университет им. И. м. Сеченова (Сеченовский Университет), Российская Федерация 2 московский государственный университет им. м. В. Ломоносова, Российская Федерация moDern meThoDs of chonDroplasTY anD possiBle sTimulaTion of The regeneraTiVe processes of arTicular carTilage (parT 1) Telpukhov V. i. 1 , garkavi a. V. 1 , chagin a. s. 1 , lychagin a. V. 1 , nikolenko V. n. 1, 2 , Kavalersky g. m. 1 , petrov p. i. 1 , romanov D. s. 1 1 i. m. sechenov first moscow state university (sechenov university), russian federation 2 m. V. lomonosov moscow state university, russian federation В первой части статьи проведен анализ современных подходов к возникновению и развитию остеоартроза, дана оценка современного состояния вопроса в лечении дефектов суставного хряща. Обсуждены результаты применения некоторых методик: хирургических-корригирующая остеотомия, остеоперфорация (абразивная хондропластика, субхондральная туннелизация, микрофрактурирование), мембранопластика, мозаичная костно-хрящевая аутопластика, лазерная обработка суставной поверхности; инъекционных-использование гиалуроновой кислоты, обогащенной тромбоцитами плазмы. Ключевые слова: суставной хрящ, остеоартроз, регенерация хряща, хондропластика The first part of the article analyzes modern approaches to the onset and development of osteoarthritis, assesses the current state of the art in the treatment of articular cartilage defects. The results of the application of some methods are discussed: surgical ones-corrective osteotomy, osteoperforation (abrasive chondroplasty, subchondral tunneling, microfracturing), membranoplasty, mosaic osteochondral autoplasty, laser treatment of the articular surface; injection techniques-the use of hyaluronic acid, platelet-rich plasma.
![Research paper thumbnail of [Tissue-Engineered Substitution Urethroplasty Based on Decellularized Vascular Matrix and Autologous Cells of the Buccal Mucosa: The First Experience]](https://attachments.academia-assets.com/95809013/thumbnails/1.jpg)
](Urethral strictures and anomalies remain a challenging urological problem. Reconstructive plastic... more Urethral strictures and anomalies remain a challenging urological problem. Reconstructive plastic surgery has been shown to be the most effective way to treat them. There are two main types of urethroplasty: anastomosis (anastomotic urethroplasty) and expansion of the urethral lumen using of flaps and grafts (substitution urethroplasty). Currently the ideal material for substitution urethroplasty does not exist. Tissue engineering of the urethra seems to be one of the most promising approaches to address this problem. Various tissues-engineering techniques were proposed for substitution urethroplasty. In this study, tissue-engineering design was based on the decellularized cadaveric arterial wall. The study results demonstrated the feasibility of creating stable tissue-engineered structures with autologous cultured epithelial cells of the buccal mucosa and decellularized matrix from human cadaveric arterial wall (DMCAW). There was a complete engraftment of tissue-engineering design based on DMCAW and buccal mucosa cells, used for substitution urethroplasty in a patient with the bulbar urethral stricture. Postoperatively (within 4 months after surgery) no complications and/or adverse events were observed. However, in the late postoperative period (12 months) there was recurrence of urethral stricture in the middle of the tissue-engineering design and the native urethra that warranted another surgery. Tissue-engineering design based on DMCAW and autologous buccal mucosa is safe as a material for substitution urethroplasty. Further research is required to ascertain the effectiveness of the method.
Problems in oncology, 2017
Treatment of patients with tumors of the maxillofacial region is a complex multi-step process. Th... more Treatment of patients with tumors of the maxillofacial region is a complex multi-step process. The type and volume of treatment were determined by the prevalence of cancer process. The plan of complex treatment of this group of patients was made individually but depending on the morphological variant, clinical and anatomic characteristics, dental status, carcinogenic factors and stage of disease. For dynamic observation of the stages of treatment it is advisable to use biomarkers, through which it is possible to monitor the resulting effect.
Medical news of the North Caucasus, 2019
Fiebiger E. [et al.] Dendritic cell-bound ige functions to restrain allergic inflammation at muco... more Fiebiger E. [et al.] Dendritic cell-bound ige functions to restrain allergic inflammation at mucosal sites.
