Xiao-nong Zhou - Academia.edu (original) (raw)
Papers by Xiao-nong Zhou
Background: The Focused screening and treatment (FSAT) has been identified as one of the key appr... more Background: The Focused screening and treatment (FSAT) has been identified as one of the key approaches for reducing the malaria burden in Tanzania. However, the diagnostic performance of the local standard health system microscopy and rapid diagnostic tests (RDT) for the malaria infections is yet to be established. Thus, we aimed to evaluate the performance of the local standard health system microscopy and RDTs in comparison to that of the gold standard modality through the re-examination of blood slide microscopy findings. Methods: We used the paired RDTs and standard health system microscopy results from the participants screened in the FSAT during 2015–2016. With the gold standard modality as reference, the results of local standard health system microscopy and RDTs were evaluated according to their sensitivity, specificity and reliability.Results: A total of 1,497 paired standard health system microscopy and RDTs results were analysed. Of these, 679 (45.4%) samples and 818 (54...
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Background Reliable and field-applicable diagnosis of schistosome infections in non-human animals... more Background Reliable and field-applicable diagnosis of schistosome infections in non-human animals is important for surveillance, control, and verification of interruption of human schistosomiasis transmission. This study aimed to summarize uses of available diagnostic techniques through a systematic review and meta-analysis. Methods and principal findings We systematically searched the literature and reports comparing two or more diagnostic tests in non-human animals for schistosome infection. Out of 4,909 articles and reports screened, 18 met our inclusion criteria, four of which were considered in the meta-analysis. A total of 14 techniques (parasitologic, immunologic, and molecular) and nine types of non-human animals were involved in the studies. Notably, four studies compared parasitologic tests (miracidium hatching test (MHT), Kato-Katz (KK), the Danish Bilharziasis Laboratory technique (DBL), and formalin-ethyl acetate sedimentation-digestion (FED-SD)) with quantitative polym...
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Advances in parasitology, 2019
From the time it was conceptualized in 1998 to the present, RNAS+ has largely concentrated on res... more From the time it was conceptualized in 1998 to the present, RNAS+ has largely concentrated on research that will generate results to facilitate control, prevention and elimination of its target diseases. Diagnostics has remained an active field of research in order to develop tools that are appropriate for each stage from the first efforts until attempts to block transmission. For example, with regard to schistosomiasis, chemotherapy has excellent impact on morbidity, while better diagnostics and vaccine research have been promoted to complement the other components of the control programme. The need for surveillance in areas where the prevalence has been brought down to very low levels necessitated development of spatio-temporal tools and ecological models based on geographical information systems (GIS) to produce risk and distribution maps for monitoring and evaluation of programme success. New knowledge and experiences in management of the diseases contribute to the formulation o...
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PLOS Medicine, 2015
<p>This includes enteric protozoa to complete the picture on foodborne parasitic diseases. ... more <p>This includes enteric protozoa to complete the picture on foodborne parasitic diseases. However, details about enteric protozoa are reported in the research article by Kirk et al on foodborne enteric pathogens [<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001920#pmed.1001920.ref005" target="_blank">5</a>].</p
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PLOS Medicine, 2015
<p>Missing data by country: number of hazards for which no data were available.</p
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PLOS Neglected Tropical Diseases, 2021
Echinococcosis is a serious zoonotic parasitic disease transmitted from canines to humans and liv... more Echinococcosis is a serious zoonotic parasitic disease transmitted from canines to humans and livestock. Periodic deworming is recommended by the WHO/OIE as a highly effective measure against echinococcosis. However, manual deworming involves significant challenges, particularly in remote areas with scarce resources. The insufficient awareness delivering praziquantel (PZQ) baits for dogs leads to low compliance rate. The aim of this study was therefore to develop a novel smart collar for dogs to address these challenges. We developed a smart Internet of Things (IoT)-based deworming collar which can deliver PZQ baits for dogs automatically, regularly, quantitatively with predominant characteristics of being waterproof, anti-collision, cold-proof and long life battery. Its performance was tested in two remote locations on the Tibetan Plateau. A cross-sectional survey was conducted to evaluate the compliance of the dog owners. Further, a randomized controlled study was performed to eva...
