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Papers by Artanto Wahyono
Advances in health sciences research, Dec 31, 2022
Background: Branchial cleft cyst is a benign lesion of the neck caused by altered development of ... more Background: Branchial cleft cyst is a benign lesion of the neck caused by altered development of branchial apparatus. It is one of the most common congenital lesions of the neck, usually diagnosed before adulthood. The cyst can increase in size and cause asymmetry of the neck. Purpose: To provide information regarding management of giant branchial cleft cyst. Case Report: We reported a female patient, 35 year old with mass on the right neck, MSCT scan showed iso-hypodense lesion which extends to right supraclavicular region and deviates the trachea and surrounding tissue to the left. Patient was diagnosed with right branchial cleft cyst and surgical excision was done to remove the cyst. The large cyst has adhered to adjacent structure and some strap muscles has to be sacrificed during the procedure. Method: Literature search using the keyword 'Branchial Cyst' AND 'Neck Cyst' AND 'Large' AND 'Surgery' was done on PubMed, ScienceDirect, and Google Scholar. Result: The search obtained 9 articles published in the last 5 years. Based on inclusion and exclusion criteria, 3 studies related to the topic was selected. Conclusion: Surgical excision with approach of transverse wide cervical incision remains the treatment of choice for branchial cleft cyst. Careful identification and separation of the cyst and critical neck structures in the surrounding is important. Aspiration of the cyst during the procedure can be done to reduce the volume of the cyst when necessary. Endoscopic approach can be done if the cyst is small in size. Incision and drainage, sclerosing therapy and repeated aspiration of the cyst should be avoided to reduce recurrency and disrupt the surgical planes for later surgery.
Anaesthesia, 2021
SummarySARS‐CoV‐2 has been associated with an increased rate of venous thromboembolism in critica... more SummarySARS‐CoV‐2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri‐operative or prior SARS‐CoV‐2 were at further increased risk of venous thromboembolism. We conducted a planned sub‐study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS‐CoV‐2 diagnosis was defined as peri‐operative (7 days before to 30 days after surgery); recent (1–6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre‐operative anti‐coagulation for baseline comorbidities was no...
Anaesthesia, 2021
SummaryPeri‐operative SARS‐CoV‐2 infection increases postoperative mortality. The aim of this stu... more SummaryPeri‐operative SARS‐CoV‐2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS‐CoV‐2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre‐operative SARS‐CoV‐2 infection were compared with those without previous SARS‐CoV‐2 infection. The primary outcome measure was 30‐day postoperative mortality. Logistic regression models were used to calculate adjusted 30‐day mortality rates stratified by time from diagnosis of SARS‐CoV‐2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre‐operative SARS‐CoV‐2 diagnosis. Adjusted 30‐day mortality in patients without SARS‐CoV‐2 infection was 1.5% (95%CI 1.4–1.5). In patients with a pre‐operative SARS‐CoV‐2 diagnosis, mortality was increased in patients having surgery wi...
Annals of Medicine and Surgery
Universitas Gadjah Mada, 2016
Universitas Gadjah Mada, 2016
Universitas Gadjah Mada, 2016
Universitas Gadjah Mada, 2016
Universitas Gadjah Mada, 2016
Annals of Medicine and Surgery, 2022
Introduction Distant spread to the jaw is a rare metastatic manifestation from papillary thyroid ... more Introduction Distant spread to the jaw is a rare metastatic manifestation from papillary thyroid cancer. Complete resection of tumor extension in the facial and oral regions requires consideration to compromise mastication functioning and facial aesthetics. Current advances in the microvascular surgery have facilitated excellent restoration of patient's functioning. Inadequate expertise, facility, longer surgery time and inpatient care, and healthcare insurance disbursement are common challenges in developing countries to perform microvascular surgery. Case presentation A 54-year female presented in an oncology clinic with a rapid progressive lump in the jaw without inflammatory signs. CT-scan revealed a 5.9x5.3 × 5cm lesion with osteo-destruction in the left mandible body. Biopsy was performed indicating a papillary adenocarcinoma invasion. Neck sonography showed hypoechoic nodule with regular border in the thyroid lobes. Fine-needle aspiration biopsy revealed benign follicular cells with Bethesda class II. Total thyroidectomy with frozen section and left hemi-mandibulectomy without bony reconstruction were then performed. Histopathological examination showed papillary thyroid cancer with follicular variant in the thyroid and mandible lesion. Thyroid ablation, TSH suppression, and chewing rehabilitation programs were accomplished by the patient. Discussion Partial mandibulectomy without bony reconstruction might be an option for selected patients with careful consideration from multidisciplinary team members in which extensive surgery with immediate bony reconstruction is not possible.
Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia, 2020
Breast cancer is the most common cancer in women worldwide. miR-155 has been discovered to have a... more Breast cancer is the most common cancer in women worldwide. miR-155 has been discovered to have an important role in the development of breast cancer. miR-155 targets many mRNAs of tumor suppressor genes, one of them is SOCS1. The discovery of miRNA in body fluids provides a novel alternative for the development of minimally invasive biomarker in cancer. However, limited study has been reported on the expression of miR-155 and SOCS1 mRNA in plasma breast cancer patients especially in Indonesian population.This study analyzed expressions of miR-155 and SOCS1 mRNA in plasma breast cancer patients This study was conducted using cross-sectional design, 32 plasma samples were collected from Dr.Sardjito Hospital. RNA was extracted from plasma and then cDNA was synthesized from RNA samples. Real-time qPCR was used to detect expression of miR-155 and mRNA SOCS1. Both expression was analyzed using Livak's method. The significance of the results were tested statistically using independence T-test. Expression of miR-155 at advanced stage was 2.43 higher than the early stages (p=0.047), while the mRNA expression of SOCS1 at advanced stage was 1.29 lower than early stage (p=0.170). Expression of miR-155 in ER, PR, & HER2 status revealed differences among subgroups, while the mRNA expression of SOCS1 was not significantly different. Other result showed that miR-155 expression was higher in triple negative tumor, while SOCS1 higher in luminal A tumor. Nevertheless, the difference was also not statistically significant (p value > 0,05). This study showed that expressions of miR-155 and SOCS1 mRNA was deregulated in breast cancer plasma and it believed to have an important role in breast cancer. 1
Background: Breast cancer under 40 years concerns a relatively small subgroup of cases that tend ... more Background: Breast cancer under 40 years concerns a relatively small subgroup of cases that tend to display a more aggressive phenotype. Compatible with this, early age of onset has been known as one of clinical characteristic of hereditary breast cancers associated with germline BRCA1 or BRCA1 mutations. As early onset breast cancer is frequent in Indonesia, we investigated the histopathological and immunohistochemical characteristics of early onset (< 40 years) Indonesian breast cancer patients, as such features can be used to distinguish between BRCA and non-BRCA germline mutation carriers among these young women. Method: Thirty-five formalin-fixed and paraffin-embedded tissue sections of young women (mean 36 years, range 22-40 years) who underwent surgical resection at the Department of Surgery of the Sardjito Hospital Yogyakarta were examined for pathological features, estrogen and progesterone receptor status, proliferation as determined by Ki67 labeling, EGFR and CK5/6 and...
Asian Pacific Journal of Cancer Prevention, 2019
Objectives: Breast cancer tend to be more progressive with poorer prognosis in younger patients t... more Objectives: Breast cancer tend to be more progressive with poorer prognosis in younger patients than those at an older age. Single Nucleotide Polymorphisms (SNPs) of P53 Pro72Arg, MDM2 SNP309, P21 Ser31Arg, ER SNP594, HER2 Ile655Val, and FGFR2 rs2981582 have drawn attention as genetic factors associated with cancer risk. However, there were contradictory results involving different races and their association is still unknown in Indonesian populations. This study was performed to examine the proportion of these six genes polymorphisms and their associations with age of onset of breast cancer patients in Yogyakarta, Indonesia. Methods: Biorepository DNA from 199 patients registered at Dr. Sardjito Hospital Yogyakarta from 2006-2013 were tested for polymorphisms using the PCR-RFLP method. Samples were taken from two age groups; early-onset (<40 years) and late-onset of breast cancer (>55 years). Chisquare tests with odds ratio were used for data analysis. Results: The mean age of the early-onset group was 36±4.2 years, while the late-onset group was 62±6.9 years. AA genotype and A allele of P21 and TT genotypes and T allele of FGFR2 were significantly more frequent and were associated with an increased risk of early-onset of breast cancer (95%CI: 2.54 and 1.59; 2.63 and 1.64, respectively). Conclusions: Our study indicates that the A allele of P21 and the allele T of FGFR2 may be associated with an increased risk of early-onset of breast cancer in Yogyakarta, Indonesia. Further analysis is needed to confirm the findings.
