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Papers by Wiranee Sriwiang

Journal of Physics: Conference Series, 2019

Bombesin is a 14-amino-acid peptide having the ability to specifically bind gastrin releasing pep... more Bombesin is a 14-amino-acid peptide having the ability to specifically bind gastrin releasing peptide receptors (GRPR) which show over-expression in many types of cancer cells. Therefore, bombesin analogs have been complexed with radionuclides and reported as radiopharmaceuticals for cancer diagnosis and therapy. Lutetium-177 (Lu-177) is a beta emitting radionuclide that decays with a half-life of 6.65 days. The medium beta energy and the relatively long half-life of Lu-177 make it one of the ideal radionuclides used in targeted radionuclide therapy. As the oxidation state of this radioisotope is 3+, it requires multidentate chelators such as DOTA to form stable complex. In this work, the commercially available conjugated peptide, DOTA-[Pro1, Tyr4]-bombesin, was labeled with Lu-177 for preliminary formulation as a therapeutic radiopharmaceutical. The aim was to evaluate the radiolabeling efficiency using various amounts of the peptide and the stability in human serum for 7 days. The...

Atmosphere

This study reports the mass concentrations, elemental characterization and identification of the ... more This study reports the mass concentrations, elemental characterization and identification of the possible sources of PM2.5 and PM10 at a suburban site in Pathum Thani, Thailand. The sampling was done from 18 February 2021 to 14 September 2021. PM2.5 concentrations were between 0.39 μg/m3 and 174.26 μg/m3, while PM10 concentration ranged from 12.75 μg/m3 to 242.02 μg/m3. The average concentration of PM2.5 in the wet season (61.96 μg/m3) in the study area exceeded the national ambient air quality standards (NAAQS). Particle-induced X-ray emission (PIXE) was used to measure the element concentrations. The main elements, namely Fe, K, Cr and Ca, in both PM2.5 and PM10 showed significantly higher concentrations in the summer season. A qualitative inter-elemental correlation analysis, principal component analysis (PCA) and cluster analysis (CA) were applied for source identification of PM2.5 and PM10. The results for the three procedures were in good agreement. Four and three factors of s...

Yttrium-90 (Y-90) is a radioisotope having a short half-life of 64 hours and emitting high energy... more Yttrium-90 (Y-90) is a radioisotope having a short half-life of 64 hours and emitting high energy beta radiation at 2.28 MeV. It becomes one of the radionuclides being used for the targeted cancer treatment. Y-90 can be generated from radioactive decay of strontium-90 (Sr90), which is one of the fission products of uranium fuel in the nuclear reactor. Y-90 must be highly pure and free from Sr-90 and other metal ions to achieve high efficient uses. Process for separation and purification of Y-90 from Sr-90 by extraction chromatographic technique has been investigated using two columns packed with different types of solvent impregnated resins namely, 0.3 M di(2-ethylhexyl) phosphoric acid (D2EHPA) in dodecane and 1.0 M n-octyl(phenyl)N,N-diisobutylcarbamoyl-methylphosphine oxide (CMPO) in tri-n-butyl phosphate (TBP). Feed solutions used in the study were the mixture of the stable isotopes Y and Sr in HNO3 at the concentration ratio Y:Sr of 0.18:756 simulating the equilibrium compositi...

Yttrium-90 (Y-90) is one of radionuclides used widely for cancer treatment and it can be generate... more Yttrium-90 (Y-90) is one of radionuclides used widely for cancer treatment and it can be generated by radioactive decay of strontium-90 (Sr-90). It is essential to obtain Y-90 with high purity and free from Sr-90. Process for separation and purification of Y by extraction chromatography technique has been investigated using 2 columns of solvent impregnated resins. First column was packed with XAD-16 resin impregnated with solvent of 0.3 M di(2-ethylhexyl) phosphoric acid (D2EHPA) in dodecane and the second column was packed with XAD-16 resin impregnated with solvent of 1.0 M n-octyl(phenyl)-N,N-diisobutylcarbamoyl-methylphosphine oxide (CMPO) in tri-n-butyl phosphate (TBP). Feed solution used in the study was the mixture of Y and Sr in 0.3 M HNO 3 having concentration of 700 and 0.2 mg/L, respectively resembling the usual composition ratio of these radionuclides used for the feed. Feed solution was loaded into the first column at 0.3 mL/min and 7 M HNO 3 was used to elute the adsorb...

Hydrogeology Journal

The Quaternary sequences in the Phrae Basin, northern Thailand, can be classified into three aqui... more The Quaternary sequences in the Phrae Basin, northern Thailand, can be classified into three aquifers based on depth. The groundwater dynamics and recharge of these aquifers were assessed using isotope techniques, and flow directions were acquired using groundwater level of selected wells. Groundwater flows from northwest and west to the centre of the basin on the western side of the Yom River, while flow is from northeast and east to centre on the eastern side. The groundwater mean residence time (MRT) within the shallow aquifer is 1–30 years using 3H time series, estimated by the exponential piston-flow model (EPM), which is one option of the selected lumped-parameter model (TracerLPM). Groundwater in the shallow aquifer mainly originated from local rainfall and surface water. Recharge rates were estimated using MRT and chloride mass balance, with results of 305 mm year−1 and 301–309 mm year−1, respectively. The groundwater age range (1,087–22,920 years BP) was determined by 14C dating and corrected using 14C-DIC models. The horizontal velocities of the deep aquifer were between 3 and 5 m year−1, and vertical velocity was ~0.0235 m year−1 based on 14C ages and depth. Groundwater in the intermediate and deep aquifers was recharged mainly from local rainfall at 220–300 m above mean sea level. Interactions between groundwater and river water were detected close to the Yom River when it was in full flow. These findings on groundwater dynamics and quantity could aid water resource management within the Phrae Basin.

Energy Procedia, 2016

Yittrium-90 (Y-90) is a radioisotope having half-life 64 hour and emitting strong energy beta rad... more Yittrium-90 (Y-90) is a radioisotope having half-life 64 hour and emitting strong energy beta radiation at 2.28 MeV. It is one of the radionuclides suitable to the applications in targeted therapy. Y-90 can be generated from radioactive decay of strontium-90 (Sr-90), which is one of the fission products of uranium fuel in the nuclear reactor. Y-90 must be highly pure and free form Sr-90 and other metal ions to get high efficient uses. In this study, process for separation of Y from Sr in 4-7 M HNO 3 with extraction chromatography technique has been investigated using column of Sr resin, column of RE resin and combined columns of both resins. Most feed solutions used in the study contained Y and Sr at the concentration ratio of Y : Sr around 0.18 : 756 to simulate the equilibrium composition ratio of their radionuclides, Y-90 and Sr-90. It was found that a series of 3 columns packed with 0.35 g Sr resin each was required to adsorb Sr up to 4 mg from 4 mL feed in 4 M HNO 3 and Y was barely adsorbed by Sr resin. A column packed with 0.25 g of RE resin could be used to continuously purify Y in effluent from Sr column by selectively adsorb Sr. The adsorbed species could be eluted with dilute nitric acid, 0.05-0.1 M. Feed solution spiked with trace of Sr-90/Y-90 was also used to determine the purity of the obtained Y product and it was found that the activity ratio of Sr-90 to Y-90 was in the order of 10-4. This process was found to be simple to operate continuously and the recovery of Y-90 was higher than 80%.

Journal of Physics: Conference Series, 2019

Atmosphere

Hydrogeology Journal

Energy Procedia, 2016