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Social Science Research Network, 2020
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Acta Tropica, 2015
The overall aim of the Regional Network for Asian Schistosomiasis and other Helminth Zoonoses (RN... more The overall aim of the Regional Network for Asian Schistosomiasis and other Helminth Zoonoses (RNAS(+)) is to strengthen collaboration between control authorities in the regional, endemic countries. The network has provided critical research input during its 12 years of existence developing gradually from a small forum for information exchange. RNAS(+) now provides advice on regional strategies regularly and contributes to the mobilization of resources with respect to multi-country projects on several parasitic diseases in Southeast Asia, primarily schistosomiasis but also other helminth infections including polyparasitism. To make progress towards these goals, RNAS(+) has focused on platform design and technical standardization aiming at fostering research capacity and the development of networking capacities with easy access to information databases. This administrative body is largely virtual connecting RNAS(+) members via the Internet, providing database and administrative back-up. This strategy, aiming at boosting research on the target diseases, strongly emphasizes ways and means to alleviate the spectre of disease and poverty from the endemic areas.
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Background: Gene mutations on target sites can be a valuable reference to the status of insectici... more Background: Gene mutations on target sites can be a valuable reference to the status of insecticide resistance. Jeddah, a global commercial and major port-of-entry city, is bearing the most (>70%) dengue disease burden and the population of the dengue vector Aedes aegypti in Saudi Arabia. Culex quinquefasciatus is a second example as one of the major arboviral vectors in the region. However, the status of insecticide resistance and targeted site mutations on the responsible genes are not fully characterized.Methods: We randomly sampled both mosquito species, Ae. aegypti and Cx. quinquefasciatus across Jeddah by daily mosquito surveillance in 2016 to detect the resistance-associated target site mutations on the voltage gated sodium channel (VGSC) and acetylcholinesterase 1 (ace-1) genes. Results: Our findings showed that Ae. aegypti resistance-associated VGSC gene mutations revealed polymorphic mutations on the 989, 1016, and 1534 sites. Additionally, we documented two types of in...
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Pathogens, 2022
Schistosomiasis japonica caused by the trematode flukes of Schistosoma japonicum was one of the m... more Schistosomiasis japonica caused by the trematode flukes of Schistosoma japonicum was one of the most grievous infectious diseases in China in the mid-20th century, while its elimination has been placed on the agenda of the national strategic plan of healthy China 2030 after 70 years of continuous control campaigns. Diagnostic tools play a pivotal role in warfare against schistosomiasis but must adapt to the endemic status and objectives of activities. With the decrease of prevalence and infection intensity of schistosomiasis in human beings and livestock, optimal methodologies with high sensitivity and absolute specificity are needed for the detection of asymptomatic cases or light infections, as well as disease surveillance to verify elimination. In comparison with the parasitological methods with relatively low sensitivity and serological techniques lacking specificity, which both had been widely used in previous control stages, the molecular detection methods based on the amplifi...
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PLOS Neglected Tropical Diseases, 2021
Background Echinococcosis is a zoonotic parasitic disease caused by larval stages of cestodes bel... more Background Echinococcosis is a zoonotic parasitic disease caused by larval stages of cestodes belonging to the genus Echinococcus. The infection affects people’s health and safety as well as agropastoral sector. In China, human echinococcosis is a major public health burden, especially in western China. Echinococcosis affects people health as well as agricultural and pastoral economy. Therefore, it is important to understand the prevalence status and spatial distribution of human echinococcosis in order to advance our knowledge of basic information for prevention and control measures reinforcement. Methods Report data on echinococcosis were collected in 370 counties in China in 2018 and were used to assess prevalence and spatial distribution. SPSS 21.0 was used to obtain the prevalence rate for CE and AE. For statistical analyses and mapping, all data were processed using SPSS 21.0 and ArcGIS 10.4, respectively. Chi-square test and Exact probability method were used to assess spatia...