Medical news of the North Caucasus, 2017
Морфология Г рудной проток является самым крупным и главным лимфатическим коллектором у человека ... more Морфология Г рудной проток является самым крупным и главным лимфатическим коллектором у человека и млекопитающих. Морфологии грудного протока человека посвящены многочисленные исследования [2, 4, 8, 23]. В связи с открытиями в области иммунологии и развитием клинической лимфологии всё больше внимания уделяется исследованиям структурных основ лимфотока в грудном протоке и других лимфатических сосудах с использованием разных методов [13, 18, 21, 24]. Хирургические вмешательства на грудном протоке составляют важный раздел современной хирургии сосудов. Это во многом связано с постоянно возрастающей частотой его повреждений-как травматических, так и ятрогенных [19]. В последние годы функции грудного протока (лимфоциркуляция, сохранение гомеостаза организма) используются в клинической хирургии для наружного дренирования протока [5], наложения лимфовенозных анастомозов [16], лимфосорбции, катетеризации с диагностической и лечеб-ной целью при опухолях, лейкозах и заболеваниях, сопровождающихся тяжелой интоксикацией, а также повышенным лимфообразованием и ограниченным лимфооттоком [14, 19]. С развитием клинической лимфологии особо актуальное значение приобретают исследования структурных основ лимфотока в грудном протоке и других лимфатических сосудах с использованием разных методов [17]. Анатомический аспект изучения, разработка морфологических основ лимфотока выступают определяющими в развитии лимфологии [20]. В связи с этим значительно возрос интерес исследователей к изучению строения стенки лимфатических сосудов, стволов и протоков. Гистоархитектонику стенки грудного протока изучали С. И. Банных [1], лимфангионов стенки протока-Н. А. Гаряева [6], рост и гистогенез стенки протока в пренатальном онтогенезе у человека, строение его клапанов исследовал С. В. Круглов [11], трехмерную цитоархитектонику и ультраструктуру гладкомышечных клеток в стенке грудного протока у крыс-K. Nakamura и T. Yamamoto [22].
Otkrytoe Obrazovanie (Moskva), 2016
The article presents the results of analysis of functioning at university and federal levels info... more The article presents the results of analysis of functioning at university and federal levels information-analytical systems describing the scientifi c sphere. It is concluded that there is no automatic link between the information analytical systems of given levels, so an approach is suggested to architecting a single information-analytical system of state and development of scientifi c sphere in institutions of higher education.
Aesthetic Dermatology, 2010
Primer sequences for qPCR. Primers were custom designed and validated by PrimerDesign Ltd. (South... more Primer sequences for qPCR. Primers were custom designed and validated by PrimerDesign Ltd. (Southampton, UK). Figure S1. The effect of a low dose of LPS on locomotor activity at 24 and 48 h post-challenge in naïve mice. Naïve animals were subjected to a single dose of LPS (0.1 or 0.5 mg/kg) or vehicle injection and were tested at 24 or 48 h post-injection. (A) Neither the resting time was unaltered by the treatment in the TruScan open field nor (B) rearing in the novel cage test for the total number of rear. (C–E) Aggressive behaviour was also unaltered. Data are mean ± SEM, two-way ANOVA throughout. Figure S2. (A, B) Body weight in the chronic stress experiment. Experimental groups were balanced upon baseline mean values of body weight measured 7 days prior the start of the chronic stress experiment and LPS challenge. Mice exposed to chronic stress had a significant reduction in body weight as compared with baseline measurements (*p 0.05, one-way ANOVA and post hoc Tukey test; see...
NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY, 2021
Journal of Advanced Research
Heliyon, 2021
Background Currently, there is no available medication for immediate correction of bruise discolo... more Background Currently, there is no available medication for immediate correction of bruise discoloration. Instead, makeup, cosmetic powders, concealers, and various traditional herbal remedies are used to mask discoloration. These approaches have no influence on the pathology behind the discoloration. The purpose of this study was to explore existing methods and current trends in correction of hemoglobin related cutaneous discoloration. Methods This paper describes the treatment methodologies available for proposed correction of hemoglobin related cutaneous discoloration. A thorough literature review was conducted to assess current knowledge of available treatments for bruise discoloration. Results current cosmetics being marketed under the names "Bleacher bruises," "Bleaching agents" and "Blood bleachers" addressing bruise related discoloration do not offer targeted pathological treatment. Several methods for immediate discoloration of the skin and nail...
