Wiktoria Wojciechowska - Academia.edu (original) (raw)
Papers by Wiktoria Wojciechowska
Polskie Archiwum Medycyny Wewnetrznej-polish Archives of Internal Medicine, Aug 22, 2022
Frontiers in Cardiovascular Medicine
BackgroundThe impact of COVID-19 on the outcome of patients with MI has not been studied widely. ... more BackgroundThe impact of COVID-19 on the outcome of patients with MI has not been studied widely. We aimed to evaluate the relationship between concomitant COVID-19 and the clinical course of patients admitted due to acute myocardial infarction (MI).MethodsThere was a comparison of retrospective data between patients with MI who were qualified for coronary angiography with concomitant COVID-19 and control group of patients treated for MI in the preceding year before the onset of the pandemic. In-hospital clinical data and the incidence of death from any cause on 30 days were obtained.ResultsData of 39 MI patients with concomitant COVID-19 (COVID-19 MI) and 196 MI patients without COVID-19 in pre-pandemic era (non-COVID-19 MI) were assessed. Compared with non-COVID-19 MI, COVID-19 MI was in a more severe clinical state on admission (lower systolic blood pressure: 128.51 ± 19.76 vs. 141.11 ± 32.47 mmHg, p = 0.024), higher: respiratory rate [median (interquartile range), 16 (14–18) vs. ...
Mózgowy peptyd natriuretyczny u kobiet z łagodnym nadciśnieniem tętniczym w okresie okołomenopauz... more Mózgowy peptyd natriuretyczny u kobiet z łagodnym nadciśnieniem tętniczym w okresie okołomenopauzalnym Brain natriuretic peptide in women with mild hypertension in perimenopausal period Summary Background Morbidity and mortality from cardiovascu-lar diseases increase rapidly in women after menopause. Relationship between menopause and hypertension has been a topic of investigation for several years. There are no evidences about the influence of menopause on brain natriuretic peptide level. Present studies indicate the important prognostic value of this parameter in this group of patients. The aim of this study was to assess the level of N-terminal part of brain natriuretic peptide as well as the correlation of this factor with values of blood pressure in hypertensive women in relation to post-and premenopausal hormonal status. Material and methods The study included 112 women aged 45 to 55 years (mean age 50.73 ± 1.82 years) with mild essential hypertension confirmed by conventional...
Journal of Hypertension, 2021
Objective: The COVID-19 lockdown caused unprecedented decline in environmental noise pollution We... more Objective: The COVID-19 lockdown caused unprecedented decline in environmental noise pollution We aimed to evaluate the impact of aircraft noise exposure decrease during lockdown on blood pressure (BP) and selected hypertensionmediated organ damages Design and method: As previously reported (J Hypertens 2019;37) in 2015 (1st observation) we examined group of inhabitants exposed to high (>60 dB) aircraft noise living near Cracow Airport (n=101), and compared them to unexposed group (<55 dB) (n=100) In June 2020, 4 months after COVID-19 pandemic restrictions introduction, we reassessed (2nd observation) 74 and 75 participants from previously exposed and unexposed groups, respectively, using the same study protocol We collected medical history, office and ambulatory BP, echocardiographic and arterial stiffness data Results: In exposed to aircraft noise group the prevalence of arterial hypertension increased from 1st to 2nd observation (P<0 05) During lockdown in the noise exposed group office and 24 hour diastolic BP (DBP, P<0 022) decreased signifi-cantly, which was accompanied by a significant drop in annoyance (P=0 006) In this group in 2nd observation DBP was significantly lower than estimated DBP (i e calculated as a sum of DBP at 1st observation and parameter estimates of crosssectional association of DBP and age multiplied by 5 5 year-time period between observations) (P=0 047) The obtained decline in DBP from 1st to 2nd observation was grater in noise exposed than unexposed participants, even after adjustment for covariates The carotid-femoral pulse