Win Kim - Academia.edu (original) (raw)

Papers by Win Kim

International Journal of Neuroscience, 2009

The purpose of this study was to examine the emotions experienced by spectators when their favori... more The purpose of this study was to examine the emotions experienced by spectators when their favorite team wins or loses a soccer match using fMRI. Those who watched winning scenes showed activation of the right and left occipital lobes, left temporal lobe, left limbic lobe, middle occipital gyrus, superior temporal gyrus, cuneus, and uncus. Those who watched losing scenes showed activation of the right frontal lobe and right limbic lobe. This result suggests that emotional suppression is much stronger in negative emotional responses than in positive responses.

Science, 2010

Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only fro... more Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes for assimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution toward obligate biotrophy.

Journal of Leadership & Organizational Studies, 1996

Archives of Internal Medicine, 2006

... 8. References [1] P.Selvi and Dr.NPGopalan, “SEMANTIC TEXT SIMILARITY COMPUTATION USING MULTI... more ... 8. References [1] P.Selvi and Dr.NPGopalan, “SEMANTIC TEXT SIMILARITY COMPUTATION USING MULTIPLE INFORMATION SOURCES”, International Journal of Computer Science and Network Security, VOL.7, No.12, December 2007. [2] Abhinay Pandya and Pushpak ...

Physiological and Molecular Plant Pathology, 2003

Apple scab (black spot) is caused by the fungus, Venturia inaequalis. Race 1 isolates of this fun... more Apple scab (black spot) is caused by the fungus, Venturia inaequalis. Race 1 isolates of this fungus are avirulent on Malus hosts carrying the resistance gene V m : Detached leaves from a V m host (resistant, differential host 5) and 'Royal Gala' (susceptible, host 1) were inoculated with a conidial suspension of V. inaequalis. In the resistant reaction, a hypersensitive response (HR), characterised by necrosis and the accumulation of autofluorescent materials in epidermal and mesophyll cells, was observed at the site of fungal penetration. No HR was observed in the susceptible host. V. inaequalis grown in vitro produced an elicitor that induced necrosis, similar to the HR, when infiltrated into leaves of the resistant V m host. No response, however, was observed in the susceptible host. The elicitor was proteinaceous and a fraction with elicitor activity was isolated using ultra-filtration, acetone precipitation and ion-exchange chromatography. The elicitor activity was resistant to boiling but it was abolished by digestion with proteinase K. The protein fraction contained three major proteins all with low isoelectric points (pI 3·0-4·5). The fraction also elicited necrosis in the differential host 4, but not in any of the other resistant hosts tested, including differential hosts 2, 3, and 6. Therefore, the fraction may contain elicitors with more than one host specificity. q

Supply chain management (SCM) is becoming extremely important to achieve competitiveness in the c... more Supply chain management (SCM) is becoming extremely important to achieve competitiveness in the current business environment. Moreover, supply chain partnership between suppliers and buyers in SCM have had a significant impact on supply chain performance. In this study, we develop a quantitative model based on the supply chain partnership under several assumptions. For this purpose, we first prove several basic theorems which verify the relationship between supplier and buyer's total profit for two cases, with and without supply chain partnership. We then prove that there exists the supplier's selling price per unit which makes the maximum total profits for both supplier and buyer with supply chain partnership greater than those for any given supplier's selling price per unit without supply chain partnership.

