Xing He - Academia.edu (original) (raw)
Papers by Xing He
ABSTRACT This paper studies the problem of L2 almost disturbance decoupling with global asymptoti... more ABSTRACT This paper studies the problem of L2 almost disturbance decoupling with global asymptotic stability for a class of strict feedback nonlinear system with time delays. A new recursive design method is proposed. Based on backstepping design method, it can conclude that there exists a robust control that solves the almost disturbance attenuation problem for nonlinear system with time delay
Physical Review E, 2013
Plasma defocusing and higher-order Kerr effects on multiple filamentation and pattern formation o... more Plasma defocusing and higher-order Kerr effects on multiple filamentation and pattern formation of ultrashort laser pulse propagation in air are investigated. Linear analyses and numerical results show that these two saturable nonlinear effects can destroy the coherent evolution of the laser field, and small-scale spatial turbulent structures rapidly appear. For the two-dimensional case, numerical simulations show that blow-up-like solutions, spatial chaos, and pseudorecurrence can appear at higher laser intensities if only plasma defocusing is included. These complex patterns result from the stochastic evolution of the higher- or shorter-wavelength modes of the laser light spectrum. From the viewpoint of nonlinear dynamics, filamentation can be attributed to the modulational instability of these spatial incoherent localized structures. Furthermore, filament patterns associated with multiphoton ionization of the air molecules with and without higher-order Kerr effects are compared.
Oncology reports, 2015
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide, yet effective treat... more Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide, yet effective treatment for this disease is lacking. Thus, there is an urgent need to identify novel therapeutic targets for this dreadful disease. Numerous studies have established that overexpression of astrocyte-elevated gene-1 (AEG-1) is frequently observed in multiple types of cancers including HCC, and its expression levels are correlated with the stage and grade of the disease. Further studies revealed that AEG-1 plays a key role in several crucial aspects of HCC progression, including growth, transformation, cell survival, invasion, metastasis and chemoresistance. Moreover, AEG-1 overexpression activates the Wnt/β-catenin, mitogen-actived protein kinase (MAPK), nuclear factor (NF)-κB, and PI3K/Akt signaling pathways, and promotes its downstream gene expression to facilitate malignant potential. Recently, transgenic mice with hepatocyte-specific expression of AEG-1 (Alb/AEG-1) and AEG-1-knockout mou...
2014 International Joint Conference on Neural Networks (IJCNN), 2014
World journal of gastroenterology : WJG, Jan 28, 2014
To clarify the molecular mechanism involved in pathogenesis of colorectal cancer as well as clini... more To clarify the molecular mechanism involved in pathogenesis of colorectal cancer as well as clinical significance of genetic analysis of histological samples. A total of 480 blood and tissue specimens were collected in our hospital from January 2011 to October 2012. In the observation group, there were 120 blood specimens and 120 intestinal tract tissue specimens collected from patients with neoplastic intestinal polyps. In the control group I there were 80 blood specimens and 80 intestinal tract tissue specimens collected from patients with colorectal cancer. In the control group II there were 40 blood specimens and 40 intestinal tract tissue specimens collected from healthy individuals. The gene segments were amplified using PCR and DNA gel electrophoresis along with DNA sequence analysis were employed for the detection of the following single nucleotide polymorphisms (SNPs): K-RAS codons 12 and 13; hMLH1 (human mutS homolog 1) gene missense mutation at Va1384Asp; hMSH2 (human mut...
Hepatology (Baltimore, Md.), Jan 24, 2014
Schistosomiasis is a serious parasitic disease in humans, which can lead to liver fibrosis and de... more Schistosomiasis is a serious parasitic disease in humans, which can lead to liver fibrosis and death. Accumulating evidence indicated that targeting the deregulated microRNAs could mitigate disease outcomes. Here, we showed that progressive hepatic schistosomiasis caused elevation of miR-21 and efficient and sustained inhibition of miR-21 by using highly hepatic tropic adeno-associated virus serotype 8 (rAAV8) protected mice against the lethal schistosome infection through the attenuation of hepatic fibrosis. We demonstrated an additive role of IL-13 and TGF-β1 in up-regulating the miR-21 expression in the hepatic stellate cells (HSCs) by activation of the SMAD proteins. Further, the down-regulation of miR-21 in the HSCs reversed hepatic fibrosis by enhancing SMAD7 expression, thus repressing TGF-β1/Smad and IL-13/Smad pathways. Conclusion: Our study revealed the mechanism of IL-13-mediated schistosomiasis hepatic fibrosis by up-regulation of miR-21 and highlights the potential of r...