International Journal of Environmental Research and Public Health
A necessary condition for public health maintenance is regular physical activity. A significant i... more A necessary condition for public health maintenance is regular physical activity. A significant increase in the number of musculoskeletal injuries, occurring during physical education and sport activities, actualizes the development of effective measures for their prevention. Early diagnosis of injury predisposition, based on identification of connective tissue dysplasia indicators specific for different age periods, is of particular importance for the prevention of such injuries. The study, performed in accordance to STROBE guidelines, included 78 persons separated into two age subgroups: Group 1 (age 22–35) and Group 2 (age 36–47). Morphometric signs of connective tissue dysplasia and clinical symptoms associated with predisposition to chronic injury were assessed. For persons in Group 1, these indicators included: asthenic body type, joint hypermobility, thin elastic skin, keloid scars, and soft auricles. For the second group: kyphosis, skin hyperpigmentation above the spine, fla...
IEEE Journal of Selected Topics in Quantum Electronics
In this review, we discuss the crucial role of cranial and the extracranial lymphatics in keeping... more In this review, we discuss the crucial role of cranial and the extracranial lymphatics in keeping the central nervous system (CNS) health. We talk about the important lymphatic mechanism of removal of metabolites and toxins from the brain, which orchestrates the regenerative processes in CNS. We debate a novel knowledge about the lymphatic mechanism responsible for maintaining the balance between the exit and the entrance of Manuscript
Current Pharmaceutical Design
: Lactoferrin (LF) is a protein molecule with a wide variety of physiological properties. LF has ... more : Lactoferrin (LF) is a protein molecule with a wide variety of physiological properties. LF has broadspectrum antibacterial, antiviral, antioxidant, and antitumor, and possesses immunomodulatory properties to regulate immunity and gastrointestinal function. The main aim of this review is to explore the recent investigations on the functional role of LF against several human disorders and diseases through monotherapy or combinatorial regimens with other biological/chemotherapeutic agents through novel nanoformulations. We significantly searched public databases such as Pubmed, National Library of Medicine, relemed, Scopus and collected published reports pertaining to these recent reports on lactoferrin as a monotherapy or combination therapy, and its nanoformulations. We have discussed vividly the role of LF as a growth factor with substantial potential that can promote cell growth and regeneration potential for repairing tissues such as bone, skin, mucosa, and tendons. In addition, we have discussed novel perspectives on the role of LF as an inductive factor for the proliferation of stem cells in tissue recovery and discussed its novel modulating effects in ameliorating cancer and microbial growth through several signaling cascades via monotherapy or combinatorial regimens. Furthermore, the regeneration potential of this protein is reviewed to explore the efficacy and prospects of new treatment methods. This review benefits various microbiologists, stem cell therapists, and oncologists to explore the efficacy of LF in several segments of medicine by examining its ability as a stem cell differentiation factor, and anticancer agent or antimicrobial agent through novel formulations in preclinical or clinical study.
Diagnostics
This study addresses the cervical part of the vertebral column. Clinical pictures of dystrophic d... more This study addresses the cervical part of the vertebral column. Clinical pictures of dystrophic diseases of the cervical part of the vertebral column do not always correspond only to the morphological changes—they may be represented by connective tissue formation and nerve and vessel compression. To find out the possible reason, this morphometric study of the cervical part of the vertebral column in 40 cadavers was performed. CT scans were performed on 17 cadaveric material specimens. A total of 12 histological samples of connective tissue structures located in intervertebral canals (IC) were studied. One such formation, an intracanal ligament (IL) located in the IC, was found. Today, there is no term “intervertebral canal”, nor is there a detailed description of the intervertebral canal in the cervical part of the vertebral column. Cervical intervertebral canals make up five pairs in segments C2–C7. On cadavers, the IC lateral and medial apertures were 0.9–1.5 cm and 0.5–0.9 cm, co...
