Xiaonan Gao - Academia.edu (original) (raw)

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Papers by Xiaonan Gao

Research paper thumbnail of M atrix metalloproteinase-2 mediates cytokine-induced myocardial contractile dysfunction

Objective: Pro-inflammatory cytokines depress myocardial contractile function by enhancing peroxy... more Objective: Pro-inflammatory cytokines depress myocardial contractile function by enhancing peroxynitrite production, yet the mechanism by which peroxynitrite does this is unknown. As matrix metalloproteinases (MMPs) can be activated by peroxynitrite and can proteolytically cleave troponin I in hearts, we determined whether this occurs in cytokine-induced myocardial dysfunction. Methods: Isolated working rat hearts were perfused with buffer containing interleukin-1 b, interferon-g,

Research paper thumbnail of M atrix metalloproteinase-2 mediates cytokine-induced myocardial contractile dysfunction

Objective: Pro-inflammatory cytokines depress myocardial contractile function by enhancing peroxy... more Objective: Pro-inflammatory cytokines depress myocardial contractile function by enhancing peroxynitrite production, yet the mechanism by which peroxynitrite does this is unknown. As matrix metalloproteinases (MMPs) can be activated by peroxynitrite and can proteolytically cleave troponin I in hearts, we determined whether this occurs in cytokine-induced myocardial dysfunction. Methods: Isolated working rat hearts were perfused with buffer containing interleukin-1 b, interferon-g,

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