Recently, some algorithms have been proposed for optimal real-time price in smart grid based on o... more Recently, some algorithms have been proposed for optimal real-time price in smart grid based on optimization theory. In this paper, a recurrent neural network modeled by means of a differential inclusion is proposed for solving this problem. Compared with the existing algorithms, recurrent neural network as parallel computational models for real-time optimization and applications have received substantial attention in the literature. Our model has the least number of state variables and simple structure. Using nonsmooth analysis, the theory of differential inclusions and Lyapunov-like method, the equilibrium point of the proposed neural networks can converge to an optimal solution of optimal realtime price under certain conditions. Finally, simulation results on two numerical examples show the effectiveness and performance of the proposed neural network. . He has published more than 100 journal papers. His current research interest covers computational intelligence, neural networks, memristive systems, chaos control and synchronization, and impulsive dynamical systems.
ABSTRACT In this paper, the generalized synchronization of nonlinear chaotic systems is investiga... more ABSTRACT In this paper, the generalized synchronization of nonlinear chaotic systems is investigated. Based upon reversibility of the Jacobian matrix and matrix theory, we carry out a series of elementary column transformations to Jacobian matrix. And then, according to Lyapunov function theory, sufficient conditions for generalized synchronization between drive system and response system with different dimensions are obtained. Numerical simulations are also given to demonstrate the effectiveness of the proposed scheme.
ABSTRACT This paper reports the nonlinear dynamics of a novel three-scroll chaotic system. The lo... more ABSTRACT This paper reports the nonlinear dynamics of a novel three-scroll chaotic system. The local stability of hyperbolic equilibrium and non-hyperbolic equilibrium are investigated by using center manifold theorem. Pitchfork bifurcation, degenerate pitchfork bifurcation and Hopf bifurcation are analyzed when the parameters are varied in the space of parameter. For a suitable choice of the parameters, the existence of singularly degenerate heteroclinic cycles and Hopf bifurcation without parameters are also investigated. Some numerical simulations are given to support the analytic results.
Neural Networks, 2014
In this paper, based on an equivalent mixed linear complementarity problem, we propose a neural n... more In this paper, based on an equivalent mixed linear complementarity problem, we propose a neural network to solve multiuser power control optimization problems (MPCOP), which is modeled as the noncooperative Nash game in modern digital subscriber line (DSL). If the channel crosstalk coefficients matrix is positive semidefinite, it is shown that the proposed neural network is stable in the sense of Lyapunov and global convergence to a Nash equilibrium, and the Nash equilibrium is unique if the channel crosstalk coefficients matrix is positive definite. Finally, simulation results on two numerical examples show the effectiveness and performance of the proposed neural network.
Ieee Transactions on Neural Networks and Learning Systems, 2014
In this brief, based on the method of penalty functions, a recurrent neural network (NN) modeled ... more In this brief, based on the method of penalty functions, a recurrent neural network (NN) modeled by means of a differential inclusion is proposed for solving the bilevel linear programming problem (BLPP). Compared with the existing NNs for BLPP, the model has the least number of state variables and simple structure. Using nonsmooth analysis, the theory of differential inclusions, and Lyapunov-like method, the equilibrium point sequence of the proposed NNs can approximately converge to an optimal solution of BLPP under certain conditions. Finally, the numerical simulations of a supply chain distribution model have shown excellent performance of the proposed recurrent NNs.
International Journal of Control Automation and Systems, 2013
ABSTRACT This paper further investigates the problem of intermittent control of a memristor-based... more ABSTRACT This paper further investigates the problem of intermittent control of a memristor-based Chua’s oscillator and presents the oscillator as the T-S fuzzy model system. Based on Lyapunov stability theory, we design an intermittent controller to guarantee the stability of the chaotic system. Simulation results are presented to verify the effectiveness of the method.
Ieee Transactions on Neural Networks and Learning Systems, 2013
This brief reports a retarded functional differential equation modeling tri-neuron network with t... more This brief reports a retarded functional differential equation modeling tri-neuron network with time delay. The Bogdanov-Takens (B-T) bifurcation is investigated by using the center manifold reduction and the normal form method. We get the versal unfolding of the norm forms at the B-T singularity and show that the model can exhibit pitchfork, Hopf, homoclinic, and double-limit cycles bifurcations. Some numerical simulations are given to support the analytic results and explore chaotic dynamics. Finally, an algorithm is given to show that chaotic tri-neuron networks can be used for encrypting a color image.
