Wei Lu - Academia.edu (original) (raw)

Papers by Wei Lu

Research paper thumbnail of Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1

Research paper thumbnail of Single-crystal metallic nanowires and metal/semiconductor nanowire heterostructures

Research paper thumbnail of Effects of Shape and Strain Distribution of Quantum Dots on Optical Transition in the Quantum Dot Infrared Photodetectors

Nanoscale Research Letters, 2008

Research paper thumbnail of Copper sulfide nanoparticles for photothermal ablation of tumor cells

Research paper thumbnail of Preparation of carbon-coated iron oxide nanoparticles dispersed on graphene sheets and applications as advanced anode materials for lithium-ion batteries

Research paper thumbnail of Coherent Single Charge Transport in Molecular-Scale Silicon Nanowires

Research paper thumbnail of Strong and Tunable Spin−Orbit Coupling of One-Dimensional Holes in Ge/Si Core/Shell Nanowires

Research paper thumbnail of Si/a-Si Core/Shell Nanowires as Nonvolatile Crossbar Switches

Research paper thumbnail of Biodistribution, Pharmacokinetics, and Nuclear Imaging Studies of 111In-labeled rGel/BLyS Fusion Toxin in SCID Mice Bearing B Cell Lymphoma

Molecular Imaging and Biology, 2011

Research paper thumbnail of A known functional polymorphism (Ile120Val) of the human PCMT1 gene and risk of spina bifida

Molecular Genetics and Metabolism, 2006

Research paper thumbnail of Genome-wide transcriptome and proteome analysis of Escherichia coli expressing IrrE, a global regulator of Deinococcus radiodurans

Molecular BioSystems, 2011

Gram-negative bacterium Escherichia coli and the Gram-positive Deinococcus radiodurans fundamenta... more Gram-negative bacterium Escherichia coli and the Gram-positive Deinococcus radiodurans fundamentally differ in their cell structures and gene regulations. We have previously reported that IrrE, a Deinococcus genus-specific global regulator, confers significantly enhanced tolerance to various abiotic stresses. To better understand the global effects of IrrE on the regulatory networks, we carried out combined transcriptome and proteome analysis of E. coli expressing the IrrE protein. Our analysis showed that 216 (4.8%) of all E. coli genes were induced and 149 (3.3%) genes were repressed, including those for trehalose biosynthesis, nucleotides biosynthesis, carbon source utilization, amino acid utilization, acid resistance, a hydrogenase and an oxidase. Also regulated were the EvgSA two-component system, the GadE, GadX and PurR master regulators, and 10 transcription factors (AppY, GadW, YhiF, AsnC, BetI, CynR, MhpR, PrpR, TdcA and KdgR). These results demonstrated that IrrE acts as global regulator and consequently improves abiotic stress tolerances in the heterologous host E. coli. The implication of our findings is discussed in relation to the evolutionary role of horizontal gene transfer in bacterial regulatory networks and environmental adaptation.

Research paper thumbnail of Down-regulation of specific gene expression by double-strand RNA induces neural stem cell differentiation in vitro

Molecular and Cellular Biochemistry, 2005

Research paper thumbnail of Surface plasmon polariton coupling induced transmission of subwavelength metallic grating with waveguide layer

Microelectronic Engineering, 2010

ABSTRACT In this paper, we present the nanofabrication of a potentially coupled waveguide–surface... more ABSTRACT In this paper, we present the nanofabrication of a potentially coupled waveguide–surface plasmon resonance biosensor (CWSPRBs) by nanoimprint lithography. Subwavelength metallic gratings (SWMGs) with the pitches of 300 and 500nm were fabricated by direct imprinting on PMMA layer which subsequently covered with a layer of Au. The key issue in this device is the coupling of surface plasmon with waveguide modes, which has been carefully investigated by measuring the coupling induced enhancement of light transmission. Both our measurement and simulation results indicate that the resonant coupling does exist for both 300 and 500nm pitched gratings. This proves that the developed nanoimprint lithography is applicable for the CWSPRBs sensors which has significant advantages over traditional ones with a prism.

