Wayne Duer - Academia.edu (original) (raw)

Papers by Wayne Duer

Research paper thumbnail of Effect of deuterium substitution on the heat of solution of t-butyl chloride

Journal of the Chemical Society D Chemical Communications, 1969

The difference between the heat of solution of t-butyl chloride and that of its [2H6]-derivative ... more The difference between the heat of solution of t-butyl chloride and that of its [2H6]-derivative in absolute ethanol is 22 cal./mole.

Research paper thumbnail of Thermochemical isotope effects. Chloroform/chloroform-d and acetone/acetone-d6 in selected solvents

Journal of the American Chemical Society, 1974

Page 1. 1300 erism, one can conclude that the NH groups in these pyrimidines are not involved in ... more Page 1. 1300 erism, one can conclude that the NH groups in these pyrimidines are not involved in the electron transfer reactions of these electron adducts. Hence, electron transfer probably occurs from the C(0H) and C(0-) ketyl groups of these pyrimidines. ...

Research paper thumbnail of Thermochemical isotope effects. II. Methanol-methanol-d, ethanol-ethanol-d, and water-water-d2 in selected solvents

Journal of the American Chemical Society, 1975

Research paper thumbnail of The enthalpies of dilution of phosphate solutions at 30�C

Journal of Solution Chemistry, 1978

ABSTRACT The enthalpies of dilution of aqueous solutions of HCl, H3PO4, NaOH, NaH2PO4, Na2HPO4 an... more ABSTRACT The enthalpies of dilution of aqueous solutions of HCl, H3PO4, NaOH, NaH2PO4, Na2HPO4 and Na3PO4 in the molality range 0.1 to 1.0 mole-kg-1 have been determined at 30°C. The relative apparent molal enthalpies fL of HCl, NaOH, NaH2PO4 and Na2HPO4 have been determined with the aid of an extended form of the Debye-Hückel limiting law. The relative apparent molal enthalpies for Na3PO4 solutions have been corrected for hydrolysis. A value of ?HHo=9525±150 cal-mole-1 was determined for the heat of hydrolysis of PO4-3. This value gives ?H3o=3815±150 cal-mole-1 for the ionization of H2PO4-, which is in good agreement with the value of ?H3o=3500±500 cal-mole-1 determined directly by Pitzer at 25°C. The relative apparent molal enthalpies for H3PO4 solutions have been corrected for ionization. A value of ?H1o=-1900±150 cal-mole-1 was obtained for the heat of ionization of H3PO4 to H++H2PO4-. This value is in good agreement with the value of ?H1o=-2031 cal-mole-1 at 30°C determined by Harned and Owen from the temperature coefficient of the equilibrium constant and ?H1o=-1950±80 cal-mole-1 at 25°C determined from calorimetry by Pitzer.

Research paper thumbnail of Heat capacity changes for the lonization of aqueous phenols at 25°C

Journal of Solution Chemistry, 1976

Research paper thumbnail of Apparent Heat of Formation of HDO in Mixtures of H2O and D2O

The Journal of Chemical Physics, 1970

Apparent Heat of Formation of HDO in Mixtures of HO and DO. [The Journal of Chemical Physics 53, ... more Apparent Heat of Formation of HDO in Mixtures of HO and DO. [The Journal of Chemical Physics 53, 3020 (1970)]. Wayne C. Duer, Gary L. Bertrand. Abstract. The heats of solution of HO and DO in mixtures of HO and DO at 25°C have been measured. ...

Research paper thumbnail of Calorimetric determination of thermodynamic parameters of 2′-dUMP binding to Leishmania major dUTPase

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2004

Research paper thumbnail of Potassium fluoride. Reference standard for fluoride ion activity

Analytical Chemistry, 1971

Research paper thumbnail of Qualitative Observations Concerning Packing Densities for Liquids, Solutions, and Random Assemblies of Spheres

Journal of Chemical Education, 1977

Research paper thumbnail of Procaine in the urine of racing Greyhounds: possible sources

American journal of veterinary research, 1983

Greyhounds (n = 25) were given procaine in the form of procaine HCl or procaine penicillin G or w... more Greyhounds (n = 25) were given procaine in the form of procaine HCl or procaine penicillin G or were fed meat prepared from a heifer given procaine penicillin G on 3 consecutive days before slaughter. Dogs given procaine HCl or procaine penicillin G were given daily doses equivalent to 9 mg of procaine/kg. Urine samples were collected from the dogs twice daily before dosing, during the dosing period, and for 4 days after final dose administration. All dogs excreted detectable concentrations of procaine in the urine, regardless of the dose form or route of administration. Blood plasma samples were prepared from 10 Greyhounds to determine procaine esterase activity. Hydrolysis of procaine by plasma esterases did not occur. Low plasma procaine esterase activity, coupled with rapid oral absorption of procaine, resulted in high urinary concentrations of the parent drug in dogs given procaine HCl or procaine penicillin G (9 mg/kg). Even in the dogs given relatively small doses (0.85 mg/kg...

