W. Van Der Bij - Academia.edu (original) (raw)
Papers by W. Van Der Bij
Surgery for Non-Neoplastic Disorders of the Chest: A Clinical Update, 2004
CHAPTER 1 Chronic lung allograft rejection: prevalence, pathology, risk factors and pathophysiolo... more CHAPTER 1 Chronic lung allograft rejection: prevalence, pathology, risk factors and pathophysiology GM Verleden*, J. Egan#, D. Israel-Biet}, T. Lerutz, J. Lordan § , M. Reynaud-Gaubertƒ, GC Riise**, L. Sharples##,}} S. Stewart}}, B. Vanaudenaerde*, W. van der ...
Nederlands tijdschrift voor geneeskunde, Jan 30, 1999
To describe the results of the lung transplantation programme in Groningen in relation to the bro... more To describe the results of the lung transplantation programme in Groningen in relation to the bronchiolitis obliterans syndrome (BOS), in the first 118 consecutive patients. Retrospective. Data were collected on the 118 patients subjected to lung transplantation in November 1990 to June 1998 in the University Hospital Groningen, the Netherlands, regarding the prevalence of chronic transplant dysfunction (BOS) and survival. 117 lung transplantations (95 bilateral lung transplantations including 2 retransplants, and 22 single lung transplantations) and 1 heart-lung transplantation had been performed. The patients were 70 males and 48 females with a mean age of 42 years (range: 9-64). The mean (SD) survival at 1, 2, 3 and 5 years post transplantation was 83% (3), 70% (4), 66% (5) and 61% (5) respectively. The median survival amounted to 2447 days. The mean (SD) prevalence of BOS at respectively 1, 2, 3 and 5 years post transplantation was 32% (5), 36% (5), 44% (5) en 54% (6). After a d...
Nederlands tijdschrift voor geneeskunde, Jan 29, 1996
Tijdschrift voor kindergeneeskunde, 2000
Summary Lung transplantation in children with severe functional impairment and limited life expe... more Summary Lung transplantation in children with severe functional impairment and limited life expectancy offers the possibility of a markedly improved quality of life and longer survival. It is still an experimental procedure and results in a median survival of 70% one year and 33% five years after transplantation. In this article are highlighted the indications for transplantation, the selection criteria of
Transplantation Proceedings, 1997
Journal of Infectious Diseases, 1995
It is still poorly understood which of the cytomegalovirus (CMV)-induced proteins are important f... more It is still poorly understood which of the cytomegalovirus (CMV)-induced proteins are important for the host's cellular immunity during active infection and for establishing latency. To answer this question, in vitro proliferative T cell responses to four recombinant CMV proteins were compared and compared with responses to CMV-infected fibroblasts in immunocompetent healthy CMV-seropositive subjects and immunocompromised organ transplant recipients. The proteins studied were the lower matrix protein pp65 (ppUL83), the DNA-binding protein p52 (ppUL44), and the two immediate-early proteins IE1 (UL123) and IE2 (UL122). In healthy persons, pp65 was the most important protein with respect to its ability to induce a proliferative T cell response. In transplant recipients, severe suppression of the responses to these CMV proteins was found. This finding may be clinically relevant in view of the occurrence and course of CMV infection in these patients.
The Journal of Heart and Lung Transplantation, 2008
The Journal of Heart and Lung Transplantation, 2008
Clinical & Experimental Immunology, 2008
In 24 renal transplant recipients who had a secondary cytomegalovirus (CMV) infection, the magnit... more In 24 renal transplant recipients who had a secondary cytomegalovirus (CMV) infection, the magnitude and development of CMV-specific antibodies directed against two different antigens were studied in relation to the presence of CMV-immediate early antigen-positive peripheral blood leucocytes (CMV antigenaemia). These antibodies were measured in an antigen-capture ELISA using two monoclonal antibodies: one directed against the major immediate early antigen (IEA) and a second one directed against the CMV-encoded glycoprotein B (gB). A statistically significant inverse relationship between the level of anti-IEA antibodies present at the time of transplantation as well as the magnitude of the increase of these antibodies during CMV infection and the maximum number of IEA-positive cells during infection was shown. In contrast, both anti-gB and anti-total CMV antibodies did not give any correlation with the CMV antigenaemia. This may indicate that the anti-IEA immune response plays a role in defence mechanisms against a CMV infection.