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Hongmei Li National Institute of Parasitic Diseases https://orcid.org/0000-0002-6765-0599 Yingjun... more Hongmei Li National Institute of Parasitic Diseases https://orcid.org/0000-0002-6765-0599 Yingjun Qian National Institute of Parasitic Diseases Kun Yang Jiangsu Institute of Parasitic Diseases Wei Ding National Institute of Parasitic Diseases Lulu Huang National Institute of Parastic Diseases Xuejiao Ma National Institute of Parasitic Diseases Lei Duan National Institute of parasitic Diseases Duoquan Wang National Institute of Parasitic Diseases Yayi Guan National Institute of Parasitic Diseases Ning Xiao National Institute of Parasitic Diseases Xiao-Nong Zhou ( zhouxn1@chinacdc.cn ) National Institute of Parasitic Diseases https://orcid.org/0000-0003-1417-8427
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China CDC Weekly, 2020
In the Memorandum of Understanding on Health Technology Cooperation issued in Beijing in 1978, th... more In the Memorandum of Understanding on Health Technology Cooperation issued in Beijing in 1978, the Ministry of Health (MOH) of China and the World Health Organization (WHO) agreed to create a series of WHO Collaborating Centres (WHOCC). The Institute of Parasitic Diseases at the Chinese Academy of Medical Sciences (the predecessor of the National Institute of Parasitic Diseases [NIPD] at China CDC) was officially designated as a “WHO Collaborating Centre for Malaria, Schistosomiasis, and Filariasis” in 1980 based in Shanghai (1). Since then, the WHOCC for Malaria, Schistosomiasis, and Filariasis has played an important role in promoting the development of medical science in China. From 1980 to 2015, the WHOCC for Malaria, Schistosomiasis, and Filariasis has conducted fruitful cooperative activities facilitating the building of a firstrate organization for research and control of malaria, schistosomiasis, and filariasis (2). It has hosted international conferences and training course...
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Malaria Journal, 2020
Background In 2015, a China-UK-Tanzania tripartite pilot project was implemented in southeastern ... more Background In 2015, a China-UK-Tanzania tripartite pilot project was implemented in southeastern Tanzania to explore a new model for reducing malaria burden and possibly scaling-out the approach into other malaria-endemic countries. The 1,7-malaria Reactive Community-based Testing and Response (1,7-mRCTR) which is a locally-tailored approach for reporting febrile malaria cases in endemic villages was developed to stop transmission and Plasmodium life-cycle. The (1,7-mRCTR) utilizes existing health facility data and locally trained community health workers to conduct community-level testing and treatment. Methods The pilot project was implemented from September 2015 to June 2018 in Rufiji District, southern Tanzania. The study took place in four wards, two with low incidence and two with a higher incidence. One ward of each type was selected for each of the control and intervention arms. The control wards implemented the existing Ministry of Health programmes. The 1,7-mRCTR activitie...
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Background: A national control program for echinococcosis has been in effect since 2005 in China.... more Background: A national control program for echinococcosis has been in effect since 2005 in China. This program has applied a comprehensive strategy, and good control results have been achieved[A1] （human echinococcosis prevalence rate decrease from 1.08% in 2004 to 0.24% in 2012） The objective of this study is focusing on [A2] assessment of the programme with two indices, including patient treatment and registered dogs deworming, in endemic areas of echincoccosis control over the period of 10 years (2004–2014) in China. Methods: ten provinces and autonomous regions of China were chosen for this study and a database was established that included demography at county and township levels, methods of epidemiological descriptive, instead the expectation-maximization (EM) for missing value filling for grouping available patients into those subjected to surgery and those receiving drug treatment after population screening[A3] and the dogs population after registered by deworming. (and were...
