Wbeimar Andrey Rivera - Academia.edu (original) (raw)
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Papers by Wbeimar Andrey Rivera
International Journal of Molecular Sciences, 2020
Streptococcus mutans is the main early colonizing cariogenic bacteria because it recognizes saliv... more Streptococcus mutans is the main early colonizing cariogenic bacteria because it recognizes salivary pellicle receptors. The Antigen I/II (Ag I/II) of S. mutans is among the most important adhesins in this process, and is involved in the adhesion to the tooth surface and the bacterial co-aggregation in the early stage of biofilm formation. However, this protein has not been used as a target in a virtual strategy search for inhibitors. Based on the predicted binding affinities, drug-like properties and toxicity, molecules were selected and evaluated for their ability to reduce S. mutans adhesion. A virtual screening of 883,551 molecules was conducted; cytotoxicity analysis on fibroblast cells, S. mutans adhesion studies, scanning electron microscopy analysis for bacterial integrity and molecular dynamics simulation were also performed. We found three molecules ZINC19835187 (ZI-187), ZINC19924939 (ZI-939) and ZINC19924906 (ZI-906) without cytotoxic activity, which inhibited about 90% ...
IEEE Transactions on Reliability, 1967
A procedure is proposed for identification and diagnosis Lederberg.[2] The inlgeniious applicatio... more A procedure is proposed for identification and diagnosis Lederberg.[2] The inlgeniious applicationi of computer- of faults in multiterminal devices. A combinatorial technique aided combinatorial techniques by such an eminent in- determines the number of x-terminal y-port nonredundant subnetworks which can be generated from a z-terminal parent network. vestigator as Lederberg has stimulated parallel develop- This information is intended to identify and isolate internal faults iynenit of algorithms for the exploitationi of simiiilar tech- of the system through an optimal set of external measurements. iinques for fault isolation. An elementary tutorial introduction to the terminology and procedures of combinatorial analysis aims to make this account B. EYlemnentary Concepts and Examliple self-contained and useful to the reliability engineer without a spe- Figs. 1 and 2 illustrate the deteination of N(4, 3, 2) cialized mathematical background. ad NgS 1 4, 2 it iics t choose three of Four-terminal and five-terminal devices are examined first. The and N(5, 4, 2). In Fig , it is necessary to choose three of results are then so formulated as to yield algorithms for computer-four ter-inials of the parenit nietwork. One terminial can be oriented procedures to identify the complete set of nonredundant left free, or aniy two cani be joinied as a single terminial; configurations of a multiterminal network. The flowchart of opera-either arranigemenit results in the required three term-linals. tions suitable for a computer program is presented. Each such 3-terminiial subiietwxork admits three 9-port systems: ports 12 and 23, 13 aind 12, aind 23 anid 13. The figures illustrate how complex inetworks require a
International Journal of Molecular Sciences, 2020
Streptococcus mutans is the main early colonizing cariogenic bacteria because it recognizes saliv... more Streptococcus mutans is the main early colonizing cariogenic bacteria because it recognizes salivary pellicle receptors. The Antigen I/II (Ag I/II) of S. mutans is among the most important adhesins in this process, and is involved in the adhesion to the tooth surface and the bacterial co-aggregation in the early stage of biofilm formation. However, this protein has not been used as a target in a virtual strategy search for inhibitors. Based on the predicted binding affinities, drug-like properties and toxicity, molecules were selected and evaluated for their ability to reduce S. mutans adhesion. A virtual screening of 883,551 molecules was conducted; cytotoxicity analysis on fibroblast cells, S. mutans adhesion studies, scanning electron microscopy analysis for bacterial integrity and molecular dynamics simulation were also performed. We found three molecules ZINC19835187 (ZI-187), ZINC19924939 (ZI-939) and ZINC19924906 (ZI-906) without cytotoxic activity, which inhibited about 90% ...
IEEE Transactions on Reliability, 1967
A procedure is proposed for identification and diagnosis Lederberg.[2] The inlgeniious applicatio... more A procedure is proposed for identification and diagnosis Lederberg.[2] The inlgeniious applicationi of computer- of faults in multiterminal devices. A combinatorial technique aided combinatorial techniques by such an eminent in- determines the number of x-terminal y-port nonredundant subnetworks which can be generated from a z-terminal parent network. vestigator as Lederberg has stimulated parallel develop- This information is intended to identify and isolate internal faults iynenit of algorithms for the exploitationi of simiiilar tech- of the system through an optimal set of external measurements. iinques for fault isolation. An elementary tutorial introduction to the terminology and procedures of combinatorial analysis aims to make this account B. EYlemnentary Concepts and Examliple self-contained and useful to the reliability engineer without a spe- Figs. 1 and 2 illustrate the deteination of N(4, 3, 2) cialized mathematical background. ad NgS 1 4, 2 it iics t choose three of Four-terminal and five-terminal devices are examined first. The and N(5, 4, 2). In Fig , it is necessary to choose three of results are then so formulated as to yield algorithms for computer-four ter-inials of the parenit nietwork. One terminial can be oriented procedures to identify the complete set of nonredundant left free, or aniy two cani be joinied as a single terminial; configurations of a multiterminal network. The flowchart of opera-either arranigemenit results in the required three term-linals. tions suitable for a computer program is presented. Each such 3-terminiial subiietwxork admits three 9-port systems: ports 12 and 23, 13 aind 12, aind 23 anid 13. The figures illustrate how complex inetworks require a