Research paper thumbnail of 4D-CT motion estimation using deformable image registration and 5D respiratory motion modeling

Research paper thumbnail of SU-GG-J-03: 3D Pathology Validation for Head-And-Neck Tumor Segmentation in PET/CT/MRI Images

Research paper thumbnail of SU-GG-I-99: Validation and Comparison of 3D Image Registration Approaches for Adaptive IMRT in Head-And-Neck Cancer

Research paper thumbnail of TH-D-213A-04: Application of Supervised Spectral Clustering for PET Tumor Delineation: A Phantom Study

Research paper thumbnail of TH-D-213A-02: An Improved Iterative Thresholding Approach for 3D PET Tumor Delineation: Phantom Study

Research paper thumbnail of Application of the continuity equation to a breathing motion model

Research paper thumbnail of Technical Note: Deformable image registration on partially matched images for radiotherapy applications

Medical Physics, 2010

In radiation therapy applications, deformable image registrations (DIRs) are often carried out be... more In radiation therapy applications, deformable image registrations (DIRs) are often carried out between two images that only partially match. Image mismatching could present as superior-inferior coverage differences, field-of-view (FOV) cutoffs, or motion crossing the image boundaries. In this study, the authors propose a method to improve the existing DIR algorithms so that DIR can be carried out in such situations. The basic idea is to extend the image volumes and define the extension voxels (outside the FOV or outside the original image volume) as NaN (not-a-number) values that are transparent to all floating-point computations in the DIR algorithms. Registrations are then carried out with one additional rule that NaN voxels can match any voxels. In this way, the matched sections of the images are registered properly, and the mismatched sections of the images are registered to NaN voxels. This method makes it possible to perform DIR on partially matched images that otherwise are difficult to register. It may also improve DIR accuracy, especially near or in the mismatched image regions.

Research paper thumbnail of Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1

Research paper thumbnail of Single-crystal metallic nanowires and metal/semiconductor nanowire heterostructures

Research paper thumbnail of Effects of Shape and Strain Distribution of Quantum Dots on Optical Transition in the Quantum Dot Infrared Photodetectors

Nanoscale Research Letters, 2008

Research paper thumbnail of Copper sulfide nanoparticles for photothermal ablation of tumor cells

Research paper thumbnail of Preparation of carbon-coated iron oxide nanoparticles dispersed on graphene sheets and applications as advanced anode materials for lithium-ion batteries

Research paper thumbnail of Coherent Single Charge Transport in Molecular-Scale Silicon Nanowires

Research paper thumbnail of Strong and Tunable Spin−Orbit Coupling of One-Dimensional Holes in Ge/Si Core/Shell Nanowires

Research paper thumbnail of Si/a-Si Core/Shell Nanowires as Nonvolatile Crossbar Switches

Research paper thumbnail of Biodistribution, Pharmacokinetics, and Nuclear Imaging Studies of 111In-labeled rGel/BLyS Fusion Toxin in SCID Mice Bearing B Cell Lymphoma

Molecular Imaging and Biology, 2011

Research paper thumbnail of A known functional polymorphism (Ile120Val) of the human PCMT1 gene and risk of spina bifida

Molecular Genetics and Metabolism, 2006

Research paper thumbnail of Genome-wide transcriptome and proteome analysis of Escherichia coli expressing IrrE, a global regulator of Deinococcus radiodurans