wave velocity (PWV), initially higher in noise exposed group, decreased from 1st to 2nd observation in both groups, however this was more pronounced in the exposed than unexposed group (P=0 003) In 1st observation PWV in noise exposed participants did not show any relationship with age (Parameter Estimate (PE)=0 01 m/s/year;P= 0 71), while in 2nd observation, during aircraft noise decline caused by COVID-19 lockdown, the expected positive relation of PWV with age was reinstituted (PE=0 15 m/s/year;P<0 001) Conclusions: As our previous study indicated, aircraft noise exposure may increase BP and accelerate arterial stiffening The decrease in BP and PWV due to noise intensity diminution, observed during COVID-19 lockdown, in fact provides evidence for this observation
Journal of Hypertension, 2021
Journal of Hypertension, 2021
Wstep Celem badania bylo ustalenie związku polimorfizmow G-6A genu AGT, D/I genu ACE i A1166C gen... more Wstep Celem badania bylo ustalenie związku polimorfizmow G-6A genu AGT, D/I genu ACE i A1166C genu AGTR1 z wartościami ciśnienia tetniczego i usztywnienia tetnic oraz ocena lącznego wplywu wymienionych polimorfizmow genetycznych na wybrane parametry. Material i metody Badaniem objeto 52 rodziny (82 rodzicow i 103 dzieci). U kazdego uczestnika dokonano pomiarow ciśnienia tetniczego: obwodowego (metoda konwencjonalna - SBP P , DBP P , PP P i 24-godzinny zapis - SBP A , DBP A , PP A ) i centralnego (analiza fali tetna - SBP C> , DBP C , PP C ) oraz wlasności elastycznych tetnic (wzmocnienie fali aortalnej - AG, obwodowy - AIx P i centralny - AIx C , wskaźniki wzmocnienia fali). Ponadto wśrod osob uczestniczących w badaniu wykonano analizy genetyczne. Wyniki Analizy, dotyczące pojedynczych polimorfizmow, wykazaly zaleznośc miedzy polimorfizmem D/I genu ACE a SBP A , SBP C , PP A i PP C . Ponadto, stwierdzono obecnośc istotnych statystycznie interakcji miedzy polimorfizmami D/I genu A...
We describe 2 patients with arrhythmogenic right ventricular cardiomyopathy (ARVD): 58 year-old f... more We describe 2 patients with arrhythmogenic right ventricular cardiomyopathy (ARVD): 58 year-old female and 48 year-old man. Both patients presented with echocardiographic features typical for ARVD and impaired systolic left ventricular function. Both patients had symptoms resembling acute coronary syndrome and received cardioverter-defibrillator due to recurrent sustained ventricular tachycardia.
Wpływ wybranych polimorfizmów genów angiotensynogenu, konwertazy angiotensyny I oraz receptora ty... more Wpływ wybranych polimorfizmów genów angiotensynogenu, konwertazy angiotensyny I oraz receptora typu 1 dla angiotensyny II na ciśnienie tętnicze oraz parametry usztywnienia dużych tętnic-zależność od spożycia sodu Influence of selected genetic polymorphisms of angiotensinogen, angiotensin-converting enzyme and type-1 angiotensin II receptor on arterial pressure and large artery stiffness parameters-depending on sodium intake Adres do korespondencji: dr med.
Arterial Hypertension, 2008
Wstep Związek pomiedzy menopauzą a rozwojem nadciśnienia tetniczego jest przedmiotem badan od wie... more Wstep Związek pomiedzy menopauzą a rozwojem nadciśnienia tetniczego jest przedmiotem badan od wielu lat. U kobiet po menopauzie zapadalnośc na chorobe niedokrwienną serca gwaltownie wzrasta, podobnie jak związana z nią śmiertelnośc. Dotychczas brakuje danych klinicznych charakteryzujących wplyw menopauzy na stezenie mozgowego peptydu natriuretycznego (BNP). Wydaje sie jednak, ze moze on stanowic istotny czynnik prognostyczny u kobiet z nadciśnieniem tetniczym w okresie pomenopauzalnym. Celem badania bylo określenie stezenia N-koncowej cześci mozgowego peptydu natriuretycznego (NT-proBNP) u kobiet przed i po menopauzie z lagodnym nadciśnieniem tetniczym oraz ocena korelacji tych stezen ze stanem hormonalnym i wartościami ciśnienia tetniczego krwi. Material i metody Badaniem objeto 112 kobiet w wieku 45–55 lat (50,73 ± 1,82 roku) z pierwotnym lagodnym nadciśnieniem tetniczym, rozpoznanym na podstawie pomiarow gabinetowyche i potwierdzonym calodobową automatyczną rejestracją ciśnienia ...