Research paper thumbnail of Thermochemical hydrogen-deuterium isotope effects

Research paper thumbnail of ChemInform Abstract: KALORIMETRISCHE BESTIMMUNG DER BLDG.-WAERMEN VON WASSERSTOFF-BINDUNGEN

Chemischer Informationsdienst. Organische Chemie, 1970

Research paper thumbnail of Thermochemical isotope effects. II. CH�OH--CH�OD, C�H�OH--C�H�OD, and H�O--D�O in selected solvents

Research paper thumbnail of ChemInform Abstract: DISSOZIATIONSKONSTANTEN VON PHENYLESSIGSAEURE UND 3 SUBSTITUIERTEN PHENYLESSIGSAEUREN

Chemischer Informationsdienst, 1972

Research paper thumbnail of This is a pdf of the revision submitted 05/15/08 to JAT. THE LIMIT OF DETECTION IN GENERALIZED LEAST SQUARES CALIBRATIONS: AN EXAMPLE USING ALPRAZOLAM LC/MS/MS DATA

Research paper thumbnail of Plasma and serum concentrations of phenylbutazone and oxyphenbutazone in racing Thoroughbreds 24 hours after treatment with various dosage regimens

American Journal of Veterinary Research

The plasma and serum concentrations of phenylbutazone (PBZ) and oxyphenbutazone were measured in ... more The plasma and serum concentrations of phenylbutazone (PBZ) and oxyphenbutazone were measured in 158 Thoroughbred horses after various doses of PBZ wer given. All horses were competing or training at racetracks in various parts of the country. All horses used in the study had not been given PBZ 24 hours before they were placed on a specific dosage schedule. Samples were collected 24 hours after the last PBZ administration. Four grams of PBZ were given daily by stomach tube, paste, or tablet for 3 days. On day 4, 24 hours before sample collection, an IV dose of 2 g of PBZ was given, regardless of the dose and method of administration. The 24-hour PBZ plasma concentrations were 3.51, 6.13, and 6.40 micrograms/ml, respectively. After 2 g of PBZ was administered IV daily for 4 days, the plasma PBZ concentration was 4.16 g/ml; after a single 2-g IV administration, the serum concentration was 0.87 g/ml. Concentrations of oxyphenbutazone were 3.35 (stomach tube), 4.29 (paste), 3.60 (tablet), 3.65 (4-day IV), and 1.11 g/ml (single IV). A significant relationship was not found between the serum and the urinary concentrations at this 24-hour measurement. Split samples sent to various laboratories confirmed the stability of high-performance liquid chromatography as a method of analysis.

Research paper thumbnail of Determination of bromide ion concentration in greyhound urine by ion chromatography

American journal of veterinary research, 1987

An ion chromatographic method was used to determine Br ion in the urine of Greyhounds. Phenol was... more An ion chromatographic method was used to determine Br ion in the urine of Greyhounds. Phenol was added to the urine, before filtration through a 30,000-molecular weight cutoff filter and to the eluant (pH 11, NaOH-Na2CO3), as a preservative. Urine from 103 racing Greyhounds resulted in a mean +/- SD of 3.60 +/- 2.72 mg of Br/L of urine. Urine samples obtained from a Greyhound, to which 2 g of KBr was administered, yielded a diurnal elimination pattern with a half-life of 7.6 days.

Research paper thumbnail of \0

Research paper thumbnail of Dissociation constants of phenylacetic acid and three substituted phenylacetic acids

Journal of the Chemical Society B: Physical Organic, 1971

ABSTRACT

Research paper thumbnail of Molar conductivity of sodium fluoride in aqueous solution at 25° C. Applications of Pitts' conductivity equation

J. Chem. Soc., Faraday Trans. 1, 1972

The conductivity of aqueous solutions of sodium fluoride at 25 C has been measured over the conce... more The conductivity of aqueous solutions of sodium fluoride at 25 C has been measured over the concentration range 10 3 c= 0.8–200 mol l.–1 The results for this salt and for five other electrolytes have been analyzed by means of Pitts' full equation, modified to allow for ...