Plastic and reconstructive surgery, 2012
Cancer research, 2008
The chemokine receptor CXCR4 and its ligand, stromal cell-derived factor-1 (SDF-1), play importan... more The chemokine receptor CXCR4 and its ligand, stromal cell-derived factor-1 (SDF-1), play important roles in hematopoiesis regulation, lymphocyte activation, and trafficking, as well as in developmental processes, including organogenesis, vascularization, and embryogenesis. The receptor is also involved in HIV infection and tumor growth and metastasis. Antagonists of CXCR4 have been widely evaluated for drugs against HIV and tumors. In an effort to identify novel CXCR4 antagonists, we screened a small library of compounds derived from marine organisms and found bryostatin-5, which potently inhibits chemotaxis induced by SDF-1 in Jurkat cells. Bryostatin-5 is a member of the macrolactones, and its analogue bryostatin-1 is currently being evaluated in clinical trials for its chemotherapeutic potential. The involvement of bryostatins in the SDF-1/CXCR4 signaling process has never been reported. In this study, we found that bryostatin-5 potently inhibits SDF-1-induced chemotaxis but does...
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2013
To compare three different methods in transfection of plasmid pGPU6/GFP/Neo into chicken embryo f... more To compare three different methods in transfection of plasmid pGPU6/GFP/Neo into chicken embryo fibroblast. Different doses (1.25 μl,2 μl,2.5 μl) of Lipofec-tamin2000, Gbfectene-Elite and HilyMax were used to transfect 1 μg plasmid pGPU6/GFP/Neo. The transfection efficiency was observed by the fluorescence and the cell viabilities were measured. The transfection efficiency of HilyMax was significant higher than that of Lipofectamin2000 and Gbfectene-Elite (86.85%±2.32% compared with 48.33%±3.24% and compared with 37.35%±5.41%; F=18.882, P<0.05). The transfection efficiency of 2.5 μl HilyMax was highest(90.53%±1.15%). The cell viability of Lipofectamin2000 was significantly lower than that of HilyMax and Gbfectene-Elite(65.76%±5.78% compared with 89.54%±0.86% and compared with 82.45%±3.56%;F=90.676, P<0.05). HilyMax has the highest transfection efficiency and the lowest cell toxicity in transfection of plasmid pGPU6/GFP/Neo into chicken embryo fibroblast, with the optimal ratio...
ABSTRACT This paper studies the problem of L2 almost disturbance decoupling with global asymptoti... more ABSTRACT This paper studies the problem of L2 almost disturbance decoupling with global asymptotic stability for a class of strict feedback nonlinear system with time delays. A new recursive design method is proposed. Based on backstepping design method, it can conclude that there exists a robust control that solves the almost disturbance attenuation problem for nonlinear system with time delay
Physical Review E, 2013
Plasma defocusing and higher-order Kerr effects on multiple filamentation and pattern formation o... more Plasma defocusing and higher-order Kerr effects on multiple filamentation and pattern formation of ultrashort laser pulse propagation in air are investigated. Linear analyses and numerical results show that these two saturable nonlinear effects can destroy the coherent evolution of the laser field, and small-scale spatial turbulent structures rapidly appear. For the two-dimensional case, numerical simulations show that blow-up-like solutions, spatial chaos, and pseudorecurrence can appear at higher laser intensities if only plasma defocusing is included. These complex patterns result from the stochastic evolution of the higher- or shorter-wavelength modes of the laser light spectrum. From the viewpoint of nonlinear dynamics, filamentation can be attributed to the modulational instability of these spatial incoherent localized structures. Furthermore, filament patterns associated with multiphoton ionization of the air molecules with and without higher-order Kerr effects are compared.
Oncology reports, 2015
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide, yet effective treat... more Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide, yet effective treatment for this disease is lacking. Thus, there is an urgent need to identify novel therapeutic targets for this dreadful disease. Numerous studies have established that overexpression of astrocyte-elevated gene-1 (AEG-1) is frequently observed in multiple types of cancers including HCC, and its expression levels are correlated with the stage and grade of the disease. Further studies revealed that AEG-1 plays a key role in several crucial aspects of HCC progression, including growth, transformation, cell survival, invasion, metastasis and chemoresistance. Moreover, AEG-1 overexpression activates the Wnt/β-catenin, mitogen-actived protein kinase (MAPK), nuclear factor (NF)-κB, and PI3K/Akt signaling pathways, and promotes its downstream gene expression to facilitate malignant potential. Recently, transgenic mice with hepatocyte-specific expression of AEG-1 (Alb/AEG-1) and AEG-1-knockout mou...