Kardiologia Polska, 2021
We would like to thank for the interest in our article. It has been confirmed in numerous studies... more We would like to thank for the interest in our article. It has been confirmed in numerous studies that COVID-19 can lead to increased risk of a poor outcome, which is particularly
Kardiologia Polska, 2021
w w w. j o u r n a l s. v i a m e d i c a. p l / k a r d i o l o g i a _ p o l s k a
Journal of Hypertension, 2018
Objective: Intracranial atherosclerotic stenosis (ICAS) contributes to nearly 50% of stroke in Ch... more Objective: Intracranial atherosclerotic stenosis (ICAS) contributes to nearly 50% of stroke in China, especially in patients with hypertension. Urine albumin-tocreatinine ratio (ACR) has been related to stroke and other atherosclerotic cardiovascular diseases. However, there is limited information about the effect of ACR on early impairment of cerebral vessels. Hereby we assessed the association between ICAS and ACR in a stroke-free hypertensive population. Design and method: Computed tomography angiography was performed to detect atherosclerotic stenosis of intracranial arteries in 889 hypertension patients. A random spot urine was sampled to evaluate ACR. Logistic regression was carried out to analyze the association of ACR with the presence, extent and lesion number of ICAS. Risk factors which we previously identifi ed were also added in the adjustment to determine whether the association of elevated ACR with ICAS was independent. Results: There were 336 patients (37.8%) with ICAS. Elevated ACR (> = 30 mg/g) was associated with ICAS after adjustment of confounding factors (OR = 1.65, 95% CI: 1.21-2.27). This association remained signifi cant in patients who were male, > = 65 years and without diabetes. Patients with elevated ACR were more prone to develop moderate to severe stenosis (OR = 1.57, 95%CI: 1.16-2.12) and more lesions (OR = 1.58, 95%CI: 1.16-2.15). The association of elevated ACR with ICAS was independent of previously discovered risk factors. Conclusions: Our fi ndings suggested that ACR was associated with asymptomatic ICAS in an aged stroke-free hypertensive population. ACR may serve as a convenient and independent early marker of ICAS in clinical practice.
Cardiology Journal, 2013
Background: Atherosclerosis is as a systemic inflammatory disease associated with the activation ... more Background: Atherosclerosis is as a systemic inflammatory disease associated with the activation of many mediators, including matrix metalloproteinases (MMPs), and may be amplified by abnormal high serum uric acid (UA) concentration (hyperuricemia, HU). The aim of the study was to determine the relationship between serum UA concentration and activity of MMPs and their correlation with the hypertensionmediated organ damage (HMOD) intensity. Methods: 109 patients untreated with antihypertensive, hypolipemic or urate-lowering drugs with diagnosed stage 1-2 essential hypertension were included in this study. In all participants blood pressure (BP) was measured, carotid-femoral pulse wave velocity (PWV), intima-media thickness (IMT), echocardiography and blood tests including UA, lipids and serum concentrations of MMPs (1, 2, 3, 9) were observed. The participants were divided into hyper-and normuricemic groups. Results: Uric acid concentration in the whole study group positively correlated with some HMOD parameters (IMT, PWV, left ventricular mass index, left atrial dimension). Among the studied metalloproteinases only MMP-3 activity positively correlated with serum UA concentration independently of age, body mass index and serum lipids (R2 = 0.11, p = 0.048). Multivariate regression analysis showed positive association between IMT and BP, UA concentration and MMP-3 activity, independently of waist circumference and serum lipids (R2 = 0.328, p < 0.002). Patients with HU were characterized by higher activity of MMP-3 than those without (19.41 [14.45; 21.74] vs. 13.98 [9.52; 18.97] ng/mL, p = 0.016). Conclusions: The present results may support the thesis that UA and the increased by UA activity of MMPs may take part in the development of HMOD, especially IMT.
Journal of Hypertension, 2019
Objective: To assess the impact of long-term exposure to aircraft noise on blood pressure (BP), p... more Objective: To assess the impact of long-term exposure to aircraft noise on blood pressure (BP), prevalence of arterial hypertension, and indices of asymptomatic organ damage. Methods: Using acoustic maps, we selected and further compared people living (average 35 years) in areas exposed to high, more than 60 dB (n ¼ 101), and low aircraft noise, less than 55 dB (n ¼ 100). Medical history taking, office BP measurement, ambulatory BP monitoring, and echocardiographic and arterial stiffness measurements were performed. Results: Exposure to aircraft noise did not increase the prevalence of arterial hypertension (50%, both groups) but was associated with higher office (88.3 AE 11.4 vs. 79.8 AE 8.6 mmHg, P < 0.001) and night-time DBP (66.6 AE 9.5 vs. 63.6 AE 7.3 mmHg, P < 0.01). Participants exposed to a high aircraft noise level had a higher carotidfemoral pulse wave velocity (PWV) (10.3 AE 1.8 vs. 9.4 AE 1.4 m/s, P < 0.01) and lower early mitral annulus velocity (e 0) (8.4 AE 2.9 vs. 9.2 AE 3.4 cm/s, P ¼ 0.047). These differences were independent of age, sex, BMI, education, time spent at home, smoking status, alcohol consumption, and antihypertensive treatment. Higher office and nighttime DBP, PWV, and e 0 values were explicitly observed in exposed normotensive participants. PWV in aircraft noiseexposed normotensive participants was equal to that of two decades older unexposed normotensive participants and was significantly associated with noise annoyance. Conclusion: Long-term aircraft noise exposure is related to higher office and night-time DBP, more advanced arterial stiffness, and unfavourable left ventricle diastolic function changes. Accelerated arterial stiffening was observed in those exposed to aircraft noise, even normotensive participants, to a degree depending on noise annoyance.
