William Simon - Academia.edu (original) (raw)

Papers by William Simon

Notre Dame Law Review, 2002

OF THESIS INVESTIGATION OF PHANEROCHAETE CHRYSOSPORIUM AND CLOSTRIDIUM THERMOCELLUM FOR IMPROVED ... more OF THESIS INVESTIGATION OF PHANEROCHAETE CHRYSOSPORIUM AND CLOSTRIDIUM THERMOCELLUM FOR IMPROVED SACCHARIFICATION OF LIGNOCELLULOSE UNDER NONSTERILE CONDITIONS Current research efforts are directed at developing competitive processes that can utilize lignocellulose as a feedstock for biorefineries. The purpose of this study was to investigate methods of processing lignocellulosic material so that its monosacharides can be more easily accessed for fermentation, the lack of which is hindering the economics and widescale adoption of lignocellulosic biorefining. The monosaccharides are of interest because they can be used by Clostridium beijerinckii downstream of P. chrysosporium and C. thermocellum in a sequential bioprocess to produce butanol. Butanol is an attractive biofuel because it can be utilized without modifying current transportation infrastructure. Butanol is also used as a starting material in organic synthesis. In the first study, the potential for C. thermocellum' s (...

ADVOCATE 387 (3rd ed. 1879); A.B.A. Op. No. 281; ABA CODE OF PROFESSIONAL RESPONSIBILITY , DR 7-1... more ADVOCATE 387 (3rd ed. 1879); A.B.A. Op. No. 281; ABA CODE OF PROFESSIONAL RESPONSIBILITY , DR 7-101(B) (1976) [hereinafter cited as ABA CODE]. 15. ABA CODE, supra note 14, at EC 7-24.

Proceedings of the 56th Annual Design Automation Conference 2019

As the computational complexity of applications on the consumer market, such as high-definition v... more As the computational complexity of applications on the consumer market, such as high-definition video encoding and deep neural networks, become ever more demanding, novel ways to efficiently compute data intensive workloads are being explored. In this context, In-Memory Computing (IMC) solutions, and particularly bitline computing in SRAM, appear promising as they mitigate one of the most energy consuming aspects in computation: data movement. While IMC architectural level characteristics have been defined by the research community, only a few works so far have explored the implementation of such memories at a low level. Furthermore, these proposed solutions are either slow (lt1(\lt1(lt1 GHz), area hungry (10T SRAM), or suffer from read disturb and corruption issues. Overall, there is no extensive design study considering realistic assumptions at the circuit level. In this work we propose a fast (up to 2.2Ghz), 6T SRAM-based, reliable (no read disturb issues), and wide voltage range (from 0.6 to 1V) IMC architecture using local bitlines. Beyond standard read and write, the proposed architecture can perform copy, addition and shift operations at the array level. As addition is the slowest operation, we propose a modified carry chain adder, providing a 2× carry propagation improvement. The proposed architecture is validated using a 28nm bulk high performances technology PDK with CMOS variability and post-layout simulations. High density SRAM bitcells (0.127mumathrmm)(0.127_{\mu }\mathrm{m})(0.127mumathrmm) enable area efficiency of 59.7% for a 256times128256_{\times} 128256times128 array, on par with current industrial standards.

Computer Graphics and Image Processing

Abstract A simple device for producing an autostereoscopic visual computer display is described.

California Law Review, 2007

The Articles in this symposium and the experiences they report show that, for lawyers, Community ... more The Articles in this symposium and the experiences they report show that, for lawyers, Community Economic Development (CED) has become a more expansive and more complex subject than it was when we discovered it two decades or so ago. The Articles and the experiences are particularly revealing about what I would guess have been the two central preoccupations of lawyers in the field. The first, of course, is what we mean by community, and more specifically, how a community can become-or be regarded as-a legal and political actor. The second concerns lawyer accountability. Progressive lawyers have long been preoccupied with accountability to their disadvantaged clients-too much, I sometimes think-but the concern seems particularly pressing where lawyers represent groups. CED is the newest and in some respects most mysterious form of group representation. I COMMUNITY These Articles suggest that the concept of community is becoming more capacious and flexible. We have not solved the problem of defining community, but we are becoming more comfortable with its ambiguity. I take three points about the evolving conception of community from these Articles. First, community need not, as some of us once assumed, be defined exclusively or even primarily in terms of residential proximity. Of course, residential proximity remains a prominent link, as four of these Articles show. The residents of West Harlem, West Oakland, Umoja Village, and Inglewood have ties to each other and practical interests that arise in

The most basic division among legal ethicists is about whether legal ethics practice norms should... more The most basic division among legal ethicists is about whether legal ethics practice norms should take the form of rules or principles. Not all scholars address this issue, and no one has comprehensively analysed it. Yet, it seems to be the concern that most drives differences in both specific conclusions and general perspectives.

Stanford Law Review, Apr 1, 2008

Berkeley Journal of Employment Labor Law, 2014

$Research paper thumbnail of Isolation and fractionation of the endoplasmic reticulum from castor bean (Ricinus communis) endosperm for proteomic analyses$

Methods in molecular biology (Clifton, N.J.), 2008

This chapter describes the preparation and isolation of highly purified endoplasmic reticulum (ER... more This chapter describes the preparation and isolation of highly purified endoplasmic reticulum (ER) from the endosperm of developing and germinating castor bean (Ricinus communis) seeds to provide a purified organelle fraction for differential proteomic analyses. The method uses a two-step ultracentrifugation protocol first described by Coughlan (1) and uses sucrose density gradients and a sucrose flotation step to yield purified ER devoid of other contaminating endomembrane material. Using a combination of one dimensional (1D) and two dimensional (2D) gel electrophoresis the complexity and reproducibility of the protein profile of the purified organelle is evaluated prior to detailed proteomic analyses using mass spectrometry based techniques.

PLANT PHYSIOLOGY, 2005

Histidine kinases (Hiks) in Synechocystis sp. PCC 6803 are involved in the transduction of signal... more Histidine kinases (Hiks) in Synechocystis sp. PCC 6803 are involved in the transduction of signals associated with various kinds of environmental stress. To examine the potential role in thermotolerance of Hiks, we used genome microarray analysis to screen a Hik knockout library for mutations that affected the expression of genes for heat shock proteins. Mutation of the hik34 gene enhanced the levels of transcripts of a number of heat shock genes, including htpG and groESL1. Overexpression of the hik34 gene repressed the expression of these heat shock genes. In addition, the cells with a mutant gene for Hik34 (ΔHik34 cells) survived incubation at 48°C for 3 h, while wild-type cells and cells with mutations in other Hiks were killed. However, mutation of the hik34 gene had only an insignificant effect on the global expression of genes upon incubation of the mutant cells at 44°C for 20 min. Quantitative two-dimensional gel electrophoresis revealed that levels of GroES and HspA were el...

Law <html_ent glyph="@amp;" ascii="&"/> Social Inquiry, 1998

Journal of Molecular Biology, 2007

Journal of Autism and Developmental Disorders, 1985

Numbers of neurons and glia were counted in the cerebral cortex of one well-documented case of au... more Numbers of neurons and glia were counted in the cerebral cortex of one well-documented case of autism and two age- and sex-matched controls. Areas in which cell counts were made were primary auditory cortex, Broca's speech area, and auditory association cortex. No consistent differences in cell density were found between the brains of the autistic patient and the control patients.