The purpose of this research is to understand the nature, size, and lifecycle of online co-design... more The purpose of this research is to understand the nature, size, and lifecycle of online co-design community interactions through a focused case study of a real business with an aim to provide actionable strategies for co-design service innovation and advancement, and help to forecast future trends in crowd-sourced co-design.Crowd-sourced, socially-empowered design environments not only reduce the cost of design sourcing and production, but also address individual user's needs for experience sharing, entertainment, and relationship building in the virtual world. Although a great body of research has been established in both co-design (Hoftijzer, J., 2009; Piller, 2008; Relph-Knight, L., 2008; Piller et al, 2005, 2004; Ives, and Piccoli, 2003) and social network analysis (Mehler, and Skiena, 2009; Lin et al., 2009; Agichtein, and Liu, 2009; Ko et al., 2006; Wu, and Huberman 2004; Suh, and Kim, 2002; Park, and Choi, 2001), they often appear to be in two separate fields. Our study aims to better understand the nature of interactions in these unique design environments to better maximize the value of co-design communities.Threadless.com is a t-shirt co-design website that holds an ongoing competition for t-shirt artwork submissions. Anyone can create an account on the website and submit a design, as well as critique and vote on others’ designs. Threadless selects final winning designs from the highest rated designs and awards winners a cash prize. The winning designs are also produced and put up for sale on their website.Our study examines the Critiques Forum of Threadless, where users can upload multiple versions of their designs to be rated and commented on by other members within the community. The critiques of the submitted designs are a great arena for understanding co-design community interactions not only because the Critiques Forum is one of the most essential forums of Threadless, but also because they demonstrate the differences between interactions among co-designers on co-design websites and interactions among the general public on other social networking websites.A total of 367 submissions were included in this study over the period from September 29, 2009, to October 08, 2009. We conducted a content analysis of all the critiquing comments left by the Threadless co-design community on these submissions. From analyzing, sorting, and classifying the meaningful units of the comments, two large categories emerged: “design category” comments and “community category” comments. Subcategories in the “design category” comments included: color, shape/line, orientation/placement, text/slogan, general design ideas/concepts, add/remove attributes, production concerns, and prototype t-shirt color. Subcategories in the “community category” included: encouragement, discouragement, building ties, humor, and commercial. Other important aspects such as the community votes (“submit this,” “needs work,” or “don't submit”), number of co-designers involved in commenting, number of design sub-categories the original user took advice in, lifecycle of submissions, and total number of comments for each submission were also recorded.The 367 submissions resulted in a total of 2,085 comments left by 1890 co-designers. On average, each submission had 1.75 versions of designs uploaded, 5.68 comments left by 5.15 co-designers, and a 30.28-day lifecycle. A content analysis of the 2,085 total comments showed that the number of community category comments slightly exceeded that of the design category, indicating that co-designers’ interactions are geared towards not only designing, but also building a friendly and supportive community. In descending order, the “design categories” that received the most attention were: add/remove attributes, general design ideas/concepts, color, orientation/placement, shape/line, text/slogan, prototype t-shirt color, and production concerns. In descending order, the “community categories” that received the most attention were: encouragement, building ties, commercial, humor, and discouragement.One of the co-designers’ goals was to maximize the community votes for “submit this” and to minimize the votes for “don't submit” by sharing and revising their artwork. Let S be community success, B be the number of votes for “submit this” and D be the number of votes for “don't submit.” The community success of any submission i can be measured by the following equation: S(i) = B(i) - D(i) After computing the community success using the above equation, Pearson correlations (one tail) were tested. Positive correlations were identified between community success and the following variables: versions of design, number of categories the co-designer took advice in, number of co-designers, number of comments, and lifecycle of the submissions. Community success was also found to be positively correlated with both the number of community category comments and design category comments. Furthermore, the number of versions uploaded for each submission is significantly correlated with the number of comments and number of co-designers involved in commenting.Crowd sourcing has expanded the role of online customers from buyers to co-designers, co-marketers, and co-sellers. One key to the success of crowd-sourced co-design is to understand the flow of collective attention in co-design community interactions, which is a primary focus of this research. Our findings shed light on how crowd-sourced businesses should enhance and modify their interactive platforms, compensation, and decision-making strategies to build more vibrant co-design communities., 0 (Hoftijzer, J., 2009; Piller, 2008; Relph-Knight, L.2008; Piller et al.2005, 2004; Ives & Piccoli, 2003) (Wu & Huberman 2004; Mehler & Skiena, 2009; Lin et al.? 2009; Agichtein & Liu, 2009)Threadless.com0 0 Threadless0ThreadlessiMO Threadlesso20099 29 2009 10 8 3670 0 “”“”“” ://///0 “”: (“”“”“”) , , 367 189020850 1.755.155.68•30.28 0 2085 “”: ///, /T “”o“”“’0 SB “”D“”0 iSO) = B(i) - D(i) () 0 :0 , 0