Archives of Medical Science, 2018
IntroductionThe aim of this study was to assess the relations between plasma renin activity (PRA)... more IntroductionThe aim of this study was to assess the relations between plasma renin activity (PRA), serum aldosterone concentration (ALDO) and selected asymptomatic organ damage (AOD) indices in mild primary arterial hypertension (AH).Material and MethodsWe measured PRA, ALDO, and selected AOD indices (carotid-femoral pulse wave velocity (cfPWV), central aortic pulse pressure (cPP), estimated glomerular filtration rate (eGFR)) in 122 patients with untreated AH.ResultsPatients with high PRA (≥ 0.65 ng/ml/h) were characterized by lower plasma sodium and aldosterone to renin ratio (ARR), higher ALDO, but a similar level of AOD indices compared to patients with low PRA. cfPWV (p = 0.04) and cPP (p = 0.019) increased with ARR, while eGFR decreased with ALDO (p = 0.008). Only eGFR was independently correlated with ALDO. In subjects with simultaneously high PRA and ARR values, we found significantly higher cfPWV (p = 0.02) and cPP (p = 0.04) and lower eGFR (p = 0.02) than in those with high...
Journal of Hypertension, 2018
Methods: A total of 78 hypertensive patients with coronary atherosclerotic heart disease from Oct... more Methods: A total of 78 hypertensive patients with coronary atherosclerotic heart disease from October 2016 to October 2017 were taken as observation group, and 49 hypertensive patients as the control group. Compared the differences of sex, age, occupation, diet and sleep, smoking history, drinking history, history of diabetes, history of hypertension, body mass index (BMI), total cholesterol (CHO), triacylglycerol (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and other related levels in two groups. The mini-mental state examination (MMSE) score were used to assessed cognitive function. For those patients with cognitive impairment, The Montreal cognitive assessment (MoCA) were used to assessed cognitive impairment domains. Results: The average score of MMSE in patients with coronary atherosclerotic heart disease was not signifi cantly different from those in control group (P > 0.05), but the incidence of mild cognitive impairment was higher in patients with coronary atherosclerotic heart disease (P < 0.05); With the increasing of blood pressure, the score of MMSE showed a decreasing trend. The average scores of MMSE of those patients whose blood pressure above Grade 3 were signifi cantly decreased than those whose blood pressure below Grade 2 (P < 0.05), but the incidence of mild cognitive impairment has no signifi cant difference (P > 0.05); Memory, attention and computational power, abstraction ability and delayed recall of the selected patients were signifi cantly decreased. Conclusion: Patients with hypertension,coronary atherosclerotic heart disease are prone to mild cognitive impairment; There is a close relation between hypertension and cognitive impairment.
Medicine, 2017
Left atrial enlargement (LAE) is a risk factor for cardiovascular complications and death. In hyp... more Left atrial enlargement (LAE) is a risk factor for cardiovascular complications and death. In hypertensive patients, LAE is usually due to left ventricular (LV) hypertrophy and diastolic dysfunction. We aimed to identify factors associated with LAE in patients with increased and normal left ventricular mass index (LVMI) with reference to pulsatile and steady components of blood pressure (BP).The study was carried out as a cross-sectional observation. In a group of inhabitants of suburban area of Cracow, Poland, we measured office, ambulatory and central BP, carotid-femoral pulse wave velocity (PWV), as well as echocardiographic indices and gathered anthropometric data, information on habits and relevant medical history. Further, with division according to sex-stratified dichotomised LVMI, we performed correlation analysis to identify possibly significant relations between measures of left atrial volume and other studied parameters. We also fitted regression models in order to assess...