2014 International Joint Conference on Neural Networks (IJCNN), 2014
World journal of gastroenterology : WJG, Jan 28, 2014
To clarify the molecular mechanism involved in pathogenesis of colorectal cancer as well as clini... more To clarify the molecular mechanism involved in pathogenesis of colorectal cancer as well as clinical significance of genetic analysis of histological samples. A total of 480 blood and tissue specimens were collected in our hospital from January 2011 to October 2012. In the observation group, there were 120 blood specimens and 120 intestinal tract tissue specimens collected from patients with neoplastic intestinal polyps. In the control group I there were 80 blood specimens and 80 intestinal tract tissue specimens collected from patients with colorectal cancer. In the control group II there were 40 blood specimens and 40 intestinal tract tissue specimens collected from healthy individuals. The gene segments were amplified using PCR and DNA gel electrophoresis along with DNA sequence analysis were employed for the detection of the following single nucleotide polymorphisms (SNPs): K-RAS codons 12 and 13; hMLH1 (human mutS homolog 1) gene missense mutation at Va1384Asp; hMSH2 (human mut...
Hepatology (Baltimore, Md.), Jan 24, 2014
Schistosomiasis is a serious parasitic disease in humans, which can lead to liver fibrosis and de... more Schistosomiasis is a serious parasitic disease in humans, which can lead to liver fibrosis and death. Accumulating evidence indicated that targeting the deregulated microRNAs could mitigate disease outcomes. Here, we showed that progressive hepatic schistosomiasis caused elevation of miR-21 and efficient and sustained inhibition of miR-21 by using highly hepatic tropic adeno-associated virus serotype 8 (rAAV8) protected mice against the lethal schistosome infection through the attenuation of hepatic fibrosis. We demonstrated an additive role of IL-13 and TGF-β1 in up-regulating the miR-21 expression in the hepatic stellate cells (HSCs) by activation of the SMAD proteins. Further, the down-regulation of miR-21 in the HSCs reversed hepatic fibrosis by enhancing SMAD7 expression, thus repressing TGF-β1/Smad and IL-13/Smad pathways. Conclusion: Our study revealed the mechanism of IL-13-mediated schistosomiasis hepatic fibrosis by up-regulation of miR-21 and highlights the potential of r...
Recently, some algorithms have been proposed for optimal real-time price in smart grid based on o... more Recently, some algorithms have been proposed for optimal real-time price in smart grid based on optimization theory. In this paper, a recurrent neural network modeled by means of a differential inclusion is proposed for solving this problem. Compared with the existing algorithms, recurrent neural network as parallel computational models for real-time optimization and applications have received substantial attention in the literature. Our model has the least number of state variables and simple structure. Using nonsmooth analysis, the theory of differential inclusions and Lyapunov-like method, the equilibrium point of the proposed neural networks can converge to an optimal solution of optimal realtime price under certain conditions. Finally, simulation results on two numerical examples show the effectiveness and performance of the proposed neural network. . He has published more than 100 journal papers. His current research interest covers computational intelligence, neural networks, memristive systems, chaos control and synchronization, and impulsive dynamical systems.
ABSTRACT In this paper, the generalized synchronization of nonlinear chaotic systems is investiga... more ABSTRACT In this paper, the generalized synchronization of nonlinear chaotic systems is investigated. Based upon reversibility of the Jacobian matrix and matrix theory, we carry out a series of elementary column transformations to Jacobian matrix. And then, according to Lyapunov function theory, sufficient conditions for generalized synchronization between drive system and response system with different dimensions are obtained. Numerical simulations are also given to demonstrate the effectiveness of the proposed scheme.
ABSTRACT This paper reports the nonlinear dynamics of a novel three-scroll chaotic system. The lo... more ABSTRACT This paper reports the nonlinear dynamics of a novel three-scroll chaotic system. The local stability of hyperbolic equilibrium and non-hyperbolic equilibrium are investigated by using center manifold theorem. Pitchfork bifurcation, degenerate pitchfork bifurcation and Hopf bifurcation are analyzed when the parameters are varied in the space of parameter. For a suitable choice of the parameters, the existence of singularly degenerate heteroclinic cycles and Hopf bifurcation without parameters are also investigated. Some numerical simulations are given to support the analytic results.