Molecular BioSystems, 2011

Gram-negative bacterium Escherichia coli and the Gram-positive Deinococcus radiodurans fundamenta... more Gram-negative bacterium Escherichia coli and the Gram-positive Deinococcus radiodurans fundamentally differ in their cell structures and gene regulations. We have previously reported that IrrE, a Deinococcus genus-specific global regulator, confers significantly enhanced tolerance to various abiotic stresses. To better understand the global effects of IrrE on the regulatory networks, we carried out combined transcriptome and proteome analysis of E. coli expressing the IrrE protein. Our analysis showed that 216 (4.8%) of all E. coli genes were induced and 149 (3.3%) genes were repressed, including those for trehalose biosynthesis, nucleotides biosynthesis, carbon source utilization, amino acid utilization, acid resistance, a hydrogenase and an oxidase. Also regulated were the EvgSA two-component system, the GadE, GadX and PurR master regulators, and 10 transcription factors (AppY, GadW, YhiF, AsnC, BetI, CynR, MhpR, PrpR, TdcA and KdgR). These results demonstrated that IrrE acts as global regulator and consequently improves abiotic stress tolerances in the heterologous host E. coli. The implication of our findings is discussed in relation to the evolutionary role of horizontal gene transfer in bacterial regulatory networks and environmental adaptation.

Research paper thumbnail of Down-regulation of specific gene expression by double-strand RNA induces neural stem cell differentiation in vitro

Molecular and Cellular Biochemistry, 2005

Research paper thumbnail of Surface plasmon polariton coupling induced transmission of subwavelength metallic grating with waveguide layer

Microelectronic Engineering, 2010

ABSTRACT In this paper, we present the nanofabrication of a potentially coupled waveguide–surface... more ABSTRACT In this paper, we present the nanofabrication of a potentially coupled waveguide–surface plasmon resonance biosensor (CWSPRBs) by nanoimprint lithography. Subwavelength metallic gratings (SWMGs) with the pitches of 300 and 500nm were fabricated by direct imprinting on PMMA layer which subsequently covered with a layer of Au. The key issue in this device is the coupling of surface plasmon with waveguide modes, which has been carefully investigated by measuring the coupling induced enhancement of light transmission. Both our measurement and simulation results indicate that the resonant coupling does exist for both 300 and 500nm pitched gratings. This proves that the developed nanoimprint lithography is applicable for the CWSPRBs sensors which has significant advantages over traditional ones with a prism.

Research paper thumbnail of 4D-CT motion estimation using deformable image registration and 5D respiratory motion modeling

Research paper thumbnail of SU-GG-J-03: 3D Pathology Validation for Head-And-Neck Tumor Segmentation in PET/CT/MRI Images

Research paper thumbnail of SU-GG-I-99: Validation and Comparison of 3D Image Registration Approaches for Adaptive IMRT in Head-And-Neck Cancer

Research paper thumbnail of TH-D-213A-04: Application of Supervised Spectral Clustering for PET Tumor Delineation: A Phantom Study

Research paper thumbnail of TH-D-213A-02: An Improved Iterative Thresholding Approach for 3D PET Tumor Delineation: Phantom Study

Research paper thumbnail of Application of the continuity equation to a breathing motion model

Research paper thumbnail of Technical Note: Deformable image registration on partially matched images for radiotherapy applications

Medical Physics, 2010

In radiation therapy applications, deformable image registrations (DIRs) are often carried out be... more In radiation therapy applications, deformable image registrations (DIRs) are often carried out between two images that only partially match. Image mismatching could present as superior-inferior coverage differences, field-of-view (FOV) cutoffs, or motion crossing the image boundaries. In this study, the authors propose a method to improve the existing DIR algorithms so that DIR can be carried out in such situations. The basic idea is to extend the image volumes and define the extension voxels (outside the FOV or outside the original image volume) as NaN (not-a-number) values that are transparent to all floating-point computations in the DIR algorithms. Registrations are then carried out with one additional rule that NaN voxels can match any voxels. In this way, the matched sections of the images are registered properly, and the mismatched sections of the images are registered to NaN voxels. This method makes it possible to perform DIR on partially matched images that otherwise are difficult to register. It may also improve DIR accuracy, especially near or in the mismatched image regions.