Endocrinology, 2000

Members of the winged helix transcription factor family are known to regulate epithelial cell dif... more Members of the winged helix transcription factor family are known to regulate epithelial cell differentiation by regulating cell-specific gene expression. rWIN is a newly discovered member of the winged helix family shown to be present in the adult rat testis. In the testis the human homolog of rWIN, HFH-11, was localized to the germ cells (i.e. spermatocytes and spermatids) undergoing spermatogenesis. In the present study we show that rWIN is also expressed in testicular Sertoli cells. Sertoli cells are the epithelial component of the seminiferous tubule and provide both the cytoarchitectural support and the microenvironment for developing germ cells. The presence of rWIN in Sertoli cells was confirmed by Northern blot and RT-PCR analysis. The rWIN transcript size in the Sertoli cells was different from the germ cell transcript that is probably due to alternative splicing or modifications of the 3'-untranslated region. At least two spliced variants of rWIN were observed in the Sertoli cells corresponding to the deletion of an exon in the DNA-binding region. Long term stimulation of cultured Sertoli cells with the gonadotropin FSH down-regulated rWIN expression. In contrast, short-term stimulation (2 h) transiently up-regulated rWIN expression. The FSH-induced transient stimulation of rWIN precedes expression of the transferrin gene that is a marker of Sertoli cell differentiation. FSH-induced transferrin promoter activity was inhibited when cultured Sertoli cells were treated with an antisense oligonucleotide to rWIN. Interestingly, the constitutive overexpression of the DNA-binding domain of rWIN also down-regulated transferrin promoter activity. Analysis of the transferrin promoter with various deletion mutations suggested that rWIN acts at an upstream gene of the transferrin promoter. The results indicate that a transient up-regulation of rWIN in part mediates the ability of FSH to activate the transferrin promoter, which can be inhibited with a rWIN antisense oligonucleotide or constitutive expression of the rWIN DNA-binding domain. The current study demonstrates that rWIN acts as an early event gene for FSH actions on Sertoli cells and that rWIN appears to have a role in the regulation of Sertoli cell differentiated functions.

International Journal of Neuroscience, 2009

The purpose of this study was to examine the emotions experienced by spectators when their favori... more The purpose of this study was to examine the emotions experienced by spectators when their favorite team wins or loses a soccer match using fMRI. Those who watched winning scenes showed activation of the right and left occipital lobes, left temporal lobe, left limbic lobe, middle occipital gyrus, superior temporal gyrus, cuneus, and uncus. Those who watched losing scenes showed activation of the right frontal lobe and right limbic lobe. This result suggests that emotional suppression is much stronger in negative emotional responses than in positive responses.

Science, 2010

Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only fro... more Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes for assimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution toward obligate biotrophy.

Journal of Leadership & Organizational Studies, 1996

Archives of Internal Medicine, 2006

... 8. References [1] P.Selvi and Dr.NPGopalan, “SEMANTIC TEXT SIMILARITY COMPUTATION USING MULTI... more ... 8. References [1] P.Selvi and Dr.NPGopalan, “SEMANTIC TEXT SIMILARITY COMPUTATION USING MULTIPLE INFORMATION SOURCES”, International Journal of Computer Science and Network Security, VOL.7, No.12, December 2007. [2] Abhinay Pandya and Pushpak ...

Physiological and Molecular Plant Pathology, 2003

Apple scab (black spot) is caused by the fungus, Venturia inaequalis. Race 1 isolates of this fun... more Apple scab (black spot) is caused by the fungus, Venturia inaequalis. Race 1 isolates of this fungus are avirulent on Malus hosts carrying the resistance gene V m : Detached leaves from a V m host (resistant, differential host 5) and 'Royal Gala' (susceptible, host 1) were inoculated with a conidial suspension of V. inaequalis. In the resistant reaction, a hypersensitive response (HR), characterised by necrosis and the accumulation of autofluorescent materials in epidermal and mesophyll cells, was observed at the site of fungal penetration. No HR was observed in the susceptible host. V. inaequalis grown in vitro produced an elicitor that induced necrosis, similar to the HR, when infiltrated into leaves of the resistant V m host. No response, however, was observed in the susceptible host. The elicitor was proteinaceous and a fraction with elicitor activity was isolated using ultra-filtration, acetone precipitation and ion-exchange chromatography. The elicitor activity was resistant to boiling but it was abolished by digestion with proteinase K. The protein fraction contained three major proteins all with low isoelectric points (pI 3·0-4·5). The fraction also elicited necrosis in the differential host 4, but not in any of the other resistant hosts tested, including differential hosts 2, 3, and 6. Therefore, the fraction may contain elicitors with more than one host specificity. q