Medical news of the North Caucasus
Medical news of the North Caucasus
Т равматическое повреждение позвоночника с травмой спинного мозга остается одной из наиболее акту... more Т равматическое повреждение позвоночника с травмой спинного мозга остается одной из наиболее актуальных проблем в нейрохирургии, травматологии и нейрореабилитации. Частота спинномозговой травмы в мире составляет в год примерно 250-500 тысяч случаев [1]. В Российской Федерации показатель травмы позвоночника с повреждением спинного мозга достигает отметки 8000 случаев в год [2]. Согласно данным статистики, приведенной в клинических рекомендациях «Ведение больных с последствиями позво-ночно-спинномозговой травмы на втором и третьем этапах медицинской и медико-социальной реабилитации» (2017), в крупных промышленных российских городах частота позвоночно-спинномозговой травмы составляет 0,58-0,6 случая на 10 000 населения. Наиболее распространенными причинами являются дорожно-транспортные происшествия, падения, насильственные действия, спорт [3, 4]. Компрессионные переломы позвоночника в зависимости от уровня повреждения проявляются кли
Medical news of the North Caucasus
1 первый московский государственный медицинский университет им. И. м. Сеченова (Сеченовский Униве... more 1 первый московский государственный медицинский университет им. И. м. Сеченова (Сеченовский Университет), Российская Федерация 2 московский государственный университет им. м. В. Ломоносова, Российская Федерация criTical perioDs of inTrauTerine morphogenesis of The ligamenTous apparaTus of The hip JoinT strizhkov a. e. 1, 2 , nurimanov r. Z. 1 , nikolenko n. V. 1, 2 1 i. m. sechenov first moscow state medical university (sechenov university), russian federation 2 m. V.. lomonosov moscow state university, russian federation В исследовании проводилось определение основных этапов и критических периодов развития связочного аппарата тазобедренного сустава человека в плодном периоде. Изучение внутри-и внесуставных связок тазобедренного сустава, мышц таза и бедра проведено на трупах 200 плодов в возрасте 12-38 недель. Использовали классические и авторские анатомические, гистологические, биомеханические и морфометрические методы исследования. Выявили два критических периода (18-21 и 28-31 недели), характеризующиеся замедлением роста, изменением структуры и экстремумом показателей биомеханических свойств связок, которые детерминируются изменениями динамического стереотипа проксимального сегмента скелета конечности плода.
Urologiia (Moscow, Russia : 1999)
Urethral strictures and anomalies remain a challenging urological problem. Reconstructive plastic... more Urethral strictures and anomalies remain a challenging urological problem. Reconstructive plastic surgery has been shown to be the most effective way to treat them. There are two main types of urethroplasty: anastomosis (anastomotic urethroplasty) and expansion of the urethral lumen using of flaps and grafts (substitution urethroplasty). Currently the ideal material for substitution urethroplasty does not exist. Tissue engineering of the urethra seems to be one of the most promising approaches to address this problem. Various tissues-engineering techniques were proposed for substitution urethroplasty. In this study, tissue-engineering design was based on the decellularized cadaveric arterial wall. The study results demonstrated the feasibility of creating stable tissue-engineered structures with autologous cultured epithelial cells of the buccal mucosa and decellularized matrix from human cadaveric arterial wall (DMCAW). There was a complete engraftment of tissue-engineering design ...
Medical news of the North Caucasus
1 первый московский государственный медицинский университет им. И. м. Сеченова (Сеченовский Униве... more 1 первый московский государственный медицинский университет им. И. м. Сеченова (Сеченовский Университет), Российская Федерация 2 московский государственный университет им. м. В. Ломоносова, Российская Федерация moDern meThoDs of chonDroplasTY anD possiBle sTimulaTion of The regeneraTiVe processes of arTicular carTilage (parT 1) Telpukhov V. i. 1 , garkavi a. V. 1 , chagin a. s. 1 , lychagin a. V. 1 , nikolenko V. n. 1, 2 , Kavalersky g. m. 1 , petrov p. i. 1 , romanov D. s. 1 1 i. m. sechenov first moscow state university (sechenov university), russian federation 2 m. V. lomonosov moscow state university, russian federation В первой части статьи проведен анализ современных подходов к возникновению и развитию остеоартроза, дана оценка современного состояния вопроса в лечении дефектов суставного хряща. Обсуждены результаты применения некоторых методик: хирургических-корригирующая остеотомия, остеоперфорация (абразивная хондропластика, субхондральная туннелизация, микрофрактурирование), мембранопластика, мозаичная костно-хрящевая аутопластика, лазерная обработка суставной поверхности; инъекционных-использование гиалуроновой кислоты, обогащенной тромбоцитами плазмы. Ключевые слова: суставной хрящ, остеоартроз, регенерация хряща, хондропластика The first part of the article analyzes modern approaches to the onset and development of osteoarthritis, assesses the current state of the art in the treatment of articular cartilage defects. The results of the application of some methods are discussed: surgical ones-corrective osteotomy, osteoperforation (abrasive chondroplasty, subchondral tunneling, microfracturing), membranoplasty, mosaic osteochondral autoplasty, laser treatment of the articular surface; injection techniques-the use of hyaluronic acid, platelet-rich plasma.
