Wan Jin Jahng - Academia.edu (original) (raw)

Wan Jin Jahng

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Papers by Wan Jin Jahng

Research paper thumbnail of Retinoid Affinity Biotinylation Reveals a Retinoid Binding Role For Rpe65

Investigative Ophthalmology & Visual Science, May 1, 2003

Research paper thumbnail of Circadian Clock Controls RPE65 in Melatonin Deficient Mice

Investigative Ophthalmology & Visual Science, May 10, 2007

Research paper thumbnail of A New Retinoid Signaling Molecule in the Retinal Pigment Epithelium: RPE45

Investigative Ophthalmology & Visual Science, May 14, 2008

ABSTRACT Purpose:The control elements that regulate the overall biosynthetic pathway to 11-cis-re... more ABSTRACT Purpose:The control elements that regulate the overall biosynthetic pathway to 11-cis-retinal under light and oxidative stress are not well understood. In order to study this important isomerization/hydrolysis step, we used a differential proteomics approach with bovine, murine and human retinal pigment epithelial cells to study the effects of the light and oxidative stress on RPE65 expression and RPE45, a caspase-mediated cleavage form of RPE65.

Research paper thumbnail of Erythropoietin as a Pro Angiogenic factor in the Retina and Retinal Pigment Epithelium

Investigative Ophthalmology & Visual Science, Apr 22, 2011

Research paper thumbnail of Synthesis of 1(2,2-Dimethylpropyl)-Cyclopropene (1-DCP) as an Ethylene Antagonist

Research paper thumbnail of Disruption of Angiogenesis by Anthocyanin-Rich Extract of Hibiscus sabdariffa

Investigative Ophthalmology & Visual Science, Jun 11, 2015

Research paper thumbnail of 2007;67:9229-9237. Cancer Res

Growth Factor Receptor Trafficking to the Nucleus The Phosphoinositide Kinase PIKfyve Mediates Ep... more Growth Factor Receptor Trafficking to the Nucleus The Phosphoinositide Kinase PIKfyve Mediates Epidermal Updated version

Research paper thumbnail of RPE45 Is the Caspase-Mediated Fragment of RPE65 and an Oxidative Stress Biomarker

Investigative Ophthalmology & Visual Science, 2007

Research paper thumbnail of Mitochondria-Nucleus Communication by Shuttle Proteome in the RPE under Oxidative Stress

Investigative Ophthalmology & Visual Science, 2012

Research paper thumbnail of Hypoxia and Hyperoxia Induce RPE Apoptosis through RPE65 Cleavage

Investigative Ophthalmology & Visual Science, 2011

Research paper thumbnail of Erythropoietin Interaction Network Under the Redox Imbalance Condition

Investigative Ophthalmology & Visual Science, 2010

Research paper thumbnail of Amd Biomarker Mapping Guided by Tissue-Specific Phosphorylations

Investigative Ophthalmology & Visual Science, 2015

Research paper thumbnail of Altered Thioredoxin System in the Retina of Aged Mice Overexpressing Amyloid Beta

Investigative Ophthalmology & Visual Science, 2009

Research paper thumbnail of Establishing a Proteomic Inventory of 11–cis–Retinoid Binding Proteins in RPE

Investigative Ophthalmology & Visual Science, 2006

Research paper thumbnail of Loss of thioredoxin reductase-1 in the hyperglycemic milieu stimulates retinal vessel senescence and senescence-associated pro-inflammatory phenotype

Investigative Ophthalmology & Visual Science, 2016

Research paper thumbnail of Regulation Of Thioredoxin Interacting Protein (TXNIP) Activity By PKC Delta In The Diabetic Retina

Investigative Ophthalmology & Visual Science, 2012

Research paper thumbnail of Cholesterol Modulation Changes Membrane Composition and Prohibitin Localization in RPE and Retina

Investigative Ophthalmology & Visual Science, 2011

Research paper thumbnail of Positive Correlation of Prohibitin-Phospholipid to Age-Related Macular Degeneration

Investigative Ophthalmology & Visual Science, 2014

Research paper thumbnail of Reply to Comment on: Association of Age-Related Macular Degeneration on Alzheimer or Parkinson Disease: A Retrospective Cohort Study

American Journal of Ophthalmology, 2020

Research paper thumbnail of Age- and sex-based evaluation of the association between refractive error and age-related macular degeneration in the Korean population

PLOS ONE, 2020

The aim of this study was to investigate the association between refractive error and prevalence ... more The aim of this study was to investigate the association between refractive error and prevalence of age-related macular degeneration (AMD) in Korean adults, based on the sex and age group. Methods This was a nationwide population-based cross-sectional study that included 17,676 subjects aged over 40 years who participated in the 2008-2012 Korean National Health and Nutrition Examination Survey. Digital fundus images (45˚) were obtained for both eyes under physiologic mydriasis and were graded using the international classification and grading system for age-related macular degeneration. The spherical equivalents of refractive errors were calculated in diopters using auto-refraction data. Results After adjustment for potential confounders, myopia was associated with lower risk of any age-related macular degeneration [odds ratio (OR), 0.74; 95% Confidence Interval (CI), 0.61-0.91]. In particular, myopia was significantly associated with lower odds of age-related macular degeneration in female participants (any AMD: OR, 0.71; 95% CI, 0.54-0.93; early AMD: OR, 0.70; 95% CI, 0.53-0.93) and in participants younger than 50 years (any AMD: OR, 0.46; 95% CI, 0.24-0.90; early AMD: OR, 0.47; 95% CI, 0.24-0.93). There was no significant association between myopia and age-related macular degeneration in male participants and in participants older than 50 years.