European Journal of Surgical Oncology, 2021
Annals of Oncology, 2012
Agreement between the new Dako HER2 IQFISH pharmDx™ and the traditional Dako HER2 FISH pharmDx™ K... more Agreement between the new Dako HER2 IQFISH pharmDx™ and the traditional Dako HER2 FISH pharmDx™ Kit. P3.05 Fig. 2: Agreement between the new Dako TOP2A IQFISH pharmDx™ and the traditional Dako TOP2A FISH pharmDx™ Kit.
European Journal of Surgical Oncology, 2020
European Journal of Surgical Oncology, 2019
Almost 66 % of the patients were female). Majority of the group underwent dermatoscopy (100% in p... more Almost 66 % of the patients were female). Majority of the group underwent dermatoscopy (100% in private practice group, almost 61 % in Cancer Center). 97% of the participants were referred for the biopsy by a specialist (24 people by a dermatologist, 13 by a surgeon, 9 by a family doctor, 2 decided about the need for biopsy on their own. All of the patients from private practice had dermatoscopy and nearly 60% in Oncology Center. Respondents with preoperative dermatoscopy 17 cases histopathology came out benign (17%). On contrary, patients without dermatoscopy were diagnosed with benign lesions in 84% (11 out of 13 cases). There were 18 cases of dysplastic nevi, 13 non-melanoma skin cancers, 6 meltumps and 1 melanoma in dermatoscopy group. Conclusions: Results of this pilot study show that majority of patients reporting for excisional biopsy of suspicious skin lesions undergo dermatoscopy as recommended by experts and they are referred for the procedure by specialists. Performing preoperative dermatoscopy could allow to avoid unnecessary resections of benign lesions and increase the percentage of detecting non-melanoma skin cancers, dysplastic nevi and melanoma. The study will be continued in order to verify preliminary findings with statistical measures. Conflict of interest: No conflict of interest.
Advances in health sciences research, Dec 31, 2022
Background: Branchial cleft cyst is a benign lesion of the neck caused by altered development of ... more Background: Branchial cleft cyst is a benign lesion of the neck caused by altered development of branchial apparatus. It is one of the most common congenital lesions of the neck, usually diagnosed before adulthood. The cyst can increase in size and cause asymmetry of the neck. Purpose: To provide information regarding management of giant branchial cleft cyst. Case Report: We reported a female patient, 35 year old with mass on the right neck, MSCT scan showed iso-hypodense lesion which extends to right supraclavicular region and deviates the trachea and surrounding tissue to the left. Patient was diagnosed with right branchial cleft cyst and surgical excision was done to remove the cyst. The large cyst has adhered to adjacent structure and some strap muscles has to be sacrificed during the procedure. Method: Literature search using the keyword 'Branchial Cyst' AND 'Neck Cyst' AND 'Large' AND 'Surgery' was done on PubMed, ScienceDirect, and Google Scholar. Result: The search obtained 9 articles published in the last 5 years. Based on inclusion and exclusion criteria, 3 studies related to the topic was selected. Conclusion: Surgical excision with approach of transverse wide cervical incision remains the treatment of choice for branchial cleft cyst. Careful identification and separation of the cyst and critical neck structures in the surrounding is important. Aspiration of the cyst during the procedure can be done to reduce the volume of the cyst when necessary. Endoscopic approach can be done if the cyst is small in size. Incision and drainage, sclerosing therapy and repeated aspiration of the cyst should be avoided to reduce recurrency and disrupt the surgical planes for later surgery.
Anaesthesia, 2021
SummarySARS‐CoV‐2 has been associated with an increased rate of venous thromboembolism in critica... more SummarySARS‐CoV‐2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri‐operative or prior SARS‐CoV‐2 were at further increased risk of venous thromboembolism. We conducted a planned sub‐study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS‐CoV‐2 diagnosis was defined as peri‐operative (7 days before to 30 days after surgery); recent (1–6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre‐operative anti‐coagulation for baseline comorbidities was no...