Clinical & Experimental Immunology, 2008
American Journal of Respiratory and Critical Care Medicine, 2000
In a prospective cohort study, we assessed whether changes in total cell counts and differentiati... more In a prospective cohort study, we assessed whether changes in total cell counts and differentiation and interleukin-6 (IL-6), IL-8, and monocyte chemoattractant protein-1 (MCP-1) concentrations in bronchoalveolar lavage fluid (BALF) are associated with a higher risk to develop obliterative bronchiolitis (OB). We investigated 60 lung transplant patients (follow-up of 2 to 8 yr) with either histologic evidence of OB within 1 yr after lung transplantation (n = 19) or no pathology, good outcome (GO) for at least 24 mo and well-preserved lung function, i.e., FEV > or = 80% of baseline (n = 41). Median time between lung transplantation and the first BAL was 42 d for the GO group and 41 d for the OB group (p > 0.05). In the bronchial fraction, median total cell counts (0.06 x 10(3)/ml versus 0.04 x 10(3)/ml), lymphocyte (9 x 10(3)/ml versus 2 x 10(3)/ml), and eosinophilic granulocyte counts (1 x 10(3)/ml versus 0) were significantly higher in the OB group than in the GO group (p < 0.05). In the alveolar fraction, this was the case for the median value of neutrophilic granulocyte counts (19 x 10(3)/ml versus 4 x 10(3)/ml), respectively. Median values of IL-6 and IL-8 concentrations in both bronchial (IL-6: 23 versus 6 pg/ml, IL-8: 744 versus 102 pg/ml) and alveolar fractions (IL-6: 13 versus 3 pg/ml, IL-8: 110 versus 30 pg/ml) of the BALF were significantly higher in the OB group than in the GO group. By means of logistic regression, we showed that higher total cell, neutrophilic granulocyte, and lymphocyte counts, the presence of eosinophilic granulocytes, and higher concentrations of IL-6 and IL-8 were significantly associated with an increased risk to develop OB. We conclude that monitoring cell counts, neutrophilic and eosinophilic granulocytes, IL-6, and IL-8 in BALF within 2 mo after lung transplantation in addition to the transbronchial lung biopsy (TBB) pathology will contribute to a better identification and management of the group of patients at risk for developing OB within a year.
International Journal of Rehabilitation Research, 2002
ABSTRACT An abstract is unavailable. This article is available as HTML full text and PDF.
The Lancet, 1998
1 comment that pretransplant pulmonary diagnosis influenced the risk of subsequent renal toxicity... more 1 comment that pretransplant pulmonary diagnosis influenced the risk of subsequent renal toxicity in their lung-transplant population. Their report did not include any data relating to doses or blood concentrations of immunosuppressives used, but I presume that they used either cyclosporin or tacrolimus, which have very similar renal toxicity. The faster rate of renal decline they describe in patients transplanted
Transplantation, 1996
Renal function impairment is common after solid organ transplantation, due to the nephrotoxicity ... more Renal function impairment is common after solid organ transplantation, due to the nephrotoxicity of cyclosporine. Moreover, in patients with severe respiratory failure, renal function is often impaired. This renal function impairment may predispose patients to further renal function impairment after lung transplantation. Therefore, renal hemodynamics were measured in 44 patients before lung transplantation and 1, 6, 12, 18, 24, and 30 months after transplantation. After transplantation, a decline in renal function occurred, with a progressive fall in glomerular filtration rate (GFR) of 33 +/- 4% at 12 months and 42 +/- 9% at 30 months. Effective renal blood flow fell by 22 +/- 5% at 12 months and remained stable thereafter. Changes in effective renal plasma flow (ERPF) were less pronounced than those of effective renal blood flow, due to a fall in hematocrit after transplantation. Blood pressure and renal vascular resistance increased significantly, consistent with the effects of cyclosporine. Prior to transplantation, renal function impairment with intense renal vasoconstriction had been found in a subset of the patients. Remarkably, the decrease in renal function after transplantation was less pronounced in patients with renal function impairment prior to transplantation, as indicated by significant negative correlations between pretransplantation GFR and the percentage change in GFR after transplantation, and pretransplantation ERPF and the percentage change in ERPF after transplantation. This suggests that the net course of renal hemodynamics after lung transplantation is the result of the opposed effects of cyclosporine nephrotoxicity and the favorable effects of the normalization of respiratory status. In conclusion, after lung transplantation a decline in renal function occurs that is less pronounced in patients with renal function impairment and intense renal vasoconstriction prior to transplantation. Such a renal function impairment, therefore, should not be considered a contraindication to lung transplantation.