Neural Networks, 2014
In this paper, based on an equivalent mixed linear complementarity problem, we propose a neural n... more In this paper, based on an equivalent mixed linear complementarity problem, we propose a neural network to solve multiuser power control optimization problems (MPCOP), which is modeled as the noncooperative Nash game in modern digital subscriber line (DSL). If the channel crosstalk coefficients matrix is positive semidefinite, it is shown that the proposed neural network is stable in the sense of Lyapunov and global convergence to a Nash equilibrium, and the Nash equilibrium is unique if the channel crosstalk coefficients matrix is positive definite. Finally, simulation results on two numerical examples show the effectiveness and performance of the proposed neural network.
Ieee Transactions on Neural Networks and Learning Systems, 2014
In this brief, based on the method of penalty functions, a recurrent neural network (NN) modeled ... more In this brief, based on the method of penalty functions, a recurrent neural network (NN) modeled by means of a differential inclusion is proposed for solving the bilevel linear programming problem (BLPP). Compared with the existing NNs for BLPP, the model has the least number of state variables and simple structure. Using nonsmooth analysis, the theory of differential inclusions, and Lyapunov-like method, the equilibrium point sequence of the proposed NNs can approximately converge to an optimal solution of BLPP under certain conditions. Finally, the numerical simulations of a supply chain distribution model have shown excellent performance of the proposed recurrent NNs.
International Journal of Control Automation and Systems, 2013
ABSTRACT This paper further investigates the problem of intermittent control of a memristor-based... more ABSTRACT This paper further investigates the problem of intermittent control of a memristor-based Chua’s oscillator and presents the oscillator as the T-S fuzzy model system. Based on Lyapunov stability theory, we design an intermittent controller to guarantee the stability of the chaotic system. Simulation results are presented to verify the effectiveness of the method.
Ieee Transactions on Neural Networks and Learning Systems, 2013
This brief reports a retarded functional differential equation modeling tri-neuron network with t... more This brief reports a retarded functional differential equation modeling tri-neuron network with time delay. The Bogdanov-Takens (B-T) bifurcation is investigated by using the center manifold reduction and the normal form method. We get the versal unfolding of the norm forms at the B-T singularity and show that the model can exhibit pitchfork, Hopf, homoclinic, and double-limit cycles bifurcations. Some numerical simulations are given to support the analytic results and explore chaotic dynamics. Finally, an algorithm is given to show that chaotic tri-neuron networks can be used for encrypting a color image.
Plastic and reconstructive surgery, 2012
Cancer research, 2008
The chemokine receptor CXCR4 and its ligand, stromal cell-derived factor-1 (SDF-1), play importan... more The chemokine receptor CXCR4 and its ligand, stromal cell-derived factor-1 (SDF-1), play important roles in hematopoiesis regulation, lymphocyte activation, and trafficking, as well as in developmental processes, including organogenesis, vascularization, and embryogenesis. The receptor is also involved in HIV infection and tumor growth and metastasis. Antagonists of CXCR4 have been widely evaluated for drugs against HIV and tumors. In an effort to identify novel CXCR4 antagonists, we screened a small library of compounds derived from marine organisms and found bryostatin-5, which potently inhibits chemotaxis induced by SDF-1 in Jurkat cells. Bryostatin-5 is a member of the macrolactones, and its analogue bryostatin-1 is currently being evaluated in clinical trials for its chemotherapeutic potential. The involvement of bryostatins in the SDF-1/CXCR4 signaling process has never been reported. In this study, we found that bryostatin-5 potently inhibits SDF-1-induced chemotaxis but does...
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2013
To compare three different methods in transfection of plasmid pGPU6/GFP/Neo into chicken embryo f... more To compare three different methods in transfection of plasmid pGPU6/GFP/Neo into chicken embryo fibroblast. Different doses (1.25 μl,2 μl,2.5 μl) of Lipofec-tamin2000, Gbfectene-Elite and HilyMax were used to transfect 1 μg plasmid pGPU6/GFP/Neo. The transfection efficiency was observed by the fluorescence and the cell viabilities were measured. The transfection efficiency of HilyMax was significant higher than that of Lipofectamin2000 and Gbfectene-Elite (86.85%±2.32% compared with 48.33%±3.24% and compared with 37.35%±5.41%; F=18.882, P<0.05). The transfection efficiency of 2.5 μl HilyMax was highest(90.53%±1.15%). The cell viability of Lipofectamin2000 was significantly lower than that of HilyMax and Gbfectene-Elite(65.76%±5.78% compared with 89.54%±0.86% and compared with 82.45%±3.56%;F=90.676, P<0.05). HilyMax has the highest transfection efficiency and the lowest cell toxicity in transfection of plasmid pGPU6/GFP/Neo into chicken embryo fibroblast, with the optimal ratio...