Anaesthesia, 2021
SummaryPeri‐operative SARS‐CoV‐2 infection increases postoperative mortality. The aim of this stu... more SummaryPeri‐operative SARS‐CoV‐2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS‐CoV‐2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre‐operative SARS‐CoV‐2 infection were compared with those without previous SARS‐CoV‐2 infection. The primary outcome measure was 30‐day postoperative mortality. Logistic regression models were used to calculate adjusted 30‐day mortality rates stratified by time from diagnosis of SARS‐CoV‐2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre‐operative SARS‐CoV‐2 diagnosis. Adjusted 30‐day mortality in patients without SARS‐CoV‐2 infection was 1.5% (95%CI 1.4–1.5). In patients with a pre‐operative SARS‐CoV‐2 diagnosis, mortality was increased in patients having surgery wi...
Annals of Medicine and Surgery
Universitas Gadjah Mada, 2016
Universitas Gadjah Mada, 2016
Universitas Gadjah Mada, 2016
Universitas Gadjah Mada, 2016
Universitas Gadjah Mada, 2016
Annals of Medicine and Surgery, 2022
Introduction Distant spread to the jaw is a rare metastatic manifestation from papillary thyroid ... more Introduction Distant spread to the jaw is a rare metastatic manifestation from papillary thyroid cancer. Complete resection of tumor extension in the facial and oral regions requires consideration to compromise mastication functioning and facial aesthetics. Current advances in the microvascular surgery have facilitated excellent restoration of patient's functioning. Inadequate expertise, facility, longer surgery time and inpatient care, and healthcare insurance disbursement are common challenges in developing countries to perform microvascular surgery. Case presentation A 54-year female presented in an oncology clinic with a rapid progressive lump in the jaw without inflammatory signs. CT-scan revealed a 5.9x5.3 × 5cm lesion with osteo-destruction in the left mandible body. Biopsy was performed indicating a papillary adenocarcinoma invasion. Neck sonography showed hypoechoic nodule with regular border in the thyroid lobes. Fine-needle aspiration biopsy revealed benign follicular cells with Bethesda class II. Total thyroidectomy with frozen section and left hemi-mandibulectomy without bony reconstruction were then performed. Histopathological examination showed papillary thyroid cancer with follicular variant in the thyroid and mandible lesion. Thyroid ablation, TSH suppression, and chewing rehabilitation programs were accomplished by the patient. Discussion Partial mandibulectomy without bony reconstruction might be an option for selected patients with careful consideration from multidisciplinary team members in which extensive surgery with immediate bony reconstruction is not possible.
Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia, 2020
Breast cancer is the most common cancer in women worldwide. miR-155 has been discovered to have a... more Breast cancer is the most common cancer in women worldwide. miR-155 has been discovered to have an important role in the development of breast cancer. miR-155 targets many mRNAs of tumor suppressor genes, one of them is SOCS1. The discovery of miRNA in body fluids provides a novel alternative for the development of minimally invasive biomarker in cancer. However, limited study has been reported on the expression of miR-155 and SOCS1 mRNA in plasma breast cancer patients especially in Indonesian population.This study analyzed expressions of miR-155 and SOCS1 mRNA in plasma breast cancer patients This study was conducted using cross-sectional design, 32 plasma samples were collected from Dr.Sardjito Hospital. RNA was extracted from plasma and then cDNA was synthesized from RNA samples. Real-time qPCR was used to detect expression of miR-155 and mRNA SOCS1. Both expression was analyzed using Livak's method. The significance of the results were tested statistically using independence T-test. Expression of miR-155 at advanced stage was 2.43 higher than the early stages (p=0.047), while the mRNA expression of SOCS1 at advanced stage was 1.29 lower than early stage (p=0.170). Expression of miR-155 in ER, PR, & HER2 status revealed differences among subgroups, while the mRNA expression of SOCS1 was not significantly different. Other result showed that miR-155 expression was higher in triple negative tumor, while SOCS1 higher in luminal A tumor. Nevertheless, the difference was also not statistically significant (p value > 0,05). This study showed that expressions of miR-155 and SOCS1 mRNA was deregulated in breast cancer plasma and it believed to have an important role in breast cancer. 1
Background: Breast cancer under 40 years concerns a relatively small subgroup of cases that tend ... more Background: Breast cancer under 40 years concerns a relatively small subgroup of cases that tend to display a more aggressive phenotype. Compatible with this, early age of onset has been known as one of clinical characteristic of hereditary breast cancers associated with germline BRCA1 or BRCA1 mutations. As early onset breast cancer is frequent in Indonesia, we investigated the histopathological and immunohistochemical characteristics of early onset (< 40 years) Indonesian breast cancer patients, as such features can be used to distinguish between BRCA and non-BRCA germline mutation carriers among these young women. Method: Thirty-five formalin-fixed and paraffin-embedded tissue sections of young women (mean 36 years, range 22-40 years) who underwent surgical resection at the Department of Surgery of the Sardjito Hospital Yogyakarta were examined for pathological features, estrogen and progesterone receptor status, proliferation as determined by Ki67 labeling, EGFR and CK5/6 and...