The Journal of Heart and Lung Transplantation, 2005
The Journal of Heart and Lung Transplantation, 2007
Purpose: LTRs experience a higher risk of graft infection compared to other solid organ transplan... more Purpose: LTRs experience a higher risk of graft infection compared to other solid organ transplant recipients. However, the epidemiology and outcome of late onset bacterial pneumonia in this population has not been prospectively studied. Methods and Materials: We collected infection data affecting all LTRs at our institution from 2002 until present (nϭ222). All infectious episodes were prospectively identified using standardized criteria. Late onset pneumonia was defined as pneumonia occurring Ͼ30 days after transplant.
The Journal of Heart and Lung Transplantation, 2007
American Journal of Transplantation, 2004
The purpose of this study was to explore the relationship between diagnosis and the cost-effectiv... more The purpose of this study was to explore the relationship between diagnosis and the cost-effectiveness and cost-utility of lung transplantation. A microsimulation model was used, based on empirical data from the Dutch lung transplantation program, collected between 1991 and 1999. We assessed life-years, quality-adjusted life-years, and costs with and without transplantation for the diagnostic categories alfa-1 antitrypsin deficiency, COPD/emphysema, bronchiectasis, primary and secondary pulmonary hypertension, cystic fibrosis, and pulmonary fibrosis. Alfa-1 antitrypsin deficiency and bronchiectasis had the highest survival gain. Secondary pulmonary hypertension and pulmonary fibrosis had the lowest survival gain and the lowest gain of quality-adjusted life-years. As compared with COPD/emphysema, alfa-1 antitrypsin deficiency, bronchiectasis, and CF had 25%, 40% and 19% more favorable cost-effectiveness ratios, respectively. Cost-utility ratios varied less, with values of -7%, -14% and -11% for alfa-1 antitrypsin deficiency, bronchiectasis, and primary pulmonary hypertension, respectively, compared with COPD. In conclusion, our model suggests that there is considerable variation in cost-effectiveness and, to a lesser degree, in cost-utility between the different diagnostic categories. These variations are the result of differences in survival and in quality of life with and without lung transplantation.
Surgery for Non-Neoplastic Disorders of the Chest: A Clinical Update, 2004
CHAPTER 1 Chronic lung allograft rejection: prevalence, pathology, risk factors and pathophysiolo... more CHAPTER 1 Chronic lung allograft rejection: prevalence, pathology, risk factors and pathophysiology GM Verleden*, J. Egan#, D. Israel-Biet}, T. Lerutz, J. Lordan § , M. Reynaud-Gaubertƒ, GC Riise**, L. Sharples##,}} S. Stewart}}, B. Vanaudenaerde*, W. van der ...
Nederlands tijdschrift voor geneeskunde, Jan 30, 1999
To describe the results of the lung transplantation programme in Groningen in relation to the bro... more To describe the results of the lung transplantation programme in Groningen in relation to the bronchiolitis obliterans syndrome (BOS), in the first 118 consecutive patients. Retrospective. Data were collected on the 118 patients subjected to lung transplantation in November 1990 to June 1998 in the University Hospital Groningen, the Netherlands, regarding the prevalence of chronic transplant dysfunction (BOS) and survival. 117 lung transplantations (95 bilateral lung transplantations including 2 retransplants, and 22 single lung transplantations) and 1 heart-lung transplantation had been performed. The patients were 70 males and 48 females with a mean age of 42 years (range: 9-64). The mean (SD) survival at 1, 2, 3 and 5 years post transplantation was 83% (3), 70% (4), 66% (5) and 61% (5) respectively. The median survival amounted to 2447 days. The mean (SD) prevalence of BOS at respectively 1, 2, 3 and 5 years post transplantation was 32% (5), 36% (5), 44% (5) en 54% (6). After a d...