Polskie Archiwum Medycyny Wewnetrznej-polish Archives of Internal Medicine, Aug 22, 2022
Frontiers in Cardiovascular Medicine
BackgroundThe impact of COVID-19 on the outcome of patients with MI has not been studied widely. ... more BackgroundThe impact of COVID-19 on the outcome of patients with MI has not been studied widely. We aimed to evaluate the relationship between concomitant COVID-19 and the clinical course of patients admitted due to acute myocardial infarction (MI).MethodsThere was a comparison of retrospective data between patients with MI who were qualified for coronary angiography with concomitant COVID-19 and control group of patients treated for MI in the preceding year before the onset of the pandemic. In-hospital clinical data and the incidence of death from any cause on 30 days were obtained.ResultsData of 39 MI patients with concomitant COVID-19 (COVID-19 MI) and 196 MI patients without COVID-19 in pre-pandemic era (non-COVID-19 MI) were assessed. Compared with non-COVID-19 MI, COVID-19 MI was in a more severe clinical state on admission (lower systolic blood pressure: 128.51 ± 19.76 vs. 141.11 ± 32.47 mmHg, p = 0.024), higher: respiratory rate [median (interquartile range), 16 (14–18) vs. ...
Mózgowy peptyd natriuretyczny u kobiet z łagodnym nadciśnieniem tętniczym w okresie okołomenopauz... more Mózgowy peptyd natriuretyczny u kobiet z łagodnym nadciśnieniem tętniczym w okresie okołomenopauzalnym Brain natriuretic peptide in women with mild hypertension in perimenopausal period Summary Background Morbidity and mortality from cardiovascu-lar diseases increase rapidly in women after menopause. Relationship between menopause and hypertension has been a topic of investigation for several years. There are no evidences about the influence of menopause on brain natriuretic peptide level. Present studies indicate the important prognostic value of this parameter in this group of patients. The aim of this study was to assess the level of N-terminal part of brain natriuretic peptide as well as the correlation of this factor with values of blood pressure in hypertensive women in relation to post-and premenopausal hormonal status. Material and methods The study included 112 women aged 45 to 55 years (mean age 50.73 ± 1.82 years) with mild essential hypertension confirmed by conventional...
Journal of Hypertension, 2021
Objective: The COVID-19 lockdown caused unprecedented decline in environmental noise pollution We... more Objective: The COVID-19 lockdown caused unprecedented decline in environmental noise pollution We aimed to evaluate the impact of aircraft noise exposure decrease during lockdown on blood pressure (BP) and selected hypertensionmediated organ damages Design and method: As previously reported (J Hypertens 2019;37) in 2015 (1st observation) we examined group of inhabitants exposed to high (>60 dB) aircraft noise living near Cracow Airport (n=101), and compared them to unexposed group (<55 dB) (n=100) In June 2020, 4 months after COVID-19 pandemic restrictions introduction, we reassessed (2nd observation) 74 and 75 participants from previously exposed and unexposed groups, respectively, using the same study protocol We collected medical history, office and ambulatory BP, echocardiographic and arterial stiffness data Results: In exposed to aircraft noise group the prevalence of arterial hypertension increased from 1st to 2nd observation (P<0 05) During lockdown in the noise exposed group office and 24 hour diastolic BP (DBP, P<0 022) decreased signifi-cantly, which was accompanied by a significant drop in annoyance (P=0 006) In this group in 2nd observation DBP was significantly lower than estimated DBP (i e calculated as a sum of DBP at 1st observation and parameter estimates of crosssectional association of DBP and age multiplied by 5 5 year-time period between observations) (P=0 047) The obtained decline in DBP from 1st to 2nd observation was grater in noise exposed than unexposed participants, even after adjustment for covariates The carotid-femoral pulse wave velocity (PWV), initially higher in noise