Asian Pacific Journal of Cancer Prevention, 2019
Objectives: Breast cancer tend to be more progressive with poorer prognosis in younger patients t... more Objectives: Breast cancer tend to be more progressive with poorer prognosis in younger patients than those at an older age. Single Nucleotide Polymorphisms (SNPs) of P53 Pro72Arg, MDM2 SNP309, P21 Ser31Arg, ER SNP594, HER2 Ile655Val, and FGFR2 rs2981582 have drawn attention as genetic factors associated with cancer risk. However, there were contradictory results involving different races and their association is still unknown in Indonesian populations. This study was performed to examine the proportion of these six genes polymorphisms and their associations with age of onset of breast cancer patients in Yogyakarta, Indonesia. Methods: Biorepository DNA from 199 patients registered at Dr. Sardjito Hospital Yogyakarta from 2006-2013 were tested for polymorphisms using the PCR-RFLP method. Samples were taken from two age groups; early-onset (<40 years) and late-onset of breast cancer (>55 years). Chisquare tests with odds ratio were used for data analysis. Results: The mean age of the early-onset group was 36±4.2 years, while the late-onset group was 62±6.9 years. AA genotype and A allele of P21 and TT genotypes and T allele of FGFR2 were significantly more frequent and were associated with an increased risk of early-onset of breast cancer (95%CI: 2.54 and 1.59; 2.63 and 1.64, respectively). Conclusions: Our study indicates that the A allele of P21 and the allele T of FGFR2 may be associated with an increased risk of early-onset of breast cancer in Yogyakarta, Indonesia. Further analysis is needed to confirm the findings.
European Journal of Surgical Oncology, 2021
Annals of Oncology, 2012
Agreement between the new Dako HER2 IQFISH pharmDx™ and the traditional Dako HER2 FISH pharmDx™ K... more Agreement between the new Dako HER2 IQFISH pharmDx™ and the traditional Dako HER2 FISH pharmDx™ Kit. P3.05 Fig. 2: Agreement between the new Dako TOP2A IQFISH pharmDx™ and the traditional Dako TOP2A FISH pharmDx™ Kit.
European Journal of Surgical Oncology, 2020
European Journal of Surgical Oncology, 2019
Almost 66 % of the patients were female). Majority of the group underwent dermatoscopy (100% in p... more Almost 66 % of the patients were female). Majority of the group underwent dermatoscopy (100% in private practice group, almost 61 % in Cancer Center). 97% of the participants were referred for the biopsy by a specialist (24 people by a dermatologist, 13 by a surgeon, 9 by a family doctor, 2 decided about the need for biopsy on their own. All of the patients from private practice had dermatoscopy and nearly 60% in Oncology Center. Respondents with preoperative dermatoscopy 17 cases histopathology came out benign (17%). On contrary, patients without dermatoscopy were diagnosed with benign lesions in 84% (11 out of 13 cases). There were 18 cases of dysplastic nevi, 13 non-melanoma skin cancers, 6 meltumps and 1 melanoma in dermatoscopy group. Conclusions: Results of this pilot study show that majority of patients reporting for excisional biopsy of suspicious skin lesions undergo dermatoscopy as recommended by experts and they are referred for the procedure by specialists. Performing preoperative dermatoscopy could allow to avoid unnecessary resections of benign lesions and increase the percentage of detecting non-melanoma skin cancers, dysplastic nevi and melanoma. The study will be continued in order to verify preliminary findings with statistical measures. Conflict of interest: No conflict of interest.