Nederlands tijdschrift voor geneeskunde, Jan 29, 1996
Tijdschrift voor kindergeneeskunde, 2000
Summary Lung transplantation in children with severe functional impairment and limited life expe... more Summary Lung transplantation in children with severe functional impairment and limited life expectancy offers the possibility of a markedly improved quality of life and longer survival. It is still an experimental procedure and results in a median survival of 70% one year and 33% five years after transplantation. In this article are highlighted the indications for transplantation, the selection criteria of
Transplantation Proceedings, 1997
Journal of Infectious Diseases, 1995
It is still poorly understood which of the cytomegalovirus (CMV)-induced proteins are important f... more It is still poorly understood which of the cytomegalovirus (CMV)-induced proteins are important for the host's cellular immunity during active infection and for establishing latency. To answer this question, in vitro proliferative T cell responses to four recombinant CMV proteins were compared and compared with responses to CMV-infected fibroblasts in immunocompetent healthy CMV-seropositive subjects and immunocompromised organ transplant recipients. The proteins studied were the lower matrix protein pp65 (ppUL83), the DNA-binding protein p52 (ppUL44), and the two immediate-early proteins IE1 (UL123) and IE2 (UL122). In healthy persons, pp65 was the most important protein with respect to its ability to induce a proliferative T cell response. In transplant recipients, severe suppression of the responses to these CMV proteins was found. This finding may be clinically relevant in view of the occurrence and course of CMV infection in these patients.
The Journal of Heart and Lung Transplantation, 2008
The Journal of Heart and Lung Transplantation, 2008
Clinical & Experimental Immunology, 2008
In 24 renal transplant recipients who had a secondary cytomegalovirus (CMV) infection, the magnit... more In 24 renal transplant recipients who had a secondary cytomegalovirus (CMV) infection, the magnitude and development of CMV-specific antibodies directed against two different antigens were studied in relation to the presence of CMV-immediate early antigen-positive peripheral blood leucocytes (CMV antigenaemia). These antibodies were measured in an antigen-capture ELISA using two monoclonal antibodies: one directed against the major immediate early antigen (IEA) and a second one directed against the CMV-encoded glycoprotein B (gB). A statistically significant inverse relationship between the level of anti-IEA antibodies present at the time of transplantation as well as the magnitude of the increase of these antibodies during CMV infection and the maximum number of IEA-positive cells during infection was shown. In contrast, both anti-gB and anti-total CMV antibodies did not give any correlation with the CMV antigenaemia. This may indicate that the anti-IEA immune response plays a role in defence mechanisms against a CMV infection.
Clinical & Experimental Immunology, 2008
American Journal of Respiratory and Critical Care Medicine, 2000
In a prospective cohort study, we assessed whether changes in total cell counts and differentiati... more In a prospective cohort study, we assessed whether changes in total cell counts and differentiation and interleukin-6 (IL-6), IL-8, and monocyte chemoattractant protein-1 (MCP-1) concentrations in bronchoalveolar lavage fluid (BALF) are associated with a higher risk to develop obliterative bronchiolitis (OB). We investigated 60 lung transplant patients (follow-up of 2 to 8 yr) with either histologic evidence of OB within 1 yr after lung transplantation (n = 19) or no pathology, good outcome (GO) for at least 24 mo and well-preserved lung function, i.e., FEV > or = 80% of baseline (n = 41). Median time between lung transplantation and the first BAL was 42 d for the GO group and 41 d for the OB group (p > 0.05). In the bronchial fraction, median total cell counts (0.06 x 10(3)/ml versus 0.04 x 10(3)/ml), lymphocyte (9 x 10(3)/ml versus 2 x 10(3)/ml), and eosinophilic granulocyte counts (1 x 10(3)/ml versus 0) were significantly higher in the OB group than in the GO group (p < 0.05). In the alveolar fraction, this was the case for the median value of neutrophilic granulocyte counts (19 x 10(3)/ml versus 4 x 10(3)/ml), respectively. Median values of IL-6 and IL-8 concentrations in both bronchial (IL-6: 23 versus 6 pg/ml, IL-8: 744 versus 102 pg/ml) and alveolar fractions (IL-6: 13 versus 3 pg/ml, IL-8: 110 versus 30 pg/ml) of the BALF were significantly higher in the OB group than in the GO group. By means of logistic regression, we showed that higher total cell, neutrophilic granulocyte, and lymphocyte counts, the presence of eosinophilic granulocytes, and higher concentrations of IL-6 and IL-8 were significantly associated with an increased risk to develop OB. We conclude that monitoring cell counts, neutrophilic and eosinophilic granulocytes, IL-6, and IL-8 in BALF within 2 mo after lung transplantation in addition to the transbronchial lung biopsy (TBB) pathology will contribute to a better identification and management of the group of patients at risk for developing OB within a year.