exposed group, decreased from 1st to 2nd observation in both groups, however this was more pronounced in the exposed than unexposed group (P=0 003) In 1st observation PWV in noise exposed participants did not show any relationship with age (Parameter Estimate (PE)=0 01 m/s/year;P= 0 71), while in 2nd observation, during aircraft noise decline caused by COVID-19 lockdown, the expected positive relation of PWV with age was reinstituted (PE=0 15 m/s/year;P<0 001) Conclusions: As our previous study indicated, aircraft noise exposure may increase BP and accelerate arterial stiffening The decrease in BP and PWV due to noise intensity diminution, observed during COVID-19 lockdown, in fact provides evidence for this observation
Journal of Hypertension, 2021
Journal of Hypertension, 2021
Wstep Celem badania bylo ustalenie związku polimorfizmow G-6A genu AGT, D/I genu ACE i A1166C gen... more Wstep Celem badania bylo ustalenie związku polimorfizmow G-6A genu AGT, D/I genu ACE i A1166C genu AGTR1 z wartościami ciśnienia tetniczego i usztywnienia tetnic oraz ocena lącznego wplywu wymienionych polimorfizmow genetycznych na wybrane parametry. Material i metody Badaniem objeto 52 rodziny (82 rodzicow i 103 dzieci). U kazdego uczestnika dokonano pomiarow ciśnienia tetniczego: obwodowego (metoda konwencjonalna - SBP P , DBP P , PP P i 24-godzinny zapis - SBP A , DBP A , PP A ) i centralnego (analiza fali tetna - SBP C> , DBP C , PP C ) oraz wlasności elastycznych tetnic (wzmocnienie fali aortalnej - AG, obwodowy - AIx P i centralny - AIx C , wskaźniki wzmocnienia fali). Ponadto wśrod osob uczestniczących w badaniu wykonano analizy genetyczne. Wyniki Analizy, dotyczące pojedynczych polimorfizmow, wykazaly zaleznośc miedzy polimorfizmem D/I genu ACE a SBP A , SBP C , PP A i PP C . Ponadto, stwierdzono obecnośc istotnych statystycznie interakcji miedzy polimorfizmami D/I genu A...
We describe 2 patients with arrhythmogenic right ventricular cardiomyopathy (ARVD): 58 year-old f... more We describe 2 patients with arrhythmogenic right ventricular cardiomyopathy (ARVD): 58 year-old female and 48 year-old man. Both patients presented with echocardiographic features typical for ARVD and impaired systolic left ventricular function. Both patients had symptoms resembling acute coronary syndrome and received cardioverter-defibrillator due to recurrent sustained ventricular tachycardia.
Wpływ wybranych polimorfizmów genów angiotensynogenu, konwertazy angiotensyny I oraz receptora ty... more Wpływ wybranych polimorfizmów genów angiotensynogenu, konwertazy angiotensyny I oraz receptora typu 1 dla angiotensyny II na ciśnienie tętnicze oraz parametry usztywnienia dużych tętnic-zależność od spożycia sodu Influence of selected genetic polymorphisms of angiotensinogen, angiotensin-converting enzyme and type-1 angiotensin II receptor on arterial pressure and large artery stiffness parameters-depending on sodium intake Adres do korespondencji: dr med.
Arterial Hypertension, 2008
Wstep Związek pomiedzy menopauzą a rozwojem nadciśnienia tetniczego jest przedmiotem badan od wie... more Wstep Związek pomiedzy menopauzą a rozwojem nadciśnienia tetniczego jest przedmiotem badan od wielu lat. U kobiet po menopauzie zapadalnośc na chorobe niedokrwienną serca gwaltownie wzrasta, podobnie jak związana z nią śmiertelnośc. Dotychczas brakuje danych klinicznych charakteryzujących wplyw menopauzy na stezenie mozgowego peptydu natriuretycznego (BNP). Wydaje sie jednak, ze moze on stanowic istotny czynnik prognostyczny u kobiet z nadciśnieniem tetniczym w okresie pomenopauzalnym. Celem badania bylo określenie stezenia N-koncowej cześci mozgowego peptydu natriuretycznego (NT-proBNP) u kobiet przed i po menopauzie z lagodnym nadciśnieniem tetniczym oraz ocena korelacji tych stezen ze stanem hormonalnym i wartościami ciśnienia tetniczego krwi. Material i metody Badaniem objeto 112 kobiet w wieku 45–55 lat (50,73 ± 1,82 roku) z pierwotnym lagodnym nadciśnieniem tetniczym, rozpoznanym na podstawie pomiarow gabinetowyche i potwierdzonym calodobową automatyczną rejestracją ciśnienia ...