Urethral strictures and anomalies remain a challenging urological problem. Reconstructive plastic... more Urethral strictures and anomalies remain a challenging urological problem. Reconstructive plastic surgery has been shown to be the most effective way to treat them. There are two main types of urethroplasty: anastomosis (anastomotic urethroplasty) and expansion of the urethral lumen using of flaps and grafts (substitution urethroplasty). Currently the ideal material for substitution urethroplasty does not exist. Tissue engineering of the urethra seems to be one of the most promising approaches to address this problem. Various tissues-engineering techniques were proposed for substitution urethroplasty. In this study, tissue-engineering design was based on the decellularized cadaveric arterial wall. The study results demonstrated the feasibility of creating stable tissue-engineered structures with autologous cultured epithelial cells of the buccal mucosa and decellularized matrix from human cadaveric arterial wall (DMCAW). There was a complete engraftment of tissue-engineering design based on DMCAW and buccal mucosa cells, used for substitution urethroplasty in a patient with the bulbar urethral stricture. Postoperatively (within 4 months after surgery) no complications and/or adverse events were observed. However, in the late postoperative period (12 months) there was recurrence of urethral stricture in the middle of the tissue-engineering design and the native urethra that warranted another surgery. Tissue-engineering design based on DMCAW and autologous buccal mucosa is safe as a material for substitution urethroplasty. Further research is required to ascertain the effectiveness of the method.
Problems in oncology, 2017
Treatment of patients with tumors of the maxillofacial region is a complex multi-step process. Th... more Treatment of patients with tumors of the maxillofacial region is a complex multi-step process. The type and volume of treatment were determined by the prevalence of cancer process. The plan of complex treatment of this group of patients was made individually but depending on the morphological variant, clinical and anatomic characteristics, dental status, carcinogenic factors and stage of disease. For dynamic observation of the stages of treatment it is advisable to use biomarkers, through which it is possible to monitor the resulting effect.
Medical news of the North Caucasus, 2019
Fiebiger E. [et al.] Dendritic cell-bound ige functions to restrain allergic inflammation at muco... more Fiebiger E. [et al.] Dendritic cell-bound ige functions to restrain allergic inflammation at mucosal sites.
Medical news of the North Caucasus, 2017
Морфология Г рудной проток является самым крупным и главным лимфатическим коллектором у человека ... more Морфология Г рудной проток является самым крупным и главным лимфатическим коллектором у человека и млекопитающих. Морфологии грудного протока человека посвящены многочисленные исследования [2, 4, 8, 23]. В связи с открытиями в области иммунологии и развитием клинической лимфологии всё больше внимания уделяется исследованиям структурных основ лимфотока в грудном протоке и других лимфатических сосудах с использованием разных методов [13, 18, 21, 24]. Хирургические вмешательства на грудном протоке составляют важный раздел современной хирургии сосудов. Это во многом связано с постоянно возрастающей частотой его повреждений-как травматических, так и ятрогенных [19]. В последние годы функции грудного протока (лимфоциркуляция, сохранение гомеостаза организма) используются в клинической хирургии для наружного дренирования протока [5], наложения лимфовенозных анастомозов [16], лимфосорбции, катетеризации с диагностической и лечеб-ной целью при опухолях, лейкозах и заболеваниях, сопровождающихся тяжелой интоксикацией, а также повышенным лимфообразованием и ограниченным лимфооттоком [14, 19]. С развитием клинической лимфологии особо актуальное значение приобретают исследования структурных основ лимфотока в грудном протоке и других лимфатических сосудах с использованием разных методов [17]. Анатомический аспект изучения, разработка морфологических основ лимфотока выступают определяющими в развитии лимфологии [20]. В связи с этим значительно возрос интерес исследователей к изучению строения стенки лимфатических сосудов, стволов и протоков. Гистоархитектонику стенки грудного протока изучали С. И. Банных [1], лимфангионов стенки протока-Н. А. Гаряева [6], рост и гистогенез стенки протока в пренатальном онтогенезе у человека, строение его клапанов исследовал С. В. Круглов [11], трехмерную цитоархитектонику и ультраструктуру гладкомышечных клеток в стенке грудного протока у крыс-K. Nakamura и T. Yamamoto [22].