Supply chain management (SCM) is becoming extremely important to achieve competitiveness in the c... more Supply chain management (SCM) is becoming extremely important to achieve competitiveness in the current business environment. Moreover, supply chain partnership between suppliers and buyers in SCM have had a significant impact on supply chain performance. In this study, we develop a quantitative model based on the supply chain partnership under several assumptions. For this purpose, we first prove several basic theorems which verify the relationship between supplier and buyer's total profit for two cases, with and without supply chain partnership. We then prove that there exists the supplier's selling price per unit which makes the maximum total profits for both supplier and buyer with supply chain partnership greater than those for any given supplier's selling price per unit without supply chain partnership.

The purpose of this research is to understand the nature, size, and lifecycle of online co-design... more The purpose of this research is to understand the nature, size, and lifecycle of online co-design community interactions through a focused case study of a real business with an aim to provide actionable strategies for co-design service innovation and advancement, and help to forecast future trends in crowd-sourced co-design.Crowd-sourced, socially-empowered design environments not only reduce the cost of design sourcing and production, but also address individual user's needs for experience sharing, entertainment, and relationship building in the virtual world. Although a great body of research has been established in both co-design (Hoftijzer, J., 2009; Piller, 2008; Relph-Knight, L., 2008; Piller et al, 2005, 2004; Ives, and Piccoli, 2003) and social network analysis (Mehler, and Skiena, 2009; Lin et al., 2009; Agichtein, and Liu, 2009; Ko et al., 2006; Wu, and Huberman 2004; Suh, and Kim, 2002; Park, and Choi, 2001), they often appear to be in two separate fields. Our study aims to better understand the nature of interactions in these unique design environments to better maximize the value of co-design communities.Threadless.com is a t-shirt co-design website that holds an ongoing competition for t-shirt artwork submissions. Anyone can create an account on the website and submit a design, as well as critique and vote on others’ designs. Threadless selects final winning designs from the highest rated designs and awards winners a cash prize. The winning designs are also produced and put up for sale on their website.Our study examines the Critiques Forum of Threadless, where users can upload multiple versions of their designs to be rated and commented on by other members within the community. The critiques of the submitted designs are a great arena for understanding co-design community interactions not only because the Critiques Forum is one of the most essential forums of Threadless, but also because they demonstrate the differences between interactions among co-designers on co-design websites and interactions among the general public on other social networking websites.A total of 367 submissions were included in this study over the period from September 29, 2009, to October 08, 2009. We conducted a content analysis of all the critiquing comments left by the Threadless co-design community on these submissions. From analyzing, sorting, and classifying the meaningful units of the comments, two large categories emerged: “design category” comments and “community category” comments. Subcategories in the “design category” comments included: color, shape/line, orientation/placement, text/slogan, general design ideas/concepts, add/remove attributes, production concerns, and prototype t-shirt color. Subcategories in the “community category” included: encouragement, discouragement, building ties, humor, and commercial. Other important aspects such as the community votes (“submit this,” “needs work,” or “don't submit”), number of co-designers involved in commenting, number of design sub-categories the original user took advice in, lifecycle of submissions, and total number of comments for each submission were also recorded.The 367 submissions resulted in a total of 2,085 comments left by 1890 co-designers. On average, each submission had 1.75 versions of designs uploaded, 5.68 comments left by 5.15 co-designers, and a 30.28-day lifecycle. A content analysis of the 2,085 total comments showed that the number of community category comments slightly exceeded that of the design category, indicating that co-designers’ interactions are geared towards not only designing, but also building a friendly and supportive community. In descending order, the “design categories” that received the most attention were: add/remove attributes, general design ideas/concepts, color, orientation/placement, shape/line, text/slogan, prototype t-shirt color, and production concerns. In descending order, the “community categories” that received the most attention were: encouragement, building ties, commercial, humor, and discouragement.One of the co-designers’ goals was to maximize the community votes for “submit this” and to minimize the votes for “don't submit” by sharing and revising their artwork. Let S be community success, B be the number of votes for “submit this” and D be the number of votes for “don't submit.” The community success of any submission i can be measured by the following equation: S(i) = B(i) - D(i) After computing the community success using the above equation, Pearson correlations (one tail) were tested. Positive correlations were identified between community success and the following variables: versions of design, number of categories the co-designer took advice in, number of co-designers, number of comments, and lifecycle of the submissions. Community success was also found to be positively correlated with both the number of community category comments and design category comments. Furthermore, the number of versions uploaded for each submission is significantly correlated with the number of comments and number of co-designers involved in commenting.Crowd sourcing has expanded the role of online customers from buyers to co-designers, co-marketers, and co-sellers. One key to the success of crowd-sourced co-design is to understand the flow of collective attention in co-design community interactions, which is a primary focus of this research. Our findings shed light on how crowd-sourced businesses should enhance and modify their interactive platforms, compensation, and decision-making strategies to build more vibrant co-design communities., 0 (Hoftijzer, J., 2009; Piller, 2008; Relph-Knight, L.2008; Piller et al.2005, 2004; Ives & Piccoli, 2003) (Wu & Huberman 2004; Mehler & Skiena, 2009; Lin et al.? 2009; Agichtein & Liu, 2009)Threadless.com0 0 Threadless0ThreadlessiMO Threadlesso20099 29 2009 10 8 3670 0 “”“”“” ://///0 “”: (“”“”“”) , , 367 189020850 1.755.155.68•30.28 0 2085 “”: ///, /T “”o“”“’0 SB “”D“”0 iSO) = B(i) - D(i) () 0 :0 , 0