Kardiologia Polska, 2021
We would like to thank for the interest in our article. It has been confirmed in numerous studies... more We would like to thank for the interest in our article. It has been confirmed in numerous studies that COVID-19 can lead to increased risk of a poor outcome, which is particularly
Kardiologia Polska, 2021
w w w. j o u r n a l s. v i a m e d i c a. p l / k a r d i o l o g i a _ p o l s k a
Journal of Hypertension, 2018
Objective: Intracranial atherosclerotic stenosis (ICAS) contributes to nearly 50% of stroke in Ch... more Objective: Intracranial atherosclerotic stenosis (ICAS) contributes to nearly 50% of stroke in China, especially in patients with hypertension. Urine albumin-tocreatinine ratio (ACR) has been related to stroke and other atherosclerotic cardiovascular diseases. However, there is limited information about the effect of ACR on early impairment of cerebral vessels. Hereby we assessed the association between ICAS and ACR in a stroke-free hypertensive population. Design and method: Computed tomography angiography was performed to detect atherosclerotic stenosis of intracranial arteries in 889 hypertension patients. A random spot urine was sampled to evaluate ACR. Logistic regression was carried out to analyze the association of ACR with the presence, extent and lesion number of ICAS. Risk factors which we previously identifi ed were also added in the adjustment to determine whether the association of elevated ACR with ICAS was independent. Results: There were 336 patients (37.8%) with ICAS. Elevated ACR (> = 30 mg/g) was associated with ICAS after adjustment of confounding factors (OR = 1.65, 95% CI: 1.21-2.27). This association remained signifi cant in patients who were male, > = 65 years and without diabetes. Patients with elevated ACR were more prone to develop moderate to severe stenosis (OR = 1.57, 95%CI: 1.16-2.12) and more lesions (OR = 1.58, 95%CI: 1.16-2.15). The association of elevated ACR with ICAS was independent of previously discovered risk factors. Conclusions: Our fi ndings suggested that ACR was associated with asymptomatic ICAS in an aged stroke-free hypertensive population. ACR may serve as a convenient and independent early marker of ICAS in clinical practice.
Cardiology Journal, 2013
Background: Atherosclerosis is as a systemic inflammatory disease associated with the activation ... more Background: Atherosclerosis is as a systemic inflammatory disease associated with the activation of many mediators, including matrix metalloproteinases (MMPs), and may be amplified by abnormal high serum uric acid (UA) concentration (hyperuricemia, HU). The aim of the study was to determine the relationship between serum UA concentration and activity of MMPs and their correlation with the hypertensionmediated organ damage (HMOD) intensity. Methods: 109 patients untreated with antihypertensive, hypolipemic or urate-lowering drugs with diagnosed stage 1-2 essential hypertension were included in this study. In all participants blood pressure (BP) was measured, carotid-femoral pulse wave velocity (PWV), intima-media thickness (IMT), echocardiography and blood tests including UA, lipids and serum concentrations of MMPs (1, 2, 3, 9) were observed. The participants were divided into hyper-and normuricemic groups. Results: Uric acid concentration in the whole study group positively correlated with some HMOD parameters (IMT, PWV, left ventricular mass index, left atrial dimension). Among the studied metalloproteinases only MMP-3 activity positively correlated with serum UA concentration independently of age, body mass index and serum lipids (R2 = 0.11, p = 0.048). Multivariate regression analysis showed positive association between IMT and BP, UA concentration and MMP-3 activity, independently of waist circumference and serum lipids (R2 = 0.328, p < 0.002). Patients with HU were characterized by higher activity of MMP-3 than those without (19.41 [14.45; 21.74] vs. 13.98 [9.52; 18.97] ng/mL, p = 0.016). Conclusions: The present results may support the thesis that UA and the increased by UA activity of MMPs may take part in the development of HMOD, especially IMT.
Journal of Hypertension, 2019
Objective: To assess the impact of long-term exposure to aircraft noise on blood pressure (BP), p... more Objective: To assess the impact of long-term exposure to aircraft noise on blood pressure (BP), prevalence of arterial hypertension, and indices of asymptomatic organ damage. Methods: Using acoustic maps, we selected and further compared people living (average 35 years) in areas exposed to high, more than 60 dB (n ¼ 101), and low aircraft noise, less than 55 dB (n ¼ 100). Medical history taking, office BP measurement, ambulatory BP monitoring, and echocardiographic and arterial stiffness measurements were performed. Results: Exposure to aircraft noise did not increase the prevalence of arterial hypertension (50%, both groups) but was associated with higher office (88.3 AE 11.4 vs. 79.8 AE 8.6 mmHg, P < 0.001) and night-time DBP (66.6 AE 9.5 vs. 63.6 AE 7.3 mmHg, P < 0.01). Participants exposed to a high aircraft noise level had a higher carotidfemoral pulse wave velocity (PWV) (10.3 AE 1.8 vs. 9.4 AE 1.4 m/s, P < 0.01) and lower early mitral annulus velocity (e 0) (8.4 AE 2.9 vs. 9.2 AE 3.4 cm/s, P ¼ 0.047). These differences were independent of age, sex, BMI, education, time spent at home, smoking status, alcohol consumption, and antihypertensive treatment. Higher office and nighttime DBP, PWV, and e 0 values were explicitly observed in exposed normotensive participants. PWV in aircraft noiseexposed normotensive participants was equal to that of two decades older unexposed normotensive participants and was significantly associated with noise annoyance. Conclusion: Long-term aircraft noise exposure is related to higher office and night-time DBP, more advanced arterial stiffness, and unfavourable left ventricle diastolic function changes. Accelerated arterial stiffening was observed in those exposed to aircraft noise, even normotensive participants, to a degree depending on noise annoyance.