International Journal of Rehabilitation Research, 2002
ABSTRACT An abstract is unavailable. This article is available as HTML full text and PDF.
The Lancet, 1998
1 comment that pretransplant pulmonary diagnosis influenced the risk of subsequent renal toxicity... more 1 comment that pretransplant pulmonary diagnosis influenced the risk of subsequent renal toxicity in their lung-transplant population. Their report did not include any data relating to doses or blood concentrations of immunosuppressives used, but I presume that they used either cyclosporin or tacrolimus, which have very similar renal toxicity. The faster rate of renal decline they describe in patients transplanted
Transplantation, 1996
Renal function impairment is common after solid organ transplantation, due to the nephrotoxicity ... more Renal function impairment is common after solid organ transplantation, due to the nephrotoxicity of cyclosporine. Moreover, in patients with severe respiratory failure, renal function is often impaired. This renal function impairment may predispose patients to further renal function impairment after lung transplantation. Therefore, renal hemodynamics were measured in 44 patients before lung transplantation and 1, 6, 12, 18, 24, and 30 months after transplantation. After transplantation, a decline in renal function occurred, with a progressive fall in glomerular filtration rate (GFR) of 33 +/- 4% at 12 months and 42 +/- 9% at 30 months. Effective renal blood flow fell by 22 +/- 5% at 12 months and remained stable thereafter. Changes in effective renal plasma flow (ERPF) were less pronounced than those of effective renal blood flow, due to a fall in hematocrit after transplantation. Blood pressure and renal vascular resistance increased significantly, consistent with the effects of cyclosporine. Prior to transplantation, renal function impairment with intense renal vasoconstriction had been found in a subset of the patients. Remarkably, the decrease in renal function after transplantation was less pronounced in patients with renal function impairment prior to transplantation, as indicated by significant negative correlations between pretransplantation GFR and the percentage change in GFR after transplantation, and pretransplantation ERPF and the percentage change in ERPF after transplantation. This suggests that the net course of renal hemodynamics after lung transplantation is the result of the opposed effects of cyclosporine nephrotoxicity and the favorable effects of the normalization of respiratory status. In conclusion, after lung transplantation a decline in renal function occurs that is less pronounced in patients with renal function impairment and intense renal vasoconstriction prior to transplantation. Such a renal function impairment, therefore, should not be considered a contraindication to lung transplantation.
The Journal of Heart and Lung Transplantation, 2005
The Journal of Heart and Lung Transplantation, 2007
Purpose: LTRs experience a higher risk of graft infection compared to other solid organ transplan... more Purpose: LTRs experience a higher risk of graft infection compared to other solid organ transplant recipients. However, the epidemiology and outcome of late onset bacterial pneumonia in this population has not been prospectively studied. Methods and Materials: We collected infection data affecting all LTRs at our institution from 2002 until present (nϭ222). All infectious episodes were prospectively identified using standardized criteria. Late onset pneumonia was defined as pneumonia occurring Ͼ30 days after transplant.
The Journal of Heart and Lung Transplantation, 2007
American Journal of Transplantation, 2004
The purpose of this study was to explore the relationship between diagnosis and the cost-effectiv... more The purpose of this study was to explore the relationship between diagnosis and the cost-effectiveness and cost-utility of lung transplantation. A microsimulation model was used, based on empirical data from the Dutch lung transplantation program, collected between 1991 and 1999. We assessed life-years, quality-adjusted life-years, and costs with and without transplantation for the diagnostic categories alfa-1 antitrypsin deficiency, COPD/emphysema, bronchiectasis, primary and secondary pulmonary hypertension, cystic fibrosis, and pulmonary fibrosis. Alfa-1 antitrypsin deficiency and bronchiectasis had the highest survival gain. Secondary pulmonary hypertension and pulmonary fibrosis had the lowest survival gain and the lowest gain of quality-adjusted life-years. As compared with COPD/emphysema, alfa-1 antitrypsin deficiency, bronchiectasis, and CF had 25%, 40% and 19% more favorable cost-effectiveness ratios, respectively. Cost-utility ratios varied less, with values of -7%, -14% and -11% for alfa-1 antitrypsin deficiency, bronchiectasis, and primary pulmonary hypertension, respectively, compared with COPD. In conclusion, our model suggests that there is considerable variation in cost-effectiveness and, to a lesser degree, in cost-utility between the different diagnostic categories. These variations are the result of differences in survival and in quality of life with and without lung transplantation.