Research paper thumbnail of Retinoid Affinity Biotinylation Reveals a Retinoid Binding Role For Rpe65

Investigative Ophthalmology & Visual Science, May 1, 2003

Research paper thumbnail of Circadian Clock Controls RPE65 in Melatonin Deficient Mice

Investigative Ophthalmology & Visual Science, May 10, 2007

Research paper thumbnail of A New Retinoid Signaling Molecule in the Retinal Pigment Epithelium: RPE45

Investigative Ophthalmology & Visual Science, May 14, 2008

ABSTRACT Purpose:The control elements that regulate the overall biosynthetic pathway to 11-cis-re... more ABSTRACT Purpose:The control elements that regulate the overall biosynthetic pathway to 11-cis-retinal under light and oxidative stress are not well understood. In order to study this important isomerization/hydrolysis step, we used a differential proteomics approach with bovine, murine and human retinal pigment epithelial cells to study the effects of the light and oxidative stress on RPE65 expression and RPE45, a caspase-mediated cleavage form of RPE65.

Research paper thumbnail of Erythropoietin as a Pro Angiogenic factor in the Retina and Retinal Pigment Epithelium

Investigative Ophthalmology & Visual Science, Apr 22, 2011

Research paper thumbnail of Synthesis of 1(2,2-Dimethylpropyl)-Cyclopropene (1-DCP) as an Ethylene Antagonist

Research paper thumbnail of Disruption of Angiogenesis by Anthocyanin-Rich Extract of Hibiscus sabdariffa

Investigative Ophthalmology & Visual Science, Jun 11, 2015

Research paper thumbnail of 2007;67:9229-9237. Cancer Res

Growth Factor Receptor Trafficking to the Nucleus The Phosphoinositide Kinase PIKfyve Mediates Ep... more Growth Factor Receptor Trafficking to the Nucleus The Phosphoinositide Kinase PIKfyve Mediates Epidermal Updated version

Research paper thumbnail of RPE45 Is the Caspase-Mediated Fragment of RPE65 and an Oxidative Stress Biomarker

Investigative Ophthalmology & Visual Science, 2007

Research paper thumbnail of Mitochondria-Nucleus Communication by Shuttle Proteome in the RPE under Oxidative Stress

Investigative Ophthalmology & Visual Science, 2012

Research paper thumbnail of Hypoxia and Hyperoxia Induce RPE Apoptosis through RPE65 Cleavage

Investigative Ophthalmology & Visual Science, 2011

Research paper thumbnail of Erythropoietin Interaction Network Under the Redox Imbalance Condition

Investigative Ophthalmology & Visual Science, 2010

Research paper thumbnail of Amd Biomarker Mapping Guided by Tissue-Specific Phosphorylations

Investigative Ophthalmology & Visual Science, 2015

Research paper thumbnail of Altered Thioredoxin System in the Retina of Aged Mice Overexpressing Amyloid Beta

Investigative Ophthalmology & Visual Science, 2009

Research paper thumbnail of Establishing a Proteomic Inventory of 11–cis–Retinoid Binding Proteins in RPE

Investigative Ophthalmology & Visual Science, 2006

Research paper thumbnail of Loss of thioredoxin reductase-1 in the hyperglycemic milieu stimulates retinal vessel senescence and senescence-associated pro-inflammatory phenotype

Investigative Ophthalmology & Visual Science, 2016

Research paper thumbnail of Regulation Of Thioredoxin Interacting Protein (TXNIP) Activity By PKC Delta In The Diabetic Retina

Investigative Ophthalmology & Visual Science, 2012

Research paper thumbnail of Cholesterol Modulation Changes Membrane Composition and Prohibitin Localization in RPE and Retina

Investigative Ophthalmology & Visual Science, 2011

Research paper thumbnail of Positive Correlation of Prohibitin-Phospholipid to Age-Related Macular Degeneration

Investigative Ophthalmology & Visual Science, 2014

Research paper thumbnail of Reply to Comment on: Association of Age-Related Macular Degeneration on Alzheimer or Parkinson Disease: A Retrospective Cohort Study

American Journal of Ophthalmology, 2020

Research paper thumbnail of Age- and sex-based evaluation of the association between refractive error and age-related macular degeneration in the Korean population

PLOS ONE, 2020

The aim of this study was to investigate the association between refractive error and prevalence ... more The aim of this study was to investigate the association between refractive error and prevalence of age-related macular degeneration (AMD) in Korean adults, based on the sex and age group. Methods This was a nationwide population-based cross-sectional study that included 17,676 subjects aged over 40 years who participated in the 2008-2012 Korean National Health and Nutrition Examination Survey. Digital fundus images (45˚) were obtained for both eyes under physiologic mydriasis and were graded using the international classification and grading system for age-related macular degeneration. The spherical equivalents of refractive errors were calculated in diopters using auto-refraction data. Results After adjustment for potential confounders, myopia was associated with lower risk of any age-related macular degeneration [odds ratio (OR), 0.74; 95% Confidence Interval (CI), 0.61-0.91]. In particular, myopia was significantly associated with lower odds of age-related macular degeneration in female participants (any AMD: OR, 0.71; 95% CI, 0.54-0.93; early AMD: OR, 0.70; 95% CI, 0.53-0.93) and in participants younger than 50 years (any AMD: OR, 0.46; 95% CI, 0.24-0.90; early AMD: OR, 0.47; 95% CI, 0.24-0.93). There was no significant association between myopia and age-related macular degeneration in male participants and in participants older than 50 years.

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