Archives of Medical Science, 2018
IntroductionThe aim of this study was to assess the relations between plasma renin activity (PRA)... more IntroductionThe aim of this study was to assess the relations between plasma renin activity (PRA), serum aldosterone concentration (ALDO) and selected asymptomatic organ damage (AOD) indices in mild primary arterial hypertension (AH).Material and MethodsWe measured PRA, ALDO, and selected AOD indices (carotid-femoral pulse wave velocity (cfPWV), central aortic pulse pressure (cPP), estimated glomerular filtration rate (eGFR)) in 122 patients with untreated AH.ResultsPatients with high PRA (≥ 0.65 ng/ml/h) were characterized by lower plasma sodium and aldosterone to renin ratio (ARR), higher ALDO, but a similar level of AOD indices compared to patients with low PRA. cfPWV (p = 0.04) and cPP (p = 0.019) increased with ARR, while eGFR decreased with ALDO (p = 0.008). Only eGFR was independently correlated with ALDO. In subjects with simultaneously high PRA and ARR values, we found significantly higher cfPWV (p = 0.02) and cPP (p = 0.04) and lower eGFR (p = 0.02) than in those with high...
Journal of Hypertension, 2018
Methods: A total of 78 hypertensive patients with coronary atherosclerotic heart disease from Oct... more Methods: A total of 78 hypertensive patients with coronary atherosclerotic heart disease from October 2016 to October 2017 were taken as observation group, and 49 hypertensive patients as the control group. Compared the differences of sex, age, occupation, diet and sleep, smoking history, drinking history, history of diabetes, history of hypertension, body mass index (BMI), total cholesterol (CHO), triacylglycerol (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and other related levels in two groups. The mini-mental state examination (MMSE) score were used to assessed cognitive function. For those patients with cognitive impairment, The Montreal cognitive assessment (MoCA) were used to assessed cognitive impairment domains. Results: The average score of MMSE in patients with coronary atherosclerotic heart disease was not signifi cantly different from those in control group (P > 0.05), but the incidence of mild cognitive impairment was higher in patients with coronary atherosclerotic heart disease (P < 0.05); With the increasing of blood pressure, the score of MMSE showed a decreasing trend. The average scores of MMSE of those patients whose blood pressure above Grade 3 were signifi cantly decreased than those whose blood pressure below Grade 2 (P < 0.05), but the incidence of mild cognitive impairment has no signifi cant difference (P > 0.05); Memory, attention and computational power, abstraction ability and delayed recall of the selected patients were signifi cantly decreased. Conclusion: Patients with hypertension,coronary atherosclerotic heart disease are prone to mild cognitive impairment; There is a close relation between hypertension and cognitive impairment.
Medicine, 2017
Left atrial enlargement (LAE) is a risk factor for cardiovascular complications and death. In hyp... more Left atrial enlargement (LAE) is a risk factor for cardiovascular complications and death. In hypertensive patients, LAE is usually due to left ventricular (LV) hypertrophy and diastolic dysfunction. We aimed to identify factors associated with LAE in patients with increased and normal left ventricular mass index (LVMI) with reference to pulsatile and steady components of blood pressure (BP).The study was carried out as a cross-sectional observation. In a group of inhabitants of suburban area of Cracow, Poland, we measured office, ambulatory and central BP, carotid-femoral pulse wave velocity (PWV), as well as echocardiographic indices and gathered anthropometric data, information on habits and relevant medical history. Further, with division according to sex-stratified dichotomised LVMI, we performed correlation analysis to identify possibly significant relations between measures of left atrial volume and other studied parameters. We also fitted regression models in order to assess...