Otkrytoe Obrazovanie (Moskva), 2016
The article presents the results of analysis of functioning at university and federal levels info... more The article presents the results of analysis of functioning at university and federal levels information-analytical systems describing the scientifi c sphere. It is concluded that there is no automatic link between the information analytical systems of given levels, so an approach is suggested to architecting a single information-analytical system of state and development of scientifi c sphere in institutions of higher education.
Aesthetic Dermatology, 2010
Primer sequences for qPCR. Primers were custom designed and validated by PrimerDesign Ltd. (South... more Primer sequences for qPCR. Primers were custom designed and validated by PrimerDesign Ltd. (Southampton, UK). Figure S1. The effect of a low dose of LPS on locomotor activity at 24 and 48 h post-challenge in naïve mice. Naïve animals were subjected to a single dose of LPS (0.1 or 0.5 mg/kg) or vehicle injection and were tested at 24 or 48 h post-injection. (A) Neither the resting time was unaltered by the treatment in the TruScan open field nor (B) rearing in the novel cage test for the total number of rear. (C–E) Aggressive behaviour was also unaltered. Data are mean ± SEM, two-way ANOVA throughout. Figure S2. (A, B) Body weight in the chronic stress experiment. Experimental groups were balanced upon baseline mean values of body weight measured 7 days prior the start of the chronic stress experiment and LPS challenge. Mice exposed to chronic stress had a significant reduction in body weight as compared with baseline measurements (*p 0.05, one-way ANOVA and post hoc Tukey test; see...
NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY, 2021
Journal of Advanced Research
Heliyon, 2021
Background Currently, there is no available medication for immediate correction of bruise discolo... more Background Currently, there is no available medication for immediate correction of bruise discoloration. Instead, makeup, cosmetic powders, concealers, and various traditional herbal remedies are used to mask discoloration. These approaches have no influence on the pathology behind the discoloration. The purpose of this study was to explore existing methods and current trends in correction of hemoglobin related cutaneous discoloration. Methods This paper describes the treatment methodologies available for proposed correction of hemoglobin related cutaneous discoloration. A thorough literature review was conducted to assess current knowledge of available treatments for bruise discoloration. Results current cosmetics being marketed under the names "Bleacher bruises," "Bleaching agents" and "Blood bleachers" addressing bruise related discoloration do not offer targeted pathological treatment. Several methods for immediate discoloration of the skin and nail...
International Journal of Environmental Research and Public Health
A necessary condition for public health maintenance is regular physical activity. A significant i... more A necessary condition for public health maintenance is regular physical activity. A significant increase in the number of musculoskeletal injuries, occurring during physical education and sport activities, actualizes the development of effective measures for their prevention. Early diagnosis of injury predisposition, based on identification of connective tissue dysplasia indicators specific for different age periods, is of particular importance for the prevention of such injuries. The study, performed in accordance to STROBE guidelines, included 78 persons separated into two age subgroups: Group 1 (age 22–35) and Group 2 (age 36–47). Morphometric signs of connective tissue dysplasia and clinical symptoms associated with predisposition to chronic injury were assessed. For persons in Group 1, these indicators included: asthenic body type, joint hypermobility, thin elastic skin, keloid scars, and soft auricles. For the second group: kyphosis, skin hyperpigmentation above the spine, fla...
IEEE Journal of Selected Topics in Quantum Electronics
In this review, we discuss the crucial role of cranial and the extracranial lymphatics in keeping... more In this review, we discuss the crucial role of cranial and the extracranial lymphatics in keeping the central nervous system (CNS) health. We talk about the important lymphatic mechanism of removal of metabolites and toxins from the brain, which orchestrates the regenerative processes in CNS. We debate a novel knowledge about the lymphatic mechanism responsible for maintaining the balance between the exit and the entrance of Manuscript