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China CDC Weekly, 2020
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PLOS Neglected Tropical Diseases, 2019
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Global Health Journal, 2017
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Acta Tropica, 2019
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Background: The Focused screening and treatment (FSAT) has been identified as one of the key appr... more Background: The Focused screening and treatment (FSAT) has been identified as one of the key approaches for reducing the malaria burden in Tanzania. However, the diagnostic performance of the local standard health system microscopy and rapid diagnostic tests (RDT) for the malaria infections is yet to be established. Thus, we aimed to evaluate the performance of the local standard health system microscopy and RDTs in comparison to that of the gold standard modality through the re-examination of blood slide microscopy findings. Methods: We used the paired RDTs and standard health system microscopy results from the participants screened in the FSAT during 2015–2016. With the gold standard modality as reference, the results of local standard health system microscopy and RDTs were evaluated according to their sensitivity, specificity and reliability.Results: A total of 1,497 paired standard health system microscopy and RDTs results were analysed. Of these, 679 (45.4%) samples and 818 (54...
Bookmarks Related papers MentionsView impact
Background Reliable and field-applicable diagnosis of schistosome infections in non-human animals... more Background Reliable and field-applicable diagnosis of schistosome infections in non-human animals is important for surveillance, control, and verification of interruption of human schistosomiasis transmission. This study aimed to summarize uses of available diagnostic techniques through a systematic review and meta-analysis. Methods and principal findings We systematically searched the literature and reports comparing two or more diagnostic tests in non-human animals for schistosome infection. Out of 4,909 articles and reports screened, 18 met our inclusion criteria, four of which were considered in the meta-analysis. A total of 14 techniques (parasitologic, immunologic, and molecular) and nine types of non-human animals were involved in the studies. Notably, four studies compared parasitologic tests (miracidium hatching test (MHT), Kato-Katz (KK), the Danish Bilharziasis Laboratory technique (DBL), and formalin-ethyl acetate sedimentation-digestion (FED-SD)) with quantitative polym...
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Advances in parasitology, 2019
From the time it was conceptualized in 1998 to the present, RNAS+ has largely concentrated on res... more From the time it was conceptualized in 1998 to the present, RNAS+ has largely concentrated on research that will generate results to facilitate control, prevention and elimination of its target diseases. Diagnostics has remained an active field of research in order to develop tools that are appropriate for each stage from the first efforts until attempts to block transmission. For example, with regard to schistosomiasis, chemotherapy has excellent impact on morbidity, while better diagnostics and vaccine research have been promoted to complement the other components of the control programme. The need for surveillance in areas where the prevalence has been brought down to very low levels necessitated development of spatio-temporal tools and ecological models based on geographical information systems (GIS) to produce risk and distribution maps for monitoring and evaluation of programme success. New knowledge and experiences in management of the diseases contribute to the formulation o...
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PLOS Medicine, 2015
<p>This includes enteric protozoa to complete the picture on foodborne parasitic diseases. ... more <p>This includes enteric protozoa to complete the picture on foodborne parasitic diseases. However, details about enteric protozoa are reported in the research article by Kirk et al on foodborne enteric pathogens [<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001920#pmed.1001920.ref005" target="_blank">5</a>].</p
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PLOS Medicine, 2015
<p>Missing data by country: number of hazards for which no data were available.</p
Bookmarks Related papers MentionsView impact
PLOS Neglected Tropical Diseases, 2021
Echinococcosis is a serious zoonotic parasitic disease transmitted from canines to humans and liv... more Echinococcosis is a serious zoonotic parasitic disease transmitted from canines to humans and livestock. Periodic deworming is recommended by the WHO/OIE as a highly effective measure against echinococcosis. However, manual deworming involves significant challenges, particularly in remote areas with scarce resources. The insufficient awareness delivering praziquantel (PZQ) baits for dogs leads to low compliance rate. The aim of this study was therefore to develop a novel smart collar for dogs to address these challenges. We developed a smart Internet of Things (IoT)-based deworming collar which can deliver PZQ baits for dogs automatically, regularly, quantitatively with predominant characteristics of being waterproof, anti-collision, cold-proof and long life battery. Its performance was tested in two remote locations on the Tibetan Plateau. A cross-sectional survey was conducted to evaluate the compliance of the dog owners. Further, a randomized controlled study was performed to eva...