Endocrinology, 2000

Members of the winged helix transcription factor family are known to regulate epithelial cell dif... more Members of the winged helix transcription factor family are known to regulate epithelial cell differentiation by regulating cell-specific gene expression. rWIN is a newly discovered member of the winged helix family shown to be present in the adult rat testis. In the testis the human homolog of rWIN, HFH-11, was localized to the germ cells (i.e. spermatocytes and spermatids) undergoing spermatogenesis. In the present study we show that rWIN is also expressed in testicular Sertoli cells. Sertoli cells are the epithelial component of the seminiferous tubule and provide both the cytoarchitectural support and the microenvironment for developing germ cells. The presence of rWIN in Sertoli cells was confirmed by Northern blot and RT-PCR analysis. The rWIN transcript size in the Sertoli cells was different from the germ cell transcript that is probably due to alternative splicing or modifications of the 3'-untranslated region. At least two spliced variants of rWIN were observed in the Sertoli cells corresponding to the deletion of an exon in the DNA-binding region. Long term stimulation of cultured Sertoli cells with the gonadotropin FSH down-regulated rWIN expression. In contrast, short-term stimulation (2 h) transiently up-regulated rWIN expression. The FSH-induced transient stimulation of rWIN precedes expression of the transferrin gene that is a marker of Sertoli cell differentiation. FSH-induced transferrin promoter activity was inhibited when cultured Sertoli cells were treated with an antisense oligonucleotide to rWIN. Interestingly, the constitutive overexpression of the DNA-binding domain of rWIN also down-regulated transferrin promoter activity. Analysis of the transferrin promoter with various deletion mutations suggested that rWIN acts at an upstream gene of the transferrin promoter. The results indicate that a transient up-regulation of rWIN in part mediates the ability of FSH to activate the transferrin promoter, which can be inhibited with a rWIN antisense oligonucleotide or constitutive expression of the rWIN DNA-binding domain. The current study demonstrates that rWIN acts as an early event gene for FSH actions on Sertoli cells and that rWIN appears to have a role in the regulation of Sertoli cell differentiated functions.