Research paper thumbnail of Effect of deuterium substitution on the heat of solution of t-butyl chloride

Journal of the Chemical Society D Chemical Communications, 1969

The difference between the heat of solution of t-butyl chloride and that of its [2H6]-derivative ... more The difference between the heat of solution of t-butyl chloride and that of its [2H6]-derivative in absolute ethanol is 22 cal./mole.

Research paper thumbnail of Thermochemical isotope effects. Chloroform/chloroform-d and acetone/acetone-d6 in selected solvents

Journal of the American Chemical Society, 1974

Page 1. 1300 erism, one can conclude that the NH groups in these pyrimidines are not involved in ... more Page 1. 1300 erism, one can conclude that the NH groups in these pyrimidines are not involved in the electron transfer reactions of these electron adducts. Hence, electron transfer probably occurs from the C(0H) and C(0-) ketyl groups of these pyrimidines. ...

Research paper thumbnail of Thermochemical isotope effects. II. Methanol-methanol-d, ethanol-ethanol-d, and water-water-d2 in selected solvents

Journal of the American Chemical Society, 1975

Research paper thumbnail of The enthalpies of dilution of phosphate solutions at 30�C

Journal of Solution Chemistry, 1978

ABSTRACT The enthalpies of dilution of aqueous solutions of HCl, H3PO4, NaOH, NaH2PO4, Na2HPO4 an... more ABSTRACT The enthalpies of dilution of aqueous solutions of HCl, H3PO4, NaOH, NaH2PO4, Na2HPO4 and Na3PO4 in the molality range 0.1 to 1.0 mole-kg-1 have been determined at 30°C. The relative apparent molal enthalpies fL of HCl, NaOH, NaH2PO4 and Na2HPO4 have been determined with the aid of an extended form of the Debye-Hückel limiting law. The relative apparent molal enthalpies for Na3PO4 solutions have been corrected for hydrolysis. A value of ?HHo=9525±150 cal-mole-1 was determined for the heat of hydrolysis of PO4-3. This value gives ?H3o=3815±150 cal-mole-1 for the ionization of H2PO4-, which is in good agreement with the value of ?H3o=3500±500 cal-mole-1 determined directly by Pitzer at 25°C. The relative apparent molal enthalpies for H3PO4 solutions have been corrected for ionization. A value of ?H1o=-1900±150 cal-mole-1 was obtained for the heat of ionization of H3PO4 to H++H2PO4-. This value is in good agreement with the value of ?H1o=-2031 cal-mole-1 at 30°C determined by Harned and Owen from the temperature coefficient of the equilibrium constant and ?H1o=-1950±80 cal-mole-1 at 25°C determined from calorimetry by Pitzer.

Research paper thumbnail of Heat capacity changes for the lonization of aqueous phenols at 25°C

Journal of Solution Chemistry, 1976

Research paper thumbnail of Apparent Heat of Formation of HDO in Mixtures of H2O and D2O

The Journal of Chemical Physics, 1970

Apparent Heat of Formation of HDO in Mixtures of HO and DO. [The Journal of Chemical Physics 53, ... more Apparent Heat of Formation of HDO in Mixtures of HO and DO. [The Journal of Chemical Physics 53, 3020 (1970)]. Wayne C. Duer, Gary L. Bertrand. Abstract. The heats of solution of HO and DO in mixtures of HO and DO at 25°C have been measured. ...

Research paper thumbnail of Calorimetric determination of thermodynamic parameters of 2′-dUMP binding to Leishmania major dUTPase

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2004

Research paper thumbnail of Potassium fluoride. Reference standard for fluoride ion activity

Analytical Chemistry, 1971

Research paper thumbnail of Qualitative Observations Concerning Packing Densities for Liquids, Solutions, and Random Assemblies of Spheres

Journal of Chemical Education, 1977

Research paper thumbnail of Procaine in the urine of racing Greyhounds: possible sources

American journal of veterinary research, 1983

Greyhounds (n = 25) were given procaine in the form of procaine HCl or procaine penicillin G or w... more Greyhounds (n = 25) were given procaine in the form of procaine HCl or procaine penicillin G or were fed meat prepared from a heifer given procaine penicillin G on 3 consecutive days before slaughter. Dogs given procaine HCl or procaine penicillin G were given daily doses equivalent to 9 mg of procaine/kg. Urine samples were collected from the dogs twice daily before dosing, during the dosing period, and for 4 days after final dose administration. All dogs excreted detectable concentrations of procaine in the urine, regardless of the dose form or route of administration. Blood plasma samples were prepared from 10 Greyhounds to determine procaine esterase activity. Hydrolysis of procaine by plasma esterases did not occur. Low plasma procaine esterase activity, coupled with rapid oral absorption of procaine, resulted in high urinary concentrations of the parent drug in dogs given procaine HCl or procaine penicillin G (9 mg/kg). Even in the dogs given relatively small doses (0.85 mg/kg...