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Social Science Research Network, 2020
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Acta Tropica, 2015
The overall aim of the Regional Network for Asian Schistosomiasis and other Helminth Zoonoses (RN... more The overall aim of the Regional Network for Asian Schistosomiasis and other Helminth Zoonoses (RNAS(+)) is to strengthen collaboration between control authorities in the regional, endemic countries. The network has provided critical research input during its 12 years of existence developing gradually from a small forum for information exchange. RNAS(+) now provides advice on regional strategies regularly and contributes to the mobilization of resources with respect to multi-country projects on several parasitic diseases in Southeast Asia, primarily schistosomiasis but also other helminth infections including polyparasitism. To make progress towards these goals, RNAS(+) has focused on platform design and technical standardization aiming at fostering research capacity and the development of networking capacities with easy access to information databases. This administrative body is largely virtual connecting RNAS(+) members via the Internet, providing database and administrative back-up. This strategy, aiming at boosting research on the target diseases, strongly emphasizes ways and means to alleviate the spectre of disease and poverty from the endemic areas.
Bookmarks Related papers MentionsView impact
Background: Gene mutations on target sites can be a valuable reference to the status of insectici... more Background: Gene mutations on target sites can be a valuable reference to the status of insecticide resistance. Jeddah, a global commercial and major port-of-entry city, is bearing the most (>70%) dengue disease burden and the population of the dengue vector Aedes aegypti in Saudi Arabia. Culex quinquefasciatus is a second example as one of the major arboviral vectors in the region. However, the status of insecticide resistance and targeted site mutations on the responsible genes are not fully characterized.Methods: We randomly sampled both mosquito species, Ae. aegypti and Cx. quinquefasciatus across Jeddah by daily mosquito surveillance in 2016 to detect the resistance-associated target site mutations on the voltage gated sodium channel (VGSC) and acetylcholinesterase 1 (ace-1) genes. Results: Our findings showed that Ae. aegypti resistance-associated VGSC gene mutations revealed polymorphic mutations on the 989, 1016, and 1534 sites. Additionally, we documented two types of in...
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Pathogens, 2022
Schistosomiasis japonica caused by the trematode flukes of Schistosoma japonicum was one of the m... more Schistosomiasis japonica caused by the trematode flukes of Schistosoma japonicum was one of the most grievous infectious diseases in China in the mid-20th century, while its elimination has been placed on the agenda of the national strategic plan of healthy China 2030 after 70 years of continuous control campaigns. Diagnostic tools play a pivotal role in warfare against schistosomiasis but must adapt to the endemic status and objectives of activities. With the decrease of prevalence and infection intensity of schistosomiasis in human beings and livestock, optimal methodologies with high sensitivity and absolute specificity are needed for the detection of asymptomatic cases or light infections, as well as disease surveillance to verify elimination. In comparison with the parasitological methods with relatively low sensitivity and serological techniques lacking specificity, which both had been widely used in previous control stages, the molecular detection methods based on the amplifi...
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PLOS Neglected Tropical Diseases, 2021
Background Echinococcosis is a zoonotic parasitic disease caused by larval stages of cestodes bel... more Background Echinococcosis is a zoonotic parasitic disease caused by larval stages of cestodes belonging to the genus Echinococcus. The infection affects people’s health and safety as well as agropastoral sector. In China, human echinococcosis is a major public health burden, especially in western China. Echinococcosis affects people health as well as agricultural and pastoral economy. Therefore, it is important to understand the prevalence status and spatial distribution of human echinococcosis in order to advance our knowledge of basic information for prevention and control measures reinforcement. Methods Report data on echinococcosis were collected in 370 counties in China in 2018 and were used to assess prevalence and spatial distribution. SPSS 21.0 was used to obtain the prevalence rate for CE and AE. For statistical analyses and mapping, all data were processed using SPSS 21.0 and ArcGIS 10.4, respectively. Chi-square test and Exact probability method were used to assess spatia...
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Hongmei Li National Institute of Parasitic Diseases https://orcid.org/0000-0002-6765-0599 Yingjun... more Hongmei Li National Institute of Parasitic Diseases https://orcid.org/0000-0002-6765-0599 Yingjun Qian National Institute of Parasitic Diseases Kun Yang Jiangsu Institute of Parasitic Diseases Wei Ding National Institute of Parasitic Diseases Lulu Huang National Institute of Parastic Diseases Xuejiao Ma National Institute of Parasitic Diseases Lei Duan National Institute of parasitic Diseases Duoquan Wang National Institute of Parasitic Diseases Yayi Guan National Institute of Parasitic Diseases Ning Xiao National Institute of Parasitic Diseases Xiao-Nong Zhou ( zhouxn1@chinacdc.cn ) National Institute of Parasitic Diseases https://orcid.org/0000-0003-1417-8427
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China CDC Weekly, 2020
In the Memorandum of Understanding on Health Technology Cooperation issued in Beijing in 1978, th... more In the Memorandum of Understanding on Health Technology Cooperation issued in Beijing in 1978, the Ministry of Health (MOH) of China and the World Health Organization (WHO) agreed to create a series of WHO Collaborating Centres (WHOCC). The Institute of Parasitic Diseases at the Chinese Academy of Medical Sciences (the predecessor of the National Institute of Parasitic Diseases [NIPD] at China CDC) was officially designated as a “WHO Collaborating Centre for Malaria, Schistosomiasis, and Filariasis” in 1980 based in Shanghai (1). Since then, the WHOCC for Malaria, Schistosomiasis, and Filariasis has played an important role in promoting the development of medical science in China. From 1980 to 2015, the WHOCC for Malaria, Schistosomiasis, and Filariasis has conducted fruitful cooperative activities facilitating the building of a firstrate organization for research and control of malaria, schistosomiasis, and filariasis (2). It has hosted international conferences and training course...
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Malaria Journal, 2020
Background In 2015, a China-UK-Tanzania tripartite pilot project was implemented in southeastern ... more Background In 2015, a China-UK-Tanzania tripartite pilot project was implemented in southeastern Tanzania to explore a new model for reducing malaria burden and possibly scaling-out the approach into other malaria-endemic countries. The 1,7-malaria Reactive Community-based Testing and Response (1,7-mRCTR) which is a locally-tailored approach for reporting febrile malaria cases in endemic villages was developed to stop transmission and Plasmodium life-cycle. The (1,7-mRCTR) utilizes existing health facility data and locally trained community health workers to conduct community-level testing and treatment. Methods The pilot project was implemented from September 2015 to June 2018 in Rufiji District, southern Tanzania. The study took place in four wards, two with low incidence and two with a higher incidence. One ward of each type was selected for each of the control and intervention arms. The control wards implemented the existing Ministry of Health programmes. The 1,7-mRCTR activitie...
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Background: A national control program for echinococcosis has been in effect since 2005 in China.... more Background: A national control program for echinococcosis has been in effect since 2005 in China. This program has applied a comprehensive strategy, and good control results have been achieved[A1] （human echinococcosis prevalence rate decrease from 1.08% in 2004 to 0.24% in 2012） The objective of this study is focusing on [A2] assessment of the programme with two indices, including patient treatment and registered dogs deworming, in endemic areas of echincoccosis control over the period of 10 years (2004–2014) in China. Methods: ten provinces and autonomous regions of China were chosen for this study and a database was established that included demography at county and township levels, methods of epidemiological descriptive, instead the expectation-maximization (EM) for missing value filling for grouping available patients into those subjected to surgery and those receiving drug treatment after population screening[A3] and the dogs population after registered by deworming. (and were...
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China CDC Weekly, 2020
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PLOS Neglected Tropical Diseases, 2019
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Global Health Journal, 2017
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Acta Tropica, 2019
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