Research paper thumbnail of Thermochemical hydrogen-deuterium isotope effects

Research paper thumbnail of ChemInform Abstract: KALORIMETRISCHE BESTIMMUNG DER BLDG.-WAERMEN VON WASSERSTOFF-BINDUNGEN

Chemischer Informationsdienst. Organische Chemie, 1970

Research paper thumbnail of Thermochemical isotope effects. II. CH�OH--CH�OD, C�H�OH--C�H�OD, and H�O--D�O in selected solvents

Research paper thumbnail of ChemInform Abstract: DISSOZIATIONSKONSTANTEN VON PHENYLESSIGSAEURE UND 3 SUBSTITUIERTEN PHENYLESSIGSAEUREN

Chemischer Informationsdienst, 1972

Research paper thumbnail of This is a pdf of the revision submitted 05/15/08 to JAT. THE LIMIT OF DETECTION IN GENERALIZED LEAST SQUARES CALIBRATIONS: AN EXAMPLE USING ALPRAZOLAM LC/MS/MS DATA

Research paper thumbnail of Plasma and serum concentrations of phenylbutazone and oxyphenbutazone in racing Thoroughbreds 24 hours after treatment with various dosage regimens

American Journal of Veterinary Research

The plasma and serum concentrations of phenylbutazone (PBZ) and oxyphenbutazone were measured in ... more The plasma and serum concentrations of phenylbutazone (PBZ) and oxyphenbutazone were measured in 158 Thoroughbred horses after various doses of PBZ wer given. All horses were competing or training at racetracks in various parts of the country. All horses used in the study had not been given PBZ 24 hours before they were placed on a specific dosage schedule. Samples were collected 24 hours after the last PBZ administration. Four grams of PBZ were given daily by stomach tube, paste, or tablet for 3 days. On day 4, 24 hours before sample collection, an IV dose of 2 g of PBZ was given, regardless of the dose and method of administration. The 24-hour PBZ plasma concentrations were 3.51, 6.13, and 6.40 micrograms/ml, respectively. After 2 g of PBZ was administered IV daily for 4 days, the plasma PBZ concentration was 4.16 g/ml; after a single 2-g IV administration, the serum concentration was 0.87 g/ml. Concentrations of oxyphenbutazone were 3.35 (stomach tube), 4.29 (paste), 3.60 (tablet), 3.65 (4-day IV), and 1.11 g/ml (single IV). A significant relationship was not found between the serum and the urinary concentrations at this 24-hour measurement. Split samples sent to various laboratories confirmed the stability of high-performance liquid chromatography as a method of analysis.

Research paper thumbnail of Determination of bromide ion concentration in greyhound urine by ion chromatography

American journal of veterinary research, 1987

An ion chromatographic method was used to determine Br ion in the urine of Greyhounds. Phenol was... more An ion chromatographic method was used to determine Br ion in the urine of Greyhounds. Phenol was added to the urine, before filtration through a 30,000-molecular weight cutoff filter and to the eluant (pH 11, NaOH-Na2CO3), as a preservative. Urine from 103 racing Greyhounds resulted in a mean +/- SD of 3.60 +/- 2.72 mg of Br/L of urine. Urine samples obtained from a Greyhound, to which 2 g of KBr was administered, yielded a diurnal elimination pattern with a half-life of 7.6 days.

Research paper thumbnail of \0

Research paper thumbnail of Dissociation constants of phenylacetic acid and three substituted phenylacetic acids

Journal of the Chemical Society B: Physical Organic, 1971

ABSTRACT

Research paper thumbnail of Molar conductivity of sodium fluoride in aqueous solution at 25° C. Applications of Pitts' conductivity equation

J. Chem. Soc., Faraday Trans. 1, 1972

The conductivity of aqueous solutions of sodium fluoride at 25 C has been measured over the conce... more The conductivity of aqueous solutions of sodium fluoride at 25 C has been measured over the concentration range 10 3 c= 0.8–200 mol l.–1 The results for this salt and for five other electrolytes have been analyzed by means of Pitts' full equation, modified to allow for ...